Selected Publications

Hunter TL, Bao Y, Zhang Y, Matsuda D, Riener R, Wang A, Li JJ, Soldevila F, Chu DSH, Nguyen DP, Yong QC, Ross B, Nguyen M, Vestal J, Roberts S, Galvan D, Vega JB, Jhung D, Butcher M, Nguyen J, Zhang S, Fernandez C, Chen J, Herrera C, Kuo Y, Pica EM, Mondal G, Mammen AL, Scholler J, Tanis SP, Sievers SA, Frantz AM, Adams GB, Shawver L, Farzaneh-Far R, Rosenzweig M, Karmali PP, Bot AI, June CH, Aghajanian H.: In vivo CAR T cell generation to treat cancer and autoimmune disease. Science 388: 1311-1317, Jun 2025.

Caitlin M. Tilsed, Barzan A. Sadiq, Tyler E. Papp, Phurin Areesawangkit, Kenji Kimura, Estela Noguera-Ortega, John Scholler, Nicholas Cerda, Haig Aghajanian, Adrian Bot, Barbara Mui, Ying, Drew Weissman, Carl H. June : IL7 increases targeted lipid nanoparticle–mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation. PNAS 121(13): e2319856121, Mar 26 2024.

Haig Aghajanian, Joel G Rurik, Jonathan A Epstein: CAR-based therapies: opportunities for immuno-medicine beyond cancer. Nature Metab. 4(2): 163-169, Feb 2022.

Joel G. Rurik1, István Tombácz, Amir Yadegari, Pedro O. Méndez Fernández, Swapnil V. Shewale, Li Li, Toru Kimura, Ousamah Younoss Soliman, Tyler E. Papp, Ying K. Tam, Barbara L. Mui, Steven M. Albelda, Ellen Puré, Carl H. June, Haig Aghajanian, Drew Weissman, Hamideh Parhiz, Jonathan A. Epstein: CAR T cells produced in vivo to treat cardiac injury. Science 375(6576): 91-96, Jan 7 2022.

Rurik JG, Aghajanian H, Epstein JA: Immune Cells and Immunotherapy for Cardiac Injury and Repair. Circ Res 128(11): 1766-1779, May 2021.

Aghajanian H, Kimura T, Hancock AS, Li L, Scholler J, Han W, Wang T, Bedi K, Morley MP, Wirth D, Margulies KB, Jain R, Puré E, Albelda SM, June CH, Epstein JA: Targeting cardiac fibrosis with engineered T cells. Nature 573(7774): 430-433, Sep 2019.

Artap S, Manderfield LJ, Smith CL, Poleshko A, Aghajanian H, See K, Li L, Jain R, Epstein JA: Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol 440(1): 22-30, Aug 2018.

Pauerstein P, Tellez K, Willmarth KB, Park KM, Hsueh B, Arda HE, Gu X, Aghajanian H, Deisseroth K, Epstein JA, Kim SE: A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis. Development 144(20): 3744-3754, Oct 2017.

Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R: Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell 171(3): 573-587, Oct 2017.

Aghajanian H, Cho YK, Rizer NW, Wang Q, Li L, Degenhardt K, Jain R: Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries. Dis Model Mech 10(9): 1101-1108, Sep 2017.