Jarcy Zee, PhD

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Assistant Professor of Biostatistics in Biostatistics and Epidemiology at the Children's Hospital of Philadelphia
Senior Scholar, Center for Clinical Epidemiology and Biostatistics (CCEB)
Core Faculty Member, Kidney Innovation Center (KIC)
Analysis Core Co-Director, Center for Improving Care Delivery for the Aging (CICADA)
Department: Biostatistics and Epidemiology

Contact information
Department of Biostatistics, Epidemiology and Informatics
University of Pennsylvania, Perelman School of Medicine
210 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-573-8545
Fax: 215-573-1050
Education:
BS (Mathematics and Economics)
University of Delaware, 2007.
MS (Biostatistics)
University of Pennsylvania, 2012.
PhD (Biostatistics)
University of Pennsylvania, 2014.
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Description of Research Expertise

Survival analysis, longitudinal data analysis, observational data analysis, measurement error, biomarkers, surrogate endpoints, machine learning, glomerular disease, chronic kidney disease, women's health, patient-reported outcomes

Selected Publications

Zee J, Liu Q, Smith AR, Hodgin JB, Rosenberg A, Gillespie BW, Holzman LB, Barisoni L, Mariani: Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis. Journal of the American Society of Nephrology 33(7): 1411-1426, July 2022.

Zee J, Mariani LH, Barisoni L, Mahajan P, Gillespie BW: A Novel Agreement Statistic Using Data on Uncertainty in Ratings. Journal of the Royal Statistical Society, series C 72(5): 1293, November 2023.

Mondal A, Thoonkuzhy C, Mariani LH, Zee J: Evaluation of Biomarker-Based GFR Estimating Equations in Glomerular Disease. Glomerular Diseases 4(1): 119-128, May 2024.

Zee, Jarcy; Mansfield, Sarah; Mariani, Laura H; Gillespie, Brenda W.: Using All Longitudinal Data to Define Time to Specified Percentages of Estimated GFR Decline: A Simulation Study. American Journal of Kidney Diseases 73(1): 82-89, January 2019.

Liu Q, Smith AR, Nair V, Mariani LH, Zee J: Methods for Assessing Longitudinal Biomarkers of Time-to-Event Outcomes in CKD: A Simulation Study. Clinical Journal of the American Society of Nephrology 14(9): 1315-1323, September 2019.

Rubin J, Mariani L, Smith A, Zee J: Ridge Regression for Functional Form Identification of Continuous Predictors of Clinical Outcomes in Glomerular Disease. Glomerular Diseases 3(1): 47-55, December 2022.

Glenn DA, Zee J, Mansfield S, O’Shaughnessy MM, Bomback AS, Gibson K, Greenbaum LA, Mariani L, Falk R, Hogan S, Mottl A, Denburg MR on behalf of the CureGN Consortium: Immunosuppression Exposure and Risk of Infection-related Acute Care Events in Patients with Glomerular Disease: An Observational Cohort Study. Kidney Medicine 4(11): 100553, November 2022.

Lutnick B, Manthey D, Becker J, Ginley B, Moos K, Zuckerman J, Rodrigues L, Gallan A, Barisoni L, Alpers C, Wang X, Myakala K, Jones B, Levi M, Kopp J, Yoshida T, Zee J, Han SS, Jain S, Rosenberg A, Jen KY: A User-Friendly Tool for Cloud-Based Whole Slide Image Segmentation, with Examples from Renal Histopathology. Communications Medicine 2: 105, August 2022.

*Royal V, *Zee J, Liu Q, Avila-Casado C, Smith AR, Liu G, Mariani LH, Hewitt S, Holzman LB, Gillespie BW, Hodgin JB, Barisoni L: Ultrastructural Characterization of Proteinuric Patients Predicts Clinical Outcomes Journal of the American Society of Nephrology 31(4): 841-854, April 2020 Notes: *Contributed equally as primary authors.

*Smith AR, *Zee J, Ji N, Troost JP, Gillespie BW, Nair V, Liu Q, Gibson KL, Kretzler M, Mariani LH: Predictors of Non-linearity in eGFR Trajectories in the Nephrotic Syndrome Study Network (NEPTUNE). Kidney Medicine 2(4): 407-417, June 2020 Notes: *Contributed equally as primary authors.

Zee J, McNulty MT, Hodgin JB, Zhdanova O, Wang CS, Vento S, Tuttle KR, Trachtman H, Srivastava T, Singer P, Sethna CB, Sambandam KK, Reich HN, Patel J, O'Toole J, Nast CC, Meyers KE, Matar RB, Lin JJ, Lieske JC, Lemley KV, Lafayette RA, Kopp JB, Kretzler M, Kaskel FJ, Jefferson JA, Holzman LB, Hogan MC, Hogan J, Hladunewich MA, Hingorani S, Greenbaum LA, Gipson DS, Gibson KL, Gadegbeku CA, Fornoni A, Fervenza FC, Derebail VK, Dell KM, Chen D, Brown E, Bagnasco S, Atkinson MA, Athavale AM, Appel G, Adler SG, Barisoni L, Sampson MG: APOL1 Genotype- and Gene Expression-Associated Morphologic Changes among Patients with Focal Segmental Glomerulosclerosis. Pediatric Nephrology 36: 2747-2757, September 2021.

*Hodgin J, *Mariani L, *Zee J, Liu Q, Smith AR, Eddy S, Hartman J, Hamidi H, Gaut JP, Palmer MB, Nast CC, Chang A, Hewitt S, Gillespie BW, Kretzler M, Holzman LB, Barisoni L: Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome. American Journal of Kidney Diseases 79(6): 807-819, June 2021 Notes: *Contributed equally as primary authors.

Zee J, Muenz D, McCullough K, Bieber B, Metzger M, Alencar de Pinho N, Lopes AA, Fliser D, Robinson B, Young E, Pisoni RL, Stengel B, Pecoits-Filho R: Potential Surrogate Outcomes for Kidney Failure in Advanced CKD: Evaluation of Power and Predictive Ability in CKDopps. Kidney Medicine 4(2): 100395, December 2021.

Reynolds M, Oliverio A, Zee J, Hendren E, O'Shaugnessy M, Ayoub I, Almaani S, Vasylyeva T, Twombley K, Wadhwani S, Steinke J, Rizk D, Waldman M, Helmuth M, Avila-Casado C, Alachkar N, Nester C, Hladunewich M, Mariani LH: Pregnancy History and Disease Progression Among Women Enrolled in Cure Glomerulonephropathy. Kidney International Reports 8(4): 805-817, February 2023.

Bressman E, Long JA, Burke RE, Ahn A, Honig K, Zee J, Mcglaughlin N, Balachandran M, Asch DA, Morgan A: Automated Text Message-Based Program to Reduce Use of Acute Care Resources After Hospital Discharge. JAMA Network Open 7(4), April 2024.

Glenn DA, Andrews C, Liu Q, Zee J, Mansfield S, Smith A, O'Shaughnessy M, Bomback A, Gibson K, Greenbaum LA, Mariani L, Falk R, Hogan S, Mottl A, Denburg M, on behalf of the CureGN Consortium: Glucocorticoid Exposure and Infection in Children and Adults with Glomerular Disease: Findings From the Cure Glomerulonephropathy Study. American Journal of Kidney Diseases 2024, in press.

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Last updated: 03/21/2025
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