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Roddy O'Connor, B.Sc., M.S., Ph.D.
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Research Assistant Professor of Pathology and Laboratory Medicine
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Department: Pathology and Laboratory Medicine
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Graduate Group Affiliations
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Contact information
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3400 Civic Center Blvd
11 8-105 SPE
3e Perelman School of Medicine
Philadelphia, PA 19104
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11 8-105 SPE
3e Perelman School of Medicine
Philadelphia, PA 19104
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Publications
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Links
b2 Search PubMed for articles
e2 Understanding how Artificial Intelligence can expedite media formulation
3a The first web-link includes two segments of biomedical correspondence for FoxNEWS. 2 50 I was also the subject of a Penn undergraduate student's documentary.
ef This webinar focuses on understanding what is in your cell culture media and why owning your formulations is imperative.
dd This webinar will focus on understanding the time and cost of custom media and its importance for cell therapy
ad My lab's website in the Center for Cellular Immunotherapies, Perelman School of Medicine,
f4 Informative webinar describing how fuel metabolism supports CAR-T cell differentiation
1ee Informative webinar providing insight into how unique CAR co-stimulatory domains influence the growth, differentiation, and metabolic function of T cells
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b2 Search PubMed for articles
e2 Understanding how Artificial Intelligence can expedite media formulation
3a The first web-link includes two segments of biomedical correspondence for FoxNEWS. 2 50 I was also the subject of a Penn undergraduate student's documentary.
ef This webinar focuses on understanding what is in your cell culture media and why owning your formulations is imperative.
dd This webinar will focus on understanding the time and cost of custom media and its importance for cell therapy
ad My lab's website in the Center for Cellular Immunotherapies, Perelman School of Medicine,
f4 Informative webinar describing how fuel metabolism supports CAR-T cell differentiation
1ee Informative webinar providing insight into how unique CAR co-stimulatory domains influence the growth, differentiation, and metabolic function of T cells
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Education:
21 a B.Sc. 20 (Exercise Physiology) c
2f University of Limerick, 1997.
21 9 M.S. 1e (Muscle Metabolism) c
31 Georgia State University, 1999.
21 a Ph.D. 23 (Molecular Pharmacology) c
3c Emory University School of Medicine, 2007.
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Permanent link21 a B.Sc. 20 (Exercise Physiology) c
2f University of Limerick, 1997.
21 9 M.S. 1e (Muscle Metabolism) c
31 Georgia State University, 1999.
21 a Ph.D. 23 (Molecular Pharmacology) c
3c Emory University School of Medicine, 2007.
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Description of Research Expertise
119 CAR-T cell metabolism; T cell activation, proliferation and differentiation; Lentiviral, retroviral and mRNA-based gene transfer; Post-transcriptional gene suppression by shRNA and microRNA's; Bio-engineered cell culture platforms; Tissue stem cell differentiation;65
Description of Clinical Expertise
2d Clinical Research Coordinator62
Description of Other Expertise
38 Biomedical Expert (Local News Affiliate)e 29
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11a Veliz K, Shen F, Shestova O, Shestov M, Shestov A, Sleiman S, Hansen T, O'Connor RS, Gill S.: Deletion of CD38 enhances CD19 chimeric antigen receptor T cell function. Mol Therapy Oncolytics 32((2)), May 2024.
16f Roselle C, Horikawa I, Chen L, Kelly AR, Gonzales D, Da T, Wellhausen N, Rommel PC, Baker D, Suhoski M, Scholler J, O'Connor RS, Young RM, Harris CC, June CH.: Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α PNAS 121((10)), March 2024.
1f5 Yan Tang, Wei Liu, Siddhant Kadu, Omar Johnson, Zainul S Hasanali, Andre Kelly, Alexander Shestov, Raymone Pajarillo, Eli Greenblatt, Matthew Holmes, Li-Ping Wang, Natalie Shih, Roddy S O'Connor, Marco Ruella, Alfred L Garfall , David Allman, Dan T Vogl, Adam Cohen, Carl H June, Neil C Sheppard: Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy. Blood 143((2)), Jan 11, 2024.
10b Lee CS, Chen S, Berry CT, Kelly AR, Herman PJ, Oh S, O'Connor RS, Payne AS, Ellebrecht CT.: Fate induction in CD8 CAR T cells through asymmetric cell division. Nature 633((8030)): 670-677, 2024.
17f Zhang C, Kadu S, Xiao Y, Johnson O, Kelly A, O'Connor RS, Lai M, Kong H, Srivatsa S, Tai V, Greenblatt E, Holmes M, Riley JL, June CH, Sheppard NC.: Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function. Cancer Immunol Res 11((11)): 1524-1537, Nov 1 2023.
231 Frank Cichocki, Bin Zhang, Cheng-Ying Wu, Emily Chiu, Abderrahman Day, Roddy S O'Connor, Dima Yackoubov, Ronit Simantov, David H McKenna, Qing Cao, Todd E Defor, Murali Janakiram, Rose Wangen, Zuzan Cayci, Nathaniel Snyder, Akhilesh Kumar, Bartosz Grzywacz, Justin Hwang, Yona Geffen, Jeffrey S Miller, Joseph Maakaron, Veronika Bachanova: Nicotinamide enhances natural killer cell function and yields remissions in patients with non-Hodgkin lymphoma. Sci Transl Med 705(19;15), Jul 2023.
