Eric Diffenderfer, Ph.D.

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
B.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
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Description of Research Expertise

Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.

Description of Clinical Expertise

Proton and X-ray therapy physics and dosimetry.

Selected Publications

Anastasia Velalopoulou, Ilias V. Karagounis, Gwendolyn M. Cramer, Michele M. Kim, Giorgos Skoufos, Denisa Goia, Sarah Hagan, Ioannis I. Verginadis, Khayrullo Shoniyozov, June Chiango, Michelle Cerullo, Kelley Varner, Lutian Yao, Ling Qin, Artemis G. Hatzigeorgiou, Andy J. Minn, Mary Putt, Matthew Lanza, Charles-Antoine Assenmacher, Enrico Radaelli, Jennifer Huck, Eric Diffenderfer, Lei Dong, James Metz, Constantinos Koumenis, Keith A. Cengel, Amit Maity and Theresa M. Busch: FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research September 2021 Notes: DOI: 10.1158/0008-5472.CAN-21-1500.

Michele M. Kim †, Ioannis I. Verginadis †, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Wei Zou, Amit Maity, Theresa M. Busch, James M. Metz, Keith A. Cengel, Lei Dong, Costas Koumenis and Eric S. Diffenderfer: Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model. Cancers 13(16): 4244, August 2021 Notes:

Wei Zou, Eric S Diffenderfer, Kan Ota, Paul Boisseau, Michele M Kim, Yongliang Cai, Steven M Avery, David J Carlson, Rodney D Wiersma, Alexander Lin, Costas Koumenis, Keith Cengel, James M Metz, Lei Dong, Boonkeng K Teo: Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery. Medical Physics April 2021 Notes:

Ioannis Verginadis, Anastasia Velalopoulou, Sarah Hagan, Denisa Goia, Khayrullo Shoniyozov, Michele Kim, Eric Diffenderfer, Lei Dong, James Metz, Keith Cengel, Theresa Busch, Andy Minn, Amit Maity, Constantinos Koumenis: Preclinical studies with proton FLASH radiotherapy in mice and canines: Biological effects, biophysical considerations and potential mechanisms. Clinical Cancer Research 27(8), March 2021 Notes: Proceedings of the AACR Virtual Special Conference on Radiation Science and Medicine: Abstract IA-019.

Jose M. Luna Castaneda, Andrew Barsky, Russell T. Shinohara, Alexandra D. Dreyfuss, Leonid Roshkovan, Michelle Hershman, Babak Haghighi, Bardia Yousefi, Peter B. Noel, Keith A. Cengel, Sharyn Katz, Eric S. Diffenderfer*, Despina Kontos*: Radiomic features predict local failure-free survival in stage III NSCLC adenocarcinoma treated with chemoradiation. Proceedings of SPIE 11597, February 2021 Notes: *denotes co-senior authorship doi: 10.1117/12.2581873.

Eric S Diffenderfer, Brita Singers Sørensen, Alejandro Mazal, David J Carlson: The Current Status of Pre-Clinical Proton FLASH Radiation and Future Directions. Medical Physics 2021 Notes: doi: 10.1002/mp.15276.

Lingshu Yin, Wei Zou, Michele M Kim, Stephen M Avery, Rodney D Wiersma, Boon-Keng K Teo, Lei Dong, Eric S Diffenderfer: Evaluation of two-voltage and three-voltage linear methods for deriving ion recombination correction factors in proton FLASH irradiation. IEEE Transactions on Radiation and Plasma Medical Sciences 2021 Notes: DOI: 10.1109/TRPMS.2021.3078885.

Michele M. Kim and Eric S. Diffenderfer: Proton Therapy Dosimetry. Radiation Therapy Dosimetry: A Practical Handbook. Arash Darafsheh (eds.). Taylor & Francis Group, 2021.

R Yang, E Diffenderfer: Simulating Spatial-Temporal Dose Rate Deposition On Tissue Sparing for Scanned Pencil-Beam Vs Double-Scattered Protons. 2021 AAPM Annual Meeting 2021 Notes: oral presentation.

M Kim*, I Verginadis, A Haertter, D Goia, K Shoniyozov, J Zou, C Koumenis, J Metz, K Cengel, L Dong, E Diffenderfer: FLASH Sparing of Normal Tissue in a Proton Spread Out Bragg Peak. 2021 AAPM Annual Meeting 2021 Notes: oral presentation, winner of BEST IN PHYSICS (THERAPY).

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Last updated: 10/17/2021
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