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Jennifer McGuire, M.D., M.S.C.E.
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Assistant Professor of Neurology at the Children's Hospital of Philadelphia
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Associate Program Director, Child Neurology Residency, Children's Hospital of Philadelphia
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Pediatric Neurology block director within MS1 Brain and Behavior course, Perelman School of Medicine at the University of Pennsylvania
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Department: Neurology
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Contact information
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The Children's Hospital of Philadelphia
26 Hub for Clinical Collaboration
29 10th Floor, Division of Neurology
39 3501 Civic Center Blvd
Philadelphia, PA 19104
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26 Hub for Clinical Collaboration
29 10th Floor, Division of Neurology
39 3501 Civic Center Blvd
Philadelphia, PA 19104
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Education:
21 9 B.S. 2c (Chemical Engineering, cum laude) c
2b Cornell University, 2000.
21 9 M.D. c
31 Dartmouth Medical School, 2005.
21 d M.S.C.E. 22 (Clinical Epidemiology) c
33 University of Pennsylvania, 2014.
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Permanent link21 9 B.S. 2c (Chemical Engineering, cum laude) c
2b Cornell University, 2000.
21 9 M.D. c
31 Dartmouth Medical School, 2005.
21 d M.S.C.E. 22 (Clinical Epidemiology) c
33 University of Pennsylvania, 2014.
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58 Host immune system modulation of viral infections in the central nervous system.
19 Viral encephalitis
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31 Infectious Diseases of the Nervous System
26 Neurologic complications of HIV
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Description of Research Expertise
47 HIV-associated neurocognitive disorders in adolescents58 Host immune system modulation of viral infections in the central nervous system.
19 Viral encephalitis
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Description of Clinical Expertise
28 General Child Neurology31 Infectious Diseases of the Nervous System
26 Neurologic complications of HIV
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d3 McGuire JL, Goodkin K, Douglas SD: The Neuropathogenesis of Central Nervous System HIV Infection. Psychiatric Annals 43(5): 217-222, 2013.
f5 JL McGuire and AM Greene: Central Nervous System Infections (Chapter 16). Pediatric Neurocritical Care. NS Abend and M Helfaer (eds.). Demos, New York, Page: 267-336, 2013.
120 JL McGuire, JH Kempen, JE Ellenberg, SD Douglas: Immune Markers of Neuropsychiatric Outcomes in HIV Infected Adolescents. International Society of Neurovirology Annual Meeting, New York, NY April 2012 Notes: poster.
fb JL McGuire, J Zorc, D Licht RL Hodinka, SS Shah: Herpes Simplex Testing in Neonates and Young Infants in the Emergency Department. Pediatric Emergency Care 28(10): 949-955, 2012.
f6 JL McGuire, V Fridman, I Koralnik, D Jacobs: Progressive Multifocal Leukoencephalopathy in a Patient with an Isolated CD8+ T Cell Deficiency. J Neurovirol 17: 500-503, 2011.
146 JL McGuire: What are the Clinical Features of Infant Bolulism? How is it Treated? (chapter 26). Curbside Consultation in Pediatric Neurology: 49 Clinical Questions. DJ Licht, N Ryan (eds.). SLACK Incorporated, Thorofare, New Jersey, Page: 123-126, 2015.
f3 JL McGuire: Mycoplasma Encephalitis (chapter 8). Symptom-Based Diagnosis in Pediatrics. SS Shah, S Ludwig (eds.). McGraw-Hill Professional, New York, Page: 208-211, 2013.
177 JS Barrett, G Bajaj, JL McGuire, D Wu, S Spitsin, G Moorthy, X Zhao, P Tebas, DL Evans, SD Douglas: Modeling and Simulation Support for Dosing and Study Design Requirements for Treating HIV-Related Neuropsychiatric Disease with the NK1r Antagonist Aprepitant. Current HIV Research 12(2): 121-131, 2014.
de JL McGuire, LA Beslow, RS Finkel, RA Zimmerman, FA Henretig: A Teenager with Focal Weakness. Pediatric Emergency Care 24(12): 875-879, December 2008.