111 Akbari B, Hosseini Z, Shahabinejad P, Ghassemi S, Mirzaei HR, O'Connor RS.: Metabolic and epigenetic orchestration of (CAR) T cell fate and function. Cancer Lett 550: 215948, Dec 2022 Notes: No issue.
1cc Zhang H, Yu P, Tomar VS, Chen X, Atherton MJ, Lu Z, Zhang HG, Li S, Ortiz A, Gui J, Leu NA, Yan F, Blanco A, Meyer-Ficca ML, Meyer RG, Beiting DP, Li J, Nunez-Cruz S, O'Connor RS, Johnson LR, Minn AJ, George SS, Koumenis C, Diehl JA, Milone MC, Zheng H, Fuchs SY.: Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors. Nat Cancer 3(7): 808-820, Jul 2022.
15b Ghassemi S, Durgin JS, Nunez-Cruz S, Patel J, Leferovich J, Pinzone M, Shen F, Cummins KD, Plesa G, Cantu VA, Reddy S, Bushman FD, Gill SI, O'Doherty U, O'Connor RS, Milone MC.: Rapid manufacturing of non-activated potent CAR T cells. Nat Biomed Eng 6(2): 118-128, Feb 2022.
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Selected Publications
212 McDonald-Hyman C, Aguilar EG, Compeer EB, Zaiken MC, Rhee SY, Mohamed FA, Larson JH, Loschi ML, Lees C, Thangavelu G, Sleeth ML, Smith KD, Whangbo JS, Ritz J, Sparwasser TD, O'Connor RS, Crawford PA, Rathmell JC, Kean LS, Zeiser R, Hippen KL, Dustin ML, Blazar BR.: Acetyl-CoA carboxylase-1 inhibition increases regulatory T-Cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion. J. Clin Invest Page: e182480, September 2025.11a Veliz K, Shen F, Shestova O, Shestov M, Shestov A, Sleiman S, Hansen T, O'Connor RS, Gill S.: Deletion of CD38 enhances CD19 chimeric antigen receptor T cell function. Mol Therapy Oncolytics 32((2)), May 2024.
16f Roselle C, Horikawa I, Chen L, Kelly AR, Gonzales D, Da T, Wellhausen N, Rommel PC, Baker D, Suhoski M, Scholler J, O'Connor RS, Young RM, Harris CC, June CH.: Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α PNAS 121((10)), March 2024.
1f5 Yan Tang, Wei Liu, Siddhant Kadu, Omar Johnson, Zainul S Hasanali, Andre Kelly, Alexander Shestov, Raymone Pajarillo, Eli Greenblatt, Matthew Holmes, Li-Ping Wang, Natalie Shih, Roddy S O'Connor, Marco Ruella, Alfred L Garfall , David Allman, Dan T Vogl, Adam Cohen, Carl H June, Neil C Sheppard: Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy. Blood 143((2)), Jan 11, 2024.
10b Lee CS, Chen S, Berry CT, Kelly AR, Herman PJ, Oh S, O'Connor RS, Payne AS, Ellebrecht CT.: Fate induction in CD8 CAR T cells through asymmetric cell division. Nature 633((8030)): 670-677, 2024.
17f Zhang C, Kadu S, Xiao Y, Johnson O, Kelly A, O'Connor RS, Lai M, Kong H, Srivatsa S, Tai V, Greenblatt E, Holmes M, Riley JL, June CH, Sheppard NC.: Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function. Cancer Immunol Res 11((11)): 1524-1537, Nov 1 2023.
231 Frank Cichocki, Bin Zhang, Cheng-Ying Wu, Emily Chiu, Abderrahman Day, Roddy S O'Connor, Dima Yackoubov, Ronit Simantov, David H McKenna, Qing Cao, Todd E Defor, Murali Janakiram, Rose Wangen, Zuzan Cayci, Nathaniel Snyder, Akhilesh Kumar, Bartosz Grzywacz, Justin Hwang, Yona Geffen, Jeffrey S Miller, Joseph Maakaron, Veronika Bachanova: Nicotinamide enhances natural killer cell function and yields remissions in patients with non-Hodgkin lymphoma. Sci Transl Med 705(19;15), Jul 2023.
111 Akbari B, Hosseini Z, Shahabinejad P, Ghassemi S, Mirzaei HR, O'Connor RS.: Metabolic and epigenetic orchestration of (CAR) T cell fate and function. Cancer Lett 550: 215948, Dec 2022 Notes: No issue.
1cc Zhang H, Yu P, Tomar VS, Chen X, Atherton MJ, Lu Z, Zhang HG, Li S, Ortiz A, Gui J, Leu NA, Yan F, Blanco A, Meyer-Ficca ML, Meyer RG, Beiting DP, Li J, Nunez-Cruz S, O'Connor RS, Johnson LR, Minn AJ, George SS, Koumenis C, Diehl JA, Milone MC, Zheng H, Fuchs SY.: Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors. Nat Cancer 3(7): 808-820, Jul 2022.
15b Ghassemi S, Durgin JS, Nunez-Cruz S, Patel J, Leferovich J, Pinzone M, Shen F, Cummins KD, Plesa G, Cantu VA, Reddy S, Bushman FD, Gill SI, O'Doherty U, O'Connor RS, Milone MC.: Rapid manufacturing of non-activated potent CAR T cells. Nat Biomed Eng 6(2): 118-128, Feb 2022.
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