Victoria E. Johnson, MBChB, Ph.D.

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Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
173 Stemmler Hall,
3450 Hamilton Walk,
Philadelphia, PA 19104
Education:
BSc (Clinical Neuroscience)
The University of Glasgow, 2003.
MBChB (Medicine)
The University of Glasgow, 2005.
Ph.D. (Neuropathology)
The University of Glasgow, 2012.
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Description of Research Expertise

Dr. Johnson received both her medical degree and PhD from the University of Glasgow, UK. She then pursued a post-doctoral fellowship with Dr. Douglas H. Smith, M.D. at the Dept. Neurosurgery, University of Pennsylvania and the Penn Center for Brain Injury and Repair.
Her research focuses on the chronic neuropathological sequelae of traumatic brain injury (TBI), including the links between TBI and neurodegenerative disease. Specifically, Dr Johnson has extensive experience in examining post—mortem brain tissue acutely and chronically following TBI in humans. In recent publications, Dr. Johnson and colleagues demonstrated that even a single TBI is associated with an increased incidence of Alzheimer-associated pathologies many years after injury. Moreover, it was identified that a single severe TBI can also induce chronic neuroinflammation, axonal pathology and blood brain barrier (BBB) permeability that can persist for months and even years in some individuals after injury. More recent work endeavors to better understand the specific mechanisms of BBB dysfunction both acutely and chronically post-TBI.
Understanding the temporal changes following TBI by examining both clinical material and utilizing novel model systems, will be critical for the development of treatments for TBI patients.

Selected Publications

Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee V M.-Y, Trojanowski JQ, Stewart W, Johnson VE: Tau ImmunoPhenotypes in Chronic Traumatic Encephalopathy Recapitulate those of Aging and Alzheimer’s Disease. Brain Accepted, 2020.

Lee Edward B, Kinch Kevin, Johnson Victoria E, Trojanowski John Q, Smith Douglas H, Stewart William: Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players. Acta neuropathologica 138(3): 389-399, Sep 2019.

Stewart William, Allinson Kieren, Al-Sarraj Safa, Bachmeier Corbin, Barlow Karen, Belli Antonio, Burns Mark P, Carson Alan, Crawford Fiona, Dams-O'Connor Kristen, Diaz-Arrastia Ramon, Dixon C Edward, Edlow Brian L, Ferguson Scott, Fischl Bruce, Folkerth Rebecca D, Gentleman Steve, Giza Christopher C, Grady M Sean, Helmy Adel, Herceg Mark, Holton Janice L, Howell David, Hutchinson Peter J, Iacono Diego, Iglesias Juan E, Ikonomovic Milos D, Johnson Victoria E, Keene C Dirk, Kofler Julia K, Koliatsos Vassilis E, Lee Edward B, Levin Harvey, Lifshitz Jonathan, Ling Helen, Loane David J, Love Seth, Maas Andrew Ir, Marklund Niklas, Master Christina L, McElvenny Damien M, Meaney David F, Menon David K, Montine Thomas J, Mouzon Benoit, Mufson Elliott J, Ojo Joseph O, Prins Mayumi, Revesz Tamas, Ritchie Craig W, Smith Colin, Sylvester Richard, Tang Cheuk Y, Trojanowski John Q, Urankar Kathryn, Vink Robert, Wellington Cheryl, Wilde Elisabeth A, Wilson Lindsay, Yeates Keith, Smith Douglas H: Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology 18(3): 231-233, Mar 2019.

Smith Douglas H, Johnson Victoria E, Trojanowski John Q, Stewart William: Chronic traumatic encephalopathy - confusion and controversies. Nature reviews. Neurology 15(3): 179-183, Mar 2019.

Ulyanova Alexandra V, Cottone Carlo, Adam Christopher D, Gagnon Kimberly G, Cullen D Kacy, Holtzman Tahl, Jamieson Brian G, Koch Paul F, Chen H Isaac, Johnson Victoria E, Wolf John A: Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals. Frontiers in neuroscience 13: 397, 2019.

Weber Maura T, Arena John D, Xiao Rui, Wolf John A, Johnson Victoria E: CLARITY reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury. Brain pathology (Zurich, Switzerland) 29(3): 437-450, 05 2019.

Weber MT, Arena JD, Xiao R, Wolf JA, Johnson VE: CLARITY Reveals a More Protracted Temporal Course of Axon Swelling and Disconnection than Previously Described Following Traumatic Brain Injury. Brain Pathology Accepted, November 2018.

Suto Yujin, Nagata Katsuhiro, Ahmed Syed M, Jacovides Christina L, Browne Kevin D, Cognetti John, Johnson Victoria E, Leone Ryan, Kaplan Lewis J, Smith Douglas H, Pascual Jose L: Cerebral Edema and Neurological Recovery after Traumatic Brain Injury Are Worsened if Accompanied by a Concomitant Long Bone Fracture. Journal of neurotrauma Sep 2018 Notes: [Epub Ahead of Print] DOI: 10.1089/neu.2018.5812.

Alexandra V Ulyanova, Paul F Koch, Michael R Grovola, Kevin D Browne, Robin J Russo, Christopher D Adam, Douglas H Smith, H. Isaac Chen, Victoria E Johnson, D. Kacy Cullen, John A Wolf: Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus. eNeuro 5(5): pii.ENEURO.0102-18-2018, Sep 2018.

Suto Yujin, Nagata Katsuhiro, Ahmed Syed M, Jacovides Christina, Browne Kevin D, Cognetti John, Weber Maura T, Johnson Victoria E, Leone Ryan, Kaplan Lewis J, Smith Douglas H, Pascual Jose L: A concomitant bone fracture delays cognitive recovery from traumatic brain injury. The journal of trauma and acute care surgery 85(2): 275-284, Aug 2018.

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Last updated: 08/05/2020
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