Roddy O'Connor, B.Sc., M.S., Ph.D.

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Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
3400 Civic Center Blvd
8-105 SPE
Perelman School of Medicine
Philadelphia, PA 19104
Education:
B.Sc. (Exercise Physiology)
University of Limerick, 1997.
M.S. (Clinical Exercise Physiology)
Georgia State University, 1999.
Ph.D. (Molecular Pharmacology)
Emory University School of Medicine, 2007.
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Description of Research Expertise

CAR-T cell metabolism; T cell activation, proliferation and differentiation; Lentiviral, retroviral and mRNA-based gene transfer; Post-transcriptional gene suppression by shRNA and microRNA's; Bio-engineered cell culture platforms; Tissue stem cell differentiation;

Description of Clinical Expertise

Clinical Research Coordinator

Description of Other Expertise

Biomedical Expert (Local News Affiliate)

Selected Publications

Sellmyer, M.A., Richman, S.A., Lohith, K., Hou, C., Weng, C-C, Mach, R.H., O'Connor, R.S., Milone, M.C., and Farwell, M.D.: Imaging CAR T Cell Trafficking with eDFHR as a PET Reporter Gene Molecular Therapy 2020.

Ghassemi, S., Martinez-Becerra, F. J., Master, A. M., Richman, S. A., Heo, D., Leferovich, J., Tu, Y., Garcia-Canaveras, J. C., Ayari, A., Lu, Y., Wang, A., Rabinowitz, J. D., Milone, M. C., June, C. H., O'Connor, R. S.: Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design. Mol Ther Methods Clin Dev 18: 595-606, 2020.

Philipson, B. I., O'Connor, R. S., May, M. J., June, C. H., Albelda, S. M., Milone, M. C.: 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-kappaB signaling. Sci Signal 13(625), 2020.

Klichinsky, M., Ruella, M., Shestova, O., Lu, X. M., Best, A., Zeeman, M., Schmierer, M., Gabrusiewicz, K., Anderson, N. R., Petty, N. E., Cummins, K. D., Shen, F., Shan, X., Veliz, K., Blouch, K., Yashiro-Ohtani, Y., Kenderian, S. S., Kim, M. Y., O'Connor, R. S., Wallace, S. R., Kozlowski, M. S., Marchione, D. M., Shestov, M., Garcia, B. A., June, C. H., Gill, S.: Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol 38(8): 947-953, 2020.

O'Connor, R.S. and Milone, M.C.: Testing the Specificity of Compounds Designed to Inhibit CPT1A in T cells. Methods Molecular Biology 2097, 2020.

Liu M, O'Connor RS, Trefely S, Graham K, Snyder NW, Beatty GL.: Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated "don't-eat-me" signal. Nature Immunology 20(3): 265-275, January 2019.

Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Zhang C, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, Melenhorst JJ, Milone MC.: Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T cells. Cancer Immunology Research 6(9): 1100-1109, September 2018.

Fraietta, J.A., Lacey, S.F., Orlando, E.J., Pruteanu-Malinici, I., Gohil, M., Lundh, S., Boesteanu, A.C., Wang, y., O'Connor, R.S., Hwang, W.T., Pequignot, E., Ambrose, D.E., Zhang, C., Wilcox, N., Bedoya, F., Dorfmeier, C., Chen, F., Tian, L., Parakandi, H., Gupta, M., Young, R.M., Johnson, F.B., Kulikovskaya, I., Liu, L., Xu, J., Kassim, S.H., Davis, M.M., Levine, B.L., Frey, N.V., Siegel, D.L., Huang, A.C., Wherry, E.J., Bitter, H., Brogdon, J.L., Porter, D.L., June, C.H., Melenhorst, J.J.: Determinants of response and resistance to CD19 chimeric antigen receptor(CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine 24(5): 563-571, May 2018 Notes: doi: 10.1038/s41591-018-0010-1. Epub 2018 Apr 30.

O'Connor, R.S., Guo, L., Ghassemi, S., Snyder, N.W., Worth, A.J., Weng, L., Kam, Y., Philipson, B., Trefely, S., Nunez-Cruz, S., Blair, I.A., June, C.H., and Milone, M.C.: The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Scientific Reports 8(1): e6289, Apr 2018 Notes: https://doi.org/10.1038/s41598-018-24676-6.

June, C.H., O’Connor, R.S., Kawalekar, O.U., Ghassemi, S., and Milone, M.C., : CAR T cell immunotherapy for human cancer. Science Immunology 359(6382): 1361-1365, March 2018.

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Last updated: 09/03/2020
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