Vikram R Paralkar, MD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
BRB II/III Room 551
421 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-9252
Lab: 215-573-9831
Education:
HSC
DG Ruparel College, Mumbai, India, 1998.
MD
Seth GS Medical College, Mumbai, India, 2004.
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Description of Clinical Expertise

Acute and Chronic Myeloid Malignancies

Description of Research Expertise

RESEARCH INTERESTS:
The Paralkar Lab studies how genes regulating chromatin configuration and ribosome biogenesis guide normal hematopoiesis, and how mutations in these genes lead to acute or chronic myeloid leukemias.

KEYWORDS:
Hematopoiesis, Leukemia, Transcription, Ribosome biogenesis, Stem cells

RESEARCH DETAILS:
Hematopoiesis is a complex and highly regulated process by which stem cells residing in bone marrow produce a constant stream of blood cells to preserve a functional hematopoietic system throughout the duration of a human lifespan. Mutations in epigenetic regulators, transcription factors, splicing proteins and tumor suppressors can derange the normal course of hematopoiesis, and lead to clonal expansion and leukemia. Several mutated proteins also regulate ribosomal biogenesis. Normal ribosomal function is crucial for hematopoiesis, and dysfunction can either lead to bone marrow failure or myeloproliferation. The mechanisms by which most of these mutated genes produce malignancy remain poorly understood.

In the Paralkar Lab, we apply state-of-the art molecular biology techniques to in vitro and in vivo models of hematopoiesis and leukemia to study normal blood development and the mechanisms of leukemogenesis, and gain insight into the delicate balance between normal differentiation and malignancy.

ROTATION PROJECTS:
Please contact vikram.paralkar@uphs.upenn.edu to discuss research projects.

LAB MEMBERS:
Roman Verner - Lab Manager
Patrick Somers - Technician
Gabrielle Ochoco - Technician
Jared Daar - Med Student
Elizabeth Traxler, PhD - Med Student, MD/PhD track

Selected Publications

Palmer LE, Weiss MJ, Paralkar VR : YODEL: Peak calling software for HITS-CLIP data. F1000Research 6: 1138, 2017.

Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ: Unlinking an lncRNA from Its Associated cis Element. Molecular Cell 62(1): 104-10, 2016 Notes: (Commentary in Molecular Cell 61(1), and selected by Faculty of 1000).

Paralkar VR, Mishra T, Luan J, Yao Y, Kossenkov AV, Anderson SM, Dunagin M, Pimkin M, Gore M, Sun D, Konuthula N, Raj A, An X, Mohandas N, Bodine DM, Hardison RC, Weiss MJ: Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Blood 123(12): 1927-37, 2014.

Paralkar VR, Weiss MJ: Long noncoding RNAs in biology and hematopoiesis. Blood 121(24): 4842-6, 2013.

Paralkar VR, Nasta SD, Morrissey K, Smith J, Vassilev P, Martin ME, Goldstein SC, Loren A, Rook AH, Kim EJ, Porter DL: Allogeneic hematopoietic SCT for primary cutaneous T cell lymphomas. Bone Marrow Transplantation 47(7): 940-5, 2012.

Paralkar VR, Weiss MJ: A new 'Linc' between noncoding RNAs and blood development. Genes & Development 25(24): 2555-8, 2011.

Paralkar V: Worlds apart - Tuberculosis in India and in the United States. The New England Journal of Medicine 358(11): 1092-1095, 2008.

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Last updated: 06/28/2018
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