Kyle Bittinger, Ph.D.
Assistant Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition) at the Children's Hospital of Philadelphia
Bioinformatics Laboratory Director, Microbiome Center, Children's Hospital of Philadelphia
Director of Analytics, Center for Microbial Medicine, Children's Hospital of Philadelphia
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
Office: 267-425-1641
Email:
bittingerk@chop.edu
bittingerk@chop.edu
Education:
B.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.
Permanent linkB.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.
Selected Publications
Mulcrone PL, Narrowe A, Jones S, Hu W, Bittinger K, Moustafa AM, Liu L, Xiao W, Firrman J: Monitoring the Impact of Chlorinated Drinking Water on the Developing Gut Microbiota of Adolescent Mice Using Genetic Profiling. Int J Environ Stud Page: In press, May 2025.Litichevskiy L, Considine M, Gill J, Shandar V, Cox TO, Descamps HC, Wright KM, Amses KR, Dohnalová L, Liou MJ, Tetlak M, Galindo-Fiallos MR, Wong AC, Lundgren P, Kim J, Uhr GT, Rahman RJ, Mason S, Merenstein C, Bushman FD, Raj A, Harding F, Chen Z, Prateek GV, Mullis M, Deighan AG, Robinson L, Tanes C, Bittinger K, Chakraborty M, Bhatt AS, Li H, Barnett I, Davenport ER, Broman KW, Levy M, Cohen RL, Botstein D, Freund A, Di Francesco A, Churchill GA, Li M, Thaiss CA: Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice. Nat Microbiol Mar 2025 Notes: doi: 10.1038/s41564-025-01963-3. Epub ahead of print.
Katona BW, Shukla A, Hu W, Nyul T, Dudzik C, Arvanitis A, Clay D, Dungan M, Weber M, Tu V, Hao F, Gan S, Chau L, Buchner AM, Falk GW, Jaffe DL, Ginsberg G, Palmer SN, Zhan X, Patterson AD, Bittinger K, Ni J: Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver. Gut Microbes 17(1): 2474141, Mar 2025.
McGann C, Phyu R, Bittinger K, Mukhopadhyay S: Role of the Microbiome in Neonatal Infection: Pathogenesis and Implications for Management. Clin Perinatol 52(1): 147, Mar 2025.
Breton J, Tu V, Tanes C, Wilson N, Quinn R, Kachelries K, Friedman ES, Bittinger K, Baldassano RN, Compher C, Albenberg L: A pro-inflammatory diet is associated with growth and virulence of Escherichia coli in pediatric Crohn's disease. J Crohns Colitis 19(2): jjaf018, Feb 2025.
Thomas S, Bittinger K, Livornese LL Jr: Utilizing the biosimulator to analyze the environmental microbiome within the intensive care units of a hospital. Biotechniques 77(2): 66-75, Feb 2025.
Teles F, Martin L, Patel M, Hu W, Bittinger K, Kallan MJ, Chandrasekaran G, Cucchiara AJ, Giannobile WV, Stephens D, Kantarci A: Gingival Crevicular Fluid Biomarkers During Periodontitis Progression and After Periodontal Treatment. J Clin Periodontol 52(1): 40, Jan 2025.
Benitez AJ, Tanes C, Friedman ES, Zackular JP, Ford E, Gerber JS, DeRusso PA, Kelly A, Li H, Elovitz MA, Wu GD, Zemel B, Bittinger K: Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants. Microbiome 13(1): 21, Jan 2025.
Breton J, Tanes C, Wilson N, Kachelries K, Bittinger K, Mattei P, Baldassano R: Mucosal Microbiome Signatures Associated with Postoperative Endoscopic Recurrence in Paediatric Crohn’s Disease. J Crohns Colitis 19(Supplement 1): i2365, Jan 2025 Notes: Congress of the European Crohn's and Colitis Organisation (ECCO) 2025, Berlin, Germany. Poster presentation.
Soto Ocaña J, Friedman ES, Keenan O, Bayard NU, Ford E, Tanes C, Munneke MJ, Beavers WN, Skaar EP, Bittinger K, Zemel BS, Wu GD, Zackular JP: Metal availability shapes early life microbial ecology and community succession. mBio 15(11): e0153424, Nov 2024.