Paul J Planet, Ph.D, M.D.

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Assistant Professor of Pediatrics (Infectious Diseases)
Chair, Institutional Biosafety Committee, CHOP Research Institute
Co-Director, Microbial Archive and Cryocollection, Children's Hospital of Philadelphia
Co-Director, Center for Microbial Medicine, Children's Hospital of Philadelphia
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson 1202A
Philadelphia, PA 19104
Office: 9175140695
Education:
BS (Molecular Biophysics & Biochemistry and Anthropology)
Yale University, New Haven, CT, 1996.
Ph.D (Integrated Program for Cellular, Molecular, and Biophysical Studies)
Columbia University College of Physicians & Surgeons, New York, NY , 2003.
MD
Columbia University College of Physicians & Surgeons, New York, NY, 2004.
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Description of Clinical Expertise

Dr. Planet is a pediatric infectious disease specialist. Dr. Planet has specific areas of interest in antibiotic resistant infections (MRSA), respiratory infections, and chronic infections in patients with cystic fibrosis.

Description of Other Expertise

Evolution of SARS-CoV-2

Description of Research Expertise

Paul J. Planet MD, PhD is an Assistant Professor of Pediatrics at the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania. He is also a senior researcher at the American Museum of Natural History.

Dr. Planet graduated from Yale University with a Bachelors degree in Anthropology and Molecular Biochemistry & Biophysics. He went on to earn his MD and PhD from Columbia University, where he also completed his residency and fellowship training at the Children’s Hospital of New York. His first faculty appointment was in the division of Pediatric Infectious Disease at Columbia University.

Dr. Planet’s research program focuses on the evolution and ecology of infectious disease. His current interests include the evolution and spread of antibiotic resistant strains, particularly community acquired MRSA, and the impact of the pulmonary microbiome in cystic fibrosis. Dr. Planet’s laboratory uses whole genome phylogenetics, high-throughput sequencing, and bioinformatics to generate hypotheses that are then tested with bench-based microbiology and molecular techniques.

Selected Publications

Fischer AJ, Planet PJ.: A birth cohort approach to understanding cystic fibrosis lung infections. J Cyst Fibros Nov 2024.

Zhang SL, McGann CM, Duranova T, Strysko J, Steenhoff AP, Gezmu A, Nakstad B, Arscott-Mills T, Bayani O, Moorad B, Tlhako N, Richard-Greenblatt M, Planet PJ, Coffin SE, Silverman MA.: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with broad protection from neonatal sepsis: a case-control study of hospitalized neonates in Botswana. medRxiv May 2024.

Soldan SS, Su C, Monaco MC, Yoon L, Kannan T, Zankharia U, Patel RJ, Dheekollu J, Vladimirova O, Dowling JW, Thebault S, Brown N, Clauze A, Andrada F, Feder A, Planet PJ, Kossenkov A, Schäffer DE, Ohayon J, Auslander N, Jacobson S, Lieberman PM.: Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active disease. Nat Microbiol May 2024.

Morreale DP, St Geme Iii JW, Planet PJ.: Phylogenomic analysis of the understudied Neisseriaceae species reveals a poly- and paraphyletic Kingella genus. Microbiol Spectr 11: e0312323, Dec 2023.

Esteves MAC, Viana AS, Viçosa GN, Botelho AMN, Moustafa AM, Mansoldo FRP, Ferreira ALP, Vermelho AB, Ferreira-Carvalho BT, Planet PJ, Figueiredo AMS.: RdJ detection tests to identify a unique MRSA clone of ST105-SCCmecII lineage and its variants disseminated in the metropolitan region of Rio de Janeiro. Front Microbiol 14: 1275918, Nov 2023.

Martini CL, Silva DNS, Viana AS, Planet PJ, Figueiredo AMS, Ferreira-Carvalho BT.: Streptococcus pyogenes Lineage ST62/emm87: The International Spread of This Potentially Invasive Lineage. Antibiotics (Basel) 12: 1530, Oct 2023.

Campbell AE, McCready-Vangi AR, Uberoi A, Murga-Garrido SM, Lovins VM, White EK, Pan JT, Knight SAB, Morgenstern AR, Bianco C, Planet PJ, Gardner SE, Grice EA.: Variable staphyloxanthin production by Staphylococcus aureus drives strain-dependent effects on diabetic wound-healing outcomes. Cell Rep 42: 113281, Oct 2023.

Pitcher NJ, Feder A, Bolden N, Zirbes CF, Pamatmat AJ, Boyken L, Hill JJ, Bartels AR, Thurman AL, Reeb VC, Porterfield HS, Moustafa AM, Planet PJ, Fischer AJ.: Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis. Microbiol Spectr 11: e0208423, Sep 2023.

Martínez JRW, Planet PJ, Spencer-Sandino M, Rivas L, Díaz L, Moustafa AM, Quesille-Villalobos A, Riquelme-Neira R, Alcalde-Rico M, Hanson B, Carvajal LP, Rincón S, Reyes J, Lam M, Calderon JF, Araos R, García P, Arias CA, Munita JM.: Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016). Microbiol Spectr 11: e0535122, Aug 2023.

Morreale DP, Porsch EA, Kern BK, St Geme JW 3rd, Planet PJ.: Acquisition, co-option, and duplication of the rtx toxin system and the emergence of virulence in Kingella. Nat Commun 14: 4281, Jul 2023.

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Last updated: 07/08/2024
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