Tatiana Akimova (nee: Tikhomirova), M.D., PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
The Children's Hospital of Philadelphia
Division of Transplant Immunology, Department of Pathology and Laboratory Medicine
916F Abramson Research Center
3615 Civic Center Blvd
Philadelphia, PA 19104
Division of Transplant Immunology, Department of Pathology and Laboratory Medicine
916F Abramson Research Center
3615 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-426-9644
Fax: 215-426-1880
Lab: 267-426-9644
Fax: 215-426-1880
Lab: 267-426-9644
Email:
akimovat@email.chop.edu
akimovat@email.chop.edu
Publications
Education:
MD (Internal Medicine)
St. Petersburg State Pavlov Medical University, St. Petersburg, Russia, 2001.
PhD (Immunology and Allergy)
Center for Molecular Medicine, St. Petersburg State Pavlov Medical University, 2006.
Certific. (2 years program in Analytics and Statistical Studies, Biostatistics certificate)
The Institute for Statistics Education, VA, USA, 2022.
Permanent linkMD (Internal Medicine)
St. Petersburg State Pavlov Medical University, St. Petersburg, Russia, 2001.
PhD (Immunology and Allergy)
Center for Molecular Medicine, St. Petersburg State Pavlov Medical University, 2006.
Certific. (2 years program in Analytics and Statistical Studies, Biostatistics certificate)
The Institute for Statistics Education, VA, USA, 2022.
Description of Research Expertise
Cancer immunology, transplant immunology, inflammation and tolerance, autoimmune diseases, obesity.My main interest is biology of human FOXP3+ regulatory T cells (Treg) and T cells.
18 years of medical, clinical and research experience.
Selected Publications
Philipp Stüve, Gloria J Godoy, Fernando N Ferreyra, Florencia Hellriegel, Fatima Boukhallouk, Yu-San Kao, Tushar H More, Anne-Marie Matthies, Tatiana Akimova, Wolf-Rainer Abraham, Volkhard Kaever, Ingo Schmitz, Karsten Hiller, Matthias Lochner, Benoît L Salomon, Ulf H Beier, Michael Rehli, Tim Sparwasser, Luciana Berod: ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance. Molecular Metabolism 94: 102111, 04 2025.Akimova T, Wang L, Bartosh Z, Christensen LM, Eruslanov E, Singhal S, Aishwarya V, Hancock WW. : Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity. Front Immunol. 15(1426657), 09 2024 Notes: First author publication.
Christensen LM, Akimova T, Wang L, Han R, Samanta A, Di Giorgio E, Hancock WW.: T-regulatory cells require Sin3a for stable expression of Foxp3. Front Immunol. 15(1444937), 08 2024.
Patterson KC, Miller WT, Hancock WW, Akimova T.: FOXP3+ regulatory T cells are associated with the severity and prognosis of sarcoidosis. Front Immunol. 14(1301991), 2023 Notes: Last author publication.
Massimo Martinelli, Gabrielle Aguilar, David SM Lee, Andrew Kromer, Nhu Nguyen, Benjamin J Wilkins, Tatiana Akimova, Ulf H Beier, Louis R Ghanem: The poly (C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation. Iscience 26(1): 105860, 1 2023.
Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han, Dmitry Negorev, Arabinda Samanta, Isaac E Sasson, Trivikram Gaddapara, Jing Jiao, Liqing Wang, Tricia R Bhatti, Matthew H Levine, Joshua M Diamond, Ulf H Beier, Rebecca A Simmons, Edward Cantu, David S Wilkes, David J Lederer, Michaela Anderson, Jason D Christie, Wayne W Hancock: Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. American Journal of Respiratory and Critical Care Medicine 204(9): 1060-1074, Nov 2021.
Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H Beier, Wayne W Hancock: A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+ Foxp3+ T-Regulatory Cells. Frontiers in Immunology 5(12): 703632, 2021.
Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen LM, Han R, Samanta A, Trevisanut M, Bhatti TR, Beier UH, Hancock WW: Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity. The Journal of Clinical Investigation 12(130), dec 2020.
Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW: Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. The Journal of Clinical Investigation 130(4): 1830-42, 2020.
Dahiya S, Beier UH, Wang L, Han R, Jiao J, Akimova T, Angelin, A., Wallace, D. C., Hancock, W. W.: HDAC10 deletion promotes Foxp3(+) T-regulatory cell function. Scientific Reports 1(10): 424, 2020.