Shekhar Kumar, PhD

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Research Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
The Children’s Hospital of Philadelphia
309E Abramson Research Building
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-2688
Education:
BS (Biotechnology)
Patna University, Patna, India, 2000.
MS (Biotechnology)
All India Institute of Medical Sciences, New Delhi, India, 2003.
PhD (Biochemistry)
Jawaharlal Nehru University, New Delhi, India, 2010.
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Selected Publications

Gunaratne, R*., Kumar, S*., Frederiksen, J.W., Stayrook, S., Lohrmann, J.L., Perry, K., Bompiani, K.M., Chabada, C.V., Thalji, N.K., Ho, M.D., Arepally, G., Camire, R.M., Krishnaswamy, K., and Sullenger, B.A: Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nature Biotechnology 36(7): 606-613, Aug 2018 Notes: * Co-first author, Featured as Paper of the Month by Oligonucleotide Therapeutics Society.

Pooja Sawhney, Shekhar Kumar, Neeraj Maheshwari, Sumeet Singh Guleria, Neelam Dhar, Radhika Kashyup, Girish Sahni: Site-Specific Thiol-mediated PEGylation of Streptokinase Leads to Improved Properties with Clinical Potential. Current Pharmaceutical Design 22(38): 5868-5878, 2016.

S Kumar, S Krishnaswamy: Thrombin Formation In: Gonzalez E., Moore H., Moore E. (eds) Trauma Induced Coagulopathy. Springer, Cham Page: 55-74, 2016.

Kumar, S., Deng, W., Stayrook, S., Li, R., Camire, R., and Krishnaswamy S: Structural Basis for the Procofactor to Cofactor Transition in Human Factor V. 45th Annual Philadelphia workshop on Hemostasis, Thrombosis, and Atherosclerosis, Philadelphia, 2016 (Oral presentation). 45th Annual Philadelphia workshop on Hemostasis, Thrombosis, and Atherosclerosis, Philadelphia, 2016 (Oral presentation) 2016.

S Kumar, W Deng, S Stayrook, R Li, RM Camire, S Krishnaswamy: Structural Basis for the Procofactor to Cofactor Transition in Human Factor V American Society of Hematology Annual Meeting, San Diego, 2016, Blood (2016) 128 (22), 253-253. (Oral presentation) 2016.

S Kumar, S Stayrook, RM Camire, S Krishnaswamy: The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox Blood 126 (23): 121-121, 2015.

S Kumar, BA Sullenger, S Stayrook, S Krishnaswamy: X-Ray Structure of an Anticoagulant RNA Aptamer Bound to Factor Xa. Structural Basis for Its Ability to Disrupt Interactions Between Xa and Va within Prothrombinase Blood 124 (21): 4232-4232. 2014.

S Kumar, S Stayrook, JA Huntington, RM Camire, S Krishnaswamy: New Structural Insights into High Affinity Membrane Binding By Coagulation Factor V/Va Blood Page: 4216-4216, 2014.

Rachna Aneja, Manish Datt, Balwinder Singh, Shekhar Kumar, Girish Sahni : Identification of a New Exosite Involved in Catalytic Turnover by the StreptokinasePlasmin Activator Complex during Human Plasminogen Activation Journal of Biological Chemistry 284(47): 32642–32650, Nov 2009.

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Last updated: 04/16/2019
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