David B. Frank, MD, PhD

Assistant Professor of Pediatrics (Cardiology)
Attending Physician, Division of Cardiology, Children's Hospital of Philadelphia
Assistant Program Director, Pediatric Cardiology T32 Training Grant, Children's Hospital of Philadelphia
Member, Lung Biology Institute, University of Pennsylvania School of Medicine
Primary Faculty, Cardiovascular Institute, University of Pennsylvania School of Medicine
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
Office: (267) 648-2626
Fax: 215-590-1340
Fax: 215-590-1340
Publications
Education:
B.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
M.D.
Vanderbilt University of School of Medicine, 2009.
Permanent linkB.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
M.D.
Vanderbilt University of School of Medicine, 2009.
Selected Publications
Vega TF, Huber M, Jensen EA, Avitabile CM, Lorch SA, Gibbs KA, O'Byrne ML, Frank DB, Bamat NA: Pulmonary vasodilator use in very preterm infants in United States children's hospitals. J Perinatol May 2025.Shirazi SP, Negretti NM, Jetter CS, Sharkey AL, Garg S, Kapp ME, Wilkins D, Fortier G, Mallapragada S, Banovich NE, Eldredge LC, Deutsch GH, Wright CVE, Frank DB, Kropski JA, Sucre JMS: Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression. Nat Commun 30(16), May 2025.
Wen J., Chandrasekaran P., Jin A., Pankin J., Lu M., Liberti D.C., Zepp J.A., Jain R., Morrisey E.E., Michki S.N., Frank D.B. : A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development. Cell Rep 44(4), April 2025.
Maureen Peers de Nieuwburgh, Mallory Hunt, Prashant Chandrasekaran, Tiffaney L Vincent, Kevin B Hayes, Isabel R Randazz, Meredith Gunder , Felix R De Bie, Arthur Colson, Minqi Lu, Hongbo Wen, Sylvia N Michki, Jack Rychik , Fréderic Debiève, Jeremy Katzen, Lisa R Young, Marcus G Davey, Alan W Flake, J William Gaynor, David B Frank: Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development. Am J Respir Cell Mol Biol 72(4): 441-452, April 2025.
Banaschewski BJH, Michki SN, Sitaraman S, Pan R, Wang JY, Stewart D, Goldy MK, Lin SM, Cantu E, Katzen JB, Basil MC, Emtiazjoo AM, Todd JL, Gokey JJ, Kropski JA, Frank DB, Zepp JA, Young LR.: Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis. Commun Biol 8(1), February 2025.
Niethamer TK, Planer JD, Morley MP, Babu A, Zhao G, Basil MC, Cantu E, Frank DB, Diamond JM, Nottingham AN, Li S, Sharma A, Hallquist H, Levin LI, Zhou S, Vaughan AE, Morrisey EE: Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states. Cell Stem Cell 32(2): 302-321, February 2025.
Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT: A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. Nat Cancer 6(1): 102-122, January 2025.
Negretti NM, Son Y, Crooke P, Plosa EJ, Benjamin JT, Jetter CS, Bunn C, Mignemi N, Marini J, Hackett AN, Ransom M, Garg S, Nichols D, Guttentag SH, Pua HH, Blackwell TS, Zacharias W, Frank DB, Kozub JA, Mahadevan-Jansen A, Krystofiak E, Kropski JA, Wright CV, Millis B, Sucre JM: Epithelial outgrowth through mesenchymal rings drives alveologenesis. JCI Insight January 2025.
Wong J, Zhao G, Adams-Tzivelekidis S, Wen H, Chandrasekaran P, Michki SN, Gentile ME, Singh M, Kass-Gergi S, Mendoza M, Holcomb NP, Li X, Tang AT, Negretti NM, Sucre JMS, Frank DB*, Vaughan AE*, * co-corresponding authors: Dynamic behavior and lineage plasticity of the pulmonary venous endothelium. Nat Cardiovasc Res 3(12): 1584-1600, December 2024.
Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR. Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome.: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight December 2024.