Eric Stanton Diffenderfer, Ph.D.

faculty photo
Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Proton Research Room Technical Director, Proton SARRP research facility.
Physics Lead - Thoracic Group, Department of Radiation Oncology, University of Pennsylvania
Proton Physics Team Lead, Department of Radiation Oncology, University of Pennsylvania
Department: Radiation Oncology
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
B.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
Permanent link
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Description of Research Expertise

FLASH radiotherapy.
Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.

Description of Clinical Expertise

Proton and X-ray therapy physics and dosimetry.

Selected Publications

Keith A. Cengel, Michele M. Kim, Eric S. Diffenderfer, Theresa M. Busch: FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma? Seminars in Radiation Oncology 34(2), March 2024 Notes: doi: 10.1016/j.semradonc.2024.02.001.

Kyle Kim, Michele M. Kim, Giorgos Skoufos, Eric S. Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G. Hatzigeorgiou, James M. Metz, Steven J. Feigenberg, Keith A. Cengel, Bonnie Ky, Costas Koumenis, Ioannis I. Verginadis: FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease. International Journal of Radiation Oncology • Biology • Physics 2024 Notes: in press.

Antonia Rotolo, Eoin C. Whelan, Matthew J. Atherton, Irina Kulikovskaya, Danuta Jarocha, Joseph A. Fraietta, Michele M. Kim, Eric S. Diffenderfer, Keith A. Cengel, Martina Piviani, Enrico Radaelli, Raimon Duran-Struuck, and Nicola J. Mason: Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients. Cell Reports Medicine 4(10), October 2023 Notes: DOI:

Hai Siong Tan, BoonKeng Kevin Teo, Lei Dong, Andrew Friberg, Constantinos Koumenis, Eric Diffenderfer, Jennifer Wei Zou: Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach. Physics in Medicine and Biology 2023 Notes: doi: 10.1088/1361-6560/ace14d.

Jeffrey Arkles, Tim Markman, Rachel Trevillian, Nikhil Yegya-Raman, Lohit Garg, Saman Nazarian, Pasquale Santangeli, Fermin Garcia, David Callans, David S Frankel, Gregory Supple, David Lin, Michael Riley, Ramanan Kumaraeswaran, Francis Marchlinski, Robert Schaller, Benois Desjardins, Hongyu Chen, Ontida Apinorasethkul, Michelle Alonso-Basanta, Eric Diffenderfer, Michele M Kim, Steven Feigenberg, Wei Zou, Jacklyn Marcel, Keith A Cengel: One-Year Outcomes Following Stereotactic Body Radiotherapy for Refractory Ventricular Tachycardia. Heart Rythym 2023 Notes: DOI: 10.1016/j.hrthm.2023.10.005.

Wei Zou PhD, Rongxiao Zhang PhD, Emil Schueler PhD, Paige A Taylor PhD , Anthony E Mascia PhD, Eric S Diffenderfer PhD, Tianyu Zhao PhD, Ahmet S Ayan PhD, Manju Sharma PhD, Shu-Jung Yu PhD, Weiguo Lu PhD, Walter R Bosch DSc, Christina Tsien PhD, Murat Surucu PhD, Julianne M Pollard-Larkin PhD, Jan Schuemann PhD, Eduardo G Moros PhD, Magdalena Bazalova-Carter PhD, David J Gladstone ScD, Heng Li PhD, Charles B Simone II MD, Kristoffer Petersson PhD , Stephen F Kry PhD, Amit Maity MDPhD, Billy W Loo Jr MDPhD, Lei Dong PhD, Peter G Maxim PhD, Ying Xiao PhD, Jeffrey C Buchsbaum MD: Framework for Quality Assurance of Ultra-High Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps. International Journal of Radiation Oncology • Biology • Physics 2023 Notes: doi: 10.1016/j.ijrobp.2023.04.018.

Wei Zou, Haram Kim, Eric S. Diffenderfer, David J. Carlson, Cameron J. Koch, Ying Xiao, BoonKeng K. Teo, Michele M. Kim, James M. Metz, Yi Fan, Amit Maity, Costas Koumenis, Theresa M. Busch, Rodney Wiersma, Keith A. Cengel and Lei Dong: A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply. Frontiers in Oncology 12, November 2022 Notes: doi: 10.3389/fonc.2022.1004121.

Van Slyke AL, El Khatib M, Velalopoulou A, Diffenderfer E, Shoniyozov K, Kim MM, Karagounis IV, Busch TM, Vinogradov SA, Koch CJ, Wiersma RD: Oxygen Monitoring in Model Solutions and In Vivo in Mice During Proton Irradiation at conventional and FLASH Dose Rates. Radiation Research 198(2): 181-189, Aug 2022 Notes: doi: 10.1667/RADE-21-0023.

Khatib, Mirna El; Van Slyke, Alexander L.; Velalopoulou, Anastasia; Kim, Michele M.; Shoniyozov, Khayrullo; Allu, Srinivasa Rao; Diffenderfer, Eric S.; Busch, Theresa M.; Wiersma, Rodney D.; Koch, Cameron J.; Vinogradov, Sergei A.: Ultrafast Tracking of Oxygen Dynamics during Proton FLASH. International Journal of Radiation Oncology • Biology • Physics 113(3): 624-634, Jul 2022 Notes: DOI: 10.1016/j.ijrobp.2022.03.016.

Eric S Diffenderfer, Brita Singers Sørensen, Alejandro Mazal, David J Carlson: The Current Status of Pre-Clinical Proton FLASH Radiation and Future Directions. Medical Physics March 2022 Notes: doi: 10.1002/mp.15276.

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Last updated: 03/19/2024
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