John B. Hogenesch, Ph.D.

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Adjunct Professor of Pharmacology
Department: Pharmacology

Contact information
T5.478
240 Albert Sabin Way
Cincinnati, OH 45229
Office: 4848424232
Education:
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
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Description of Research Expertise

Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.

Selected Publications

Gang Wu, Marc D Ruben, Lauren J Francey, David F Smith, Joseph D Sherrill, John E Oblong, Kevin J Mills, John B Hogenesch: A population-based gene expression signature of molecular clock phase from a single epidermal sample. Genome Medicine 12((1):73), Aug 2020.

Joyce Sorrell, Emily Yates, Marita Rivir, Stephen C Woods, John B Hogenesch, Diego Perez-Tilve: The central melanocortin system mediates the benefits of time-restricted feeding on energy balance. Physiology & Behavior(227), Aug 2020.

Sibel Cal-Kayitmazbatir, Eylem Kulkoyluoglu-Cotul, Jacqueline Growe, Christopher P Selby, Seth D Rhoades, Dania Malik, Hasimcan Oner, Hande Asimgil, Lauren J Francey, Aziz Sancar, Warren D Kruger, John B Hogenesch, Aalim Weljie, Ron C Anafi, Ibrahim Halil Kavakli: CRY1-CBS binding regulates circadian clock function and metabolism. FEBS May 2020.

Nayak Gowri, Zhang Kevin X, Vemaraju Shruti, Odaka Yoshinobu, Buhr Ethan D, Holt-Jones Amanda, Kernodle Stace, Smith April N, Upton Brian A, D'Souza Shane, Zhan Jesse J, Diaz Nicolás, Nguyen Minh-Thanh, Mukherjee Rajib, Gordon Shannon A, Wu Gang, Schmidt Robert, Mei Xue, Petts Nathan T, Batie Matthew, Rao Sujata, Hogenesch John B, Nakamura Takahisa, Sweeney Alison, Seeley Randy J, Van Gelder Russell N, Sanchez-Gurmaches Joan, Lang Richard A: Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell reports 30(3): 672-686.e8, Jan 2020.

Ruben Marc D, Francey Lauren J, Guo Yuping, Wu Gang, Cooper Edward B, Shah Amy S, Hogenesch John B, Smith David F: A large-scale study reveals 24-h operational rhythms in hospital treatment. Proceedings of the National Academy of Sciences of the United States of America 116(42): 20953-20958, Oct 2019.

Lee Yool, Shen Yang, Francey Lauren J, Ramanathan Chidambaram, Sehgal Amita, Liu Andrew C, Hogenesch John B: The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation. Scientific reports 9(1): 11883, Aug 2019.

Ruben Marc D, Smith David F, FitzGerald Garret A, Hogenesch John B: Dosing time matters. Science (New York, N.Y.) 365(6453): 547-549, Aug 2019.

Foteinou Panagiota T, Venkataraman Anand, Francey Lauren J, Anafi Ron C, Hogenesch John B, Doyle Francis J: Reply to Furlan et al.: The role of SIRT1 in cell autonomous clock function. Proceedings of the National Academy of Sciences of the United States of America 116(27): 13173, Jul 2019.

Resuehr David, Wu Gang, Johnson Russell L, Young Martin E, Hogenesch John B, Gamble Karen L: Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital Nurses. Journal of biological rhythms Page: 748730419826694, Feb 2019.

Zhang Zhenguang, Hunter Louise, Wu Gang, Maidstone Robert, Mizoro Yasutaka, Vonslow Ryan, Fife Mark, Hopwood Thomas, Begley Nicola, Saer Ben, Wang Ping, Cunningham Peter, Baxter Matthew, Durrington Hannah, Blaikley John F, Hussell Tracy, Rattray Magnus, Hogenesch John B, Gibbs Julie, Ray David W, Loudon Andrew S I: Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33(5): fj201801682R, Feb 2019.

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Last updated: 10/24/2020
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