David B. Frank, MD, PhD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104
Office: (267) 648-2626
Fax: 215-590-1340
Education:
B.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
M.D.
Vanderbilt University of School of Medicine, 2009.
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Selected Publications

Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP.: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nat Commun 11(1): 5640, Nov 2020.

Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS: STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nat Cell Biol 22(10): 1197-1210, Oct 2020.

Vanderver A, Adang L, Gavazzi F, McDonald K, Helman G, Frank DB, Jaffe N, Yum SW, Collins A, Keller SR, Lebon P, Meritet JF, Rhee J, Takanohashi A, Armangue T, Ulrick N, Sherbini O, Koh J, Peer K, Besnier C, Scher C, Boyle K, Dubbs H, Kramer-Golinkoff J, Pizzino A, Woidill S, Shults J: Janus Kinase Inhibition in the Aicardi-Goutières Syndrome. N Engl J Med 383(10): 986-989, Sep 2020.

Catherine M Avitabile, Yan Wang, Xuemei Zhang, Heather Griffin , Sofia Saavedra, Samantha Adams, Lisa Herkert, David B Frank, Michael D Quartermain , Natalie E Rintoul , Holly L Hedrick, Laura Mercer-Rosa : Right Heart Strain, Brain Natriuretic Peptide, and Mortality in Congenital Diaphragmatic Hernia. Annals of the American Thoracic Society Online ahead of print, July 2020.

A. Naik, Y. Issah, K. Forrest, D. B. Frank, A. Paris, A. Vaughan, S. Sengupta: Role of Circadian Clock in Lung Repair and Regeneration. American Thoracic Society International Conference Abstracts > C62. EPITHELIUM, INJURY, AND REPAIR May 2020.

D. B. Frank, K. Quansah, S. Jayachandran, M. Lu, J. Pankin, A. Sivakumar: Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate. American Journal of Respiratory and Critical Care Medicine 2020 201(A5985), May 2020.

D. B. Frank, S. Jayachandran, A. Sivakumar, M. Lu, K. Quansah, J. Pankin: Re-Initiation of Developmental Paradigms for Regeneration After Neonatal Lung Injury. American Journal of Respiratory and Critical Care Medicine 2020 201(A7679), May 2020.

Ikonomou L, Herriges MJ, Lewandowski SL, Marsland R 3rd, Villacorta-Martin C, Caballero IS, Frank DB, Sanghrajka RM, Dame K, Kańduła MM, Hicks-Berthet J, Lawton ML, Christodoulou C, Fabian AJ, Kolaczyk E, Varelas X, Morrisey EE, Shannon JM, Mehta P, Kotton DN: The in vivo genetic program of murine primordial lung epithelial progenitors. Nat Commun 11(1): 635, January 2020.

Aravind Sivakumar, David B. Frank: Paradigms That Define Lung Epithelial Progenitor Cell Fate in Development and Regeneration. Current Stem Cell Reports 5: 133–144, December 2019.

Michael L O’Byrne, Jennifer A Faerber, Hannah Katcoff, , David B Frank, Alex Davidson, Therese M Giglia, Catherine M Avitabile: Variation in utilization of pulmonary vasodilators in children and adolescents with pulmonary hypertension: An analysis of data from the Marketscan® Commercial and Medicaid Claims Databases Poster-American Heart Association Scientific Sessions, Philadelphia, PA November 2019.

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Last updated: 04/01/2021
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