Alexander Lin, M.D.

faculty photo
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
University of Pennsylvania
Department of Radiation Oncology
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
Office: 215-662-3198
Fax: 215-349-5445
B.A. (Molecular Biophysics and Biochemistry)
Yale University, 1998.
M.D. (Medicine)
University of Michigan Medical School, 2002.
Other (Certificate in Financial Accounting)
Harvard Business School Online, 2019.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Dr. Lin is Chief of the Head and Neck Oncology Service in the Department of Radiation Oncology at Penn Medicine. Dr. Lin specializes in the multidisciplinary approach to treatment of cancers of the head and neck. He works collaboratively with members of the Departments of Otorhinolaryngology (ENT), Medical Oncology, Pathology, Diagnostic Radiology, Oral Medicine, and Nuclear Medicine with a focus on improving cancer control, outcomes, and quality of life for patients.

Description of Other Expertise

Dr. Lin is the Vice Chair of Faculty Affairs in the Department of Radiation Oncology at the University of Pennsylvania. In this role, he leads departmental efforts in establishing a robust and active program for mentorship and professional development for faculty members of the Department of Radiation Oncology.

Description of Research Expertise

Alexander Lin, M.D., is Associate Professor in the Department of Radiation Oncology at the Perelman School of Medicine, and the Medical Director of the Roberts Proton Therapy Center at the University of Pennsylvania. Dr. Lin leads research programs in personalized approaches in the multidisciplinary treatment of head and neck cancer. Dr. Lin leads studies in novel methods of toxicity mitigation in patients with Human Papillomavirus (HPV)-associated cancers of the oropharynx. He also specializes in clinical trials investigating new radiosensitizing agents targeting the tumor microenvironment to improve disease outcomes, for which he receives funding from the National Cancer Institute (NCI) and National Institutes of Health (NIH).

Dr. Lin completed his undergraduate studies at Yale University and his medical training at the University of Michigan. He is a board-certified radiation oncologist and practicing physician at the University of Pennsylvania, Perelman School of Medicine.

Selected Publications

Weinstein GS, Cohen R, Lin A, O'Malley Jr BW, Lukens J, Swisher-McClure S, Shanti RM, Newman JG, Parhar HS, Tasche K, Brody RM, Chalian A, Cannady S, Palmer JN, Adappa ND, Kohanski MA, Bauml J, Aggarwal C, Montone K, Livolsi V, Baloch ZW, Jalaly JB, Cooper K, Rajaskeran K, Loevner L, Rassekh C: Penn Medicine Head and Neck Cancer Service Line COVID-19 Management Guidelines. Head and Neck 42(7): 1507-1515, July 2020.

Facompre ND, Rajagopalan P, Sahu V, Pearson AT, Montone KT, James CD, Gleber-Netto FO, Nathanson KL, Weinstein GS, Jalaly J, Cohen RB, Herlyn M, Lin A, White EA, Rustgi AK, Nakagawa H, Califano JA, Pickering CR, Windle B, Morgan IM, Gimotty PA, Basu D: Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models. International Journal of Cancer June (Online ahead of print) 2020.

Mohiuddin JJ, Chu B, Facciabene A, Wang X, Doucette A, Zheng C, Xu W, Anstadt EJ, Amaravadi RK, Karakousis GC, Mitchell TC, Shabason JE, Lin A, Swisher-McClure S, Maity A, Schuchter LM, Lukens JN: Association of antibiotic exposure with overall survival and immune-mediated colitis in patients with stage III and IV melanoma receiving immunotherapy. Journal of the National Cancer Institute April (Online ahead of print) 2020.

Grewal AS, Rajasekaran K, Cannady SB, Chalian AA, Ghiam AF, Lin A, LiVolsi V, Lukens JN, Mitra N, Montone KT, Newman JG, O’Malley Jr. BW, Rassekh CH, Weinstein GS, Swisher-McClure S: Pharyngeal Sparing Radiation for Head and Neck Carcinoma of Unknown Primary following TORS work-up The Laryngoscope 130(3): 691-697, March 2020.

Swisher-McClure S, Lukens JN, Aggarwal C, Ahn P, Basu D, Bauml JM, Brody R, Chalian A, Cohen RB, Fotouhi-Ghiam A, Geiger G, Gershowitz J, Livolsi V, Mick R, Mitra N, Montone K, Newman J, Ojerholm E, O’Malley Jr. B, Rajasekeran K, Tan E, Weinstein G, Lin A: A Phase 2 Trial of Alternative Volumes of Oropharyngeal Irradiation for De-intensification: Omission of the Resected Primary Tumor Bed Following Transoral Robotic Surgery for Human Papilloma Virus Related Squamous Cell Carcinoma of the Oropharynx. International Journal of Radiation Oncology, Biology, Physics 106(4): 725-732, March 2020.

Hague C, Aznar MC, Li T, O’Reilly S, Dong L, Fotouhi-Ghiam A, Lee LW, Lowe M, Lukens JN, McPartlin A, Slevin N, Swisher-McClure S, Thomson D, van Herk M, West C, Zou W, Lin A, Teo BK.: Inter-fraction Robustness of Intensity-Modulated Proton Therapy in the Post-operative Treatment of Oropharyngeal and Oral Cavity Squamous Cell Carcinomas. British Journal of Radiology 93(1107): 20190638, March 2020.

Diffenderfer ES, Kim MM, Verginadi II, Shoniyozov K, Hagan S, Avery S, Teo K, Zou W, Lin A, Swisher-McClure S, Koch C, Kennedy AR, Maity A, Busch TM, Dong L, Koumenis C, Metz J, Cengel KA: Design, Implementation and In Vivo Validation of a Novel Proton FLASH Radiotherapy System International Journal of Radiation Oncology, Biology, Physics 106(2): 440-448, February 2020.

Borja AJ, Hancin EC, Dreyfuss AD, Zhang V, Mathew T, Rojulpote C, Werner TJ, Patil S, Gonuguntla K, Lin A, Feigenberg SJ, Swisher-McClure S, Alavi A, Revhein M-E: F-FDG-PET/CT in the quantification of photon radiation therapy-induced vasculitis. American journal of nuclear medicine and molecular imaging 10(1): 66-73, 2020.

Jain V, Irmen P, O’Reilly S, Vogel JH, Lin L, Lin A: Predicted Secondary Malignancies Following Proton Versus Photon Radiation for Oropharyngeal Cancers. International Journal of Particle Therapy 6(4): 1-10, 2020.

Chao HH, Schonewolf C, Tan E, Swisher-McClure SS, Ghiam AF, Weinstein GS, O’Malley Jr BW, Chalian AA, Rassekh CH, Newman JG, Cohen RB, Bauml JM, Aggarwal C, Lin A*, Lukens JN*: The Impact of Treatment Package Time on Locoregional Control for HPV+ Oropharyngeal Squamous Cell Carcinoma Treated with Surgery and Postoperative (Chemo)Radiation. Head and Neck 41(11): 3858-3868, November 2019.

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Last updated: 09/16/2020
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