Selected Publications

Nicholas J. Hand: A Nutraceutical Mechanistic Model Receives a Gut Check. Cellular and Molecular Gastroenterology and Hepatology Page: doi: 10.1016/j.jcmgh.2024.02.007. Feb 2024.

Eleonora Scorletti, Yedidya Saiman, Sookyoung Jeon, Carolin V Schneider, Delfin G Buyco, Chelsea Lin, Blanca E Himes, Clementina A Mesaros, Marijana Vujkovic, Kate Townsend Creasy, Emma E Furth, Jeffrey T Billheimer, Nicholas J Hand, David E Kaplan, Kyong-Mi Chang, Philip S Tsao, Julie A Lynch, Joseph L Dempsey, Julia Harkin, Susovon Bayen, Donna Conlon, Marie Guerraty, Michael C Phillips, Daniel J Rader, Rotonya M Carr: A Missense Variant in Human Perilipin 2 (Plin2 Ser251pro) Reduces Hepatic Steatosis In Mice. JHEP Reports Page: 100902, Oct 2023.

Creasy, K.T., Mehta, M., Park, J., Schneider, C.V., Shewale, S., Millar, J.S., Hand, N.J., Baur, J.A. and Rader, D.J.: PPP1R3B is a metabolic switch that shifts hepatic energy storage from lipid to glycogen. bioRXiv 2023(3): doi.org/10.1101/2023.03.04.529958, Mar 2023.

Stankov S, Vitali C, Park J, Nguyen D, Mayne L, Englander SW; Regeneron Genetics Center; Levin MG, Vujkovic M, Hand NJ, Phillips MC, Rader DJ.: Comparison of the structure-function properties of wild-type human apoA-V and a C-terminal truncation associated with elevated plasma triglycerides. medRxiv Feb 2023.

Bi X, Stankov S, Lee PC, Wang Z, Wu X, Li L, Ko YA, Cheng L, Zhang H, Hand NJ, Rader DJ.: ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors. Arterioscler Thromb Vasc Biol 42(9): 1139-1151, July 2022.

Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program; Rader DJ, Voight BF, Chang KM.: A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nat Genet 54(6): 761-771, June 2022.

Donna Conlon, Carolin Schneider, Yi-An Ko, Amrith Rodrigues, Kathy Guo, Nicholas J. Hand, Daniel Rader: Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions. The Journal of clinical investigation 132(6): e144334, Mar 2022.

Quiroz-Figueroa K, Vitali C, Conlon DM, Millar JS, Tobias JW, Bauer RC, Hand NJ, Rader DJ.: TRIB1 regulates LDL metabolism through CEBPα-mediated effects on the LDL receptor in hepatocytes. The Journal of clinical investigation 131: e146775, Nov 2021.

Larsen LE, van den Boogert MAW, Rios-Ocampo WA, Jansen JC, Conlon D, Chong PLE, Levels JHM, Eilers RE, Sachdev VV, Zelcer N, Raabe T, He M, Hand NJ, Drenth JPH, Rader DJ, Stroes ESG, Lefeber DJ, Jonker JW, Holleboom AG.: Defective Lipid Droplet-Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115. Cellular and Molecular Gastroenterology and Hepatology Page: Online ahead of print. Oct 2021.

Marijana Vujkovic1,2,*, Shweta Ramdas3,*, Kimberly M. Lorenz1,3,4, Xiuqing Guo5, Rebecca Darlay6, Heather J. Cordell6, Jing He7, Yevgeniy Gindin8, Chuhan Chung8, Rob P Meyers8, Carolin V. Schneider3, Joseph Park3,2, Kyung M. Lee9, Marina Serper1, Rotonya M. Carr2, David E. Kaplan1, Mary E. Haas10, Matthew T. MacLean3, Walter R. Witschey11, Xiang Zhu12,13,14,15, Catherine Tcheandjieu12,16, Rachel L. Kember17,18, Henry R. Kranzler17,18, Anurag Verma1,3, Ayush Giri19, Derek M. Klarin20,21,22, Yan V. Sun23,24, Jie Huang25, Jennifer Huffman21, Kate Townsend Creasy3, Nicholas J. Hand3, Ching-Ti Liu26, Michelle T. Long27, Jie Yao5, Matthew Budoff28, Jingyi Tan5, Xiaohui Li5, Henry J. Lin5, Yii-Der Ida Chen5, Kent D. Taylor5, Ruey-Kang Chang5, Ronald M. Krauss29, Silvia Vilarinho30, Joseph Brancale30, Jonas B. Nielsen31, Adam E. Locke31, Marcus B. Jones31, Niek Verweij31, Aris Baras31, K. Rajender Reddy2, Brent A. Neuschwander-Tetri32, Jeffrey B. Schwimmer33, Arun J. Sanyal34, Naga Chalasani35, Katherine A. Ryan36, Braxton D. Mitchell37, Dipender Gill38, Andrew D. Wells39,40, Elisabetta Manduchi41, Yedidya Saiman42, Nadim Mahmud42, Donald R. Miller43,44, Peter D. Reaven45,46, Lawrence S. Phillips23,47, Sumitra Muralidhar48, Scott L. DuVall9,49, Jennifer S. Lee12,16, Themistocles L. Assimes12,16, Saiju Pyarajan21,50,51, Kelly Cho21,50, Todd L. Edwards52,53, Scott M. Damrauer1,54, Peter W. Wilson23,55, J. Michael Gaziano21,50, Christopher J. O’Donnell21,50,51, Amit V. Khera20,22,51, Struan F.A. Grant56,40, Christopher D. Brown3, Philip S. Tsao12,16, Danish Saleheen57,58,59, Luca A. Lotta31, Lisa Bastarache7, Quentin M. Anstee60,61, Ann K. Daly60, James B. Meigs22,51,62, Jerome I. Rotter5, Julie A. Lynch9,49,63, Regeneron Genetics Center, DiscovEHR Collaboration, EPoS Consortium Investigators, VA Million Veteran Program, Daniel J. Rader2,3,*, Benjamin F. Voight1,3,4,64,*, Kyong-Mi Chang1,4,* *These authors contributed equally : A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. medRxiv 10.1101/2020.12.26.20248491, Aug 2021 Notes: Now accepted in peer reviewed form by Nature Genetics.