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David B. Frank, MD, PhD
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Assistant Professor of Pediatrics (Cardiology)
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Attending Physician, Division of Cardiology, Children's Hospital of Philadelphia
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Assistant Program Director, Pediatric Cardiology T32 Training Grant, Children's Hospital of Philadelphia
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Member, Lung Biology Institute, University of Pennsylvania School of Medicine
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Primary Faculty, Cardiovascular Institute, University of Pennsylvania School of Medicine
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Department: Pediatrics
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Graduate Group Affiliations
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Contact information
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Children's Hospital of Philadelphia
1e Division of Cardiology
40 3401 Civic Center Blvd, 8NW37
Philadelphia, PA 19104
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1e Division of Cardiology
40 3401 Civic Center Blvd, 8NW37
Philadelphia, PA 19104
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Office: (267) 648-2626
32 Fax: 215-590-1340
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32 Fax: 215-590-1340
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Publications
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Education:
21 7 BS 19 (Biochemistry) c
37 University of Nebraska-Lincoln, 1997.
21 8 PhD 3a (Cell and Developmental Biology and Philosophy) c
41 Vanderbilt University School of Medicine, 2006.
21 7 MD c
44 Vanderbilt University of School of Medicine, 2009.
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Permanent link21 7 BS 19 (Biochemistry) c
37 University of Nebraska-Lincoln, 1997.
21 8 PhD 3a (Cell and Developmental Biology and Philosophy) c
41 Vanderbilt University School of Medicine, 2006.
21 7 MD c
44 Vanderbilt University of School of Medicine, 2009.
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178 Wen H, Liberti DC, Chandrasekaran P, Parveen S, Quansah KK, Kim M, Lange AN, Marquis AT, Michki SN, Jin A, Lu M, Fasan AA, Suresh S, Shirazi SP, Young LR, Sucre JM, Basil MC, Jain R, Frank DB.: BRD4 promotes endodermal cell fate during mammalian lung development. JCI Insight 11(5): e194683, March 2026.
1fd Marzolini N, Brysgel TV, Rahman RJ, Essien EO, Nwe SY, Wu J, Majumder A, Patel MN, Tiwari S, Espy CL, Dong F, Santos-De León SA, Shah A, Shuvaev VV, Hood ED, Chase LS, Weissman D, Katzen JB, Frank DB, Bennett ML, Marcos-Contreras OA, Myerson JW, Muzykantov VR, Reyes-Esteves S, Brenner JS. : Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. Advanced Science 13(14): e15480, March 2026.
139 Snitow ME, Michki SN, Chaudhry FN, Park Y, Dherwani R, Katzen JB, Frank DB, Zepp JA: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung. Cell Rep 45(1): 116750, January 2026.
163 Meluskey H, Blowey B, O'Brien AB, O'Byrne ML, Rome JJ, Frank DB, Avitabile CM, Gupta M, Tang J, Butler KL, Mavroudis CD, Fuller S, Callahan R. : Systemic Sirolimus Monitoring in Pediatric Pulmonary Vein Stenosis. Pediatr Cardiol. Page: doi: 10.1007/s00246-025-04038-6, October 2025.
2a2 Niccum M, Avitabile CM, Albizem D, Meluskey H, Penney C, Hanna BD, O'Byrne ML, Bshouty Z, Frank DB. Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 2025 Sep 1;15(3):e70156. doi: 10.1002/pul2.70156. PMID: 40904895; PMCID: PMC12401941.: Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 15(3): e70156, September 2025 Notes: Editorial accompaniment in Pulmonary Circulation https://onlinelibrary.wiley.com/doi/10.1002/pul2.70218.
232 Chen C, Xu J, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K.: Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood 145(23): 2685-2700, June 2025.
129 Vega TF, Huber M, Jensen EA, Avitabile CM, Lorch SA, Gibbs KA, O'Byrne ML, Frank DB, Bamat NA: Pulmonary vasodilator use in very preterm infants in United States children's hospitals. J Perinatol 45(10): 1382-1388, May 2025.
