Gregory J. Nadolski, M.D.

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.7892
Fax: 215.615.3545
B.S. (Biochemistry)
University of Wisconsin, Madison, WI , 2001.
M.D. (Medicine)
Indiana University School of Medicine, Indianapolis, IN , 2007.
MS (Translational Research)
University of Pennsylvania, Philadelphia, PA, 2017.
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Description of Clinical Expertise

My research and clinical interests include multimodality therapies for the treatment of hepatocellular carcinoma and liver dominant metastatic cancer.

I have initiated three clinical trials at the Hospital of the University of Pennsylvania for treating hepatocellular carcinoma. One involves combining transcatheter embolization with external beam radiation, and the other combines transcatheter embolization with an investigational oral chemotherapeutics.

Clinical Trials:
1. A Pilot Trial of Transarterial Chemoembolization With or Without Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients Awaiting Liver Transplantation, Hospital of the University of Pennsylvania (UPCC16213) -- Closed to Enrollment

2. Phase I-II Clinical Trial of the Safety of Hydroxychloroquine Combined with Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma, Hospital of the University of Pennsylvania (UPCC22213) -- Closed to Enrollment (failed to recruit)

3. Phase II Clinical Trial of the Efficacy of Transarterial Chemoembolization with Intra-arterial Hydroxychloroquine for Unresectable Hepatocellular Carcinoma (under review, pending NIH funding)

My other area of clinical and research interest is lymphatic injury, dysfunction, and malformations. Clinically, I perform thoracic duct embolization to treat chylothorax. I participate in research investigating novel lymphatic interventions to treat chylothorax, chylous ascites, refractory ascites and protein losing enteropathy.

Description of Research Expertise

My clinical and research expertise center on lymphatic interventions and multimodality cancer therapies to treat primary and secondary liver tumors. I also conduct research on diseases of the liver such as treatment of portal hypertension and ascites.

Selected Publications

Rupal Parikh, MD; Omar Abousoud, MD; Stephen Hunt, MD/PhD; Terence Gade, MD/PhD; Mandeep Dagli, MD; Jeffrey Mondschein, MD; Susan Shamimi-Noori, MD; Deepak Sudheendra, MD; S. William Stavropoulos, MD; Michael Soulen, MD; Gregory Nadolski, MD: Infection rates following hepatic embolotherapy in patients with prior biliary interventions: comparison of single-drug moxifloxacin and multidrug antibiotic prophylaxis. Journal of Vascular and Interventional Radiology 32(5): 739-744, May 2021 Notes: DOI: 10.1016/j.jvir.2021.01.273.

Currie BM, Nadolski G, Soulen MC.: Response Letter to Correspondence Regarding "Chronic Hepatotoxicity in Patients with Metastatic Neuroendocrine Tumor: Transarterial chemoembolization versus transarterial radioembolization" Journal of Vascular and Interventional Radiology 2021 Notes: epub ahead of print.

Khaddash T, Nadolski G, Asher M, Itkin M.: Successful Diagnosis and Treatment of Protein-Losing Enteropathy Using Liver Lymphangiography and Embolization of Hepatoduodenal Lymphatic Communications. Journal of Vascular and Interventional Radiology 31(11): 1924-1926, November 2020.

Sommer CM, Pieper CC, Itkin M, Nadolski GJ, Hur S, Kim J, Maleux G, Kauczor HU, Richter GM.: Conventional Lymphangiography (CL) in the Management of Postoperative Lymphatic Leakage (PLL): A Systematic Review. Rofo 192(11): 1025-1035, Nov 2020 Notes: doi: 10.1055/a-1131-7889.

CHO JK, Serna J. Clark TWI, Dagli M, Mondschein JI, Shlansky-Goldberg RD, Trerotola SO, Soulen MC, Stavropoulos SW, Nadolski GJ: Impact of PTEE-covered stent position and extension on TIPS patency. Abdominal Radiology 45(11): 3915-3922, Nov 2020 Notes: doi: 10.1007/s00261-020-02566-8.

Park BJ, Perkons NR, Profka E, Johnson O, Morley C, Appel S, Nadolski GJ, Hunt SJ, Gade TP.: Three-Dimensional Augmented Reality Visualization Informs Locoregional Therapy in a Translational Model of Hepatocellular Carcinoma. Journal of Vascular and Interventional Radiology 31(10): 1612-1618, October 2020.

Park BJ, Hunt SJ, Nadolski GJ, Gade TP.: Augmented reality improves procedural efficiency and reduces radiation dose for CT-guided lesion targeting: a phantom study using HoloLens 2. Scientific Reports 10(1), October 2020 Notes: Online only publication.

Currie BM, Nadolski G, Mondschein J, Dagli M, Sudheendra D, Stavropoulos SW, Soulen MC.: Chronic Hepatotoxicity in Patients with Metastatic Neuroendocrine Tumor: Transarterial Chemoembolization versus Transarterial Radioembolization. Journal of Vascular and Interventional Radiology 31(10): 1627-1635, October 2020.

Goity LD, Itkin M, Nadolski G.: An Algorithmic Approach to Minimally Invasive Management of Nontraumatic Chylothorax. Seminars in Interventional Radiology 37(3): 269-273, August 2020.

Itkin M, Rabinowitz D, Nadolski G, Stafler P, Mascarenas L, Adams D.: Abnormal Pulmonary Lymphatic Flow in Patients With Lymphatic Anomolies and Respiratory Compromise. Chest 158(2): 681-691, Aug 2020 Notes: DOI: 10.1016/j.chest.2020.02.058.

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Last updated: 10/27/2021
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