Andrea Facciabene, Ph.D.

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Research Associate Professor of Radiation Oncology
Department: Radiation Oncology

Contact information
University of Pennsylvania Perelman School of Medicine
Department of Radiation Oncology
Smilow Center for Translational Research Rm. 8-133
3400 Civic Center Blvd., Bldg 421
Philadelphia, PA 19104
Office: 215-746-7071
Fax: 215-898-0090
BS (Pharmaceutical Biotechnology Science (summa cum laude))
University of Bologna, Bologna, Italy (Thesis: Centre of Drug Discovery, L'Aquila, Italy) Summa Cum Laude, 2000.
PhD (Molecular and Cellular Biology)
University of Perugia, Perugia, Italy. In collaboration with the Univ of California San Diego, San Diego, CA (coursework 11/01-5/06), 2006.
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Description of Research Expertise

Dr. Andrea Facciabene’s laboratory is focused on cancer immunotherapy and the investigation of the network of immune responses to tumors, combining basic research and clinical investigation. The Facciabene Lab goals are to advance understanding of tumor immunology and to use the new findings to develop efficacious new therapies. Our basic research includes the development of two new vaccination strategies: one uses mitochondria isolated from tumors, the other utilizes new tumor vasculature antigen. We also study regulation of anticancer immune response by the gut microbiota. Our clinic research includes the development of new preclinical immunotherapies.

Selected Publications

Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, Lanitis E, Duraiswamy J, Tanyi JL, Benencia F, Conejo-Garcia J, Ramay HR, Montone KT, Powell DJ Jr, Gimotty PA, Facciabene A, Jackson DG, Weber JS, Rodig SJ, Hodi SF, Kandalaft LE, Irving M, Zhang L, Foukas P, Rusakiewicz S, Delorenzi M, Coukos G.: Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer Cell. Jun 10;35(6):.e10. doi: 10.1016/j.ccell.2019.05.004. PMID: 31185212 35: 885-900, Jun 2019

Russell KL, Gorgulho CM, Allen A, Vakaki M, Wang Y, Facciabene A, Lee D, Roy P, Buchser WJ, Appleman LJ, Maranchie J, Storkus WJ, Lotze MT.: Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. Cancer Journal 25: 165-177, May/June 2019.

Pustylnikov S1, Costabile F1, Beghi S1, Facciabene A.: Targeting mitochondria in cancer: current concepts and immunotherapy approaches. Transl Research 202: 35-51, Dec 2018

Lei J, Xie L, Zhao H, Gard C, Clemens JL, McLane MW, Feller MC, Ozen M, Novak C1, Alshehri W1, Alhejaily N, Shabi Y, Rosenzweig JM, Facciabene A, Burd I.: Maternal CD8+ T-cell depletion alleviates intrauterine inflammation-induced perinatal brain injury. Am J Reprod Immunol. 79(5):e12798, May 2018 Notes: online journal: doi: 10.1111/aji.12798.

Janos Tanyi, Mark Morgan, Andrea Facciabene: book chapter: Impact of gut microbiota on Ovarian Cancer Springer. Erle Robertson (eds.). Apr 2018.

Uribe-Herranz M, Bittinger K, Rafail S, Guedan S, Pierini S, Tanes C, Ganetsky A, Morgan MA, Gill S, Tanyi JL, Bushman FD, June CH, Facciabene A*.: Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12. JCI Insight 3(4), Feb 2018 Notes: *Corresponding Author; online journal: doi: 10.1172/jci.insight.94952. [Epub ahead of print]

De Sanctis F, Ugel S, Facciponte J, Facciabene A*: The dark side of tumor-associated endothelial cells. Semin Immunol. 35: 35-47, Feb 2018 Notes: *Corresponding Author.

Pierini S, Perales-Linares R, Uribe-Herranz M, Pol JG, Zitvogel L, Kroemer G, Facciabene A, Galluzzi L.: Trial watch: DNA-based vaccines for oncological indications. Oncoimmunology 6(12): e 1398878, Nov 2017 Notes: online journal: doi: 10.1080/2162402X.2017.1398878. eCollection 2017.

Lei J, Rosenzweig JM, Mishra MK, Alshehri W, Brancusi F, McLane M, Almalki A, Bahabry R, Arif H, Rozzah R, Alyousif G, Shabi Y, Alhehaily N, Zhong W1 Facciabene A, Kannan S, Kannan RM, Burd I.: Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury. Scientific Report 7(1): 6106, Jul 2017 Notes: online journal: doi: 10.1038/s41598-017-06113-2.

Facciabene A, De Sanctis F, Pierini S, Reis ES, Balint K, Facciponte J, Rueter J, Kagabu M, Magotti P, Lanitis E, DeAngelis RA, Buckanovich RJ, Song WC, Lambris JD, Coukos G.: Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. Oncoimmunology 6(9): e 1326442, Jun 2017 Notes: online journal: doi: 10.1080/2162402X.2017.1326442. eCollection 2017.

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Last updated: 07/23/2019
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