12d AA Link, T Kino, JA Worth, JL McGuire, ML Crane, GP Chrousos, RL Wilder, and IJ Elenkov: Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes J. Immunology 164(1): 436-442, January 2000.
160 JL McGuire: What are the Causes of Guillain-Barre Syndrome, How Often Does it Occur, and How is it Treated? (chapter 32). Curbside Consultation in Pediatric Neurology: 49 Clinical Questions. DJ Licht, N Ryan (eds.). SLACK Incorporated, Thorofare, New Jersey, Page: 157-162, 2015.
148 JS Barrett, JL McGuire, H Vezina, S Spitsin, SD Douglas: PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: Are we asking the right questions? Journal of Clinical Psychopharmacology 33(6): 725-728, December 2013.
10f JL McGuire, JS Barrett, H Vezina, S Spitsin, SD Douglas: Adjuvant Therapies for HIV-Associated Neurocognitive Disorders. Annals of Clinical and Translational Neurology 1(11): 938-952, November 2014.
10d JL McGuire, J Kempen, R Localio, JE Ellenberg, SD Douglas: Immune Markers Predictive of Neuropsychiatric Symptoms in HIV Infected Youth. Clinical and Vaccine Immunology 22(1): 27-36, January 2015.
11b AJ Lautz, B Jenssen, JL McGuire, JA St Geme: Diagnostic Dilemmas and Clinical Reasoning: A 33-month old with fever and altered mental status. Pediatrics 135(1): 120-125, 2015 Notes: Epub ahead of print 12/8/14.
113 JL McGuire, A Gill, SD Douglas, D Kolson: Central and Peripheral Markers of Neurodegeneration and Monocyte Activation in HIV-Associated Neurocognitive Disorders. J Neurovirology 21(4): 439-48, Aug 2015.
111 NS Abend, D Bearden, I Helbig, J McGuire, S Narula, JA Panzer, A Topjian, DJ Dlugos: Status Epilepticus and Refractory Status Epilepticus Management. Seminars in Pediatric Neurology 21: 263-274, 2014.
12f JL McGuire, A Gill, SD Douglas, D Kolson: The Complement System, Neuronal Injury, and Cognitive Function in Horizontally-Acquired HIV-Infected Youth. J Neurovirology 22(6): 823-830, June 2016 Notes: DOI: 10.1007/s13365-016-0460-5.
17b Gofshteyn, J; Shaw, P.A.; Teachey D.T.; Grupp, S; Maude, S; Banwell, B; Chen F; Lacey, S.F.; Melenhorst, J.J.; Edmonson M.J.; Panzer J; Barrett D.M. and McGuire, J: Neurotoxicity after CTL-19 in a Pediatric and Young Adult Cohort. Annals of Neurology 84(4): 537-546, Oct 2018 Notes: doi: 10.1002/ana.25315.
f1 McGuire JL, Tuite N, Swami S, Avery RA: Assessment of the Diagnostic Yield of Non-Culture CSF Infection Testing in Children. JAMA Network Open 2(7): e197307, July 2019.
147 Matesanz S*, McGuire JL*, Hopkins S, *co-first authors: Acute Flaccid Myelitis: Characteristics and Outcomes of 2014 and 2016 Cases at a Single Center. J Pediatr 215: 272-276.e1, December 2019 Notes: doi: 10.1016/j.jpeds.2019.07.015 [Epub ahead of print]
176 WR Otto, WZ Paden, M Connors, T Joerger, A Buzi, M Rizzi, J Huh, PB Storm, G Heuer, B Kennedy, J McGuire, S Swami, SS Lang: Suppurative intracranial complications of pediatric sinusitis: a single-center experience. J Pediatric Infect Dis Soc 10(3): 309-316, Apr 2021 Notes: doi: 10.1093/jpids/piaa101.
ef AE Becker, K Chiotos, JL McGuire, BB Bruins, AM Alcamo: Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children. J Pediatr 233: 263-267, June 2021.
