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James D. Lewis, MD, MSCE
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Professor of Medicine (Gastroenterology)
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Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania
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Senior Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine
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Director, Clinic Epi T32 Training Program, University of Pennsylvania Perelman School of Medicine
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Director, Gastroenterology and Hepatology Clinical Research Program, University of Pennsylvania Perelman School of Medicine
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Director, Human Intervention Core of the Penn-CHOP Microbiome Program
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Co-Director, Biomedical Data Science Core of the Center for Molecular Studies in Digestive and Liver Diseases (University of Pennsylvania)
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Director, Human Subject Research Core of University of Pennsylvania's Center for Nutritional Science and Medicine
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Chief of Gastroenterology and Hepatology, Penn Presbyterian Medical Center
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Co-Vice Chief for Research, Division of Gastroenterology and Hepatology, University of Pennsylvania
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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University of Pennsylvania
24 Division of Gastroenterology
3a Center for Clinical Epidemiology and Biostatistics
1a 423 Guardian Drive
39 720 Blockley Hall
Philadelphia, PA 19104-6021
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24 Division of Gastroenterology
3a Center for Clinical Epidemiology and Biostatistics
1a 423 Guardian Drive
39 720 Blockley Hall
Philadelphia, PA 19104-6021
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Office: (215) 573-5137
34 Fax: (215) 573-0813
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34 Fax: (215) 573-0813
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Email:
lewisjd@mail.med.upenn.edu
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lewisjd@mail.med.upenn.edu
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Publications
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Links
19a Search PubMed for articles
e1 Penn Medicine Inflammatory Bowel Diseases Program
b2 University of Pennsylvania Perelman School of Medicine Center for Clinical Epidemiology and Biostatistics
86 University of Pennsylvania Leonard Davis Institute of Health Economics
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19a Search PubMed for articles
e1 Penn Medicine Inflammatory Bowel Diseases Program
b2 University of Pennsylvania Perelman School of Medicine Center for Clinical Epidemiology and Biostatistics
86 University of Pennsylvania Leonard Davis Institute of Health Economics
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Education:
21 7 BA 26 (Interdisciplinary Studies) c
2f University of Virginia, 1987.
21 7 MD c
33 University of Pennsylvania, 1991.
21 9 MSCE 22 (Clinical Epidemiology) c
33 University of Pennsylvania, 1998.
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Permanent link21 7 BA 26 (Interdisciplinary Studies) c
2f University of Virginia, 1987.
21 7 MD c
33 University of Pennsylvania, 1991.
21 9 MSCE 22 (Clinical Epidemiology) c
33 University of Pennsylvania, 1998.
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Description of Research Expertise
2f Epidemiology, IBD, Colon Cancer65
Description of Clinical Expertise
33 Gastroenterology, IBD, Colon Cancer1a 29
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1ea Khan Nabeel, Lee Helen, Trivedi Chinmay, Kavani Himanshu, Medvedeva Elina, Xie Dawei, Lewis James D, Yang Yu-Xiao: Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Disease Receiving Treatment With Thiopurines. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 17(11): 2262-2268, Mar 2019.
120 Albenberg L, Brensinger C M, Wu Q, Gilroy E, Kappelman M D, Sandler R S, Lewis J D: A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares. Gastroenterology 157(1): 128-136.e5, Mar 2019.
141 Scott, F. I., Hans, A. K., Gerich, M. E., Fennimore, B., Mamtani, R., Vajravelu, R. K., Lewis, J. D.: Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn''s Disease. Clin Gastroenterol Hepatol 2020.
180 Scott, F. I., Luo, M., Shah, Y., Lasch, K., Vajravelu, R. K., Mamtani, R., Fennimore, B., Gerich, M. E., Lewis, J. D.: Identification of the Most Cost-effective Position of Vedolizumab Among the Available Biologic Drugs for the Treatment of Ulcerative Colitis. J Crohns Colitis 14(5): 575-587, Jun 2020.
