Alexander Lin, M.D.

faculty photo
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Chief, Head and Neck Service, Perelman School of Medicine, University of Pennsylvania, Department of Radiation Oncology
Medical Director, Roberts Proton Therapy Center, Perelman School of Medicine, University of Pennsylvania, Department of Radiation Oncology
Co-Director, Head and Neck Cancer Service Line, University of Pennsylvania, Abramson Cancer Center
Vice Chair of Faculty Affairs, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania
Senior Governance Committee, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania
Department: Radiation Oncology

Contact information
University of Pennsylvania
Department of Radiation Oncology
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
Office: 215-662-3198
Fax: 215-349-5445
Education:
B.A. (Molecular Biophysics and Biochemistry)
Yale University, 1998.
M.D. (Medicine)
University of Michigan Medical School, 2002.
Other (Certificate in Financial Accounting)
Harvard Business School Online, 2019.
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Description of Clinical Expertise

Dr. Lin is Chief of the Head and Neck Oncology Service in the Department of Radiation Oncology at Penn Medicine. Dr. Lin specializes in the multidisciplinary approach to treatment of cancers of the head and neck. He works collaboratively with members of the Departments of Otorhinolaryngology (ENT), Medical Oncology, Pathology, Diagnostic Radiology, Oral Medicine, and Nuclear Medicine with a focus on improving cancer control, outcomes, and quality of life for patients.

Description of Other Expertise

Dr. Lin is the Vice Chair of Faculty Affairs in the Department of Radiation Oncology at the University of Pennsylvania. In this role, he leads departmental efforts in establishing a robust and active program for mentorship and professional development for faculty members of the Department of Radiation Oncology.

Description of Research Expertise

Alexander Lin, M.D., is Associate Professor in the Department of Radiation Oncology at the Perelman School of Medicine, and the Medical Director of the Roberts Proton Therapy Center at the University of Pennsylvania. Dr. Lin leads research programs in personalized approaches in the multidisciplinary treatment of head and neck cancer. Dr. Lin leads studies in novel methods of toxicity mitigation in patients with Human Papillomavirus (HPV)-associated cancers of the oropharynx. He also specializes in clinical trials investigating new radiosensitizing agents targeting the tumor microenvironment to improve disease outcomes, for which he receives funding from the National Cancer Institute (NCI) and National Institutes of Health (NIH).

Dr. Lin completed his undergraduate studies at Yale University and his medical training at the University of Michigan. He is a board-certified radiation oncologist and practicing physician at the University of Pennsylvania, Perelman School of Medicine.

Selected Publications

Lalla RV, Treister NS, Sollecito TP, Schmidt BS, Patton LL, Helgeson ES, Lin A, Rybczyk C, Dowsett R, Hegde U, Boyd TS, Duplinsky TG, Brennan MT: Radiation Therapy for Head and Neck Cancer Leads to Gingival Recession Associated With Dental Caries Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 133(5): 539-546, May 2022.

Treister NS, Brennan MT, Sollecito TP, Schmidt BL, Patton LL, Mitchell R, Haddad RI, Tishler RB, Lin A, Shadick R, Hodges JS, Lalla RV: Exposed Bone in Patients With Head and Neck Cancer Treated With Radiation Therapy: An Analysis of the Observational Study of Dental Outcomes in Head and Neck Cancer Patients (OraRad). Cancer 128(3): 487-496, February 2022 Notes: DOI: 10.1002/cncr.33948.

Shinn JR, Carey RM, Mady LJ, Shimunov D, Parhar HS, Cannady SB, Rajasekaran K, Lukens JN, Lin A, Swisher-McClure S, Cohen RB, Bauml JM, Rassekh CH, Newman JG, Chalian AA, Basu D, Weinstein GS, Brody RM : Sex-Based Differences in Outcomes Among Surgically Treated Patients with HPV-Related Oropharyngeal Squamous Cell Carcinoma. Oral Oncology 123: 105570, December 2021.

Carey RM, Brody RM, Shimunov D, Shinn JR, Mady LJ, Rajasekaran K, Cannady SB, Lin A, Lukens JN, Swisher-McClure S, Bauml JM, Aggarwal C, Cohen RB, Chalian AA, Rassekh CH, Basu D, O’Malley, Jr. BW, Weinstein GS, Newman JG : Locoregional Recurrence Patterns and Salvage Outcomes of HPV-associated Oropharyngeal Squamous Cell Carcinoma After Transoral Robotic Surgery The Laryngoscope 131(12): E2865-E2873, December 2021.

Carmona R, de Joya E, Tobillo R, Dooley S, Freedman LM, Samuels S, Sargi ZB, Weed D, Lin A, Perez C, Samuels MA, Mell LK: Development and Validation of a Machine Learning-Based Predictor for OS and PFS in HPV-Negative HNSCC Patients With Microscopic ENE and Intermediate-Risk Disease. International Journal of Radiation Oncology, Biology, Physics Vol. 111Issue 3SupplementPublished in issue: November 01, 2021 111(3, Supplement): S113–S114, November 2021.

Anstadt EJ, Carey RM, Shimunov D, Lin A, Barsky AR, Wright CM, Doucette A, Swisher-McClure SD, Cohen R, Bauml J, Weinstein GS, O'Malley Jr. B, Chalian A, Rassekh C, Rajasekaran K, Basu D, Cannady SB, Brody R, Lukens JN: Outcomes Using TORS or Definitive Chemoradiation for T3/T4 HPV+ Oropharynx Cancer International Journal of Radiation Oncology, Biology, Physics 111(3, Supplement): e400, November 2021.

Maxwell RJL, Poirier K, Montone K, Swisher-McClure SD, Kumar S, Kuperwasser C, Bauml J, Cohen R, Newman J, Brody R, Rajasekaran K, Chalian A, Rassekh C, Weinstein GS, Lin A, Lukens JN: Detection of Plasma Circulating Tumor-Tissue Modified HPV DNA Following Trans-Oral Robotic Surgery (TORS) and Neck Dissection for p16+ Oropharyngeal Squamous Cell Carcinoma. International Journal of Radiation Oncology, Biology, Physics 111(3, Supplement): e402, November 2021.

Kim K, Doucette A, Amaniera I, Baumann BC, Harton J, Gabriel PE, Mitra N, Lukens JN, Swisher-McClure SD, Lin A, Metz JM, Wojcieszynski Jr AP: Acute Toxicity in Patients Treated With Proton vs. Photon Chemoradiotherapy for Locally Advanced Head and Neck Cancer. International Journal of Radiation Oncology, Biology, Physics 111(3, Supplement): e371–e372, November 2021.

Lee DY, Wright CM, Shimunov D, Carmona R, Barsky AR, Sun L, Cohen R, Bauml J, Brody R, Basu D, Rassekh C, O'Malley B, Chalian A, Newman J, Rajasekaran K, Weinstein GS, Lukens JN, Lin A, Swisher-McClure SD: Definitive Tumor Directed Therapy for Metachronous Oligometastatic HPV-Associated Oropharyngeal Cancer Following Trans-Oral Robotic Surgery International Journal of Radiation Oncology, Biology, Physics 111(3, Supplement): e403, November 2021.

Wright CM, Lee DY, Kim MM, Anstadt EJ, Teo K, Carlson DJ, Lukens JN, Swisher-McClure SD, Eisbruch A, Lin A: Predicting the Clinical Gains Associated With Further Reduction of Normal Tissue Dose Constraints in Oropharynx Cancer Radiotherapy. International Journal of Radiation Oncology, Biology, Physics 111(3, Supplement): e402-e403, November 2021.

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Last updated: 04/26/2022
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