192 C Del Valle Mojica, J Montoya, J McGuire, KL Plama, KV Shekdar, R McLeod, DG Contopoulos-Ioannidis: Diagnosis of Congenital Toxoplasmosis with Macrocephaly in Dizygotic Twins after Incidental Detection of Leukocoria: A Case Report. J Pediatr S0022-3476(21): Epub ahead of print. May 2021 Notes: doi: 10.1016/j.jpeds.2021.05.040.
110 V Dhawan, JL McGuire, K Busl: Emergency Neurologic Life Support: Meningitis and Encephalitis Module V 5.0. Neurocritical Care Society Publishing. G Lopez, S Peacock, and A Aysenne (eds.). March 2022.
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Selected Publications
cf McGuire JL, Douglas SD: Neuroimmune Dysregulation in HIV-Associated Neurocognitive Disorders. Psychiatric Annals 43(5): 212-216, 2013.d3 McGuire JL, Goodkin K, Douglas SD: The Neuropathogenesis of Central Nervous System HIV Infection. Psychiatric Annals 43(5): 217-222, 2013.
f5 JL McGuire and AM Greene: Central Nervous System Infections (Chapter 16). Pediatric Neurocritical Care. NS Abend and M Helfaer (eds.). Demos, New York, Page: 267-336, 2013.
120 JL McGuire, JH Kempen, JE Ellenberg, SD Douglas: Immune Markers of Neuropsychiatric Outcomes in HIV Infected Adolescents. International Society of Neurovirology Annual Meeting, New York, NY April 2012 Notes: poster.
fb JL McGuire, J Zorc, D Licht RL Hodinka, SS Shah: Herpes Simplex Testing in Neonates and Young Infants in the Emergency Department. Pediatric Emergency Care 28(10): 949-955, 2012.
f6 JL McGuire, V Fridman, I Koralnik, D Jacobs: Progressive Multifocal Leukoencephalopathy in a Patient with an Isolated CD8+ T Cell Deficiency. J Neurovirol 17: 500-503, 2011.
146 JL McGuire: What are the Clinical Features of Infant Bolulism? How is it Treated? (chapter 26). Curbside Consultation in Pediatric Neurology: 49 Clinical Questions. DJ Licht, N Ryan (eds.). SLACK Incorporated, Thorofare, New Jersey, Page: 123-126, 2015.
f3 JL McGuire: Mycoplasma Encephalitis (chapter 8). Symptom-Based Diagnosis in Pediatrics. SS Shah, S Ludwig (eds.). McGraw-Hill Professional, New York, Page: 208-211, 2013.
177 JS Barrett, G Bajaj, JL McGuire, D Wu, S Spitsin, G Moorthy, X Zhao, P Tebas, DL Evans, SD Douglas: Modeling and Simulation Support for Dosing and Study Design Requirements for Treating HIV-Related Neuropsychiatric Disease with the NK1r Antagonist Aprepitant. Current HIV Research 12(2): 121-131, 2014.
de JL McGuire, LA Beslow, RS Finkel, RA Zimmerman, FA Henretig: A Teenager with Focal Weakness. Pediatric Emergency Care 24(12): 875-879, December 2008.
12d AA Link, T Kino, JA Worth, JL McGuire, ML Crane, GP Chrousos, RL Wilder, and IJ Elenkov: Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes J. Immunology 164(1): 436-442, January 2000.
160 JL McGuire: What are the Causes of Guillain-Barre Syndrome, How Often Does it Occur, and How is it Treated? (chapter 32). Curbside Consultation in Pediatric Neurology: 49 Clinical Questions. DJ Licht, N Ryan (eds.). SLACK Incorporated, Thorofare, New Jersey, Page: 157-162, 2015.
148 JS Barrett, JL McGuire, H Vezina, S Spitsin, SD Douglas: PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: Are we asking the right questions? Journal of Clinical Psychopharmacology 33(6): 725-728, December 2013.