177 Tanes C, Bittinger K, Gao Y, Friedman ES, Nessel L, Paladhi UR, Chau L, Panfen E, Fischbach MA, Braun J, Xavier RJ, Clish CB, Li H, Bushman FD, Lewis JD, Wu GD.: Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host Microbe ell Host Microbe: 394-407, Mar 2021.
240 Lewis JD, Sandler R, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson J, Suskind D, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen B, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H; DINE-CD Study Group.: A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease. Gastroenterology May 2021.
235 Raffals LE, Saha S, Bewtra M, Norris C, Dobes A, Heller C, O'Charoen S, Fehlmann T, Sweeney S, Weaver A, Bishu S, Cross R, Dassopoulos T, Fischer M, Yarur A, Hudesman D, Parakkal D, Duerr R, Caldera F, Korzenik J, Pekow J, Wells K, Bohm M, Perera L, Kaur M, Ciorba M, Snapper S, Scoville EA, Dalal S, Wong U, Lewis JD.: The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD). Inflamm Bowel Dis 28: 192-199, Aug 2021.
1cd Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD.: Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Gastroenterology Nov 2021.
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Selected Publications
1d8 Lewis James D, Scott Frank I, Brensinger Colleen M, Roy Jason A, Osterman Mark T, Mamtani Ronac, Bewtra Meenakshi, Chen Lang, Yun Huifeng, Xie Fenglong, Curtis Jeffrey R: Increased Mortality Rates With Prolonged Corticosteroid Therapy When Compared With Antitumor Necrosis Factor-α-Directed Therapy for Inflammatory Bowel Disease. The American journal of gastroenterology 113(3): 405-417, Mar 2018.1ea Khan Nabeel, Lee Helen, Trivedi Chinmay, Kavani Himanshu, Medvedeva Elina, Xie Dawei, Lewis James D, Yang Yu-Xiao: Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Disease Receiving Treatment With Thiopurines. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 17(11): 2262-2268, Mar 2019.
120 Albenberg L, Brensinger C M, Wu Q, Gilroy E, Kappelman M D, Sandler R S, Lewis J D: A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares. Gastroenterology 157(1): 128-136.e5, Mar 2019.
141 Scott, F. I., Hans, A. K., Gerich, M. E., Fennimore, B., Mamtani, R., Vajravelu, R. K., Lewis, J. D.: Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn''s Disease. Clin Gastroenterol Hepatol 2020.
180 Scott, F. I., Luo, M., Shah, Y., Lasch, K., Vajravelu, R. K., Mamtani, R., Fennimore, B., Gerich, M. E., Lewis, J. D.: Identification of the Most Cost-effective Position of Vedolizumab Among the Available Biologic Drugs for the Treatment of Ulcerative Colitis. J Crohns Colitis 14(5): 575-587, Jun 2020.
177 Tanes C, Bittinger K, Gao Y, Friedman ES, Nessel L, Paladhi UR, Chau L, Panfen E, Fischbach MA, Braun J, Xavier RJ, Clish CB, Li H, Bushman FD, Lewis JD, Wu GD.: Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host Microbe ell Host Microbe: 394-407, Mar 2021.
240 Lewis JD, Sandler R, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson J, Suskind D, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen B, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H; DINE-CD Study Group.: A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease. Gastroenterology May 2021.
235 Raffals LE, Saha S, Bewtra M, Norris C, Dobes A, Heller C, O'Charoen S, Fehlmann T, Sweeney S, Weaver A, Bishu S, Cross R, Dassopoulos T, Fischer M, Yarur A, Hudesman D, Parakkal D, Duerr R, Caldera F, Korzenik J, Pekow J, Wells K, Bohm M, Perera L, Kaur M, Ciorba M, Snapper S, Scoville EA, Dalal S, Wong U, Lewis JD.: The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD). Inflamm Bowel Dis 28: 192-199, Aug 2021.
1cd Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD.: Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Gastroenterology Nov 2021.
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