Frank Milton Balis, M.D.

faculty photo
Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
The Louis and Amelia Canuso Family Endowed Chair for Clinical Research in Oncology, The Children's Hospital of Philadelphia Philadelphia, PA
Co-Leader, Clinical Pharmacology Research Affinity Group, Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
3501 Civic Center Blvd., Room CTRB4024
Philadelphia, PA 19104
Office: 267-426-5414
Fax: 267-425-5839
Education:
B.S. (Zoology)
University of North Carolina, 1971.
M.D. (Medicine)
Vanderbilt University, 1975.
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Description of Clinical Expertise

Solid tumors in children, renal tumors in children, clinical pharmacology of anticancer drugs

Description of Other Expertise

Clinical research infrastructure and informatics

Description of Research Expertise

Clinical pharmacology of anticancer drugs, cancer biomarkers, clinical trial design

Selected Publications

Jerry L, Swan L, Dana N, Balis FM, Greengard E, Huiping X.: Population modeling analyses of crizotinib in pediatric patients with ALK-positive advanced cancers. Pediatr Blood Cancer Jun 2024.

Hogarty MD, Ziegler DS, Franson A, Chi YY, Tsao-Wei D, Liu K, Vemu R, Gerner EW, Bruckheimer E, Shamirian A, Hasenauer B, Balis FM, Groshen S, Norris MD, Haber M, Park JR, Matthay KK, Marachelian A.: Phase 1 study of high-dose DFMO, celecoxib, cyclophosphamide and topotecan for patients with relapsed neuroblastoma: a New Approaches to Neuroblastoma Therapy trial. Br J Cancer 2024.

Singh P, Shah DA, Jouni M, Cejas RB, Crossman DK, Magdy T, Qiu S, Wang X, Zhou L, Sharafeldin N, Hageman L, McKenna DE, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Bhatia R, Burridge PW, Bhatia S.: Altered Peripheral Blood Gene Expression in Childhood Cancer Survivors With Anthracycline-Induced Cardiomyopathy - A COG-ALTE03N1 Report. J Am Heart Assoc 12: e029954, Oct 2023.

Singh P, Zhou L, Shah DA, Cejas RB, Crossman DK, Jouni M, Magdy T, Wang X, Sharafeldin N, Hageman L, McKenna DE, Horvath S, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Burridge PW, Bhatia S.: Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy. Sci Rep 13: 12683, Aug 2023.

Singh P, Crossman DK, Zhou L, Wang X, Sharafeldin N, Hageman L, Blanco JG, Burridge PW, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Bhatia S.: Haptoglobin Gene Expression and Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors: A COG-ALTE03N1 Report. JACC CardioOncol 5: 392-401, Feb 2023.

Mittal S, Long C, El-Ali A, Talwar R, Lattanzio K, Lawton B, Hamdan D, Balis FM, Mattei P, Back SJ, Kolon TF.: Utilizing RENAL nephrometry in pediatric patients undergoing nephron-sparing surgery for renal tumors: A single-institutional cohort. J Pediatr Urol 2023.

258. Mittal S, Long C, El-Ali A, Talwar R, Lattanzio K, Lawton B, Hamdan D, Balis FM, Mattei P, Back SJ, Kolon TF: Utilizing RENAL nephrometry in pediatric patients undergoing nephron-sparing surgery for renal tumors. J Pediatr Urol Page: Pub, 2023.

257. Singh P, Crossman DK, Zhou L, Wang X, Sharafeldin N, Hageman L, Blanco JG, Burridge PW, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Bhatia S: Haptoglobin gene expression and anthracycline-related cardiomyopathy in childhood cancer survivors: A COG-ALTE03N1 report. JACC CardioOncol 5: 392-401, 2023.

256. Lai C, Cole DE, Steinberg SM, Lucas N, Dombi E, Melani C, Roschewski M, Balis FM, Widemann BC, Wilson WH: Doxorubicin pharmacokinetics and toxicity in patients with aggressive lymphoma and hepatic impairment. Blood Adv 7: 529-32, 2023.

Busch CM and Balis FM: Age-dependent reference intervals in children for the disialoganglioside, G(D2), a circulating tumor biomarker for the childhood cancer, neuroblastoma. Clin Biochem 101: 1-4, 2022.

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Last updated: 06/24/2024
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