Kyle Bittinger, Ph.D.

faculty photo
Assistant Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition) at the Children's Hospital of Philadelphia
Analytical Core Director, Microbiome Center, Children's Hospital of Philadelphia/Perelman School of Medicine, University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Microbiome Center
Roberts Center for Pediatric Research
2716 South Street, 14th Floor
Philadelphia, PA 19146-2305
Office: 267-425-1641
B.S. (Chemistry)
University of Pittsburgh, 2001.
Ph.D. (Physical Chemistry)
Massachusetts Institute of Technology, 2008.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Rimal B, Collins SL, Tanes CE, Rocha ER, Granda MA, Solanki S, Hoque NJ, Gentry EC, Koo I, Reilly ER, Hao F, Paudel D, Singh V, Yan T, Kim MS, Bittinger K, Zackular JP, Krausz KW, Desai D, Amin S, Coleman JP, Shah YM, Bisanz JE, Gonzalez FJ, Vanden Heuvel JP, Wu GD, Zemel BS, Dorrestein PC, Weinert EE, Patterson AD.: Bile salt hydrolase catalyses formation of amine-conjugated bile acids. Nature Feb 2024.

Lemons JMS, Conrad M, Tanes C, Chen J, Friedman ES, Roggiani M, Curry D, Chau L, Hecht AL, Harling L, Vales J, Kachelries KE, Baldassano RN, Goulian M, Bittinger K, Master SR, Liu L, Wu GD.: Enterobacteriaceae Growth Promotion by Intestinal Acylcarnitines, a Biomarker of Dysbiosis in Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol 2024.

Singh S, Giron LB, Shaikh MW, Shankaran S, Engen PA, Bogin ZR, Bambi SA, Goldman AR, Azevedo JLLC, Orgaz L, de Pedro N, González P, Giera M, Verhoeven A, Sánchez-López E, Pandrea IV, Kannan T, Tanes CE, Bittinger K, Landay AL, Corley MJ, Keshavarzian A, Abdel-Mohsen M.: Distinct Intestinal Microbial Signatures Linked to Accelerated Biological Aging in People with HIV. Res Sq Oct 2023.

Bass R, Tanes C, Bittinger K, Li Y, Lee H, Friedman ES, Koo I, Patterson AD, Liu Q, Wu GD, Stallings VA.: Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids. J Cyst Fibros Oct 2023.

Fakharian F, Thirugnanam S, Welsh DA, Kim WK, Rappaport J, Bittinger K, Rout N: The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis. Microorganisms 11(7): 1849, Jul 2023.

Hecht AL, Harling LC, Friedman ES, Tanes C, Lee J, Firrman J, Tu V, Liu L, Bittinger K, Goulian M, Wu GD: Colonization and Dissemination of Klebsiella pneumoniae is Dependent on Dietary Carbohydrates. bioRxiv Page: 2023.05.25.542283, Jun 2023 Notes: Preprint.

Redding LE, Habing GG, Tu V, Bittinger KL, O'Day J, Pancholi P, Wang SH, Alexander A, Kelly BJ, Weese JS, Stull JW: Infrequent intrahousehold transmission of Clostridioides difficile between pet owners and their pets. Zoonoses Public Health 70(4): 341-351, Jun 2023.

Liu Y, Daniel SG, Kim HE, Koo H, Korostoff J, Teles F, Bittinger K, Hwang G: Addition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities. Microbiome 11(1): 123, Jun 2023.

Hecht A, Harling L, Lee J, Friedman ES, Tanes C, Bittinger K, Goulian M, Wu GD: Dietary carbohydrates regulate the colonization of Klebsiella pneumoniae and nitrogen composition in the gut. Gastrenterology 164(6): S-259, May 2023.

Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchetti L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel JM, Tanes C, Bittinger K, Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Sci Immunol 8(83): eade2335, May 2023.

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Last updated: 02/23/2024
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