Tatiana Akimova (nee: Tikhomirova), M.D., PhD

faculty photo
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
The Children's Hospital of Philadelphia
Division of Transplant Immunology, Department of Pathology and Laboratory Medicine
916F Abramson Research Center
3615 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-426-9644
Fax: 215-426-1880
Lab: 267-426-9644
MD (Internal Medicine)
St. Petersburg State Pavlov Medical University, St. Petersburg, Russia, 2001.
PhD (Immunology and Allergy)
Center for Molecular Medicine, St. Petersburg State Pavlov Medical University, 2006.
Certific. (2 years program in Analytics and Statistical Studies, Biostatistics certificate)
The Institute for Statistics Education, VA, USA, 2022.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Cancer immunology, transplant immunology, inflammation and tolerance, autoimmune diseases, obesity.
My main interest is biology of human FOXP3+ regulatory T cells (Treg) and T cells.
18 years of medical, clinical and research experience.

Selected Publications

Massimo Martinelli, Gabrielle Aguilar, David SM Lee, Andrew Kromer, Nhu Nguyen, Benjamin J Wilkins, Tatiana Akimova, Ulf H Beier, Louis R Ghanem: The poly (C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation. Iscience 26(1): 105860, 1 2023.

Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han, Dmitry Negorev, Arabinda Samanta, Isaac E Sasson, Trivikram Gaddapara, Jing Jiao, Liqing Wang, Tricia R Bhatti, Matthew H Levine, Joshua M Diamond, Ulf H Beier, Rebecca A Simmons, Edward Cantu, David S Wilkes, David J Lederer, Michaela Anderson, Jason D Christie, Wayne W Hancock: Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. American Journal of Respiratory and Critical Care Medicine 204(9): 1060-1074, Nov 2021.

Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H Beier, Wayne W Hancock: A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+ Foxp3+ T-Regulatory Cells. Frontiers in Immunology 5(12): 703632, 2021.

Mittal P, Wang L, Akimova T, Leach CA, Clemente JC, Sender MR, Chen Y, Turunen BJ, Hancock WW. : The CCR2/MCP-1 Chemokine Pathway and Lung Adenocarcinoma Cancers (Basel) 11(12): 3723, 2020.

Di Giorgio E, Wang L, Xiong Y, Akimova T, Christensen LM, Han R, Samanta A, Trevisanut M, Bhatti TR, Beier UH, Hancock WW: Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity. The Journal of Clinical Investigation 12(130), Drc 2020.

Dahiya S, Beier UH, Wang L, Han R, Jiao J, Akimova T, Angelin, A., Wallace, D. C., Hancock, W. W.: HDAC10 deletion promotes Foxp3(+) T-regulatory cell function. Scientific Reports 1(10): 424, 2020.

Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW: Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. The Journal of Clinical Investigation 130(4): 1830-42, 2020.

Quinn WJ 3rd, Jiao J, TeSlaa T, Stadanlick J, Wang Z, Wang L, Akimova T, Angelin A, Schafer PM, Cully MD, Perry C, Kopinski PK, Guo L, Blair IA, Ghanem LR, Leibowitz MS, Hancock WW, Moon EK, Levine MH, Eruslanov EB, Wallace DC, Baur JA, Beier UH. : Lactate Limits T Cell Proliferation via the NAD(H) