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Michael Gelfand, MD, PhD
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Associate Professor of Clinical Neurology
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Department: Neurology
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Contact information
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Department of Neurology
32 Hospital of the University of Pennsylvania
3a 3400 Spruce Street
Philadelphia, PA 19104-4283
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32 Hospital of the University of Pennsylvania
3a 3400 Spruce Street
Philadelphia, PA 19104-4283
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Office: 215-662-3606
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Education:
21 c BS & MS 33 (Molecular Biophysics and Biochemistry ) c
28 Yale University, 2001.
21 8 PhD 19 (Neuroscience) c
2f Rockefeller University, 2009.
21 7 MD 1f (Doctor of Medicine) c
36 Weill Cornell Medical College, 2010.
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Permanent link21 c BS & MS 33 (Molecular Biophysics and Biochemistry ) c
28 Yale University, 2001.
21 8 PhD 19 (Neuroscience) c
2f Rockefeller University, 2009.
21 7 MD 1f (Doctor of Medicine) c
36 Weill Cornell Medical College, 2010.
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Description of Clinical Expertise
74 Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Antiepileptic Drugs, Electrocorticography71
Description of Research Expertise
1f Clinical Trialse 29
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132 Xie K, Korzun J, Zhou DJ, Chang E, Ghosn NJ, Lavelle S, Oganisian A, Acton EK, Gelfand MA, Roth D, Litt B, Ellis CA.: Comparative effectiveness of anti-seizure medications in emulated trials using medical informatics. Brain Jul 2025.
150 Xu Z, Scheid BH, Conrad EC, Davis KA, Ganguly T, Gelfand MA, Gugger JJ, Jiang X, LaRocque JJ, Ojemann WKS, Sinha SR, Waldman GJ, Wagenaar J, Sinha N, Litt B.: Annotating neurophysiologic data at scale with optimized human input. J Neural Eng 22: 046003, Jul 2025.
185 Dave H, Sperling MR, Altalib HH, Henninger H, Porter RJ, Gelfand M, Dongre P, Elmoufti S, Martin MS, Schulz AL, French JA.: Brivaracetam effectiveness and patient-reported outcomes in clinical practice: Data from a 12-month prospective, observational study in the United States. Epilepsy Behav 173: 110565, Jul 2025.
1fd Alkofer M, Yang C, Ganglberger W, Beal J, Hegde M, Kang JY, Yoo JY, Gelfand MA, Thio LL, Kutluay E, Campbell Z, Schmitt S, Gleichgerrcht E, Waterhouse E, Lopez MR, Eisenschenk S, Galanti M, Singh RK, Wills KE, Meulenbrugge EJ, Dlugos D, Dean B, Halford JJ, Goldenholz D, Jing J, Thomas R, Westover MB.: Automated detection of interictal epileptiform discharges with few electroencephalographic channels. Epilepsia 66: e114-20, May 2025.
19c French JA, Porter RJ, Perucca E, Brodie MJ, Rogawski MA, Harden C, Qian J, Rosenblut CL, Kenney C, Beatch GN; X‐TOLE Study Group.: Interim analysis of the long-term efficacy and safety of azetukalner in an ongoing open-label extension study following a phase 2b clinical trial (X-TOLE) in adults with focal epilepsy. Epilepsia Open 2025.
157 Barnard SN, Chen Z, Kanner AM, Holmes MG, Klein P, Abou-Khalil BW, Gidal BE, French J, Perucca P; Human Epilepsy Project.: The Adverse Effects of Commonly Prescribed Antiseizure Medications in Adults With Newly Diagnosed Focal Epilepsy. Neurology 103: e209821, Oct 2024.
148 Acton EK, Hennessy S, Gelfand MA, Leonard CE, Bilker WB, Shu D, Willis AW, Kasner SE.: Direct-Acting Oral Anticoagulants and Antiseizure Medications for Atrial Fibrillation and Epilepsy and Risk of Thromboembolic Events. JAMA Neurol 81: 835-844, Aug 2024.
164 Greenwood HT, French J, Ferrer M, Jandhyala N, Thio LL, Dlugos DJ, Park KL, Kanner AM; Human Epilepsy Project Investigators.: Prevalence of Suicidality in Adolescents With Newly Diagnosed Focal Epilepsy at Diagnosis and Over the Following 36 Months. Neurology 103: e209397, Jul 2024.
