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Donald Joseph, Ph.D.
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Research Assistant Professor of Neurology
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Department: Neurology
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Contact information
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3400 Civic Center Boulevard
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Philadelphia, PA 19104
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Philadelphia, PA 19104
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Office: 646-245-3677
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32 Lab: 215-594-5285
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32 Lab: 215-594-5285
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Email:
josephd1@chop.edu
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josephd1@chop.edu
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Publications
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Links
33 Search PubMed for articles
8c Professional site for biographical and research information
a6 Professional site for biographical and research information
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33 Search PubMed for articles
8c Professional site for biographical and research information
a6 Professional site for biographical and research information
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Education:
21 7 BS 14 (Biology) c
50 Medgar Evers College of the City University of New York, 1994.
21 7 MA 26 (Neuroscience & Physiology) c
48 City College of the City University of New York, 1998.
21 7 MA 19 (Neuroscience) c
2c Columbia University, 2001.
21 a MPhil 19 (Neuroscience) c
2c Columbia University, 2003.
21 9 Ph.D 19 (Neuroscience) c
2c Columbia University, 2009.
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Permanent link21 7 BS 14 (Biology) c
50 Medgar Evers College of the City University of New York, 1994.
21 7 MA 26 (Neuroscience & Physiology) c
48 City College of the City University of New York, 1998.
21 7 MA 19 (Neuroscience) c
2c Columbia University, 2001.
21 a MPhil 19 (Neuroscience) c
2c Columbia University, 2003.
21 9 Ph.D 19 (Neuroscience) c
2c Columbia University, 2009.
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Description of Research Expertise
b4 Electrophysiology of the synapse, Calcium-imaging, Long-Term Potentiation (LTP) recording, Cognitive Testing, electroencephalogram (EEG), and Genome-wide sequencinge 29
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123 Donald J Joseph, Markus Von Deimling, Rashmi Risbud, Almedia J McCoy, Eric D Marsh: Loss of Postnatal Arx Transcriptional Activity in Parvalbumin Interneurons Reveals Non-cell Autonomous Disturbances in CA1 Pyramidal Cells. Neuroscience 43 Elsevier, May 23(24): S0306-4522, May 23 2024.
11f F Siddiqi, AL Trakimas, DJ Joseph, TT Clarke, E. Marsh, J.H. Wolfe: Fate-labeling of Islet1 population shows pervasive progeny in mouse forebrain. Cerebral Cortex 31(11): 5206–5224, November 2021 Notes: in-press.
10c Siddiqi F, Trakimas AL, Joseph DJ, Lippincott ML, Marsh ED, Wolfe JH.: Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex. Cerebral Cortex 31(11): 5206-5224, Oct 2021.
136 Joseph DJ, Von Deimling M, Hasegawa Y, Cristancho AG, Risbud R, McCoy AJ, Marsh ED.: Protocol for isolating young adult parvalbumin interneurons from the mouse brain for extraction of high-quality RNA. STAR Protoc 2(3): 100714, Aug 2021.
135 Joseph DJ, Von Deimling M, Hasegawa Y, Cristancho AG, Ahrens-Nicklas RC, Rogers SL, Risbud R, McCoy AJ, Marsh ED.: Postnatal Arx transcriptional activity regulates functional properties of PV interneurons. iScience 24: 101999, Dec 2020.
153 Joseph DJ, Liu C, Peng J, Liang G, Wei H.: Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. PLoS One 14: e0223509, Oct 2019.
123 Peng J, Drobish JK, Liang G, Wu Z, Liu C, Joseph DJ, Abdou H, Eckenhoff MF, Wei H.: Anesthetic preconditioning inhibits isoflurane-mediated apoptosis in the developing rat brain. Anesth Analg 119(4): 939-946, Oct 2014.
11e Zhao X, Yang Z, Liang G, Wu Z, Peng Y, Joseph DJ, Inan S, Wei H.: Dual effects of isoflurane on proliferation, differentiation, and survival in human neuroprogenitor cells. Anesthesiology 118(3): 537-49, Mar 2013.
120 Peng J, Liang G, Inan S, Wu Z, Joseph DJ, Meng Q, Peng Y, Eckenhoff MF, Wei H.: Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. Neurosci Lett 516(2): 274-9, May 2012.
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Selected Publications
12d Joseph DJ, Mercado-Ayon E, Flatley L, Viaene AN, Hordeaux J, Marsh ED, Lynch DR: Functional Characterization of Parallel Fiber-Purkinje Cell Synapses in Two Friedreich's Ataxia Mouse Models. Cerebellum 24(2): 42, February 2025.123 Donald J Joseph, Markus Von Deimling, Rashmi Risbud, Almedia J McCoy, Eric D Marsh: Loss of Postnatal Arx Transcriptional Activity in Parvalbumin Interneurons Reveals Non-cell Autonomous Disturbances in CA1 Pyramidal Cells. Neuroscience 43 Elsevier, May 23(24): S0306-4522, May 23 2024.
11f F Siddiqi, AL Trakimas, DJ Joseph, TT Clarke, E. Marsh, J.H. Wolfe: Fate-labeling of Islet1 population shows pervasive progeny in mouse forebrain. Cerebral Cortex 31(11): 5206–5224, November 2021 Notes: in-press.
10c Siddiqi F, Trakimas AL, Joseph DJ, Lippincott ML, Marsh ED, Wolfe JH.: Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex. Cerebral Cortex 31(11): 5206-5224, Oct 2021.
136 Joseph DJ, Von Deimling M, Hasegawa Y, Cristancho AG, Risbud R, McCoy AJ, Marsh ED.: Protocol for isolating young adult parvalbumin interneurons from the mouse brain for extraction of high-quality RNA. STAR Protoc 2(3): 100714, Aug 2021.
135 Joseph DJ, Von Deimling M, Hasegawa Y, Cristancho AG, Ahrens-Nicklas RC, Rogers SL, Risbud R, McCoy AJ, Marsh ED.: Postnatal Arx transcriptional activity regulates functional properties of PV interneurons. iScience 24: 101999, Dec 2020.
153 Joseph DJ, Liu C, Peng J, Liang G, Wei H.: Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. PLoS One 14: e0223509, Oct 2019.
123 Peng J, Drobish JK, Liang G, Wu Z, Liu C, Joseph DJ, Abdou H, Eckenhoff MF, Wei H.: Anesthetic preconditioning inhibits isoflurane-mediated apoptosis in the developing rat brain. Anesth Analg 119(4): 939-946, Oct 2014.
11e Zhao X, Yang Z, Liang G, Wu Z, Peng Y, Joseph DJ, Inan S, Wei H.: Dual effects of isoflurane on proliferation, differentiation, and survival in human neuroprogenitor cells. Anesthesiology 118(3): 537-49, Mar 2013.
120 Peng J, Liang G, Inan S, Wu Z, Joseph DJ, Meng Q, Peng Y, Eckenhoff MF, Wei H.: Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. Neurosci Lett 516(2): 274-9, May 2012.
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