Todd J. Kilbaugh, MD
Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Attending Anesthesiologist and Attending Physician, Pediatric Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia
Member, Medical Staff, Hospital of the University of Pennsylvania
Co-Director, Neurosurgical Critical Care, Children's Hospital of Philadelphia
Faculty, Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia
Medical Director, The ECMO Center , Children's Hospital of Philadelphia
Director, Resuscitation Science Center of Emphasis, Children's Hospital of Philadelphia Research Institute
Associate Chair for Research, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia
Executive Leadership, Translational Medicine , The Children's Hospital of Philadelphia, Research Insititute
Board, CHOP Clinical Innovation Committee , The Children's Hospital of Philadelphia
Cabinet Member, CHOP Strategy , The Children's Hospital of Philadelphia
Executive Board Member, Penn Health Tech, Office of Entrepreneurship and Innovation, University of Pennsylvania
Department: Anesthesiology and Critical Care
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-426-7131
Fax: 215-590-4327
Fax: 215-590-4327
Email:
kilbaugh@chop.edu
kilbaugh@chop.edu
Education:
BS (Biology)
Wake Forest University, 1994.
MD (Medicine)
Medical University of South Carolina, 1999.
Permanent linkBS (Biology)
Wake Forest University, 1994.
MD (Medicine)
Medical University of South Carolina, 1999.
Selected Publications
Silva LEV, Gaudio HA, Padmanabhan V, Forti RM, Shi L, Mason M, Sueishi T, Kirschen MP, Baker WB, Kilbaugh TJ, Morgan RW, Tsui FR, Ko TS.: Machine Learning-Based Return of Spontaneous Circulation Prediction During Cardiopulmonary Resuscitation in a Swine Model of Cardiac Arrest: Effect of Data Resolution and Multimodal Physiological Waveforms. Crit Care Med 54: 257-269, Feb 2026.Lewis A, Forti RM, Ko TS, Elmér E, McManus MJ, Yodh AG, Kilbaugh TJ, Baker WB.: Optical and Microdialysis Monitoring of Succinate Prodrug Treatment in a Rotenone-Induced Model of Mitochondrial Dysfunction in Swine. Metabolites 16: 65, Jan 2026.
McManus MJ, Zhu Y, Alves C, Kohli N, Prada-Dacasa P, Sanchez-Benito L, Sanz E, Yee I, Robinson L, Sheldon M, McHugh WJ, Ranganathan A, Meng J, Duncan N, Grönberg A, Wallace DC, Piel S, Karlsson M, Moss SJ, Webster L, Hansson MJ, Elmér E, Ehinger JK, Quintana A, Kilbaugh TJ.: The succinate prodrug NV354 prevents brain lesions and late-stage motor dysfunction in mitochondrial complex I deficiency. iScience 29: 114717, Jan 2026.
Shin SS, Browne KD, Viaene AN, Keim G, Han DJ, Degani R, Mazandi V, Morton S, Starr J, Weeks K, Widmann N, Hobson L, Gaudio H, Ko TS, Menezes-Forti R, Jang DH, Cullen DK, Kilbaugh TJ, Kao SH: Plasma and Imaging Biomarker Changes Following Rotational and Contusional Models of Traumatic Brain Injury in Adolescent Pigs. J Neurotrauma December 2025 Notes: Online ahead of print.
Loaec M, Keim G, Graham K, Kienzle MF, O'Halloran A, Shepard LN, Mehta S, Sawhney S, Donoghue M, Cooper K, Kilbaugh TJ, Nadkarni V, Topjian AA, Berg RA, Sutton RM, Morgan RW.: Comparison of vasopressin to epinephrine during pediatric in-hospital cardiac arrest: survival and physiologic responsiveness. Pediatr Res Oct 2025.
Smood B, Aronowitz DI, Noji M, Shoffler C, Abbasian D, Petucci C, Fiock KL, Hefti M, Degani R, Melchior RW, Catalano M, Arany Z, Yudkoff M, Gaynor JW, Kilbaugh T, Mavroudis CD.: Branched-Chain Amino Acids Accumulate and Glutamate Decreases in Cerebral Interstitial Fluid Following Cardiopulmonary Bypass in Neonatal Swine. Eur J Cardiothorac Surg 67: ezaf311, Oct 2025.
Morgan RW, Reeder RW, Carcillo JA, Carpenter TC, Fitzgerald JC, Graham K, Kilbaugh TJ, Meert KL, Nadkarni VM, Palmer CA, Sharron MP, Weiss SL, Wolfe HA, Ahmed T, Bell MJ, Bishop R, Burns C, Diddle JW, Fink EL, Franzon D, Frazier AH, Friess SH, Hehir DA, Horvat CM, Huard LL, Maa T, McQuillen PS, Mourani PM, Naim MY, Pollack MM, Sapru A, Srivastava N, Yates AR, Berg RA, Sutton RM; ICU-Resuscitation Project (ICU-RESUS) Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigators: Outcomes, Characteristics, and Physiology of In-Hospital Cardiac Arrest in Children With Sepsis. Critical Care Medicine 53(8): e1529-e1541, August 2025.
Siems A, Naim MY, Berg RA, Reeder RW, Ahmed T, Bell MJ, Bishop R, Bochkoris M, Burns C, Carcillo JA, Carpenter TC, Dean JM, Diddle JW, Federman M, Fernandez R, Fink EL, Franzon D, Frazier AH, Friess SH, Graham K, Hall M, Harding ML, Hehir DA, Horvat CM, Huard LL MD, Kilbaugh TJ, Maa T, Manga A, McQuillen PS, Meert KL, Mourani PM, Nadkarni VM, Notterman D, Pollack MM, Qunibi DW, Sapru A, Schneiter C, Sharron MP, Srivastava N, Tabbutt S, Tilford B, Viteri S, Wessel D, Wolfe HA, Yates AR, Zuppa AF, Morgan RW, Sutton RM.: Association of Early Epinephrine with Hemodynamics and Outcome in Pediatric In-Hospital Cardiac Arrest: A Secondary Analysis of a Multi-center, Cluster-randomized Clinical Trial (ICU-RESUS). Ann Am Thorac Soc Jun 2025.
Mazandi VM, Boggs K, Senthil K, Gabriel ED, Kumar N, Glau C, Himebauch AS, Kim CT, Kilbaugh TJ, Lang SS, Conlon T, Huh JW.: Association of left ventricular systolic dysfunction with outcome following pediatric traumatic brain injury. J Neurosurg Pediatr May 2025.
Ko TS, Greenwood JC, Morgan RW, Abella BS, Shofer FS, Mason M, Weintraub D, Bungatavula D, Lewis A, Ranieri NR, Yodh AG, Baker WB, Forti RM, Kao SH, Shin SS, Kilbaugh TJ, Jang DH.: Attenuation of mitochondrial dysfunction in a ventricular fibrillation swine model of cardiac arrest treated with carbon monoxide. Resuscitation 213: 110647, May 2025.