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David A Pegues, MD

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Professor of Medicine (Infectious Diseases) at the Hospital of the University of Pennsylvania
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Associate Medical Director, Antimicrobial Management Program, Hospital of the University of Pennsylvania
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Medical Director, Healthcare Epidemiology and Infection Control, Hospital of the University of Pennsylvania
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Department: Medicine
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46 Contact information
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Hospital of the University of Pennsylvania, 6th Floor Silverstein Building, 3400 Spruce Street,
Philadelphia, PA 19104-4283
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32 Fax: 215-662-7971
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13 Education:
21 7 BA 14 (Biology) c
2e University of Chicago, 1982.
21 7 MD 15 (Medicine) c
4a University of Chicago Pritzker School of Medicine, 1986.
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Description of Clinical Expertise

96 Transplant infectious diseases, healthcare-associated infections including catheter-associated urinary tract infections, Salmonellosis
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Description of Research Expertise

1fe Dr. Pegues’ current research interests include include developing clinical decision support tools to improve diagnostic testing stewardship and to reduce inappropriate device utilization; evaluating novel technologies and implementation strategies to reduce environmental microbial contamination and infection risk in healthcare setting; and the prevention and control of device-associated infections in high-risk patient populations, including dialysis, oncology, and solid organ transplant.
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Selected Publications

13e Wang X, Arya SV, Patel S, Saw S, Decena M, Hirsh R, Pegues DA, Ziegler MJ. : Antibiotic practice and stewardship in the management of neutropenic fever: a survey of US institutions. Infect Control Hosp Epidemiol Aug 1 online ahead of print 2024.

1b5 Dukes KC, Hockett Sherlock S, Racila AM, Herwaldt LA, Jacob J, Vijayan A, Kellogg J, Pegues D, Capocci Tolomeo P, Cobb J, Fraer M, Bleasdale SC, Ward MA, Lindsey B, Schweizer ML: Implementing nasal povidone Iodine decolonization to reduce infections in Hemodialysis units: a qualitative assessment. Infect Control Hosp Epidemiol May 23 online ahead of print 2024.

16a Harrigan JJ, Hamilton KW, Cressman L, Bilker WB, Degnan KO, David MZ, Tran D, Pegues DA, Dutcher L: Antibiotic Prescribing Patterns for Respiratory Tract Illnesses Following the Conclusion of an Education and Feedback Intervention in Primary Care. Clin Infect Dis 78(5): 1120-7, May 2024.

126 Drews FA, Martinello RA, Hebden JN, St. John K, Pegues DA: Disinfection of central venous access device needleless connectors: A human factors analysis. Infect Control Hosp Epidemiol online ahead of print: 1-6 Feb 2024.

13c Anesi GL, Amorosa VK, Athans V, et al. : Reflections on a model for rapid evidence review and dynamic practice recommendations during a public health emergency: The Penn Medicine COVID-19 Therapeutics Committee. Open Forum Infect Dis Aug 2023.

154 Patel PK, Advani S, Kofman AD, Maragakis LL, Pegues DA, Pettis AM, Saint S, Trautner B, Yokoe D, Meddings J: Strategies to prevent catheter-associated urinary tract infections in acute care hospitals: 2022 Update. Infect Control Hosp Epidemiol 44: 1209-31, Aug 2023.

142 Ziegler MJ, Flores EJ, Epps M, Hopkins K, Glaser L, Mull, NK, Pegues DA: Clostridioides difficile dynamic electronic order panel, an effective automated intervention to reduce inappropriate inpatient ordering. Infect Control Hosp Epidemiol Mar 2023.

1b5 Zhang HL, Kelly BJ, David MZ, Lautenbach E, Huang E, Bekele S, Tolomeo P, Reesey EC, Loughrey S, Pegues D, Ziegler MS : SARS-CoV-2 environmental surface contamination in staff common areas in an acute-care hospital and impact on healthcare worker infection: prospective surveillance during the COVID-19 pandemic. Infect Control Hosp Epidemiol 44: 110-3, Jan 2023.

152 Talbot BM, Jacko NF, Petit RA, Pegues DA, Shumaker MJ, Read TD, David MZ: Unsuspected clonal spread of methicillin-resistant Staphylococcus aureus causing bloodstream infection in hospitalized adults detected using whole genome sequencing. Clin Infect Dis May 2022.

ec Martinello RA, Hebden J, Drews FA, Pegues DA: Human factors analysis of disinfection of central line needleless connectors. SHEA 2022 Spring Conference Apr 2022.

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26 Last updated: 07/07/2025
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