David A Pegues, MD

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Professor of Medicine (Infectious Diseases) at the Hospital of the University of Pennsylvania
Associate Medical Director, Antimicrobial Management Program, Hospital of the University of Pennsylvania
Medical Director, Healthcare Epidemiology and Infection Control, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania, 6th Floor Silverstein Building, 3400 Spruce Street,
Philadelphia, PA 19104-4283
Office: 215-614-1614
Fax: 215-662-7971
BA (Biology)
University of Chicago, 1982.
MD (Medicine)
University of Chicago Pritzker School of Medicine, 1986.
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Description of Clinical Expertise

Transplant infectious diseases, healthcare-associated infections including catheter-associated urinary tract infections, Salmonellosis

Description of Research Expertise

Dr. Pegues’ current research interests include include developing clinical decision support tools to improve testing stewardship and to reduce inappropriate device utilization; evaluating novel technologies and implementation strategies to reduce environmental microbial contamination and infection risk in healthcare setting; and the prevention and control of device-associated infections in high-risk patient populations, including dialysis, oncology, and solid organ transplant.

Selected Publications

Anesi GL, Amorosa VK, Athans V, et al. : Reflections on a model for rapid evidence review and dynamic practice recommendations during a public health emergency: The Penn Medicine COVID-19 Therapeutics Committee. Open Forum Infect Dis Aug 2023.

Ziegler MJ, Flores EJ, Epps M, Hopkins K, Glaser L, Mull, NK, Pegues DA: Clostridioides difficile dynamic electronic order panel, an effective automated intervention to reduce inappropriate inpatient ordering. Infect Control Hosp Epidemiol Mar 2023.

Zhang HL, Kelly BJ, David MZ, Lautenbach E, Huang E, Bekele S, Tolomeo P, Reesey EC, Loughrey S, Pegues D, Ziegler MS : SARS-CoV-2 environmental surface contamination in staff common areas in an acute-care hospital and impact on healthcare worker infection: prospective surveillance during the COVID-19 pandemic. Infect Control Hosp Epidemiol 44: 110-3, Jan 2023.

Deloney VM, Patel PK, Advani S, Kofman AD, Maragakis LL, Pegues DA, Pettis AM, Saint S, Trautner B, Yokoe D, Meddings J : Strategies to prevent catheter-associated urinary tract infections in acute care hospitals: 2022 Update. Infect Control Hosp Epidemiol in press 2023.

Talbot BM, Jacko NF, Petit RA, Pegues DA, Shumaker MJ, Read TD, David MZ: Unsuspected clonal spread of methicillin-resistant Staphylococcus aureus causing bloodstream infection in hospitalized adults detected using whole genome sequencing. Clin Infect Dis May 2022.

Martinello RA, Hebden J, Drews FA, Pegues DA: Human factors analysis of disinfection of central line needleless connectors. SHEA 2022 Spring Conference Apr 2022.

Danehower S, Lazorko J, Kaplan LJ, Fegley M, Jablonski J, Owei L, Ziegler M, Pisa MA, Pegues DA, Pascual JL: Certain rooms in your ICU may harbor risk for Clostridioides difficile infection Surg Infect 23: 159-67, Mar 2022.

Ziegler MJ, Babcock HH, Welbel SF, Warren DK, Trick WE, Tolomeo P, Omorogbe J, Garcia D, Habroch-Bach T, Donceras O, Gaynes S, Cressman L, Burnham JP, Bilker W, Reddy SC, Pegues D, Lautenbach E, Kelly BJ, Fuchs B, Martin ND, Han JH: Stopping hospital infections with environmental services (SHINE): A cluster-randomized trial of intensive monitoring methods for terminal room cleaning on rates of multidrug-resistant organisms in the intensive care unit Clin Infect Dis Feb 2022.

Zhang HL, Kelly BJ, David MZ, Lauttenbach E, Huang E. Bekele S, Tolomeo P, Reesey E, Loughrey S, Pegues D, Ziegler MJ: SARS-CoV-2 RNA persists on surfaces following terminal disinfection of COVID-19 hospital isolation rooms. Am J Infect Control 50: 462-4, Jan 2022.

Pegues DA, Miller SI: Salmonellosis. Harrison’s Principles of Internal Medicine, 21st edition. Loscalzo J, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (eds.). McGraw Hill, 2022.

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Last updated: 09/11/2023
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