Lacramioara Ivanciu, PhD
Research Associate Professor of Pediatrics (Hematology)
Member, Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia
Member, Blood Center for Patient Care and Discovery, Children's Hospital of Philadelphia and University of Pennsylvania
Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
3501 Civic Center Blvd.
Philadelphia, PA 19104
3501 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-7431
Fax: 215-590-3660
Fax: 215-590-3660
Email:
ivanciul@chop.edu
ivanciul@chop.edu
Education
B.A.
University of Bucharest, Romania (Biology), 1995.
M.S.
University of Bucharest, Romania (Biology), 1996.
Ph.D.
University of Bucharest, Romania (Biology), 2004.
Permanent linkB.A.
University of Bucharest, Romania (Biology), 1995.
M.S.
University of Bucharest, Romania (Biology), 1996.
Ph.D.
University of Bucharest, Romania (Biology), 2004.
Selected Publications
Ivanciu L, Bos MHA, Parthasarathy S, Toso R, Camire RM: "Enhanced factor VIII activation accelerates thrombin generation and hemostatic potency in mice" under review in Blood 2026.Ivanciu L, Cevasco C, Gansner J, Lombardelli S, Camire RM, Slingsby ML: "Hepatic plasminogen lowering with a GalNac-conjugated siRNA in VWF knockout mice does not exacerbate provoked arterial thrombosis following factor replacement" 68th Annual Meeting of American Society of Hematology, New Orleans, LA 2026.
Leyes Porello, SE, Chau, JQ, Lee K, Suber YB, Fletcher SN, Johnsen J, Kolyadko VN, Lund J, Ivanciu L and Samelson-Jones B: "In vivo and in vitro hemostatic activity of factor VIIIa-mimetics in hemophilia B" under review in Blood 2026.
Cevasco C, Ivanciu L, Gansner JM, Camire RM, Lundberg Slingsby MH.: Hepatic plasminogen lowering with a galnac-conjugated siRNA reduces plasmin generation and fibrinolysis but has no effect on thrombin generation in rats and mice. 67th American Society of Hematology Annual Meeting, Orlando, FL, Poster presentation Dec 2025.
Leyes Porello SE, Chau JQ, Lee K, Johnsen J, Lund J, a\Ivanciu L, Sameslo-Jones BJ.: Mim8 improves the in vivo hemostasis of select hemophilia B causing factor IX variants. 67th American Society of Hematology Annual Meeting, Orlando, FL, Poster presentation Dec 2025.
Chau JQ, Leyes Porello SE, Ivanciu L, and Samelson-Jones BJ: Comparison of hemostatic dosing of factor IX and Padua (R338L) in multiple hemophilia B mouse models. 67th American Society of Hematology Annual Meeting, Orlando, FL, Poster presentation Dec 2025.
Krohn L, Ivanciu L, Cevasco C, Deaton AM, Ward LD, Gansner JM, Camire RM, and Lundberg Slingsby MH.: Lowering plasminogen is not associated with risk of thrombosis: Evidence from human proteomics, Mendelian Randomization, and mouse injury models. American Society of Human Genetics (ASHG), Boston, MA, Poster presentation October 2025.
Ivanciu L, Krohn L, Cevasco C, Deaton AM, Ward LD, LoGerfo PJ, Gansner JM, Camire RM, Slingsby MHL.: Hepatic plasminogen lowering with RNA interference for the treatment of bleeding disorders is unlikely to pose thrombotic risk based on UK Biobank analysis and mouse models of provoked thrombosis. European Hematology Association (EHA) Congress, Milan, Italy, Oral presentation Jun 2025.
Ivanciu L and Camire RM: Blood Coagulation Factor IX: structure, function and regulation. IUBMB Life; "From DNA to protein: molecular mechanisms and tailored approaches to correct genetic defects associated with human disorders" doi: https://doi.org/10.1002/iub.70024 (eds.). 2025 Notes: corresponding author.
Poncz M, Zaitsev S, Ahn H, Kowalska MA, Bdeir K, Vladimirovich K, Ivanciu L, Camire RM, Cines DB, Stepanova V.: Packaging of supplemental urokinase into alpha-granules of the in vitro-grown megakaryocytic for targeted nascent clot lysis. Blood Advances 8(14): 3798-3809, Jul 2024.