Frank Milton Balis, M.D.
Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
The Louis and Amelia Canuso Family Endowed Chair for Clinical Research in Oncology, The Children's Hospital of Philadelphia
Philadelphia, PA
Co-Leader, Clinical Pharmacology Research Affinity Group, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
The Children's Hospital of Philadelphia
3501 Civic Center Blvd., Room CTRB4024
Philadelphia, PA 19104
3501 Civic Center Blvd., Room CTRB4024
Philadelphia, PA 19104
Office: 267-426-5414
Fax: 267-425-5839
Fax: 267-425-5839
Email:
balisf@CHOP.edu
balisf@CHOP.edu
Education:
B.S. (Zoology)
University of North Carolina, 1971.
M.D. (Medicine)
Vanderbilt University, 1975.
Permanent linkB.S. (Zoology)
University of North Carolina, 1971.
M.D. (Medicine)
Vanderbilt University, 1975.
Description of Clinical Expertise
Solid tumors in children, renal tumors in children, clinical pharmacology of anticancer drugsDescription of Other Expertise
Clinical research infrastructure and informaticsDescription of Research Expertise
Clinical pharmacology of anticancer drugs, cancer biomarkers, clinical trial designSelected Publications
Nitsche LJ, Bontrager CE, Devlin PJ, Surrey LF, Pogoriler JE, Kreiger PA, Laetsch TW, Balis F, Fairman AS, Mattei P, Fuller SM.: Complex pediatric neoplasms: The role of congenital cardiothoracic surgery. JTCVS Tech 30: 137-143, Feb 2025.Balis FM, Rieger E, Bunin NJ, Gardiner J, Shaw LM, Olson TS, Milone MC.: New approach to busulfan dosing in infants and children based on a population pharmacokinetic analysis. Cancer Chemother Pharmacol 95: 32, Feb 2025.
Dela Cruz FS, Fox E, DuBois SG, Friedman GK, Croop JM, Kim A, Morgenstern DA, Balis FM, Macy ME, Pressey JG, Watt T, Krystal JI, Vo KT, Mody R, Laetsch TW, Weigel BJ, O'Hara K, He CS, Aluri J, Okpara CE, Glade Bender JL.: A Phase 1/2 Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric and Young Adult Solid Tumors. Pediatr Blood Cancer 2025.
Metts JL, Aye JM, Crane JN, Oberoi S, Balis FM, Bhatia S, Bona K, Carleton B, Dasgupta R, Dela Cruz FS, Greenzang KA, Kaufman JL, Linardic CM, Parsons SK, Robertson-Tessi M, Rudzinski ER, Soragni A, Stewart E, Weigel BJ, Wolden SL, Weiss AR, Venkatramani R, Heske CM.: Roadmap for the next generation of Children's Oncology Group rhabdomyosarcoma trials. Cancer 130: 3785-3796, Nov 2024.
Jerry L, Swan L, Dana N, Balis FM, Greengard E, Huiping X.: Population modeling analyses of crizotinib in pediatric patients with ALK-positive advanced cancers. Pediatr Blood Cancer Jun 2024.
Hogarty MD, Ziegler DS, Franson A, Chi YY, Tsao-Wei D, Liu K, Vemu R, Gerner EW, Bruckheimer E, Shamirian A, Hasenauer B, Balis FM, Groshen S, Norris MD, Haber M, Park JR, Matthay KK, Marachelian A.: Phase 1 study of high-dose DFMO, celecoxib, cyclophosphamide and topotecan for patients with relapsed neuroblastoma: a New Approaches to Neuroblastoma Therapy trial. Br J Cancer 2024.
Grossman LD, Baldino S, Zelley K, Balis F, Bagatell R, Kalish JM, MacFarland SP.: Atypical presentations of RECQL4-related syndromes. Pediatr Blood Cancer 2024.
Singh P, Shah DA, Jouni M, Cejas RB, Crossman DK, Magdy T, Qiu S, Wang X, Zhou L, Sharafeldin N, Hageman L, McKenna DE, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Bhatia R, Burridge PW, Bhatia S.: Altered Peripheral Blood Gene Expression in Childhood Cancer Survivors With Anthracycline-Induced Cardiomyopathy - A COG-ALTE03N1 Report. J Am Heart Assoc 12: e029954, Oct 2023.
Singh P, Zhou L, Shah DA, Cejas RB, Crossman DK, Jouni M, Magdy T, Wang X, Sharafeldin N, Hageman L, McKenna DE, Horvath S, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Burridge PW, Bhatia S.: Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy. Sci Rep 13: 12683, Aug 2023.
Singh P, Crossman DK, Zhou L, Wang X, Sharafeldin N, Hageman L, Blanco JG, Burridge PW, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Bhatia S.: Haptoglobin Gene Expression and Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors: A COG-ALTE03N1 Report. JACC CardioOncol 5: 392-401, Feb 2023.