Amy S. Clark, MD, MSCE

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-103
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-7096
Fax: 215-615-3349
BS (Biology)
Haverford College, 1999.
MD (Medicine)
Milton S. Hershey Penn State College of Medicine, 2006.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2012.
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Description of Clinical Expertise

I am a medical oncologist who specializes in breast cancer. I only see breast cancer patients in the outpatient setting, but treat patients will all cancers when working in the hospital.

Description of Research Expertise

My research focuses on clinical trials and drug development for those with early stage and metastatic breast cancer. I also seek to develop novel predictive biomarkers specifically using molecular imaging as companions to early phase trials.

Selected Publications

Stacy Moulder. Megan Karuturi, Denise A. Yardley, Gail Shaw Wright, Sara A. Hurvitz, Rebecca Moroose, Tara Sanft, Cynthia Ma, Amelia Zelnak, Angela DeMichele, Amy S. Clark, Das Purkayastha, Alisha Khullar, Nicola Caria, Aditya Bardia: Ribociclib in Combination With Everolimus and Exemestane in Men and Postmenopausal Women With HR+/HER2− Advanced Breast Cancer After Progression on a CDK4/6 Inhibitor: Efficacy and Safety Results From Phase 2 of the TRINITI-1 Study. Proceedings of the American Association of Cancer Research April 2018.

Finkelman Brian S, Putt Mary, Wang Teresa, Wang Le, Narayan Hari, Domchek Susan, DeMichele Angela, Fox Kevin, Matro Jennifer, Shah Payal, Clark Amy, Bradbury Angela, Narayan Vivek, Carver Joseph R, Tang W H Wilson, Ky Bonnie: Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer. Journal of the American College of Cardiology 70(2): 152-162, Jul 2017.

Vonderheide Robert H, Domchek Susan M, Clark Amy S: Immunotherapy for Breast Cancer: What Are We Missing? Clinical cancer research : an official journal of the American Association for Cancer Research 23(11): 2640-2646, Jun 2017.

Alexander I. Spira, Omid Hamid, Todd M. Bauer, Virginia F. Borges, Jeffrey S. Wasser, David C. Smith, Amy S. Clark, Emmett V. Schmidt, Yufan Zhao, Janet E. Maleski, Tara C. Gangadhar: Efficacy/safety of epacadostat plus pembrolizumab in triple-negative breast cancer and ovarian cancer: phase 1/2 ECHO-202 study. Journal of Clinical Oncology 35((suppl; abstr 1103)), June 2017 Notes: "Poster Presentation"

Katrina Korhonen, MD, Marsha C. Lynch, MD, Austin R. Pantel, MD, Angela R. Bradbury, MD, Susan Domchek, MD, Jennifer Matro, MD, Payal Shah, MD, Angela DeMichele, MD, MSCE, John H. Glick, MD, David A. Mankoff, MD, PhD, Amy S. Clark, MD: Patterns of Early Response to Endocrine Therapy seen on FDG PET/CT in Bone-Dominant Metastatic Breast Cancer: an Interim Analysis. Proceedings of the Society of Nuclear Medicine and Molecular Imaging, Denver, CO(Abstract 469), June 2017 Notes: "Oral Presentation"

Rita Nanda, Minetta C. Liu, Christina Yau, Smita Asare, Nola Hylton, Laura Van't Veer, Jane Perlmutter, Anne M. Wallace, Amy Jo Chien, Andres Forero-Torres, Erin Ellis, Heather Han, Amy Sanders Clark, Kathy S. Albain, Judy Caroline Boughey, Anthony D. Elias, Donald A. Berry, Douglas Yee, Angela DeMichele, Laura Esserman: Pembrolizumab plus standard neoadjuvant therapy for high-risk breast cancer (BC): Results from I-SPY 2. Journal of Clinical Oncology 32(abstr 506), June 2017 Notes: This was an oral abstract.

Mankoff David A, Farwell Michael D, Clark Amy S, Pryma Daniel A: Making Molecular Imaging a Clinical Tool for Precision Oncology: A Review. JAMA oncology 3(5): 695-701, May 1 2017.

Aditya Bardia, Sara Hurvitz, Denise A. Yardley, Amelia Zelnak, Angela DeMichele, Amy S. Clark, Das Purkayastha, Tania Small,6 Christopher Tucci,6 Stacy Moulder: TRINITI-1: Ribociclib + everolimus + exemestane triplet combination in men or postmenopausal women with HR+, HER2– advanced breast cancer following progression on a cyclin-dependent kinase 4/6 inhibitor. Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, TX Dec 2016 Notes: "Poster Presentation"

Angela DeMichele, Amy Clark, Robin Holmes, Melissa Volpe, Christopher Medrano, Andrea Troxel1, Anna Kalota, Kevin R. Fox, Susan M. Domchek, Jennifer Matro, Angela R. Bradbury, Natalie Shih, Michael Feldman, Elizabeth O. Hexner, Jacqueline F. Bromberg: Targeting Inflammatory Pathways: A Phase II Trial of the JAK-inhibitor Ruxolitinib in Combination with Exemestane for Aromatase Inhibitor Resistant, Estrogen-Receptor Positive Breast Cancer. Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, TX Dec 2016 Notes: "Poster Presentation"

Amy S. Clark, Nicholas P. McAndrew, Xingmei Wang, Andrea Troxel, Michael Feldman, Priti Lal, Paul Zhang, John Ndicu, Isoris Nivar, Mark Rosen, Maryann Gallagher, Jessica Burrell, Susan Domchek, Kevin R. Fox, Peter O’Dwyer, Angela DeMichele: Single Agent Palbociclib with or without Trastuzumab for the treatment of Rb+ Advanced Breast Cancer: A Phase II Trial. Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, TX Dec 2016 Notes: "Poster Presentation"

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Last updated: 04/16/2018
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