Yu-Chin Lien, Ph.D.
Research Assistant Professor of Pediatrics (Neonatology & Newborn Services)
Faculty, Center for Women's Health and Reproductive Medicine, Perelman School of Medicine, University of Pennsylvania
Investigator, Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania
Investigator, Philadelphia Regional Center for Children’s Environmental Health
Investigator, Institute for Translational Medicine and Therapeutics
Department: Pediatrics
Contact information
University of Pennsylvania
Perelman School of Medicine
421 Curie Boulevard
BRB II/III Room 1213
Philadelphia, PA 19104
Perelman School of Medicine
421 Curie Boulevard
BRB II/III Room 1213
Philadelphia, PA 19104
Office: 215-573-4117
Lab: 215-746-5138
Lab: 215-746-5138
Email:
ylien@pennmedicine.upenn.edu
ylien@pennmedicine.upenn.edu
Education
B.S. (Pharmacy)
National Taiwan University, 1996.
M.S. (Pharmaceutical Sciences)
National Taiwan University, 1998.
Ph.D. (Toxicology)
University of Kentucky, 2006.
Permanent linkB.S. (Pharmacy)
National Taiwan University, 1996.
M.S. (Pharmaceutical Sciences)
National Taiwan University, 1998.
Ph.D. (Toxicology)
University of Kentucky, 2006.
Selected Publications
Albetawi, S.N.; Meakin, A.S.; Lien, Y.C.; Wiese, M.D.; Simmons, R.A.; Morrison, J.L.: Altered gene expression and activity of human placental drug-metabolizing cytochrome P450 enzymes across gestation. Biochemical Pharmacology May 2026.Lien, Y.C.; Garifallou, J.P.; Simmons, R.A.: Single nucleus multi-omic profiling reveals sex- and cell type–specific placental dysregulation in spontaneous preterm birth. 73rd Annual Scientific Meeting, Society for Reproductive Investigation, Puerto Rico. Poster March 2026.
Paranjapye, A.; Ahmad, R.; Quaye, C.N.; Simmons, R.A.; Lien, Y.C.; Korb, E.: Exposure to a low dose mixture of endocrine disrupting chemicals alters the brain transcriptome and animal behavior. bioRxiv [Preprint] February 2026.
Yu-Chin Lien, James P. Garifallou, and Rebecca A. Simmons: Heterogeneity and Sex Differences in Mid-Gestation Human Trophoblast Development Revealed by Single-Nucleus Multiome Profiling. 2025 Epigenetics Society International Conference. Chicago, IL. Poster October 2025.
Albetawi, S.N.; Meakin, A.S.; Lien, Y.C.; Wiese, M.D.; Simmons, R.A.; Morrison, J.L.: Gestational age-dependent changes in gene expression and activity of drug-metabolizing cytochrome P450 enzymes in human placenta. Fetal and Neonatal Physiological Society Annual Meeting. Rottnest Island, Western Australia September 2025.
Puvvula, J.; Chen, A.; Simmons, R.A.; Leite, R.; Lien, Y.C. (corresponding author): Gestational fine particulate matter exposures and spontaneous preterm birth: elucidating mechanisms using placental transcriptome and metabolome signatures. Placenta September 2025.
Puvvula, J.; Chen, A.; Simmons, R.A.; Leite, R.; Lien, Y.C.: Mediating role of placental transcriptome and metabolome in the association between early pregnancy fine particulate matter exposure and spontaneous preterm birth. Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology, Atlanta, GA. Poster August 2025.
Lien, Y.C.; Simmons, R.A.: Deciphering the molecular dialogue: mitochondria, epigenetics, and extracellular vesicles in placental function and pregnancy complications. Comprehensive Physiology August 2025.
Lien, Y.C.; Kan, M.; Leite, R.; Garifallou, J.P.; Himes, B.E.; Winn, V.D.; Parry, S.; Strauss III, J.F.; Simmons, R.A.: Race and sex differences in placental lipid metabolism are associated with spontaneous early preterm birth. Biology of Reproduction April 2025.
Albetawi, S.N.; Meakin, A.S.; Lien, Y.C.; Wiese, M.D.; Simmons, R.A.; Morrison, J.L.: Gestational age-dependent changes in gene expression and activity of drug-metabolizing cytochrome P450 enzymes in human placenta. Endocrine Society of Australia – Society for Reproductive Biology Annual Scientific Meeting, Adelaide, Australia. Poster November 2024.