Wesley Baker, PhD

faculty photo
Assistant Professor of Neurology
Department: Neurology

Contact information
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 8145713886
BS (Physics)
Bucknell University, 2005.
PhD (Physics)
University of Pennsylvania, 2015.
Permanent link
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Description of Research Expertise

I am a physicist with specialization in optics in biological tissues. In 2015, I received my PhD in the Department of Physics and Astronomy at the University of Pennsylvania under the supervision of Arjun Yodh. I then completed a 2-year postdoctoral fellowship mentored by W. Andrew Kofke in the department of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania. Emergent themes from my previous work include (1) studying ischemic pathophysiology with diffuse optics, (2) formulating new analytical models/paradigms to improve the fidelity of cerebral hemodynamic data based on optical signals, and (3) devising new clinical applications for diffuse optics, such as non-invasive monitoring of cerebral perfusion pressure. As a researcher in biomedical optics, I aim to develop optical tools for clinical use. Broadly, I envision designing clinical research that furthers the prognostic utility of optical tools in the treatment of acute brain injury. I also envision harnessing cerebral hemodynamic data from optical measurements in human patients and pre-clinical animal models to illuminate etiologies of neurological injuries/disorders with the hope of establishing novel therapies (e.g., ischemic stroke, hydrocephalus).

Selected Publications

Busch, D. R., Baker, W. B., Mavroudis, C. D., Ko, T. S., Lynch, J. M., McCarthy, A. L., DuPont-Thibodeau, G., Buckley, E. M., Jacobwitz, M., Boorady, T. W., Mensah-Brown, K., Connelly, J. T., Yodh, A. G., Kilbaugh, T. J., Licht, D. J.: Noninvasive optical measurement of microvascular cerebral hemodynamics and autoregulation in the neonatal ECMO patient. Pediatr Res 2020.

Mullen Michael T, Parthasarathy Ashwin B, Zandieh Ali, Baker Wesley B, Mesquita Rickson C, Loomis Caitlin, Torres Jose, Guo Wensheng, Favilla Christopher G, Messé Steven R, Yodh Arjun G, Detre John A, Kasner Scott E: Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 28(11): 104294, Nov 2019.

Favilla Christopher G, Forti Rodrigo M, Zamzam Ahmad, Detre John A, Mullen Michael T, Yodh Arjun G, Kasner Scott E, Busch David R, Baker Wesley B, Mesquita Rickson C, Kung David, Messé Steven R: Perfusion Enhancement with Respiratory Impedance After Stroke (PERI-Stroke). Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 16(4): 1296-1303, October 2019.

Milej Daniel, He Lian, Abdalmalak Androu, Baker Wesley B, Anazodo Udunna C, Diop Mamadou, Dolui Sudipto, Kavuri Venkaiah C, Pavlosky William, Wang Lin, Balu Ramani, Detre John A, Amendolia Olivia, Quattrone Francis, Kofke W Andrew, Yodh Arjun G, St Lawrence Keith: Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: Validation against MRI. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Page: 271678X19872564, Sep 2019 Notes: epub ahead of print.

Baker Wesley B, Balu Ramani, He Lian, Kavuri Venkaiah C, Busch David R, Amendolia Olivia, Quattrone Francis, Frangos Suzanne, Maloney-Wilensky Eileen, Abramson Kenneth, Mahanna Gabrielli Elizabeth, Yodh Arjun G, Andrew Kofke W: Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 39(8): 1469-1485, August 2019.

Wang Detian, Baker Wesley B, He Hui, Gao Peng, Zhu Liguo, Peng Qixian, Li Zeren, Li Fei, Chen Tunan, Feng Hua: Influence of probe pressure on the pulsatile diffuse correlation spectroscopy blood flow signal on the forearm and forehead regions. Neurophotonics 6(3): 035013, Jul 2019.

Forti Rodrigo M, Favilla Christopher G, Cochran Jeffrey M, Baker Wesley B, Detre John A, Kasner Scott E, Mullen Michael T, Messé Steven R, Kofke W Andrew, Balu Ramani, Kung David, Pukenas Bryan A, Sedora-Roman Neda I, Hurst Robert W, Choudhri Omar A, Mesquita Rickson C, Yodh Arjun G: Transcranial Optical Monitoring of Cerebral Hemodynamics in Acute Stroke Patients during Mechanical Thrombectomy. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 28(6): 1483-1494, Jun 2019.

Wesley B. Baker, Tracy M. Flanders, Ramani Balu, Lian He, Kristina Heye, Elizabeth Mahanna-Gabrielli, John J. Flibotte, Daniel J. Licht, Gregory G. Heuer, Arjun G. Yodh, W. Andrew Kofke : Non-invasive optical assessment of intracranial pressure: pilot results in human patients. European Conferences on Biomedical Optics, Munich, Germany 2019 Notes: Podium presentation.

Busch David R, Balu Ramani, Baker Wesley B, Guo Wensheng, He Lian, Diop Mamadou, Milej Daniel, Kavuri Venkaiah, Amendolia Olivia, St Lawrence Keith, Yodh Arjun G, Kofke W Andrew: Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy. Neurocritical care 30(1): 72-80, 02 2019.

Wesley B. Baker, Pascal Heye, Kristina Heye, Tiffany S. Ko, Yuxi Lin, Nile Delso, Anna L. Roberts, Jonah Padawer-curry, Kristen N. Andersen, William P. Landis, Thomas Hallowell, Norah G. Taraska, Daniel J. Licht, Todd J. Kilbaugh: Diffuse optical biomarkers of elevated intracranial pressure in a piglet model of hydrocephalus. Society for fNIRS, Sao Carlos, Brazil 2019 Notes: Podium Presentation.

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Last updated: 07/15/2020
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