Victoria E. Johnson, MBChB, Ph.D.

faculty photo
Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
173 Stemmler Hall,
3450 Hamilton Walk,
Philadelphia, PA 19104
Office: 215 254 8637
Lab: 215 746 1866
Education:
BSc (Clinical Neuroscience)
The University of Glasgow, 2003.
MBChB (Medicine)
The University of Glasgow, 2005.
Ph.D. (Neuropathology)
The University of Glasgow, 2012.
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Description of Research Expertise

Dr. Johnson received both her medical degree and PhD from the University of Glasgow, UK. She then pursued a post-doctoral fellowship with Dr. Douglas H. Smith, M.D. at the Dept. Neurosurgery, University of Pennsylvania and the Penn Center for Brain Injury and Repair. Her research focuses on the chronic neuropathological sequelae of traumatic brain injury (TBI), including the links between TBI and Alzheimer’s disease. Specifically, Dr Johnson has extensive experience in examining post—mortem brain tissue acutely and chronically following TBI in humans. In recent publications, Dr. Johnson and colleagues demonstrated that even a single TBI is associated with an increased incidence of Alzheimer-associated pathologies many years after injury. Moreover, it was identified that a single TBI can also induce chronic neuroinflammation in association with ongoing axonal pathology and white matter degeneration for years post-trauma. As such, inflammation may be an important contributor to long-term TBI-associated neurodegeneration.
Dr. Johnson is also interested in potential genetic influences on the development of neurodegenerative pathologies after TBI. Specifically, recent work shows that a polymorphism in the neprilysin gene is able to predict the likelihood of plaque formation in patients after TBI.
Understanding the temporal changes following TBI by examining both clinical material and utilizing model systems, will be critical for the development of novel treatments for TBI patients.

Selected Publications

Katsuhiro Nagata, Kevin D. Browne, Yujin Suto, Kenichiro Kumasaka, John Cognetti, Victoria E. Johnson, Joshua Marks, Douglas H. Smith, Jose L. Pascual: Early heparin administration after traumatic brain injury: Prolonged cognitive recovery associated with reduced cerebral edema and neutrophil sequestration. Trauma Acute Care Surg 83(3): 406-412, Sept 2017.

Kovacs Gabor G, Xie Sharon X, Lee Edward B, Robinson John L, Caswell Carrie, Irwin David J, Toledo Jon B, Johnson Victoria E, Smith Douglas H, Alafuzoff Irina, Attems Johannes, Bencze Janos, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Budka Herbert, Dickson Dennis W, Dugger Brittany N, Duyckaerts Charles, Ferrer Isidro, Forrest Shelley L, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Grinberg Lea T, Halliday Glenda M, Hatanpaa Kimmo J, Hof Patrick R, Hofer Monika, Hortobágyi Tibor, Ironside James W, King Andrew, Kofler Julia, Kövari Enikö, Kril Jillian J, Love Seth, Mackenzie Ian R, Mao Qinwen, Matej Radoslav, McLean Catriona, Munoz David G, Murray Melissa E, Neltner Janna, Nelson Peter T, Ritchie Diane, Rodriguez Roberta D, Rohan Zdenek, Rozemuller Annemieke, Sakai Kenji, Schultz Christian, Seilhean Danielle, Smith Vanessa, Tacik Pawel, Takahashi Hitoshi, Takao Masaki, Rudolf Thal Dietmar, Weis Serge, Wharton Stephen B, White Charles L, Woulfe John M, Yamada Masahito, Trojanowski John Q: Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of neuropathology and experimental neurology Jun 2017.

Nagata Katsuhiro, Browne Kevin D, Suto Yujin, Kumasaka Kenichiro, Cognetti John, Johnson Victoria E, Marks Joshua, Smith Douglas H, Pascual Jose L: Early Heparin Administration After TBI: Prolonged Cognitive Recovery Associated With Reduced Cerebral Edema and Neutrophil Sequestration. The journal of trauma and acute care surgery 83(3): 406-412, May 2017.

Wolf John A, Johnson Brian N, Johnson Victoria E, Putt Mary E, Browne Kevin D, Mietus Constance J, Brown Daniel P, Wofford Kathryn L, Smith Douglas H, Grady M Sean, Cohen Akiva S, Cullen D Kacy: Concussion Induces Hippocampal Circuitry Disruption in Swine. Journal of neurotrauma Mar 2017.

Johnson Victoria E, Stewart William, Arena John D, Smith Douglas H: Traumatic Brain Injury as a Trigger of Neurodegeneration. Advances in neurobiology 15: 383-400, 2017.

Nagata Katsuhiro, Kumasaka Kenichiro, Browne Kevin D, Li Shengjie, St-Pierre Jesse, Cognetti John, Marks Joshua, Johnson Victoria E, Smith Douglas H, Pascual Jose L: Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery. The journal of trauma and acute care surgery 81(6): 1088-1094, Dec 2016.

Li Shengjie, Eisenstadt Rachel, Kumasaka Kenichiro, Johnson Victoria E, Marks Joshua, Nagata Katsuhiro, Browne Kevin D, Smith Douglas H, Pascual Jose L: Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and neurologic recovery. The journal of trauma and acute care surgery 80(3): 381-9, Mar 2016.

Hay Jennifer, Johnson Victoria E, Smith Douglas H, Stewart William: Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury. Annual review of pathology 11: 21-45, Jan 2016.

Johnson Victoria E, Stewart William, Weber Maura T, Cullen D Kacy, Siman Robert, Smith Douglas H: SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury. Acta neuropathologica 131(1): 115-35, Jan 2016.

Ali Zarina S, Johnson Victoria E, Stewart William, Zager Eric L, Xiao Rui, Heuer Gregory G, Weber Maura T, Mallela Arka N, Smith Douglas H: Neuropathological Characteristics of Brachial Plexus Avulsion Injury With and Without Concomitant Spinal Cord Injury. Journal of neuropathology and experimental neurology Dec 2015.

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Last updated: 09/01/2017
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