176 Emmert BE, Xie K, Conrad EC, Ghosn NJ, Bauman K, Korzun J, Kulick-Soper CV, Naveed O, Hartmann N, LaRocque JJ, Mindy Ganguly T, Gugger JJ, Raghupathi R, Gelfand MA, Davis KA, Sinha SR, Litt B, Shinohara RT, Ellis CA.: Alcohol for seizure induction in the epilepsy monitoring unit. Epilepsy Behav 2024.
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Selected Publications
13e Barnard SN, Chen Z, Holmes M, Kanner AM, Hegde M, Kuzniecky R, Lowenstein D, French JA; Human Epilepsy Project (1) Investigators.: Treatment Response to Antiseizure Medications in People With Newly Diagnosed Focal Epilepsy. JAMA Neurol Aug 2025.132 Xie K, Korzun J, Zhou DJ, Chang E, Ghosn NJ, Lavelle S, Oganisian A, Acton EK, Gelfand MA, Roth D, Litt B, Ellis CA.: Comparative effectiveness of anti-seizure medications in emulated trials using medical informatics. Brain Jul 2025.
150 Xu Z, Scheid BH, Conrad EC, Davis KA, Ganguly T, Gelfand MA, Gugger JJ, Jiang X, LaRocque JJ, Ojemann WKS, Sinha SR, Waldman GJ, Wagenaar J, Sinha N, Litt B.: Annotating neurophysiologic data at scale with optimized human input. J Neural Eng 22: 046003, Jul 2025.
185 Dave H, Sperling MR, Altalib HH, Henninger H, Porter RJ, Gelfand M, Dongre P, Elmoufti S, Martin MS, Schulz AL, French JA.: Brivaracetam effectiveness and patient-reported outcomes in clinical practice: Data from a 12-month prospective, observational study in the United States. Epilepsy Behav 173: 110565, Jul 2025.
1fd Alkofer M, Yang C, Ganglberger W, Beal J, Hegde M, Kang JY, Yoo JY, Gelfand MA, Thio LL, Kutluay E, Campbell Z, Schmitt S, Gleichgerrcht E, Waterhouse E, Lopez MR, Eisenschenk S, Galanti M, Singh RK, Wills KE, Meulenbrugge EJ, Dlugos D, Dean B, Halford JJ, Goldenholz D, Jing J, Thomas R, Westover MB.: Automated detection of interictal epileptiform discharges with few electroencephalographic channels. Epilepsia 66: e114-20, May 2025.
19c French JA, Porter RJ, Perucca E, Brodie MJ, Rogawski MA, Harden C, Qian J, Rosenblut CL, Kenney C, Beatch GN; X‐TOLE Study Group.: Interim analysis of the long-term efficacy and safety of azetukalner in an ongoing open-label extension study following a phase 2b clinical trial (X-TOLE) in adults with focal epilepsy. Epilepsia Open 2025.
157 Barnard SN, Chen Z, Kanner AM, Holmes MG, Klein P, Abou-Khalil BW, Gidal BE, French J, Perucca P; Human Epilepsy Project.: The Adverse Effects of Commonly Prescribed Antiseizure Medications in Adults With Newly Diagnosed Focal Epilepsy. Neurology 103: e209821, Oct 2024.
148 Acton EK, Hennessy S, Gelfand MA, Leonard CE, Bilker WB, Shu D, Willis AW, Kasner SE.: Direct-Acting Oral Anticoagulants and Antiseizure Medications for Atrial Fibrillation and Epilepsy and Risk of Thromboembolic Events. JAMA Neurol 81: 835-844, Aug 2024.
164 Greenwood HT, French J, Ferrer M, Jandhyala N, Thio LL, Dlugos DJ, Park KL, Kanner AM; Human Epilepsy Project Investigators.: Prevalence of Suicidality in Adolescents With Newly Diagnosed Focal Epilepsy at Diagnosis and Over the Following 36 Months. Neurology 103: e209397, Jul 2024.
176 Emmert BE, Xie K, Conrad EC, Ghosn NJ, Bauman K, Korzun J, Kulick-Soper CV, Naveed O, Hartmann N, LaRocque JJ, Mindy Ganguly T, Gugger JJ, Raghupathi R, Gelfand MA, Davis KA, Sinha SR, Litt B, Shinohara RT, Ellis CA.: Alcohol for seizure induction in the epilepsy monitoring unit. Epilepsy Behav 2024.
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