Eric Diffenderfer, Ph.D.

faculty photo
Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
Education:
B.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
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Description of Research Expertise

Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.

Description of Clinical Expertise

Proton and X-ray therapy physics and dosimetry.

Selected Publications

Eric S. Diffenderfer, Ioannis I. Verginadis, Michele M. Kim, Khayrullo Shoniyozovs, Anastasia Velalopoulou, PhD, Mary Putt, Sarah Hagan, Denisa Goia, Stephen Avery, Kevin Teo, Wei Zou, Alexander Lin, Samuel Swisher-McClure, Cameron Koch, Ann R Kennedy, Andy Minn, Amit Maity, Theresa M Busch, Lei Dong, Costas Koumenis, James Metz, Keith Cengel: Design, Implementation and In-Vivo Validation of a Novel Proton FLASH Radiotherapy System. International Journal of Radiation Oncology • Biology • Physics February 2020 Notes: in press.

Shannon O’Reilly, Varsha Jain, Qijie Huang, Chingyun Cheng, Boon-Keng Kevin Teo, Lingshu Yin, Miao Zhang, Eric Diffenderfer, Taoran Li, William Levin, Ying Xiao, Lei Dong, Steven Feigenberg, Abigail T. Berman, Wei Zou: Dose to Highly Functional Ventilation Zones Improves Prediction of Radiation Pneumonitis for Proton and Photon Lung Cancer Radiotherapy. International Journal of Radiation Oncology • Biology • Physics 2020.

José Marcio Luna, Hann-Hsiang Chao, Russel T. Shinohara, Lyle H. Ungar, Keith A. Cengel, Daniel A. Pryma, Chidambaram Chinniah, Abigail T. Berman, Sharyn I. Katz, Despina Kontos, Charles B. Simone, Eric S. Diffenderfer: Machine Learning Highlights the Deficiency of Conventional Dosimetric Constraints for Prevention of High-Grade Radiation Esophagitis in Non-Small Cell Lung Cancer Treated with Chemoradiation. Clinical and Translational Radiation Oncology 2020 Notes: accepted.

Gilmer Valdes, José Marcio Luna, Efstathios D. Gennatas, Lyle H. Ungar, Eric Eaton, Eric S. Diffenderfer, Shane T. Jensen, Charles B. Simone II, Jerome H. Friedman, and Timothy D. Solberg: Reply to Nock and Nielsen: On the work of Nock and Nielsen and its relationship to the Additive Tree. Proceedings of the National Academy of Sciences 2020 Notes: https://doi.org/10.1073/pnas.2002399117.

José Marcio Luna, Efstathios D. Gennatas, Lyle H. Ungar, Eric Eaton, Eric S. Diffenderfer, Shane T. Jensen, Charles B. Simone II, Jerome H. Friedman, Timothy D. Solberg, and Gilmer Valdes: Building more accurate decision trees with the additive tree. Proceedings of the National Academy of Sciences September 2019 Notes: https://doi.org/10.1073/pnas.1816748116.

Michele Kim, Peyton Irmen, Khayrullo Shoniyozov, Ioannis I Verginadis, Keith A Cengel, Costas Koumenis, James M Metz, Lei Dong, Eric Diffenderfer: Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Physics in Medicine & Biology May 2019.

José Marcio Luna, Hann-Hsiang Chao, Eric S. Diffenderfer, Gilmer Valdes, Chidambaram Chinniah, Grace Ma, Keith A. Cengel, Timothy D. Solberg, Abigail T. Berman, Charles B.Simone II: Predicting radiation pneumonitis in locally advanced stage II–III non-small cell lung cancer using machine learning. Radiotherapy and Oncology 133: 106-112, April 2019.

R L Maughan, S Avery, E S Diffenderfer, D Dolney, B-K K Teo: Recent developments at the University of Pennsylvania’s Roberts Proton Therapy Center. Journal of Physics: Conference Series( 1154), 2019.

Moyers M, Wang K, Diffenderfer E, Pankuch M, Mah C: Physics Essentials of Particle Therapy. Target Volume Delineation and Treatment Planning for Particle Therapy. Lee N., Leeman J.E., Cahlon O., Sine K., Jiang G., Lu J.J., Both S. (eds.). Springer, 2018.

José Marcio Luna, Despina Kontos, Keith A. Cengel, Charles B. Simone II, Eric Diffenderfer : Prediction of Tumor Progression in Locally Advanced Non-Small Cell Lung Cancer using Standardized Uptake Values from Thoracic PET/CT. AAPM 60th Annual Meeting, Nashville TN 2018 Notes: e-poster.

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Last updated: 05/18/2020
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