Yu-Chin Lien, Ph.D.

faculty photo
Research Assistant Professor of Pediatrics
Faculty, Center for Research on Reproduction and Women's Health
Investigator, Center of Excellence in Environmental Toxicology
Investigator, Philadelphia Regional Center for Children’s Environmental Health
Department: Pediatrics

Contact information
University of Pennsylvania
Perelman School of Medicine
421 Curie Boulevard
BRB II/III Room 1341
Philadelphia, PA 19104
Lab: 2157465138
Education:
B.S. (Pharmacy)
National Taiwan University, 1996.
M.S. (Pharmaceutical Sciences)
National Taiwan University, 1998.
Ph.D. (Toxicology)
University of Kentucky, 2006.
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Selected Publications

Lien, Y.C.; Leite, R.; Winn, V.D.; Parry, S.; Simmons, R.A.: Racial differences in the metabolome and inflammatory status in second trimester human placenta. Aspen Perinatal Biology Symposium, Aspen, CO, poster August 2022.

Hanke, S.; Joshi, A.; Lien, Y.C.; Fu, W.; Wang, P.Z.; Tarapore, P.; Simmons, R.A.; Pinney, S.E.: PFOA exposure prior to hepatocyte differentiation leads to DNA methylation and expression changes linked to non-alcoholic fatty liver disease. Aspen Perinatal Biology Symposium, Aspen, CO, poster August 2022.

Lien, Y.C.; Leite, R.; Winn, V.D.; Parry, S.; Simmons, R.A: Racial differences in the metabolome in second trimester human placenta. 69th Annual Scientific Meeting, Society for Reproductive Investigation. Denver, CO, poster March 2022.

Lien, Y.C.; Pinney, S.E.; Lu, X.M.; Simmons, R.A.: Identification of novel regulatory regions induced by intrauterine growth restriction in rat islets. Endocrinology 163(2): bqab251, 2022.

Lien, Y.C.; Zhang, Z.; Falk, M.J.; Parry, S.; Simmons, R.A.: Human placental transcriptome and metabolome reveal critical alterations in energy metabolism with fetal sex differences in spontaneous preterm birth. US DOHaD Conference, Chapel Hill, NC, poster November 2021.

Lien, Y.C.; Zhang, Z.; Cheng, Y.; Polyak, E.; Sillers, L.; Falk, M.J.; Ischiropoulos, H.; Parry, S.; Simmons, R.A.: Human placental transcriptome reveals critical alterations in inflammation and energy metabolism with fetal sex differences in spontaneous preterm birth. Int. J. Mol. Sci. 22(15): 7899, 2021.

Lien, Y.C.; Lu, X.M.; Won, K.J.; Wang, P.Z.; Osei-Bonsu, W.; Simmons, R.A.: The transcriptome and epigenome reveal novel changes in transcription regulation during pancreatic rat islet maturation. Endocrinology 162(11): bqab181, 2021.

Lien, Y.C.; Lu, X.M.; Simmons, R.A.: DNA methylation changes reveal distal regulatory regions in islets of intrauterine growth restricted rats. 80th Scientific Sessions, American Diabetes Association, virtual, poster June 2020.

Lien, Y.C.; Wang, P.Z.; Lu, X.M.; Simmons, R.A.: Altered transcription factor binding and gene bivalency in islets of intrauterine growth retarded rats. Cells 9(6): 1435, 2020.

Lien, Y.C.; Won, K.J.; Simmons, R.A.: Transcriptomic and quantitative proteomic profiling reveals signaling pathways critical for pancreatic islet maturation. Endocrinology 161(12): bqaa187, 2020.

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Last updated: 11/01/2022
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