Victoria E. Johnson, MBChB, Ph.D.

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Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
173 Stemmler Hall,
3450 Hamilton Walk,
Philadelphia, PA 19104
BSc (Clinical Neuroscience)
The University of Glasgow, 2003.
MBChB (Medicine)
The University of Glasgow, 2005.
Ph.D. (Neuropathology)
The University of Glasgow, 2012.
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Description of Research Expertise

Dr. Johnson received both her medical degree and PhD from the University of Glasgow, UK. She then pursued a post-doctoral fellowship with Dr. Douglas H. Smith, M.D. at the Dept. Neurosurgery, University of Pennsylvania and the Penn Center for Brain Injury and Repair.
Her research focuses on the chronic neuropathological sequelae of traumatic brain injury (TBI), including the links between TBI and neurodegenerative disease. Specifically, Dr Johnson has extensive experience in examining post—mortem brain tissue acutely and chronically following TBI in humans. In recent publications, Dr. Johnson and colleagues demonstrated that even a single TBI is associated with an increased incidence of Alzheimer-associated pathologies many years after injury. Moreover, it was identified that a single severe TBI can also induce chronic neuroinflammation, axonal pathology and blood brain barrier (BBB) permeability that can persist for months and even years in some individuals after injury. More recent work endeavors to better understand the specific mechanisms of BBB dysfunction both acutely and chronically post-TBI.
Understanding the temporal changes following TBI by examining both clinical material and utilizing novel model systems, will be critical for the development of treatments for TBI patients.

Selected Publications

Weber MT, Arena JD, Xiao R, Wolf JA, Johnson VE: CLARITY Reveals a More Protracted Temporal Course of Axon Swelling and Disconnection than Previously Described Following Traumatic Brain Injury. Brain Pathology Accepted, November 2018.

Suto Yujin, Nagata Katsuhiro, Ahmed Syed M, Jacovides Christina L, Browne Kevin D, Cognetti John, Johnson Victoria E, Leone Ryan, Kaplan Lewis J, Smith Douglas H, Pascual Jose L: Cerebral Edema and Neurological Recovery after Traumatic Brain Injury Are Worsened if Accompanied by a Concomitant Long Bone Fracture. Journal of neurotrauma Sep 2018 Notes: [Epub Ahead of Print] DOI: 10.1089/neu.2018.5812.

Alexandra V Ulyanova, Paul F Koch, Michael R Grovola, Kevin D Browne, Robin J Russo, Christopher D Adam, Douglas H Smith, H. Isaac Chen, Victoria E Johnson, D. Kacy Cullen, John A Wolf: Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus. eNeuro 5(5): pii.ENEURO.0102-18-2018, Sep 2018.

Suto Yujin, Nagata Katsuhiro, Ahmed Syed M, Jacovides Christina, Browne Kevin D, Cognetti John, Weber Maura T, Johnson Victoria E, Leone Ryan, Kaplan Lewis J, Smith Douglas H, Pascual Jose L: A concomitant bone fracture delays cognitive recovery from traumatic brain injury. The journal of trauma and acute care surgery 85(2): 275-284, Aug 2018.

Johnson Victoria E, Weber Maura T, Xiao Rui, Cullen D Kacy, Meaney David F, Stewart William, Smith Douglas H: Mechanical disruption of the blood-brain barrier following experimental concussion. Acta neuropathologica 135(5): 711-726, May 2018.

Nagata Katsuhiro, Suto Yujin, Cognetti John, Browne Kevin D, Kumasaka Kenichiro, Johnson Victoria E, Kaplan Lewis, Marks Joshua, Smith Douglas H, Pascual Jose L: Early low-anticoagulant desulfated heparin after traumatic brain injury: Reduced brain edema and leukocyte mobilization is associated with improved watermaze learning ability weeks after injury. The journal of trauma and acute care surgery 84(5): 727-735, May 2018.

Katsuhiro Nagata, Kevin D. Browne, Yujin Suto, Kenichiro Kumasaka, John Cognetti, Victoria E. Johnson, Joshua Marks, Douglas H. Smith, Jose L. Pascual: Early heparin administration after traumatic brain injury: Prolonged cognitive recovery associated with reduced cerebral edema and neutrophil sequestration. Trauma Acute Care Surg 83(3): 406-412, Sept 2017.

Wolf John A, Johnson Brian N, Johnson Victoria E, Putt Mary E, Browne Kevin D, Mietus Constance J, Brown Daniel P, Wofford Kathryn L, Smith Douglas H, Grady M Sean, Cohen Akiva S, Cullen D Kacy: Concussion Induces Hippocampal Circuitry Disruption in Swine. Journal of neurotrauma 34(14): 2303-2314, Jul 2017.

Kovacs Gabor G, Xie Sharon X, Lee Edward B, Robinson John L, Caswell Carrie, Irwin David J, Toledo Jon B, Johnson Victoria E, Smith Douglas H, Alafuzoff Irina, Attems Johannes, Bencze Janos, Bieniek Kevin F, Bigio Eileen H, Bodi Istvan, Budka Herbert, Dickson Dennis W, Dugger Brittany N, Duyckaerts Charles, Ferrer Isidro, Forrest Shelley L, Gelpi Ellen, Gentleman Stephen M, Giaccone Giorgio, Grinberg Lea T, Halliday Glenda M, Hatanpaa Kimmo J, Hof Patrick R, Hofer Monika, Hortobágyi Tibor, Ironside James W, King Andrew, Kofler Julia, Kövari Enikö, Kril Jillian J, Love Seth, Mackenzie Ian R, Mao Qinwen, Matej Radoslav, McLean Catriona, Munoz David G, Murray Melissa E, Neltner Janna, Nelson Peter T, Ritchie Diane, Rodriguez Roberta D, Rohan Zdenek, Rozemuller Annemieke, Sakai Kenji, Schultz Christian, Seilhean Danielle, Smith Vanessa, Tacik Pawel, Takahashi Hitoshi, Takao Masaki, Rudolf Thal Dietmar, Weis Serge, Wharton Stephen B, White Charles L, Woulfe John M, Yamada Masahito, Trojanowski John Q: Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of neuropathology and experimental neurology 76(7): 605-619, Jul 2017.

Nagata Katsuhiro, Browne Kevin D, Suto Yujin, Kumasaka Kenichiro, Cognetti John, Johnson Victoria E, Marks Joshua, Smith Douglas H, Pascual Jose L: Early Heparin Administration After TBI: Prolonged Cognitive Recovery Associated With Reduced Cerebral Edema and Neutrophil Sequestration. The journal of trauma and acute care surgery 83(3): 406-412, May 2017.

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Last updated: 01/14/2019
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