Shih-Shan Lang Chen, MD

faculty photo
Associate Professor of Neurosurgery at the Children's Hospital of Philadelphia
Attending Neurosurgeon, Children's Hospital of Philadelphia (CHOP), University of Pennsylvania
Attending Neurosurgeon, The Hospital of the University of Pennsylvania
Attending Neurosurgeon, Penn Presbyterian Medical Center
Department: Neurosurgery

Contact information
3401 Civic Center Blvd
6 Wood Center
Neurosurgery
Philadelphia, PA 19104
Office: 215-590-2780
Education:
B.S. (Neurobiological Sciences)
University of Florida, 2002.
M.D. (Medicine)
University of Florida College of Medicine, 2007.
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Description of Clinical Expertise

Vascular Neurosurgery – revascularization surgery, Aneurysms, arteriovenous malformations
Pediatric Spine Trauma and Traumatic Brain Injury
Pediatric Brain Tumors
Neonatal and Pediatric Hydrocephalus
Endoscopic Neurosurgery
Cerebral Palsy Spasticity

Selected Publications

Yousef Hattar, Julie Sesen, Tyra Martinez, Karthik Ashok, Adrian Lupieri, Shih-Shan Lang, Gregory G. Heuer, Alexander Tucker, Edward R. Smith, and Aram Ghalali: Cell Division Cycle 42 Binding Protein Beta as a Plasma-Based Biomarker for Cerebral Cavernous Malformations. ISPN 2025 Annual Meeting, France October 2025 Notes: Pending submitted in March.

Emma Mazzio, Craig Press, Alicia Alcamo, Shih-Shan Lang, Jimmy Huh, Raymond Liu, Alexis Topjian, Matthew Kirschen. : Association Between EEG Responsiveness to Hypertonic Saline Administration and Outcomes After Pediatric Acute Brain Injury. Neurocritical Care Society Conference September 2025 Notes: Pending Submitted to Neurocritical Care Society Conference in March 2025 (for Montreal, September 2025).

V. Mazandi, K. Boggs, K. Senthil, E. Gabriel, N. Kumar, C. Glau, A. Himebauch, C.T. Kim, T. Kilbaugh, S.S. Lang, T. Conlon, J. Huh. : Association of left ventricular systolic dysfunction with outcome following pediatric traumatic brain injury. Pending JNS: Peds May 2025 May 2025 Notes: under revisions 4/2025.

Ellie D. Gabriel, Ayush Lacoul, Nankee Kumar, April Giannotti, Jasleen Kaur, Kumaran Senthil, Vanessa Mazandi, Chong-Tae Kim, Todd J. Kilbaugh, Shih-Shan Lang, Jimmy W. Huh: Development and Validation of a Pre-Hospital Clinical Nomogram for Predicting Functional Outcome in Pediatric Patients With Severe Traumatic Brain Injury. American Association of Neurological Surgeons 2025 Annual Meeting, Boston, MA. April 2025 Notes: Oral Paper Poster American Association of Neurological Surgeons 2025 Annual Meeting, Boston, MA presented by Ellie Gabriel.

Ellie D. Gabriel, Nankee Kumar, Claudia Hejazi-Garcia, Clara Wang, Mix Wannasarnmetha, Aashim Bhatia, Chao Zhao, Tracy Flanders, Gregory Heuer, Jimmy W. Huh, Shih-Shan Lang: Non-invasive Near-infrared Spectroscopy Correlates in Pediatric Traumatic Brain Injury. American Association of Neurological Surgeons 2025 Annual Meeting, Boston, MA. April 2025 Notes: Oral Paper Poster American Association of Neurological Surgeons 2025 Annual Meeting, Boston, MA. Presented by Ellie Gabriel.

Flanders TM, Hwang M, Julian NW, Sarris CE, Flibotte JJ, DeMauro SB, Munson DA, Heimall LM, Collins YC, Bamberski JM, Sturak MA, Storm PB, Lang SS, Heuer GG. : Imaging and CSF biomarkers to optimize neurosurgical intervention for post-hemorrhagic hydrocephalus of prematurity. Association for Clinical and Translational Science Meeting (poster presentation). Washington DC April 2025 Notes: Poster Presentation by Tracy Flanders.

Short term outcomes in infants following primary ventriculoperitoneal (VP) shunt insertion : Moon, J., Yuan I., Oluwalade B., Rintoul N., Wild T., Lang S.S., Simpao A., Nelson O. (2025) Society for Pediatric Anesthesiology (SPA-AAP) Orlando, FL March 2025 Notes: Poster presentation.

Ayush Lacoul, Ellie Gabriel, April Giannotti, Nankee Kumar, Jasleen Kaur, Kumaran Senthil, Vanessa Mazandi, Craig Press, Matthew Kirschen, Alexis Topjian, Chong-Tae Kim, Todd Kilbaugh, Shih-Shan Lang, Jimmy Huh: Severe Pediatric Traumatic Brain Injury and Transport to a Quaternary Pediatric Facility: An Outcomes Analysis. 2025 Critical Care Conference, Orlando, FL. February 2025 Notes: Oral Presentation by Ayush Lacoul

A. Lacoul, E. Gabriel, Giannotia, N. Kumar, J. Kaur, K. Senthil, V. Mazandi, C. Press, M. Kirschen, A. Topjian, C.T. Kim, T. Kilbaugh, S.S. Lang, J. Huh: Severe Pediatric TBI and Transport to a Quaternary Pediatric Facility: An Outcome Analysis. Society of Critical Care Medicine 2025 Critical Care Congress February 2025 Notes: Oral abstract presented by Ayush Lacoul

Xu E, Zhang E, Park K, Ayub M, Zhao C, Huh JW, King JM, Paltin I, Shah AC, Storm PB, Tucker A, Madsen PJ, Lang SS. : Medical Management of Posterior Fossa Syndrome at a Quaternary Children’s Hospital Child's Nervous System February 2025 Notes: EPub ahead of print. 2025;41(1):100.

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Last updated: 04/21/2025
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