Janet L Kwiatkowski, MD, MSCE
Professor of Pediatrics (Hematology) at the Children's Hospital of Philadelphia
Consulting Hematologist, Hospital of the University of Pennsylvania
Consulting Hematologist, Pennsylvania Hospital
Director, Thalassemia Program, Children's Hospital of Philadelphia
Clinical Director, Sickle Cell and Red Cell Disorders Curative Therapy Center (CuRED)
Department: Pediatrics
Contact information
The Children's Hospital of Philadelphia
Division of Hematology
3500 Civic Center Blvd
Hub Room #13547
Philadelphia, PA 19104
Division of Hematology
3500 Civic Center Blvd
Hub Room #13547
Philadelphia, PA 19104
Office: 215-590-5286
Fax: 215-590-3992
Fax: 215-590-3992
Email:
kwiatkowski@chop.edu
kwiatkowski@chop.edu
Education
B.S. (Zoology)
Duke University, summa cum laude, 1988.
M.D.
Columbia University, College of Physicians & Surgeons, 1992.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
Permanent linkB.S. (Zoology)
Duke University, summa cum laude, 1988.
M.D.
Columbia University, College of Physicians & Surgeons, 1992.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
Description of Research Expertise
Optimization of iron chelation, monitoring transfusional iron overload, stroke prevention in sickle cell disease, headaches in sickle cell disease, complications of thalassemia, transfusion therapy, gene therapy for hemoglobinopathiesDescription of Clinical Expertise
General pediatric hematology, iron deficiency anemia, thalassemia, sickle cell disease, transfusional iron overload, chelation therapySelected Publications
Sheth S , Corbacioglu S , de la Fuente J, Algeri M , Rupprecht J , Kuo KHM , Shah A , Lang P , Merkeley H, Carpenter B, Mapara MY, Liem RI , Grupp S , Chopra Y , Li AM , Kwiatkowski JL , Kirby-Allen M , Cappellini MD, Kattamis A , Zairis S, Liu T , Hobbs W , Frangoul H , Locatelli F, Meisel R, CLIMB THAL‐111 and CLIMB‐131 Study Groups: Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion-Dependent β-Thalassemia. Am J Hematol 101(8): 1969-1979, Aug 2026.Dain AS, Mewha J, Lazarus V, Kwiatkowski JL, Friedman DF, Chou ST: Isovolemic hemodilution red cell exchange and blood use in children and young adults with sickle cell disease. Blood Red Cells Iron 2(2): 100064, June 2026.
Kwiatkowski JL, Thompson AA, Schneiderman J, Thuret I, Kulozik AE, Yannaki E, Cavazzana M, Hongeng S, Olson TS, Sauer MG, Thrasher AJ, Lal A, Rasko JEJ, Kunz JB, Kinney MA, Chawla A, Ali S, Tao G, Thakar HL, Paramore C, Witthuhn N, Walters MC, Locatelli F.: Long-term efficacy and safety results of betibeglogene autotemcel gene therapy for transfusion-dependent β-thalassemia. Blood 147(19): 2203-2214, May 2026.
Gibson NM, Nguyen N, Amaral S, Hsu J, Haney M, Heimbruch KE, Sabulski A, Zurawel A, Davidow KA, Lind KT, Scanlon S, Alva H, Hall L, Bailey LC, Olson TS, Kwiatkowski JL: Impact of iron overload on hematopoietic stem cell transplantation in pediatric patients with nonmalignant hematological disorders. Blood Adv 10(10): 3324-3334, May 2026.
Cheng AN, Kwiatkowski JL: Current therapeutic landscape of β-thalassemia: focus on gene therapy. Ther Adv Rare Dis. Mar 2026.
Gibson NM, Kwiatkowski JL, Chou ST: Emerging Considerations in Transfusion Medicine: Hematopoietic Stem and Progenitor Cell Collection for Gene Therapy for Sickle Cell Disease and Transfusion-Dependent Thalassemia Clinics in Laboratory Medicine 46(1): 89-104, Mar 2026.
Dain AS, Li Y, Master S, Bailey CL, Vossough A, Ichord RN, Raffini L, Getz K, Kwiatkowski JL: Trends in HU utilization and cerebrovascular outcomes before and after publication of the 2014 National Heart, Lung, and Blood Institute sickle cell disease guidelines. Pediatr Hematol Oncol 43(1): 39-46, Feb 2026.
Musallam KM, Sheth S, Locatelli F, Shah FT, Rivella, S, Kuo KHM, Forni GL, Kattamis A, Aydinok Y, Glenthøj A, Kwiatkowski JL, Cappellini, MD, Taher AT: The expanding therapeutic landscape of beta thalaessemia. Lancet 2026 Notes: in press.
Gibson NM, Elgarten CW, Oved JH, Wray L, Freedman J, Khandros E, Worster E, Nicholas P, Kadauke S, Wang Y, Grupp S, Kwiatkowski JL, Olson TS: Outcomes of unrelated donor stem cell transplantation with partial T cell depletion in pediatric patients with hemoglobinoopathies. Transplant Cell Therapy 31(10): e1-828, Oct 2025.
Kwiatkowski JL: Iron chelation: choice of agent, dosing, and adverse effects. Up to Date. Elliot P. Vichinsky and Jennifer S. Tirnauer (eds.). May 2025.