Eric Stanton Diffenderfer, Ph.D.

faculty photo
Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Proton Research Room Technical Director, Proton SARRP research facility.
Physics Lead - Thoracic Group, Department of Radiation Oncology, University of Pennsylvania
Department: Radiation Oncology
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
B.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
Permanent link
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Description of Research Expertise

FLASH radiotherapy.
Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.

Description of Clinical Expertise

Proton and X-ray therapy physics and dosimetry.

Selected Publications

Hai Siong Tan, BoonKeng Kevin Teo, Lei Dong, Andrew Friberg, Constantinos Koumenis, Eric Diffenderfer, Jennifer Wei Zou: Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach. Physics in Medicine and Biology 2023 Notes: doi: 10.1088/1361-6560/ace14d.

Wei Zou PhD, Rongxiao Zhang PhD, Emil Schueler PhD, Paige A Taylor PhD , Anthony E Mascia PhD, Eric S Diffenderfer PhD, Tianyu Zhao PhD, Ahmet S Ayan PhD, Manju Sharma PhD, Shu-Jung Yu PhD, Weiguo Lu PhD, Walter R Bosch DSc, Christina Tsien PhD, Murat Surucu PhD, Julianne M Pollard-Larkin PhD, Jan Schuemann PhD, Eduardo G Moros PhD, Magdalena Bazalova-Carter PhD, David J Gladstone ScD, Heng Li PhD, Charles B Simone II MD, Kristoffer Petersson PhD , Stephen F Kry PhD, Amit Maity MDPhD, Billy W Loo Jr MDPhD, Lei Dong PhD, Peter G Maxim PhD, Ying Xiao PhD, Jeffrey C Buchsbaum MD: Framework for Quality Assurance of Ultra-High Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps. International Journal of Radiation Oncology • Biology • Physics 2023 Notes: doi: 10.1016/j.ijrobp.2023.04.018.

Wei Zou, Haram Kim, Eric S. Diffenderfer, David J. Carlson, Cameron J. Koch, Ying Xiao, BoonKeng K. Teo, Michele M. Kim, James M. Metz, Yi Fan, Amit Maity, Costas Koumenis, Theresa M. Busch, Rodney Wiersma, Keith A. Cengel and Lei Dong: A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply. Frontiers in Oncology 12, November 2022 Notes: doi: 10.3389/fonc.2022.1004121.

Van Slyke AL, El Khatib M, Velalopoulou A, Diffenderfer E, Shoniyozov K, Kim MM, Karagounis IV, Busch TM, Vinogradov SA, Koch CJ, Wiersma RD: Oxygen Monitoring in Model Solutions and In Vivo in Mice During Proton Irradiation at conventional and FLASH Dose Rates. Radiation Research 198(2): 181-189, Aug 2022 Notes: doi: 10.1667/RADE-21-0023.

Khatib, Mirna El; Van Slyke, Alexander L.; Velalopoulou, Anastasia; Kim, Michele M.; Shoniyozov, Khayrullo; Allu, Srinivasa Rao; Diffenderfer, Eric S.; Busch, Theresa M.; Wiersma, Rodney D.; Koch, Cameron J.; Vinogradov, Sergei A.: Ultrafast Tracking of Oxygen Dynamics during Proton FLASH. International Journal of Radiation Oncology • Biology • Physics 113(3): 624-634, Jul 2022 Notes: DOI: 10.1016/j.ijrobp.2022.03.016.

Eric S Diffenderfer, Brita Singers Sørensen, Alejandro Mazal, David J Carlson: The Current Status of Pre-Clinical Proton FLASH Radiation and Future Directions. Medical Physics March 2022 Notes: doi: 10.1002/mp.15276.

Luna, José Marcio; Barsky, Andrew R; Shinohara, Russell T; Roshkovan, Leonid; Hershman, Michelle; Dreyfuss, Alexandra D; Horng, Hannah; Lou, Carolyn; Noël, Peter B; Cengel, Keith A; Katz, Sharyn; Diffenderfer, Eric S*; Kontos, Despina*: Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation. Cancers 14(3): 700, January 2022 Notes: * denotes co-senior authorship,

Busch, T., Velalopoulou, A., Karagounis, I., Cramer, G., Skoufos, G., Hatzigeorgiou, A. G., Lanza, M., Radaelli, E., Assenmacher, C. A., Putt, M., Kim, M., Diffenderfer, E., Dong, L., Metz, J., Koumenis, C., Cengel, K., Maity, A.: FLASH Mechanisms Track MECHANISMS OF FLASH RADIOTHERAPY SPARING OF NORMAL TISSUE AS INFORMED BY RNA-SEQ TRANSCRIPTOME ANALYSES. Physica Medica 94: S5-S5, 2022.

El Khatib, M., Van Slyke, A., Velalopoulou, A., Shoniyozov, K., Diffenderfer, E., Kim, M., Karagounis, I., Busch, T., Wiersma, R., Koch, C., Vinogradov, S.: FLASH Mechanisms Track (Oral Presentations) ULTRAFAST TRACKING OF OXYGEN DYNAMICS DURING PROTON FLASH. Physica Medica 94: S31-S31, 2022 Notes: oral presentation.

Cengel, K., Kim, M., Diffenderfer, E., Karagounis, I., Cramer, G., Skoufos, G., Hatzigeorgiou, A. G., Lanza, M., Assenmacher, C. A., Radaelli, E., Putt, M., Hagan, S., Chiango, J., Shoniyozov, K., Dong, L., Koumenis, C., Maity, A., Busch, T., Metz, J., Huck, J.: FLASH in the Clinic Track (Oral Presentations) A RANDOMIZED DOSE ESCALATION STUDY OF FLASH VS STANDARD DOSE RATE PROTON RADIOTHERAPY FOR CANINE OSTEOSARCOMA. Physica Medica 94: S24-S24, 2022 Notes: oral presentation.

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Last updated: 09/21/2023
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