John B. Hogenesch, Ph.D.
240 Albert Sabin Way
Cincinnati, OH 45229
University of Southern California, 1989.
University of Southern California, 1991.
Northwestern University, 1999.
Description of Research ExpertiseOur laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.
Selected PublicationsFoteinou Panagiota T, Venkataraman Anand, Francey Lauren J, Anafi Ron C, Hogenesch John B, Doyle Francis J: Reply to Furlan et al.: The role of SIRT1 in cell autonomous clock function. Proceedings of the National Academy of Sciences of the United States of America 116(27): 13173, Jul 2019.
Resuehr David, Wu Gang, Johnson Russell L, Young Martin E, Hogenesch John B, Gamble Karen L: Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital Nurses. Journal of biological rhythms Page: 748730419826694, Feb 2019.
Zhang Zhenguang, Hunter Louise, Wu Gang, Maidstone Robert, Mizoro Yasutaka, Vonslow Ryan, Fife Mark, Hopwood Thomas, Begley Nicola, Saer Ben, Wang Ping, Cunningham Peter, Baxter Matthew, Durrington Hannah, Blaikley John F, Hussell Tracy, Rattray Magnus, Hogenesch John B, Gibbs Julie, Ray David W, Loudon Andrew S I: Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33(5): fj201801682R, Feb 2019.
Wu Gang, Ruben Marc D, Schmidt Robert E, Francey Lauren J, Smith David F, Anafi Ron C, Hughey Jacob J, Tasseff Ryan, Sherrill Joseph D, Oblong John E, Mills Kevin J, Hogenesch John B: Population-level rhythms in human skin with implications for circadian medicine. Proceedings of the National Academy of Sciences of the United States of America Oct 2018.
Foteinou Panagiota T, Venkataraman Anand, Francey Lauren J, Anafi Ron C, Hogenesch John B, Doyle Francis J: Computational and experimental insights into the circadian effects of SIRT1. Proceedings of the National Academy of Sciences of the United States of America Oct 2018.
Merrick David, Mistry Kavita, Wu Jingshing, Gresko Nikolay, Baggs Julie E, Hogenesch John B, Sun Zhaoxia, Caplan Michael J: Polycystin-1 regulates bone development through an interaction with the transcriptional co-activator taz. Human molecular genetics Sep 2018.
von Allmen Douglas C, Francey Lauren J, Rogers Garrett M, Ruben Marc D, Cohen Aliza P, Wu Gang, Schmidt Robert E, Ishman Stacey L, Amin Raouf S, Hogenesch John B, Smith David F: Circadian Dysregulation: The Next Frontier in Obstructive Sleep Apnea Research. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Page: 194599818797311, Sep 2018.
Ruben Marc D, Wu Gang, Smith David F, Schmidt Robert E, Francey Lauren J, Lee Yin Yeng, Anafi Ron C, Hogenesch John B: A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine. Science translational medicine 10(458), Sep 2018.
Zhang Xuan, Xue Chenyi, Lin Jennie, Ferguson Jane F, Weiner Amber, Liu Wen, Han Yumiao, Hinkle Christine, Li Wenjun, Jiang Hongfeng, Gosai Sager, Hachet Melanie, Garcia Benjamin A, Gregory Brian D, Soccio Raymond E, Hogenesch John B, Seale Patrick, Li Mingyao, Reilly Muredach P: Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of in adipocyte metabolism. Science translational medicine 10(446), Jun 2018.
Ramanathan Chidambaram, Kathale Nimish D, Liu Dong, Lee Choogon, Freeman David A, Hogenesch John B, Cao Ruifeng, Liu Andrew C: mTOR signaling regulates central and peripheral circadian clock function. PLoS genetics 14(5): e1007369, May 2018.