Alexander Lin, M.D.

faculty photo
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
University of Pennsylvania
Department of Radiation Oncology
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
Office: 215-662-3198
Fax: 215-349-5445
B.A. (Molecular Biophysics and Biochemistry)
Yale University, 1998.
M.D. (Medicine)
University of Michigan Medical School, 2002.
Other (Certificate in Financial Accounting)
Harvard Business School Online, 2019.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Dr. Lin is Chief of the Head and Neck Oncology Service in the Department of Radiation Oncology at Penn Medicine. Dr. Lin specializes in the multidisciplinary approach to treatment of cancers of the head and neck. He works collaboratively with members of the Departments of Otorhinolaryngology (ENT), Medical Oncology, Pathology, Diagnostic Radiology, Oral Medicine, and Nuclear Medicine with a focus on improving cancer control, outcomes, and quality of life for patients.

Description of Other Expertise

Dr. Lin is the Vice Chair of Faculty Affairs in the Department of Radiation Oncology at the University of Pennsylvania. In this role, he leads departmental efforts in establishing a robust and active program for mentorship and professional development for faculty members of the Department of Radiation Oncology.

Description of Research Expertise

Alexander Lin, M.D., is Associate Professor in the Department of Radiation Oncology at the Perelman School of Medicine, and the Medical Director of the Roberts Proton Therapy Center at the University of Pennsylvania. Dr. Lin leads research programs in personalized approaches in the multidisciplinary treatment of head and neck cancer. Dr. Lin leads studies in novel methods of toxicity mitigation in patients with Human Papillomavirus (HPV)-associated cancers of the oropharynx. He also specializes in clinical trials investigating new radiosensitizing agents targeting the tumor microenvironment to improve disease outcomes, for which he receives funding from the National Cancer Institute (NCI) and National Institutes of Health (NIH).

Dr. Lin completed his undergraduate studies at Yale University and his medical training at the University of Michigan. He is a board-certified radiation oncologist and practicing physician at the University of Pennsylvania, Perelman School of Medicine.

Selected Publications

Carey RM, Brody RM, Shimunov D, Shinn JR, Mady LJ, Rajasekaran K, Cannady SB, Lin A, Lukens JN, Swisher-McClure S, Bauml JM, Aggarwal C, Cohen RB, Chalian AA, Rassekh CH, Basu D, O’Malley, Jr. BW, Weinstein GS, Newman JG : Locoregional Recurrence Patterns and Salvage Outcomes of HPV-associated Oropharyngeal Squamous Cell Carcinoma After Transoral Robotic Surgery The Laryngoscope Page: doi: 10.1002/lary.29659. 2021 Online ahead of print.

Treister NS, Brennan MT, Sollecito TP, Schmidt BL, Patton LL, Mitchell R, Haddad RI, Tishler RB, Lin A, Shadick R, Hodges JS, Lalla RV: Exposed Bone in Patients With Head and Neck Cancer Treated With Radiation Therapy: An Analysis of the Observational Study of Dental Outcomes in Head and Neck Cancer Patients (OraRad). Cancer 2021 (published ahead of print, online) Notes: DOI: 10.1002/cncr.33948.

Wright C, Lee DY, Shimunov D, Carmona R, Barsky AR, Sun L, Cohen RB, Bauml JM, Brody RM, Basu D, Rassekh CH, Chalian AA, Newman JG, Rajasekaran K, Weinstein GS, Lukens JN, Lin A, Swisher-McClure S: Definitive tumor directed therapy confers a survival advantage for metachronous oligometastatic HPV-associated oropharyngeal cancer following trans-oral robotic surgery. Oral Oncology 121: 105509, Oct 2021 Notes: doi: 10.1016/j.oraloncology.2021.105509.

Parhar HS, Weinstein GS, O’ Malley Jr. BW, Shimunov D, Rassekh CH, Chalian AA, Newman JG, Cannady SB, Rajasekaran K, Lin A, Lukens JN, Swisher-McClure S, Cohen RB, Bauml J, Aggarwal C, Brody RM: Oncologic Outcomes of Transoral Robotic Surgery for HPV-Negative Oropharyngeal Carcinomas. Head and Neck 43(10): 2923-2934, October 2021.

Sun L, Shimunov D, Tan E, Swisher-Mcclure S, Alexander Lin A, Lukens JN, Basu D, Chalian AA, Cannady SB, Newman JG, Karthik Rajasekaran K, O’Malley Jr BW, Rassekh CH, Weinstein GS, Aggarwal C, Singh A, Cohen RB, Bauml JM, Brody RM: Survival and toxicity in patients with human papilloma virus-associated oropharyngeal squamous cell cancer receiving trimodality therapy including trans-oral robotic surgery. Head and Neck 43(10): 3053-3061, October 2021.

Straker III RJ, Song Y, Sun J, Shannon AB, Cohen LS, Muradova E, Daou H, Krause K, Li S, Frederick DT, Rhodin KE, Brizel DM, Boland GM, Beasley GM, Wuthrick EJ, Sondak VK, Zager JS, Lin A, Lukens JN, Karakousis GC: Adjuvant radiation therapy for clinical stage III melanoma in the modern therapeutic era. Annals of Surgical Oncology 28(7): 3512-3521, July 2021.

Yver CM, Shimunov D, Weinstein GS, Rajasekaran K, Cannady SB, Lukens JN, Lin A, Swisher-McClure S, Cohen RB, Aggarwal C, Bauml JM, Loevner LL, Newman JG, Chalian AA, Rassekh CH, Basu D, O’Malley Jr BW, Brody RM: Oncologic and survival outcomes for resectable locally-advanced HPV-related oropharyngeal cancer treated with transoral robotic surgery. Oral Oncology 118: 105307, July 2021 Notes: doi: 10.1016/j.oraloncology.2021.105307.

Smith GL, Fu S, Ning MS, Nguyen N, Busse PM, Foote RL, Garden AS, Gunn GB, Fuller CD, Morrison WH, Chronowski G, Shah S, Mayo L, Phan J, Reddy JP, Snider III JW, Patel SH, Katz R, Lin A, Mohammed N, Dagan R, Lee N, Rosenthal DI, Frank SJ: Work Outcomes after Intensity-Modulated Proton Therapy (IMPT) vs. Intensity-Modulated Photon Therapy (IMRT) for Oropharyngeal Cancer. International Journal of Particle Therapy 8(1): 319–327, Jun 2021.

Kassaee A, Cheng C, Yin L, Zou W, Li T, Lin A, Swisher-McClure S, Lukens JN, Lustig RA, O’Reilly S, Dong L, Hytonen R, Teo BK: Dual Energy CT Proton Dose Calculation Using Scripting and Modified Hounsfield Units International Journal of Particle Therapy 8(1): 62-72, Jun 2021.

McGinnis GJ, Ning MS, Bvochora-Nsingo M, Chiyapo S, Balang D, Difela K, Ralefala T, Lin A, Zetola NM, Grover S: Management of head and neck cancers with or without comorbid HIV infection in Botswana. Laryngoscope 131(5): E1558–E1566, May 2021 Notes: DOI: 10.1002/lary.29206.

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Last updated: 10/22/2021
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