David B. Frank, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
Office: (267) 648-2626
Fax: 215-590-1340
B.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
Vanderbilt University of School of Medicine, 2009.
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Selected Publications

Zacharias WJ*, Frank DB*, Zepp JA, Morley MP, Alkhaleel FA, Kong J, Zhou S, Cantu E, Morrisey EE.: Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature February 2018.

Swarr DT, Peranteau WH, Pogoriler J, Frank DB, Adzick NS, Hedrick HL, Morley M, Zhou S, Morrisey EE: Novel Molecular and Phenotypic Insights into Congenital Lung Malformations. Am J Respir Crit Care Med January 2018.

Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML: Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. Developmental Cell 43(3): 274-89, November 2017.

Zepp JA, Zacharias WJ, Frank DB, Cavanaugh CA, Zhou S, Morley MP, Morrisey EE: Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung. Cell 170(6): 1134-1148, Sep 7 2017.

Frank David B, Peng Tien, Zepp Jarod A, Snitow Melinda, Vincent Tiffaney L, Penkala Ian J, Cui Zheng, Herriges Michael J, Morley Michael P, Zhou Su, Lu Min Min, Morrisey Edward E: Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell reports 17(9): 2312-2325, Nov 2016.

Wang Yi, Frank David B, Morley Michael P, Zhou Su, Wang Xiaoru, Lu Min Min, Lazar Mitchell A, Morrisey Edward E: HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation. Developmental cell 36(3): 303-15, Feb 2016.

Peng Tien, Frank David B, Kadzik Rachel S, Morley Michael P, Rathi Komal S, Wang Tao, Zhou Su, Cheng Lan, Lu Min Min, Morrisey Edward E: Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature 526(7574): 578-82, Oct 2015.

Frank David B, Crystal Matthew A, Morales David L S, Gerald Ken, Hanna Brian D, Mallory George B, Rossano Joseph W: Trends in pediatric pulmonary hypertension-related hospitalizations in the United States from 2000-2009. Pulmonary circulation 5(2): 339-48, Jun 2015.

Frank D B, Hanna B D: Pulmonary arterial hypertension associated with congenital heart disease and Eisenmenger syndrome: current practice in pediatrics. Minerva pediatrica 67(2): 169-85, Apr 2015.

Lau Kelvin C, Frank David B, Hanna Brian D, Patel Akash R: Utility of electrocardiogram in the assessment and monitoring of pulmonary hypertension (idiopathic or secondary to pulmonary developmental abnormalities) in patients≤18 years of age. The American journal of cardiology 114(2): 294-9, Jul 2014.

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Last updated: 07/02/2018
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