Tatiana Akimova (nee: Tikhomirova), M.D., PhD

faculty photo
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
The Children's Hospital of Philadelphia
Division of Transplant Immunology, Department of Pathology and Laboratory Medicine
916F Abramson Research Center
3615 Civic Center Blvd, Philadelphia, PA 19104,USA
Philadelphia, PA 19104
Office: 267-426-9644
Fax: 215-426-1880
Lab: 267-426-9644
Education:
MD (Internal Medicine)
St. Petersburg State Pavlov Medical University, St. Petersburg, Russia, 2001.
PhD (Immunology and Allergy)
Center for Molecular Medicine, St. Petersburg State Pavlov Medical University, 2006.
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Selected Publications

Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW: Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. The Journal of Clinical Investigation 130(4): 1830-42, 2020.

Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen LM, Han R, Samanta A, Trevisanut M, Bhatti TR, Beier UH, Hancock WW: Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity. The Journal of Clinical Investigation 2020.

Dahiya S, Beier UH, Wang L, Han R, Jiao J, Akimova T, Angelin, A., Wallace, D. C., Hancock, W. W.: HDAC10 deletion promotes Foxp3(+) T-regulatory cell function. Scientific Reports 1(10): 424, 2020.

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM and Eruslanov EB: Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Sci Transl Med 11(479), 2019.

Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW: Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers 4(11), 2019.

Negorev, D., Beier, U. H., Zhang, T., Quatromoni, J. G., Bhojnagarwala, P., Albelda, S. M., Singhal, S., Eruslanov, E., Lohoff, F. W., Levine, M. H., Diamond, J. M., Christie, J. D., Hancock, W. W., Akimova, T.: Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Sci Rep 8(1): 3135, 2018.

Lieber AD, Beier UH, Xiao H, Wilkins BJ, Jiao J, Li XS, Schugar RC, Strauch CM, Wang Z, Brown JM, Hazen SL, Bokulich NA, Ruggles KV, Akimova T, Hancock WW, Blaser MJ: Loss of HDAC6 alters gut microbiota and worsens obesity. FASEB J fj201701586R, 2018.

Akimova T, Hancock WW: How little is known about the role of human FOXP3+ Tregs in tumors. Expert Opin Ther Targets 22(8), 2018.

Akimova T, Zhang T, Beier UH, Jiao J, Diamond JM, Christie JD, et al. : Obesity-driven IL-18 inhibits the suppressive function of FOXP3+ T-regulatory (Treg) cells. The Journal of Immunology 200( (1 Supplement)): 166.52, 2018.

Wang L, Beier UH, Akimova T, Dahiya S, Han R, Samanta A, Levine MH, and Hancock WW: Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation. Am J Transplant 18(8), 2018.

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Last updated: 09/29/2020
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