Lubica Rauova, MD, PhD

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Research Associate Professor of Pediatrics (Hematology)
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
3615 Civic Center Blvd
ARC Room 316F
Philadelphia, PA 1910
Office: 215-426-2883
Lab: 215-590-1971
MD (Medicine)
Masaryk University, Brno, Czech Republic, 1987.
PhD (Internal Medicine)
Commenius University, Bratislava, Slovakia, 1992.
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Description of Research Expertise

I have extensive clinical training and research experience in the fields of autoimmunity and hematology, giving me an ideal background for unraveling molecular and cellular interactions involved in hemostasis and thrombosis. Most of my research for the past few years has been on the pathogenesis of heparin-induced thrombocytopenia (HIT), an immune mediated thrombotic disorder. Since 2003, I have been continuously funded through extramural grants in the field of HIT. My research on HIT has provided seminal insights into understanding the nature of the antigenic complexes formed by platelet factor 4 (PF4) and heparin, and my recent studies on the role of monocytes in HIT demonstrate the importance of monocyte-platelet interactions, altogether leading to a new concept for the thrombosis accompanying delayed HIT. I also have expertise in the use of mouse models of HIT, including both large and small vessel thrombosis, and in microfluidic models of HIT, studying platelet and leucocyte adhesion and fibrin formation under controlled shear stress conditions.

Selected Publications

Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev S, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB.: Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. Blood Page: doi: 10.1182, June 2021 Notes: epub ahead of print.

Gollomp K, Sarkar A, Harikumar S, Seeholzer SH, Arepally GM, Hudock KM, Rauova L, Kowalska MA, Poncz M.: Understanding how Fc-modification transforms a pathogenic HIT-like monoclonal antibody into a novel treatment for sepsis. Blood 135(10): 743-754, Nov 2019.

Dai J, Madeeva D, Hayes V, Ahn HS, Tutwiler V, Arepally GM, Cines DB, Poncz M, Rauova L: Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. Blood 132(7):727-734(2): 727-734, August 2018.

Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M and Rauova L: Platelet transactivation by monocytes promotes the prothrombotic state in heparin-induced thrombocytopenia. Blood 127(4): 464, Feb 2016.

Rauova L, Arepally G, Poncz M, Cines DB: Molecular and cellular pathogenesis of heparin-induced thrombocytopenia Autoimmun Rev 17(10): 1046-1052, Oct 2018.

Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. J Clin Invest 127(3): 1090-1098. March 2017.

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB, Greene MI: Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature Communications 6(8277): 9277, Sep 2015.

Finley MJ, Rauova L, Alferiev IS, Weisel JW, Levy RJ, Stachelek SJ: Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces. Biomaterials 33(24): 5803-11, Aug 2012.

Fuentes R, Wang Y, Hirsch J, Wang Ch, Rauova L, Worthen GS, Kowalska MA, Poncz M: Infusion of mature megakaryocytes into mice yields functional platelets. The Journal of clinical investigation 120(11): 3917-22, Nov 2010.

Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M: Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood 116(23): 5021-31, Dec 2010.

Rauova L, Zhai L, Kowalska MA, Arepally GM, Cines DB, Poncz M: Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood 107(6): 2346-53, Mar 2006.

Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS: Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood 105(1): 131-8, Jan 2005.

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Last updated: 01/12/2023
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