1b2 Shirazi SP, Negretti NM, Jetter CS, Sharkey AL, Garg S, Kapp ME, Wilkins D, Fortier G, Mallapragada S, Banovich NE, Eldredge LC, Deutsch GH, Wright CVE, Frank DB, Kropski JA, Sucre JMS: Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression. Nat Commun 16(1): 5004, May 2025.
14a Wen J., Chandrasekaran P., Jin A., Pankin J., Lu M., Liberti D.C., Zepp J.A., Jain R., Morrisey E.E., Michki S.N., Frank D.B. : A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development. Cell Rep 44(4): 115513, April 2025.
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Selected Publications
11f Gupta M, Frank DB: Pulmonary Vein Stenosis Medical Therapy: Current and on the Horizon. Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual Page: 10.1053/j.pcsu.2026.02.006, March 2026.178 Wen H, Liberti DC, Chandrasekaran P, Parveen S, Quansah KK, Kim M, Lange AN, Marquis AT, Michki SN, Jin A, Lu M, Fasan AA, Suresh S, Shirazi SP, Young LR, Sucre JM, Basil MC, Jain R, Frank DB.: BRD4 promotes endodermal cell fate during mammalian lung development. JCI Insight 11(5): e194683, March 2026.
1fd Marzolini N, Brysgel TV, Rahman RJ, Essien EO, Nwe SY, Wu J, Majumder A, Patel MN, Tiwari S, Espy CL, Dong F, Santos-De León SA, Shah A, Shuvaev VV, Hood ED, Chase LS, Weissman D, Katzen JB, Frank DB, Bennett ML, Marcos-Contreras OA, Myerson JW, Muzykantov VR, Reyes-Esteves S, Brenner JS. : Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. Advanced Science 13(14): e15480, March 2026.
139 Snitow ME, Michki SN, Chaudhry FN, Park Y, Dherwani R, Katzen JB, Frank DB, Zepp JA: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung. Cell Rep 45(1): 116750, January 2026.
163 Meluskey H, Blowey B, O'Brien AB, O'Byrne ML, Rome JJ, Frank DB, Avitabile CM, Gupta M, Tang J, Butler KL, Mavroudis CD, Fuller S, Callahan R. : Systemic Sirolimus Monitoring in Pediatric Pulmonary Vein Stenosis. Pediatr Cardiol. Page: doi: 10.1007/s00246-025-04038-6, October 2025.
2a2 Niccum M, Avitabile CM, Albizem D, Meluskey H, Penney C, Hanna BD, O'Byrne ML, Bshouty Z, Frank DB. Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 2025 Sep 1;15(3):e70156. doi: 10.1002/pul2.70156. PMID: 40904895; PMCID: PMC12401941.: Pulmonary Vascular Compromise Is Associated With Survival in Pediatric Pulmonary Hypertension: A New Computational Model. Pulm Circ. 15(3): e70156, September 2025 Notes: Editorial accompaniment in Pulmonary Circulation https://onlinelibrary.wiley.com/doi/10.1002/pul2.70218.
232 Chen C, Xu J, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K.: Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood 145(23): 2685-2700, June 2025.
129 Vega TF, Huber M, Jensen EA, Avitabile CM, Lorch SA, Gibbs KA, O'Byrne ML, Frank DB, Bamat NA: Pulmonary vasodilator use in very preterm infants in United States children's hospitals. J Perinatol 45(10): 1382-1388, May 2025.
1b2 Shirazi SP, Negretti NM, Jetter CS, Sharkey AL, Garg S, Kapp ME, Wilkins D, Fortier G, Mallapragada S, Banovich NE, Eldredge LC, Deutsch GH, Wright CVE, Frank DB, Kropski JA, Sucre JMS: Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression. Nat Commun 16(1): 5004, May 2025.
14a Wen J., Chandrasekaran P., Jin A., Pankin J., Lu M., Liberti D.C., Zepp J.A., Jain R., Morrisey E.E., Michki S.N., Frank D.B. : A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development. Cell Rep 44(4): 115513, April 2025.
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