Wesley B. Baker, PhD

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Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 8145713886
BS (Physics)
Bucknell University, 2005.
PhD (Physics)
University of Pennsylvania, 2015.
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Description of Research Expertise

I am a physicist with specialization in optics in biological tissues. In 2015, I received my PhD in the Department of Physics and Astronomy at the University of Pennsylvania under the supervision of Arjun Yodh. I then completed a 2-year postdoctoral fellowship mentored by W. Andrew Kofke in the department of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania. Emergent themes from my previous work include (1) studying ischemic pathophysiology with diffuse optics, (2) formulating new analytical models/paradigms to improve the fidelity of cerebral hemodynamic data based on optical signals, and (3) devising new clinical applications for diffuse optics, such as non-invasive monitoring of cerebral perfusion pressure. As a researcher in biomedical optics, I aim to develop optical tools for clinical use. Broadly, I envision designing clinical research that furthers the prognostic utility of optical tools in the treatment of acute brain injury. I also envision harnessing cerebral hemodynamic data from optical measurements in human patients and pre-clinical animal models to illuminate etiologies of neurological injuries/disorders with the hope of establishing novel therapies (e.g., ischemic stroke, hydrocephalus).

Selected Publications

Silva LEV, Shi L, Gaudio H, Padmanabahn V, Morgan RW, Slovis JM, Forti RM, Morton S, Lin Y, Laurent GH, Breimann J, Yun B, Ranieri NR, Bowe M, Baker WB, Kilbaugh TJ, Ko TS, Tsui F: Prediction of Return of Spontaneous Circulation in a Pediatric Swine Model of Cardiac Arrest Using Low-Resolution Multimodal Physiological Waveforms. IEEE J Biomed Health Inform Jul 2023.

Forti RM, Hobson LJ, Benson EJ, Ko TS, Ranieri NR, Laurent G, Weeks MK, Widmann NJ, Morton S, Davis AM, Sueishi T, Lin Y, Wulwick KS, Fagan N, Shin SS, Kao SH, Licht DJ, White BR, Kilbaugh TJ, Yodh AG, Baker WB: Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury. Biomed Opt Express 14(6): 2432-2448, Jun 2023.

Forti RM, Martins GG, Baker WB, Mesquita RC: Optimizing a two-layer method for hybrid diffuse correlation spectroscopy and frequency-domain diffuse optical spectroscopy cerebral measurements in adults. Neurophotonics 10(2): 025008, Apr 2023.

Luckl J, Baker WB, Boda K, Emri M, Yodh AG, Greenberg JH: Oxyhemoglobin and Cerebral Blood Flow Transients Detect Infarction in Rat Focal Brain Ischemia. Neuroscience 509: 132-144, Jan 2023.

WB Baker, R Forti, P Heye, K Heye, Y Lin, KN Andersen, J Jahnavi, J Breimann, H Gaudio, S Morton, AG Yodh, DJ Licht, BR White, M Hwang, TJ Kilbaugh, TS Ko: A Two-layer Modified Beer-Lambert Algorithm for Optical Monitoring of Critical Closing Pressure. Optics and the Brain, Optica Publishing Group Page: BTu3B.2, 2023.

Shaw K, Mavroudis CD, Ko TS, Jahnavi J, Jacobwitz M, Ranieri N, Forti RM, Melchior RW, Baker WB, Yodh AG, Licht DJ, Nicolson SC, Lynch JM: The use of novel diffuse optical spectroscopies for improved neuromonitoring during neonatal cardiac surgery requiring antegrade cerebral perfusion. Front Pediatr 11: 1125985, 2023.

WB Baker, RM Forti, P Heye, K Heye, NR Ranieri, EJ Benson, Y Lin, KN Andersen, J Jahnavi, J Breimann, HA Gaudio, JM Lynch, AG Yodh, DJ Licht, BR White, M Hwang, TJ Kilbaugh, TS Ko: Diffuse Optical Metrics of Intracranial Hypertension in a Pig Model of Hydrocephalus. European Conferences on Biomedical Optics Page: 12628-13, 2023.

Wang L, Cochran JM, Ko T, Baker WB, Abramson K, He L, Busch DR, Kavuri V, Linn RL, Parry S, Yodh AG, Schwartz N: Non-invasive monitoring of blood oxygenation in human placentas via concurrent diffuse optical spectroscopy and ultrasound imaging. Nat Biomed Eng 6(9): 1017-1030, Sep 2022.

White BR, Ko TS, Morgan RW, Baker WB, Benson EJ, Lafontant A, Starr JP, Landis WP, Andersen K, Jahnavi J, Breimann J, Delso N, Morton S, Roberts AL, Lin Y, Graham K, Berg RA, Yodh AG, Licht DJ, Kilbaugh TJ: Low frequency power in cerebral blood flow is a biomarker of neurologic injury in the acute period after cardiac arrest. Resuscitation 178: 12-18, Sep 2022.

Ko TS, Mavroudis CD, Benson EJ, Forti RM, Melchior RW, Boorady TW, Morano VC, Mensah-Brown K, Lin Y, Aronowitz D, Starr JP, Rosenthal TM, Shade BC, Schiavo KL, White BR, Lynch JM, Gaynor JW, Licht DJ, Yodh AG, Baker WB, Kilbaugh TJ: Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass. Metabolites 12(8), Aug 2022.

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Last updated: 07/31/2023
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