Alexander Lin, M.D.

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Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Medical Director, Roberts Proton Therapy Center, Perelman School of Medicine, University of Pennsylvania, Department of Radiation Oncology
Co-Director, Head and Neck Cancer Service Line, University of Pennsylvania, Abramson Cancer Center
Vice Chair of Faculty Affairs, Perelman School of Medicine, University of Pennsylvania, Department of Radiation Oncology
Executive Leadership Team, Perelman School of Medicine, University of Pennsylvania, Department of Radiation Oncology
Department: Radiation Oncology

Contact information
University of Pennsylvania
Department of Radiation Oncology
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
Office: 215-662-3198
Fax: 215-349-5445
B.A. (Molecular Biophysics and Biochemistry)
Yale University, 1998.
M.D. (Medicine)
University of Michigan Medical School, 2002.
Other (Certificate in Financial Accounting)
Harvard Business School Online, 2019.
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Description of Clinical Expertise

Dr. Lin specializes in the multidisciplinary approach to treatment of cancers of the head and neck. He works collaboratively with members of the Departments of Otorhinolaryngology (ENT), Medical Oncology, Pathology, Diagnostic Radiology, Oral Medicine, and Nuclear Medicine with a focus on improving cancer control, outcomes, and quality of life for patients.

Description of Other Expertise

Dr. Lin is the Vice Chair of Faculty Affairs in the Department of Radiation Oncology at the University of Pennsylvania. In this role, he leads departmental efforts in establishing a robust and active program for mentorship and professional development for faculty members of the Department of Radiation Oncology.

Description of Research Expertise

Alexander Lin, M.D., is a Professor in the Department of Radiation Oncology at the Perelman School of Medicine, and the Medical Director of the Roberts Proton Therapy Center at the University of Pennsylvania. Dr. Lin leads research programs in personalized approaches in the multidisciplinary treatment of head and neck cancer. Dr. Lin leads studies in novel methods of toxicity mitigation in patients with Human Papillomavirus (HPV)-associated cancers of the oropharynx. He also specializes in clinical trials investigating new radiosensitizing agents targeting the tumor microenvironment to improve disease outcomes, for which he receives funding from the National Cancer Institute (NCI) and National Institutes of Health (NIH).

Dr. Lin completed his undergraduate studies at Yale University and his medical training at the University of Michigan. He is a board-certified radiation oncologist and practicing physician at the University of Pennsylvania, Perelman School of Medicine.

Selected Publications

Kim KN, Harton J, Mitra N, Lukens JN, Lin A, Amaniera I, Doucette A, Gabriel P, Baumann B, Metz J,Andrzej Wojcieszynski A: Acute toxicity in patients treated with concurrent chemoradiotherapy with proton versus intensity-modulated radiation therapy for nonmetastatic head and neck cancers. Head and Neck 2022 (accepted July 3, 2022) Notes:

Su W, Wright CM, Lee DY, Kim M, Anstadt EJ, Teo BK, Carlson DJ, Lukens JN, Eisbruch A, Lin A: Stricter Postoperative Oropharyngeal Cancer Radiotherapy Normal Tissue Dose Constraints Are Feasible. Practical Radiation Oncology 12(4): e282-e285, Jul-Aug 2022.

Brennan MT, Treister NS, Sollecito TP, Schmidt BL, Patton LL, Lin A, Elting LS, Hodges JS, Lalla RV : Tooth failure post-radiotherapy in head and neck cancer International Journal of Radiation Oncology, Biology, Physics 113(2): 320-330, June 2022.

Lalla RV, Treister NS, Sollecito TP, Schmidt BS, Patton LL, Helgeson ES, Lin A, Rybczyk C, Dowsett R, Hegde U, Boyd TS, Duplinsky TG, Brennan MT: Radiation Therapy for Head and Neck Cancer Leads to Gingival Recession Associated With Dental Caries Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 133(5): 539-546, May 2022.

Brody RM, Shimunov D, Cohen RB, Lin A, Swisher-McClure S, Lukens JN, Bauml JM, Hartner L, Aggarwal C, Duvvuri U, Montone KT, Jalaly JB, LiVolsi VA, Shanti RM, Rajasekaran K, Chalian AA, Rassekh CH, Cannady SB, Newman JG, O’Malley Jr BW, Weinstein GS, Gimotty PA, Basu D: A benchmark for oncologic outcomes and model for lethal recurrence risk after transoral robotic resection of HPV-related oropharyngeal cancers Oral Oncology 127: 105798, April 2022.

Lin A, Helgeson ES, Treister NS, Schmidt BL, Patton LL, Elting LS, Lalla RV, Brennan MT, Sollecito TP, : The Impact of Head and Neck Radiotherapy on Salivary Flow and Quality of Life: Results of the ORARAD Study. Oral Oncology 127: 105783, April 2022.

Treister NS, Brennan MT, Sollecito TP, Schmidt BL, Patton LL, Mitchell R, Haddad RI, Tishler RB, Lin A, Shadick R, Hodges JS, Lalla RV: Exposed Bone in Patients With Head and Neck Cancer Treated With Radiation Therapy: An Analysis of the Observational Study of Dental Outcomes in Head and Neck Cancer Patients (OraRad). Cancer 128(3): 487-496, February 2022 Notes: DOI: 10.1002/cncr.33948.

Wright CM, Lee DY, Kim M, Barsky AR, Teo BK, Lukens JN, Swisher-McClure S, Lin A: Tubarial Salivary Gland Sparing with Proton Therapy Medical Dosimetry 47(3): 222-226, 2022.

Shinn JR, Carey RM, Mady LJ, Shimunov D, Parhar HS, Cannady SB, Rajasekaran K, Lukens JN, Lin A, Swisher-McClure S, Cohen RB, Bauml JM, Rassekh CH, Newman JG, Chalian AA, Basu D, Weinstein GS, Brody RM : Sex-Based Differences in Outcomes Among Surgically Treated Patients with HPV-Related Oropharyngeal Squamous Cell Carcinoma. Oral Oncology 123: 105570, December 2021.

Carey RM, Brody RM, Shimunov D, Shinn JR, Mady LJ, Rajasekaran K, Cannady SB, Lin A, Lukens JN, Swisher-McClure S, Bauml JM, Aggarwal C, Cohen RB, Chalian AA, Rassekh CH, Basu D, O’Malley, Jr. BW, Weinstein GS, Newman JG : Locoregional Recurrence Patterns and Salvage Outcomes of HPV-associated Oropharyngeal Squamous Cell Carcinoma After Transoral Robotic Surgery The Laryngoscope 131(12): E2865-E2873, December 2021.

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Last updated: 09/29/2022
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