Amy S. Clark, MD, MSCE

faculty photo
Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Attending, Hospital of the University of Pennsylvania
Physician Lead, Breast Cancer Clinical Research Unit, University of Pennsylvania, Abramson Cancer Center
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-154
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-7096
Fax: 215-615-3349
Education:
BS (Biology)
Haverford College, 1999.
MD (Medicine)
Milton S. Hershey Penn State College of Medicine, 2006.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2012.
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Description of Clinical Expertise

I am a medical oncologist who specializes in breast cancer. I only see breast cancer patients in the outpatient setting, but treat patients will all cancers when working in the hospital.

Description of Research Expertise

My research focuses on clinical trials and drug development for those with early stage and metastatic breast cancer. I also seek to develop novel predictive biomarkers specifically using molecular imaging as companions to early phase trials.

Selected Publications

Swain S, Tang G, Puhalla SL, Ganz PA, Henry NL, Cecchini RS, Reid SA, Rastogi P, Geyer CE, White JR, Clark AS, Haddad TC, Vidal GA, Wolmark N, Mamounas EP: Abstract # TPS612 – A phase III trial evaluating addition of adjuvant chemotherapy to ovarian function suppression + endocrine therapy in premenopausal women with pN0-1, HR+/HER2- breast cancer (BC) and oncotype recurrence score (RS) ≤25 (OFSET): NRG-BR009. Annual Meeting of the American Society of Clinical Oncology June 2024.

Giridhar, K., Clark, A: Molecular profiling of serial liquid biopsy specimens utilizing cell free DNA (cfDNA) and circulating tumor cells (CTCs) in TBCRC041: A phase II study of alisertib in endocrine resistant metastatic breast cancer (MBC). Annual Meeting of the American Society of Clinical Oncology June 2024.

Slavkova KP, McDonald ES, Cohen EA, Pantalone L, Bayne L, Nivar I, Sanchez P, Mankowski WC, Brown M, Clark AS, Rohn K, Chodosh LA, Kontos D, DeMichele A: Evaluating the association between radiomic features on breast MRI and dormant tumor cell presence in the SURMOUNT Trial. Annual Meeting of the American Society of Clinical Oncology June 2024.

Zhang, H., Clark, A.S., : A quantitative bias analysis approach to informative presence bias in electronic health records. Epidemiology 35(3): 349-358, May 1 2024.

Albain K, Yau C, Petricoin E, Wolf D, Lang J, Chien A, Haddad T, Forero-Torres A, Wallace A, Kaplan H, Pusztai L, Euhus D, Nanda R, Elias A, Clark A, Godellas C, Boughey J, Isaacs C, Tripathy D, Lu J, Yung R, Gallagher R, Wulfkuhle J, Swigart LB, Krings G, Chen YY, Potter D, Stringer-Reasor E, Blair S, Asare S, Wilson A, Hirst G, Singhrao R, Buxton M, Clennell J, Sanil A, Berry S, Asare A, Matthews J, DeMichele A, Hylton N, Melisko M, Perlmutter J, Rugo H, Symmans W, Van't Veer L, Yee D, Berry D, Esserman L: Neoadjuvant trebananib plus paclitaxel-based chemotherapy for stage II/III breast cancer in the adaptively randomized I-SPY2 trial — Efficacy and biomarker discovery. Clinical Cancer Research. (eds.). 30(4): 729-40, Feb 16 2024.

Lynce, F., Stevens, L. E., Li, Z., Brock, J. E., Gulvady, A., Huang, Y., Nakhlis, F., Patel, A., Force, J. M., Haddad, T. C., Ueno, N., Stearns, V., Wolff, A. C., Clark, A. S., Bellon, J. R., Richardson, E. T., Balko, J. M., Krop, I. E., Winer, E. P., Lange, P., Hwang E. S., King, T. A., Tolaney, S. M., Thompson, A., Gupta, G. P., Mittendorf, E. A., Regan, M. M., Overmoyer, B., Polyak, K: TBCRC 039: A phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer. Breast Cancer Research (eds.). 26(1): 20, Jan 31 2024.

Fraietta J, Fengjuan Z, Clark A, Taunk N, Xu H N, Gonzalves D, Ahmad Z, Minn A, Huang A, Nayak A, Tchou J: A high pre-existing TCR repertoire diversity may predict response to preoperative radiotherapy and pembrolizumab in early-stage breast cancer –NCT04454528 preliminary results. Society of Surgical Oncology 2023, in press.

Kyalwazi B, Yau C, Campbell MJ, Yoshimatsu TF, Chein AJ, Wallace AM, Forero-Torres A, Pusztai L, Ellis ED, Albain KS, Blaes AH, Haley BB, Boughey JC, Elias AD, Clark AS, Isaacs CJ, Nanda R, Han HS, Yung RL, Tripathy D, Edminston KK, Viscusi RK, Northfelt DW, Khan QJ, Asare SM, Wilson A, Hirst GL, Lu R, Symmans WF, Yee D, DeMichele A, Van't Veer LJ, Esserman LJ, Olopade OI: Race, Gene Expression Signatures, and Clinical Outcomes of Patients With High-Risk Early Breast Cancer. JAMA Network Open Dec 2023.

Amy S. Clark.: NRG-BR009: Phase III Trial Evaluating Addition of Adjuvant Chemotherapy to Ovarian Function Suppression + Endocrine Therapy in Premenopausal Women with pN0-1, HR+/HER2- Breast Cancer and Oncotype Recurrence Score ≤25 (OFSET). San Antonio Breast Cancer Symposium BR009 Spotlight, San Antonio, TX. Dec 2023 Notes: "Oral Presentation"

Ulaner GA, Fowler AM, Clark AS, Linden H: Estrogen Receptor-Targeted and Progesterone Receptor-Targeted PET for Patients with Breast Cancer. PET Clin 18(4): 531-542, Oct 2023.

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Last updated: 05/31/2024
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