Kyle Bittinger, Ph.D.
Assistant Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition) at the Children's Hospital of Philadelphia
Analytical Core Director, Microbiome Center, Children's Hospital of Philadelphia/Perelman School of Medicine, University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
Office: 267-425-1641
Email:
bittingerk@email.chop.edu
bittingerk@email.chop.edu
Education:
B.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.
Permanent linkB.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.
Selected Publications
Fakharian F, Thirugnanam S, Welsh DA, Kim WK, Rappaport J, Bittinger K, Rout N: The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis. Microorganisms 11(7): 1849, Jul 2023.Hecht AL, Harling LC, Friedman ES, Tanes C, Lee J, Firrman J, Tu V, Liu L, Bittinger K, Goulian M, Wu GD: Colonization and Dissemination of Klebsiella pneumoniae is Dependent on Dietary Carbohydrates. bioRxiv Page: 2023.05.25.542283, Jun 2023 Notes: Preprint.
Redding LE, Habing GG, Tu V, Bittinger KL, O'Day J, Pancholi P, Wang SH, Alexander A, Kelly BJ, Weese JS, Stull JW: Infrequent intrahousehold transmission of Clostridioides difficile between pet owners and their pets. Zoonoses Public Health 70(4): 341-351, Jun 2023.
Liu Y, Daniel SG, Kim HE, Koo H, Korostoff J, Teles F, Bittinger K, Hwang G: Addition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities. Microbiome 11(1): 123, Jun 2023.
Hecht A, Harling L, Lee J, Friedman ES, Tanes C, Bittinger K, Goulian M, Wu GD: Dietary carbohydrates regulate the colonization of Klebsiella pneumoniae and nitrogen composition in the gut. Gastrenterology 164(6): S-259, May 2023.
Williams PA, Naughton KE, Simon LA, Soto GE, Parham LR, Ma X, Danan CH, Hu W, Friedman ES, McMillan EA, Mehta H, Stoltz MA, Ocaña JS, Zackular JP, Bittinger K, Whelan KA, Karakasheva TA, Hamilton KE: Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction. Am J Physiol Gastrointest Liver Physiol 324(5): G354-G368, May 2023.
Carr RM, Li Y, Chau L, Friedman ES, Lee JJ, Adorini L, Erickson M, Zaru L, Shringarpure R, MacConell L, Bittinger K, Li H, Wu GD: An integrated analysis of fecal microbiome and metabolomic features distinguish Non-cirrhotic NASH from healthy control populations. Hepatology May 2023 Notes: Epub ahead of print. doi: 10.1097/HEP.0000000000000474.
Liu L, Narrowe AB, Firrman JA, Mahalak KK, Bobokalonov JT, Lemons JMS, Bittinger K, Daniel S, Tanes C, Mattei L, Friedman ES, Soares JW, Kobori M, Zeng WB, Tomasula PM: Lacticaseibacillus rhamnosus Strain GG (LGG) Regulate Gut Microbial Metabolites, an In Vitro Study Using Three Mature Human Gut Microbial Cultures in a Simulator of Human Intestinal Microbial Ecosystem (SHIME). Foods 12(11): 2105, May 2023.
Katona BW, Tu V, Nyul T, Bittinger K, Ni J: Characterization of microbiome differences amongst patients with colonic polyposis with and without a known genetic driver. Gastroenterology 164(6): S-251, May 2023.
Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchetti L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel JM, Tanes C, Bittinger K, Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Sci Immunol 8(83): eade2335, May 2023.