10f JL McGuire, JS Barrett, H Vezina, S Spitsin, SD Douglas: Adjuvant Therapies for HIV-Associated Neurocognitive Disorders. Annals of Clinical and Translational Neurology 1(11): 938-952, November 2014.
10d JL McGuire, J Kempen, R Localio, JE Ellenberg, SD Douglas: Immune Markers Predictive of Neuropsychiatric Symptoms in HIV Infected Youth. Clinical and Vaccine Immunology 22(1): 27-36, January 2015.
11b AJ Lautz, B Jenssen, JL McGuire, JA St Geme: Diagnostic Dilemmas and Clinical Reasoning: A 33-month old with fever and altered mental status. Pediatrics 135(1): 120-125, 2015 Notes: Epub ahead of print 12/8/14.
113 JL McGuire, A Gill, SD Douglas, D Kolson: Central and Peripheral Markers of Neurodegeneration and Monocyte Activation in HIV-Associated Neurocognitive Disorders. J Neurovirology 21(4): 439-48, Aug 2015.
111 NS Abend, D Bearden, I Helbig, J McGuire, S Narula, JA Panzer, A Topjian, DJ Dlugos: Status Epilepticus and Refractory Status Epilepticus Management. Seminars in Pediatric Neurology 21: 263-274, 2014.
12f JL McGuire, A Gill, SD Douglas, D Kolson: The Complement System, Neuronal Injury, and Cognitive Function in Horizontally-Acquired HIV-Infected Youth. J Neurovirology 22(6): 823-830, June 2016 Notes: DOI: 10.1007/s13365-016-0460-5.
17b Gofshteyn, J; Shaw, P.A.; Teachey D.T.; Grupp, S; Maude, S; Banwell, B; Chen F; Lacey, S.F.; Melenhorst, J.J.; Edmonson M.J.; Panzer J; Barrett D.M. and McGuire, J: Neurotoxicity after CTL-19 in a Pediatric and Young Adult Cohort. Annals of Neurology 84(4): 537-546, Oct 2018 Notes: doi: 10.1002/ana.25315.
f1 McGuire JL, Tuite N, Swami S, Avery RA: Assessment of the Diagnostic Yield of Non-Culture CSF Infection Testing in Children. JAMA Network Open 2(7): e197307, July 2019.
147 Matesanz S*, McGuire JL*, Hopkins S, *co-first authors: Acute Flaccid Myelitis: Characteristics and Outcomes of 2014 and 2016 Cases at a Single Center. J Pediatr 215: 272-276.e1, December 2019 Notes: doi: 10.1016/j.jpeds.2019.07.015 [Epub ahead of print]
176 WR Otto, WZ Paden, M Connors, T Joerger, A Buzi, M Rizzi, J Huh, PB Storm, G Heuer, B Kennedy, J McGuire, S Swami, SS Lang: Suppurative intracranial complications of pediatric sinusitis: a single-center experience. J Pediatric Infect Dis Soc 10(3): 309-316, Apr 2021 Notes: doi: 10.1093/jpids/piaa101.
ef AE Becker, K Chiotos, JL McGuire, BB Bruins, AM Alcamo: Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children. J Pediatr 233: 263-267, June 2021.
192 C Del Valle Mojica, J Montoya, J McGuire, KL Plama, KV Shekdar, R McLeod, DG Contopoulos-Ioannidis: Diagnosis of Congenital Toxoplasmosis with Macrocephaly in Dizygotic Twins after Incidental Detection of Leukocoria: A Case Report. J Pediatr S0022-3476(21): Epub ahead of print. May 2021 Notes: doi: 10.1016/j.jpeds.2021.05.040.
110 V Dhawan, JL McGuire, K Busl: Emergency Neurologic Life Support: Meningitis and Encephalitis Module V 5.0. Neurocritical Care Society Publishing. G Lopez, S Peacock, and A Aysenne (eds.). March 2022.
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