Yang Li, MD, PhD
Assistant Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Contact information
Abramson Research Bldg. 707C
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 2105354249
Lab: 2155909908
Lab: 2155909908
Email:
liy11@chop.edu
liy11@chop.edu
Education:
B.A. (Biophysics)
Johns Hopkins University, 2007.
M.A. (Biophysics)
Johns Hopkins University, 2008.
Ph.D. (Cell and Molecular Biology)
University of Pennsylvania, 2013.
M.D.
University of Pennsylvania, 2015.
Permanent linkB.A. (Biophysics)
Johns Hopkins University, 2007.
M.A. (Biophysics)
Johns Hopkins University, 2008.
Ph.D. (Cell and Molecular Biology)
University of Pennsylvania, 2013.
M.D.
University of Pennsylvania, 2015.
Description of Clinical Expertise
Immunogenetics/histocompatibility: HLA typing, anti-HLA antibody screening, alloimmune risk assessment, virtual and physical crossmatching, chimerism evaluation, NGS and nanopore sequencing, HLA-disease association, desensitization; Transfusion MedicineDescription of Research Expertise
Antigenicity and immunogenicity of HLAs, Chromatin interactions and gene regulation within the major histocompatibility complex (MHC), CAR T for transplantation desensitizationSelected Publications
Mosbruger, Timothy; Dinou, Amalia; Duke, Jamie; Ferriola, Deborah; Li, Yang; Hayeck, Tristan; Monos, Dimitri: Haplotypic resolution of the challenging genomic regions of MHC and KIR using a combination of targeted sequencing and a novel assembly pipeline. Nucleic Acids Research 53, June 2025 Notes: DOI: 10.1093/nar/gkaf441.Georgia F Papadaki, Yang Li, Dimitri S Monos, Vijay G Bhoj: Cars pick up another passenger: Organ transplantation. Human Immunology. Chang Liu (eds.). 86, January 2025 Notes: DOI: 10.1016/j.humimm.2024.111180.
Yang Li, Timothy Mosbruger, Deborah Ferriola, Jamie Duke, Sarah Morris, Brooke Marcellus, Dimitri Monos, Benjamin Laskin, Sandra Amaral: Both Low Eplet Mismatch and Low Indirect T-Cell Recognition Scores Are StrongPrognosticators of Reduced Alloimmune Rejection in Pediatric Kidney Transplants. World Transplant Congress 2025 2025.
Taishan Hu, Timothy L Mosbruger, Nikolaos G Tairis, Amalia Dinou, Pushkala Jayaraman, Mahdi Sarmady, Kingham Brewster, Yang Li, Tristan J Hayeck, Jamie L Duke, Dimitri S Monos: Targeted and complete genomic sequencing of the major histocompatibility complex in haplotypic form of individual heterozygous samples. Genome Research 34: 1500-1513, October 2024 Notes: DOI: 10.1101/gr.278588.123.
Hayeck, T. J., Li, Y., Mosbruger, T. L., Bradfield, J. P., Gleason, A. G., Damianos, G. L., Shaw, G. T., Duke, J. L., Conlin, L. K., Turner, T. N., Fernández-Viña, M. A., Sarmady, & M., Monos, D. S.: The impact of patterns in linkage disequilibrium and sequencing quality on the imprint of balancing selection. Genome Biology and Evolution, 16(2), February 2024 Notes: DOI: 10.1093/gbe/evae009.
Li, Y., Mosbruger, T. L., Hayeck, T. J., Wells, A. D., Grant, S. F. A., & Monos, D.: Hi-C analysis using self-reference provides a more informative MHC chromatin interaction map. ASHI 48th Annual Meeting: P98. 2022.
Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J. A. L., Gorena, K. M., Cheng, C. J., Li, Y., Nelson, J. F., Strong, R. J., Hornsby, P. J., Clark, R. A., & Li, S.: Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice. Aging Cell 19(3), February 2020 Notes: DOI: 10.1111/acel.13110.
Chen, C., Guderyon, M. J., Li, Y., Ge, G., Bhattacharjee, A., Ballard, C., He, Z., Masliah, E., Clark, R. A., O’Connor, J. C., & Li, S.: Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson’s Disease. Molecular Therapy - Methods & Clinical Development 17: 83-98, 2020 Notes: DOI: 10.1016/j.omtm.2019.11.013.
Henry, C., Zheng, N. Y., Huang, M., Cabanov, A., Rojas, K. T., Kaur, K., Andrews, S. F., Palm, A. E., Chen, Y. Q., Li, Y., Hoskova, K., Utset, H. A., Vieira, M. C., Wrammert, J., Ahmed, R., Holden-Wiltse, J., Topham, D. J., Treanor, J. J., Ertl, H. C., Schmader K.E, Cobey S., Krammer F., Hensley S. E, Greenberg H., He X.S., Wilson, P. C.: Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host & Microbe 25(3): 357-366, 2019 Notes: https://doi.org/10.1016/j.chom.2019.01.002.
Balcerek, J., Jiang, J., Li, Y., Jiang, Q., Holdreith, N., Singh, B., Chandra, V., Lv, K., Ren, J., Rozenova, K., Li, W., Greenberg, R. A., & Tong, W.: Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia. Nature Communications 9(1): 3915, 2018 Notes: DOI: 10.1038/s41467-018-06380-1.