Yu-Chin Lien, Ph.D.

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Research Assistant Professor of Pediatrics
Faculty, Center for Research on Reproduction and Women's Health
Investigator, Center of Excellence in Environmental Toxicology
Investigator, Philadelphia Regional Center for Children’s Environmental Health
Department: Pediatrics

Contact information
University of Pennsylvania
Perelman School of Medicine
421 Curie Boulevard
BRB II/III Room 1352
Philadelphia, PA 19104
Office: 215-573-4916
Lab: 215-746-5138
Education:
B.S. (Pharmacy)
National Taiwan University, 1996.
M.S. (Pharmaceutical Sciences)
National Taiwan University, 1998.
Ph.D. (Toxicology)
University of Kentucky, 2006.
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Selected Publications

Lien, Y.C.; Leite, R.; Winn, V.D.; Parry, S.; Simmons, R.A.: Racial differences in the metabolome and inflammatory status in second trimester human placenta. Aspen Perinatal Biology Symposium, Aspen, CO, poster August 2022.

Hanke, S.; Joshi, A.; Lien, Y.C.; Fu, W.; Wang, P.Z.; Tarapore, P.; Simmons, R.A.; Pinney, S.E.: PFOA exposure prior to hepatocyte differentiation leads to DNA methylation and expression changes linked to non-alcoholic fatty liver disease. Aspen Perinatal Biology Symposium, Aspen, CO, poster August 2022.

Lien, Y.C.; Leite, R.; Winn, V.D.; Parry, S.; Simmons, R.A: Racial differences in the metabolome in second trimester human placenta. 69th Annual Scientific Meeting, Society for Reproductive Investigation. Denver, CO, poster March 2022.

Lien, Y.C.; Pinney, S.E.; Lu, X.M.; Simmons, R.A.: Identification of novel regulatory regions induced by intrauterine growth restriction in rat islets. Endocrinology 163(2): bqab251, 2022.

Lien, Y.C.; Zhang, Z.; Falk, M.J.; Parry, S.; Simmons, R.A.: Human placental transcriptome and metabolome reveal critical alterations in energy metabolism with fetal sex differences in spontaneous preterm birth. US DOHaD Conference, Chapel Hill, NC, poster November 2021.

Lien, Y.C.; Zhang, Z.; Cheng, Y.; Polyak, E.; Sillers, L.; Falk, M.J.; Ischiropoulos, H.; Parry, S.; Simmons, R.A.: Human placental transcriptome reveals critical alterations in inflammation and energy metabolism with fetal sex differences in spontaneous preterm birth. Int. J. Mol. Sci. 22(15): 7899, 2021.

Lien, Y.C.; Lu, X.M.; Won, K.J.; Wang, P.Z.; Osei-Bonsu, W.; Simmons, R.A.: The transcriptome and epigenome reveal novel changes in transcription regulation during pancreatic rat islet maturation. Endocrinology 162(11): bqab181, 2021.

Lien, Y.C.; Lu, X.M.; Simmons, R.A.: DNA methylation changes reveal distal regulatory regions in islets of intrauterine growth restricted rats. 80th Scientific Sessions, American Diabetes Association, virtual, poster June 2020.

Lien, Y.C.; Wang, P.Z.; Lu, X.M.; Simmons, R.A.: Altered transcription factor binding and gene bivalency in islets of intrauterine growth retarded rats. Cells 9(6): 1435, 2020.

Lien, Y.C.; Won, K.J.; Simmons, R.A.: Transcriptomic and quantitative proteomic profiling reveals signaling pathways critical for pancreatic islet maturation. Endocrinology 161(12): bqaa187, 2020.

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Last updated: 05/31/2023
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