John P Christodouleas, M.D., M.P.H.

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Adjunct Associate Professor of Radiation Oncology
Service Line Liason - GU, University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Hospital of the University of Pennsylvania
Administrative Offices
The Perelman Center for Advanced Medicine
3400 Civic Center Blvd.
TRC-2 West
Philadelphia, PA 19104
BA (Mathematics and Philosophy)
Swarthmore College, 1998.
MD (Medicine)
School of Medicine, Tufts University, 2004.
MPH (Public Health)
Tufts University, 2004.
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Description of Clinical Expertise

Dr. Christodouleas is a radiation oncologist who specializes in the treatment of prostate and bladder cancers. His clinical interest is in the use of new diagnostic and therapeutic technologies and how these can be used to improve cancer cure rates and decrease side effects of treatments. He is a nationally recognized authority on the use of image-guided proton therapy and intensity modulated x-ray therapy.

Dr. Christodouleas has written extensively about ways to optimize cancer control and quality of life for patients with cancer and has published primary research, reviews and editorials in a variety of journals including The New England Journal of Medicine, Cancer and The International Journal of Radiation Oncology*Biology*Physics. He has authored over 20 book chapters on the care of cancer patients and is co-editor of one of the leading textbooks in radiation oncology. He has served as the University of Pennsylvania’s Primary Investigator to the Proton Collaborative Group and as a reviewer for the Journal of the National Comprehensive Cancer Center Network, Clinical Cancer Research, The International Journal of Radiation Oncology*Biology*Physics, and Practical Radiation Oncology.

Patient testimonials:

To listen to patient’s talk about their experiences with Dr. Christodouleas and PENN Medicine, follow these links:


Dr. Christodouleas earned a Bachelor of Arts in Mathematics and Philosophy at Swarthmore College. He completed a combined Doctorate in Medicine and Masters of Public Health at Tufts University where he graduated with Research Honors. While at Tufts University, he was honored with The William Dameshek Research Award, The Dolores Zohrab Liebmann Fellowship and the Presidential Award for Citizenship and Public Service. He trained in Radiation Oncology at the Johns Hopkins Hospital.

Description of Research Expertise

bladder cancer, prostate cancer, seminoma, cancer informatics

Selected Publications

Christodouleas John P, Forrest Robert D, Ainsley Christopher G, Tochner Zelig, Hahn Stephen M, Glatstein Eli: Short-Term and Long-Term Health Risks of Nuclear-Power-Plant Accidents. The New England journal of medicine 364(24): 2334-41, Apr 2011.

Christodouleas JP, Chang J: Early Stage Non-small Cell Lung Cancer. Radiation Oncology: A Question-Based Review. Hristov, B, Lin SH, Christodouleas JP (eds.). Lippincott Williams and Wilkins, 2010

Christodouleas J, Susil RJ, McNutt TR, Song DY, DeWeese TL, Bekelman J, Vapiwala N, Shinkle B, Lu H, Both S : The impact of a rectal-prostate spacer on proton radiation of the prostate: a planning study. ASTRO Annual Meeting 2010 Notes: Oral Presentation.

Christodouleas JP, DeWeese TL: Intermediate and High Risk Prostate Cancer. Radiation Oncology: A Question-Based Review. Hristov, B, Lin SH, Christodouleas JP (eds.). Lippincott Williams and Wilkins, 2010.

Christodouleas JP, Hahn SM: The need for and future of clinical trials of proton therapy. Radiation Medicine Rounds. Metz, JM (eds.). Demos Medical Publishing, 1(3): 455-469, 2010.

Marks Lawrence B, Saynak Mert, Christodouleas John P: Stage III vs. stage IV lung cancer: "Crossing a Great Divide". Lung cancer (Amsterdam, Netherlands) 67(1): 1-3, Jan 2010.

Christodouleas John P, Marks Lawrence B: Analysis of patients with oligometastases undergoing two or more curative-intent stereotactic radiotherapy courses: in regard to Milano et al. (Int J Radiat Oncol Biol Phys 2009;73:832-837). International journal of radiation oncology, biology, physics 74(5): 1628; author reply 1628-9, Aug 2009.

Christodouleas J, Fox J, DeWeese T, Song D: Radiation Therapy for Prostate Cancer. Early Diagnosis of Cancer: Prostate Cancer. Su LM (eds.). Elsevier Publishers, PA, 2009.

Christodouleas J, Yeater D, Jabbour S, Leman ES, Mangold L, R Drew, Humphreys E, Partin A, Getzenberg R, DeWeese T: Modulation of EPCA-2 levels in men with localized prostate cancer treated with radiation with or without hormonal therapy. ASTRO September 2008.

Zietman Anthony L, Christodouleas John P, Shipley William U: PSA bounces after neoadjuvant androgen deprivation and external beam radiation: impact on definitions of failure. International journal of radiation oncology, biology, physics 62(3): 714-8, Jul 2005.

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Last updated: 08/25/2023
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