David B. Frank, MD, PhD

faculty photo
Assistant Professor of Pediatrics (Cardiology)
Attending, Children's Hospital of Philadelphia
Assistant Program Director, Pediatric Cardiology T32 Training Grant, Children's Hospital of Philadelphia
Member, Penn-CHOP Lung Biology Institute, The University of Pennsylvania
Primary Faculty, Cardiovascular Institute, The University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
Office: (267) 648-2626
Fax: 215-590-1340
Education:
B.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
M.D.
Vanderbilt University of School of Medicine, 2009.
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Selected Publications

Prashant Chandrasekaran, Hongbo Wen, MinQi Lu, Nigel Michki, Annabelle Jin, Jarod A. Zepp, David B. Frank: Evolutionarily conserved mechanisms drive ontogeny and arterial endothelial heterogeneity of the lung vasculature. North American Vascular Biology Organization conference, Vascular Biology 2023 October 2023.

Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S.: Circadian regulation of lung repair and regeneration. JCI Insight 8(16), August 2023.

Guo M, Wikenheiser-Brokamp KA, Kitzmiller JA, Jiang C, Wang G, Wang A, Preissl S, Hou X, Buchanan J, Karolak JA, Miao Y, Frank DB, Zacharias WJ, Sun X, Xu Y, Gu M, Stankiewicz P, Kalinichenko VV, Wambach JA, Whitsett JA.: Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia. Am J Respir Crit Care Med Online ahead of print, July 2023.

Avitabile CM, Flohr S, Mathew L, Wang Y, Ash D, Frank DB, Tingo JE, Rintoul NE, Hedrick HL.: Quantitative Measures of Right Ventricular Size and Function by Echocardiogram Correlate with Cardiac Catheterization Hemodynamics in Congenital Diaphragmatic Hernia. J Pediatr online, June 2023.

Lin S., Frank D.B.: SOX17 at the Intersection of Sex, Transcription, and Metabolism in Pulmonary Hypertension. Am J Respir Crit Care Med March 2023.

Prashant Chandrasekaran, Nicholas M Negretti, Aravind Sivakumar, Derek C Liberti, Hongbo Wen, Maureen Peers de Nieuwburgh, Joanna Y Wang, Nigel S Michki, Fatima N Chaudhry, Sukhmani Kaur , MinQi Lu, Annabelle Jin , Jarod A Zepp, Lisa R Young, Jennifer M S Sucre, David B Frank : CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth. Development 149(21), November 2022.

Prashant Chandrasekaran*, Nicholas M. Negretti*, Aravind Sivakumar*, Derek Liberti, Hongbo Wen, Maureen Peers de Nieuwburgh, Joanna Y. Wang, Nigel S. Michki, Fatima N. Chaudhry, Sukhmani Kaur, MinQi Lu, Jarod A. Zepp, Lisa R. Young, Jennifer M.S. Sucre**, David B. Frank**: A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth. 2022 FASEB The Lung Epithelium Conference: In Health and Disease Conference August 2022.

Derek C. Liberti, Prashant Chandrasekaran, Kwaku Quansah, Hongbo Wen, MinQi Lu, Josh Pankin, Katharine G. Stolz, Aravind Sivakumar, Sukhmani Kaur, David B. Frank: Endodermal Brd4 is required for lung development. 2022 FASEB The Lung Epithelium Conference: In Health and Disease Conference August 2022.

Nigel S. Michki, Prashant Chandrasekaran, Minqi Lu, Derek C. Liberti, Sourav Bose, Jennifer Pogoriler, William H. Peranteau, David B. Frank: Characterizing the cellular mechanisms underlying congenital pulmonary airway malformation development in children 2022 FASEB The Lung Epithelium Conference: In Health and Disease Conference August 2022.

Nya D Nelson, Feng Xu, Prashant Chandrasekaran, Leslie A Litzky, William H Peranteau, David B Frank, Marilyn Li, Jennifer Pogoriler: Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features. Mod Path July 2022.

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Last updated: 08/27/2023
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