Selected Publications

Donna Conlon, Carolin Schneider, Yi-An Ko, Amrith Rodrigues, Kathy Guo, Nicholas J. Hand, Daniel Rader: Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions. The Journal of clinical investigation accepted - in press, Dec 2021.

Quiroz-Figueroa K, Vitali C, Conlon DM, Millar JS, Tobias JW, Bauer RC, Hand NJ, Rader DJ.: TRIB1 regulates LDL metabolism through CEBPα-mediated effects on the LDL receptor in hepatocytes. The Journal of clinical investigation 131: e146775, Nov 2021.

Larsen LE, van den Boogert MAW, Rios-Ocampo WA, Jansen JC, Conlon D, Chong PLE, Levels JHM, Eilers RE, Sachdev VV, Zelcer N, Raabe T, He M, Hand NJ, Drenth JPH, Rader DJ, Stroes ESG, Lefeber DJ, Jonker JW, Holleboom AG.: Defective Lipid Droplet-Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115. Cellular and Molecular Gastroenterology and Hepatology Page: Online ahead of print. Oct 2021.

Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, Schultz DC, Hand NJ, Cherry S, Rader DJ.: Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism. Clinical and Translational Science 14(4): 1369-1379, Jul 2021.

Polla DL, Edmondson AC, Duvet S, March ME, Sousa AB, Lehman A; CAUSES Study, Niyazov D, van Dijk F, Demirdas S, van Slegtenhorst MA, Kievit AJA, Schulz C, Armstrong L, Bi X, Rader DJ, Izumi K, Zackai EH, de Franco E, Jorge P, Huffels SC, Hommersom M, Ellard S, Lefeber DJ, Santani A, Hand NJ, van Bokhoven H, He M, de Brouwer APM.: Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation. American journal of human genetics 108: 1342-1349, Jul 2021.

Mathur B, Shajahan A, Arif W, Chen Q, Hand NJ, Abramowitz LK, Schoonjans K, Rader DJ, Kalsotra A, Hanover JA, Azadi P, Anakk S.: Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver. Science Advances 7: eabf4865, Apr 2021.

Bi X, Kuwano T, Lee PC, Millar JS, Li L, Shen Y, Soccio RE, Hand NJ, Rader DJ.: ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice. Circulation Research 127: 1347-1361, Nov 2020.

Abbey D, Elwyn S, Hand NJ, Musunuru K, Rader DJ.: Self-Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene. Hepatol Commun 4: 1316-1331, Jul 2020.

Hand NJ, Rader DJ.: Systematically Sifting Big Data to Identify Novel Causal Genes for Human Traits. Cell Metabolism 31: 658-659, Apr 2020.

Larsen LE, Smith MA, Abbey D, Korn A, Reeskamp LF, Hand NJ, Holleboom AG.: Hepatocyte-like cells derived from induced pluripotent stem cells: A versatile tool to understand lipid disorders. Atherosclerosis 303: 8-14, Mar 2020.