Nicholas J. Hand, Ph.D.

faculty photo
Research Assistant Professor of Genetics
Department: Genetics

Contact information
11-135 Smilow Center for Translational Research
Philadelphia, PA 19104-5156
Education:
BA (Genetics)
Trinity College, Dublin 2, Ireland, 1992.
Ph.D. (Molecular Biology (Mentor: Tom Silhavy))
Princeton University, 2002.
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Selected Publications

Kim Hye In, Raffler Johannes, Lu Wenyun, Lee Jung-Jin, Abbey Deepti, Saleheen Danish, Rabinowitz Joshua D, Bennett Michael J, Hand Nicholas J, Brown Christopher, Rader Daniel J: Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. American journal of human genetics 101(4): 489-502, Oct 2017.

Lin Wen, Vann David R, Doulias Paschalis-Thomas, Wang Tao, Landesberg Gavin, Li Xueli, Ricciotti Emanuela, Scalia Rosario, He Miao, Hand Nicholas J, Rader Daniel J: Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. The Journal of clinical investigation 127(6): 2407-2417, Jun 2017.

Mehta Minal B, Shewale Swapnil V, Sequeira Raymond N, Millar John S, Hand Nicholas J, Rader Daniel J: Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis. The Journal of biological chemistry 292(25): 10444-10454, Jun 2017.

Hsu Shu-Hao, Delgado Evan R, Otero P Anthony, Teng Kun-Yu, Kutay Huban, Meehan Kolin M, Moroney Justin B, Monga Jappmann K, Hand Nicholas J, Friedman Joshua R, Ghoshal Kalpana, Duncan Andrew W: MicroRNA-122 regulates polyploidization in the murine liver. Hepatology (Baltimore, Md.) 64(2): 599-615, Aug 2016.

Bauer Robert C, Khetarpal Sumeet A, Hand Nicholas J, Rader Daniel J: Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics. Trends in molecular medicine 22(4): 328-40, Apr 2016.

Nurnberg Sylvia T, Zhang Hanrui, Hand Nicholas J, Bauer Robert C, Saleheen Danish, Reilly Muredach P, Rader Daniel J: From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circulation research 118(4): 586-606, Feb 2016.

Zahm Adam M, Menard-Katcher Calies, Benitez Alain J, Tsoucas Daphne M, Le Guen Claire L, Hand Nicholas J, Friedman Joshua R: Pediatric eosinophilic esophagitis is associated with changes in esophageal microRNAs. American journal of physiology. Gastrointestinal and liver physiology 307(8): G803-12, Oct 2014.

Zahm Adam M, Hand Nicholas J, Tsoucas Daphne M, Le Guen Claire L, Baldassano Robert N, Friedman Joshua R: Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon. Journal of Crohn's & colitis 8(9): 1108-17, Sep 2014.

Kameswaran Vasumathi, Bramswig Nuria C, McKenna Lindsay B, Penn Melinda, Schug Jonathan, Hand Nicholas J, Chen Ying, Choi Inchan, Vourekas Anastassios, Won Kyoung-Jae, Liu Chengyang, Vivek Kumar, Naji Ali, Friedman Joshua R, Kaestner Klaus H: Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell metabolism 19(1): 135-45, Jan 2014.

Le Guen Claire L, Friedman Joshua R, Hand Nicholas J: Novel targets of miR-30, a microRNA required for biliary development. F1000Research 2: 197, Sep 2013.

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Last updated: 11/15/2017
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