Eric Diffenderfer, Ph.D.

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
B.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
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Description of Research Expertise

Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.

Description of Clinical Expertise

Proton and X-ray therapy physics and dosimetry.

Selected Publications

Jose M. Luna Castaneda, Andrew Barsky, Russell T. Shinohara, Alexandra D. Dreyfuss, Leonid Roshkovan, Michelle Hershman, Babak Haghighi, Bardia Yousefi, Peter B. Noel, Keith A. Cengel, Sharyn Katz, Eric S. Diffenderfer*, Despina Kontos*: Radiomic features predict local failure-free survival in stage III NSCLC adenocarcinoma treated with chemoradiation. Proceedings of SPIE 11597, February 2021 Notes: *denotes co-senior authorship doi: 10.1117/12.2581873.

Lingshu Yin, Wei Zou, Michele M Kim, Stephen M Avery, Rodney D Wiersma, Boon-Keng K Teo, Lei Dong, Eric S Diffenderfer: Evaluation of two-voltage and three-voltage linear methods for deriving ion recombination correction factors in proton FLASH irradiation. IEEE Transactions on Radiation and Plasma Medical Sciences 2021 Notes: in press.

Wei Zou, Eric S Diffenderfer, Kan Ota, Paul Boisseau, Michele M Kim, Yongliang Cai, Steven M Avery, David J Carlson, Rodney D Wiersma, Alexander Lin, Costas Koumenis, Keith Cengel, James M Metz, Lei Dong, Boonkeng K Teo: Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery. Medical Physics 2021 Notes: in press, doi: 10.1002/mp.14882.

Michele M. Kim and Eric S. Diffenderfer*: Proton Therapy Dosimetry. Radiation Therapy Dosimetry: A Practical Handbook. Arash Darafsheh (eds.). Taylor & Francis Group, 2021 Notes: *Corresponding author.

Anastasia Velalopoulou*, Ilias V. Karagounis, Ioannis I. Verginadis, Denisa Goia, Michele Kim, Khayrullo Shoniyozov, Keith Cengel, Eric Diffenderfer, Lei Dong, James Metz, Theresa Busch, Amit Maity and Costas Koumenis: Proton FLASH radiation spares normal skin and soft tissues of the murine leg from radiation-induced damage while being equipotent with standard proton radiation in controlling sarcoma growth. Proceedings: AACR Annual Meeting 2020 August 2020 Notes: poster.

Eric S. Diffenderfer, Ioannis I. Verginadis, Michele M. Kim, Khayrullo Shoniyozovs, Anastasia Velalopoulou, PhD, Mary Putt, Sarah Hagan, Denisa Goia, Stephen Avery, Kevin Teo, Wei Zou, Alexander Lin, Samuel Swisher-McClure, Cameron Koch, Ann R Kennedy, Andy Minn, Amit Maity, Theresa M Busch, Lei Dong, Costas Koumenis, James Metz, Keith Cengel: Design, Implementation and In-Vivo Validation of a Novel Proton FLASH Radiotherapy System. International Journal of Radiation Oncology • Biology • Physics February 2020 Notes: doi: 10.1016/j.ijrobp.2019.10.049.

Lingshu Yin*, Michele Kim, Jennifer Wei Zou, Eric Diffenderfer, Lei Dong: Measurement of the ion collection efficiency of different ion chambers in proton FLASH irradiation. 2020 AAPM/COMP Annual Meeting 2020 Notes: Therapy Blue Ribbon ePoster.

Shannon O’Reilly, Varsha Jain, Qijie Huang, Chingyun Cheng, Boon-Keng Kevin Teo, Lingshu Yin, Miao Zhang, Eric Diffenderfer, Taoran Li, William Levin, Ying Xiao, Lei Dong, Steven Feigenberg, Abigail T. Berman, Wei Zou: Dose to Highly Functional Ventilation Zones Improves Prediction of Radiation Pneumonitis for Proton and Photon Lung Cancer Radiotherapy. International Journal of Radiation Oncology • Biology • Physics 2020.

M Kim*, K Shoniyozov, C Koumenis, J Metz, K Cengel, L Dong, E Diffenderfer: Utilizing the Bragg Peak for Proton Flash Radiation. 2020 AAPM/COMP Annual Meeting 2020 Notes: poster.

H Kim*, B Teo, K Cengel, L Yin, M Kim, S Huang, J Konzer, T Li, S Avery, R Wiersma, D Carlson, A Lin, T Busch, C Koumenis, J Metz, L Dong, E Diffenderfer, W Zou: Clustered Pencil Beam Scanning (CPBS) Delivery Technique for Potential FLASH Proton Treatment. 2020 AAPM/COMP Annual Meeting 2020 Notes: poster.

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Last updated: 04/19/2021
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