Paul J Planet, Ph.D, M.D.

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Assistant Professor of Pediatrics
Chair of Institutional Biosafety Comittee, Children's Hospital of Philadelphia
Co-Director Microbial Archive and Cryocollection, Children's Hospital of Philadelphia
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson 1202A
Philadelphia, PA 19104
Office: 9175140695
BS (Molecular Biophysics & Biochemistry and Anthropology)
Yale University, New Haven, CT, 1996.
Ph.D (Integrated Program for Cellular, Molecular, and Biophysical Studies)
Columbia University College of Physicians & Surgeons, New York, NY , 2003.
Columbia University College of Physicians & Surgeons, New York, NY, 2004.
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Description of Clinical Expertise

Dr. Planet is a pediatric infectious disease specialist. Dr. Planet has specific areas of interest in antibiotic resistant infections (MRSA), respiratory infections, and chronic infections in patients with cystic fibrosis.

Description of Other Expertise

Evolution of SARS-CoV-2

Description of Research Expertise

Paul J. Planet MD, PhD is an Assistant Professor of Pediatrics at the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania. He is also a senior researcher at the American Museum of Natural History.

Dr. Planet graduated from Yale University with a Bachelors degree in Anthropology and Molecular Biochemistry & Biophysics. He went on to earn his MD and PhD from Columbia University, where he also completed his residency and fellowship training at the Children’s Hospital of New York. His first faculty appointment was in the division of Pediatric Infectious Disease at Columbia University.

Dr. Planet’s research program focuses on the evolution and ecology of infectious disease. His current interests include the evolution and spread of antibiotic resistant strains, particularly community acquired MRSA, and the impact of the pulmonary microbiome in cystic fibrosis. Dr. Planet’s laboratory uses whole genome phylogenetics, high-throughput sequencing, and bioinformatics to generate hypotheses that are then tested with bench-based microbiology and molecular techniques.

Selected Publications

Saenkham-Huntsinger P, Hyre AN, Hanson BS, Donati GL, Adams LG, Ryan C, Londoño A, Moustafa AM, Planet PJ, Subashchandrabose S: Copper Resistance Promotes Fitness of Methicillin-Resistant Staphylococcus aureus during Urinary Tract Infection. mBio 7, September 2021.

Moustafa AM, Planet PJ.: Jumping a Moving Train: SARS-CoV-2 Evolution in Real Time. J Pediatric Infect Dis Soc. August 2021.

Moustafa AM, Planet PJ.: Emerging SARS-CoV-2 diversity revealed by rapid whole genome sequence typing. Genome Biology and Evolution August 2021.

Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Planet PJ, Muller FL, Jez JM, Odom John AR.: Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife July 2021.

Moustafa AM, Bianco C, Denu L, Ahmed A, Coffin SE, Neide B, Everett J, Reddy S, Rabut E, Deseignora J, Feldman MD, Rodino KG, Bushman F, Harris RM, Chang Mell J, Planet PJ.: Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates. Open Forum Infect Dis. June 2021.

Perelman SS, James DBA, Boguslawski KM, Nelson CW, Ilmain JK, Zwack EE, Prescott RA, Mohamed A, Tam K, Chan R, Narechania A, Pawline MB, Vozhilla N, Moustafa AM, Kim SY, Dittmann M, Ekiert DC, Bhabha G, Shopsin B, Planet PJ, Koralov SB, Torres VJ.: Genetic variation of staphylococcal LukAB toxin determines receptor tropism. Nat Microbiol June 2021.

Dalton KR, Ruble K, Redding LE, Morris DO, Mueller NT, Thorpe RJ Jr, Agnew J, Carroll KC, Planet PJ, Rubenstein RC, Chen AR, Grice EA, Davis MF.: Microbial Sharing between Pediatric Patients and Therapy Dogs during Hospital Animal-Assisted Intervention Programs. Microorganisms May 2021.

Côrtes MF, Botelho AMN, Bandeira PT, Mouton W, Badiou C, Bes M, Lima NCB, Soares AER, Souza RC, Almeida LGP, Martins-Simoes P, Vasconcelos ATR, Nicolás MF, Laurent F, Planet PJ, Figueiredo AMS.: Reductive evolution of virulence repertoire to drive the divergence between community- and hospital-associated methicillin-resistant Staphylococcus aureus of the ST1 lineage. Virulence March 2021.

Moustafa AM, Velusamy SK, Denu L, Narechania A, Fine DH, Planet PJ.: Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans. mBio March 2021.

Penna B, Silva MB, Soares AER, Vasconcelos ATR, Ramundo MS, Ferreira FA, Silva-Carvalho MC, de Sousa VS, Rabello RF, Bandeira PT, de Souza VS, Planet PJ, Vieira-da-Motta O, Botelho AMN, Figueiredo AMS.: Comparative genomics of MRSA strains from human and canine origins reveals similar virulence gene repertoire. Sci Rep February 2021.

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Last updated: 09/08/2021
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