Ian Folkert

faculty photo
Assistant Professor of Surgery at the Hospital of the University of Pennsylvania
Department: Surgery

Contact information
4 Silver, 3400 Spruce Street
Philadelphia, PA 19104
Education:
BA (Classical Civilization)
New York University, 2008.
MD
Perelman School of Medicine at The University of Pennsylvania, 2013.
PhD (Cell and Molecular Biology (Cancer Biology))
Perelman School of Medicine at The University of Pennsylvania, 2022.
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Selected Publications

Haddad A, Lendoire M, Uppal A, Maki H, Folkert IW, Wang Y, Ayabe RI, Newhook TE, Chun YS, Tzeng CW, Vauthey JN, Tran Cao HS: CEA Rebound After Discontinuation of Pre-Hepatectomy Chemotherapy Predicts Worse Outcomes After Resection of Colorectal Caner Liver Metastasis. Ann Surg Oncol 32: 1021-1032, 2025.

Folkert IW, Lie JJ, Bhutiani N, Das P, Song Y, Mansfield PF, Royal RE, Scally CP, Dineen SP, Fournier KF, Helmink BA: Multidisciplinary management of locally advanced adenocarcinoma of the appendix. Society of Surgical Oncology Annual Meeting 2025.

Folkert IW, Molina Arocho WA, To TKJ, Devalaraja S, Molina IS, Shoush J, Mohei H, Zhai L, Akhtar MN, Kochat V, Arslan E, Lazar AJ, Wani K, Israel WP, Zhang Z, Chaluvadi VS, Norgard RJ, Liu Y, Fuller AM, Dang MT, Roses RE, Karakousis GC, Miura JT, Fraker DL, Eisinger-Mathason TSK, Simon MC, Weber K, Tan K, Fan Y, Rai K, Haldar M.: An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis. J Exp Med 221: e20230420, Oct 2024.

Folkert IW, Melendez B, Witt RG, Lazcano R, Singh BB, Cope BM, Onuma A, Arunkumar V, Fong LW, Morey R, Ingram DR, Wani K, Wang WL, Losh JS, Ajami NJ, Wargo JA, Lazar AJ, Roland CL, Nassif Haddad EF, Keung EZ: Spatial Transcriptomics Reveals Heterogeneity of the Intratumoral Immune Microenvironment within Undifferentiated Pleomorphic Sarcoma and Regions of Perivascular Tumor-Associated Macrophages. Society for Immunotherapy of Cancer (SITC) Annual Meeting 2024.

Li N, Zhu Q, Tian Y, Ahn KJ, Wang X, Cramer Z, Jou J, Folkert IW, Yu P, Adams-Tzivelekidis S, Sehgal P, Mahmoud NN, Aarons CB, Roses RE, Thomas-Tikhonenko A, Furth EE, Stanger BZ, Rustgi A, Haldar M, Katona BW, Tan K, Lengner CJ.: Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment. Nat Commun 14: 7915, Nov 2023.

Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, Jerrick To TK, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M.: Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Cell Rep 42: 112600, Jun 2023.

Folkert IW, Molina Arocho WA, To TKJ, Devalaraja S, Zhai L, Chaluvadi VS, Norgard RJ, Fuller AM, Dang MT, Roses RE, Karakousis GC, Miura JT, Fraker DL, Eisinger-Mathason TSK, Weber K, Haldar M: Iron Rich Tumor Associated Macrophages Promote Tumor Growth Through a Bach1-Ednrb Axis. Ali Naji Resident Research Day Poster Competition 2023.

Maddipati R, Norgard RJ, Baslan T, Rathi KS, Zhang A, Saeid A, Higashihara T, Wu F, Kumar A, Annamalai V, Bhattacharya S, Raman P, Adkisson CA, Pitarresi JR, Wengyn MD, Yamazoe T, Li J, Balli D, LaRiviere MJ, Ngo TC, Folkert IW, Millstein ID, Bermeo J, Carpenter EL, McAuliffe JC, Oktay MH, Brekken RA, Lowe SW, Iacobuzio-Donahue CA, Notta F, Stanger BZ.: MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma. Cancer Discov 12(2): 542–561, Feb 2022.

Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ.: Calcium signaling induces a partial EMT. EMBO Rep 22: e51872, Sep 2021.

Folkert IW, To TKJ, Devalaraja S, Norgard RJ, Zhai L, Haldar M: Single-cell RNA Sequencing Reveals a Unique Subset of Suppressive Macrophages in Soft Tissue Sarcomas. American College of Surgeons Clinical Congress 2021.

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Last updated: 08/15/2025
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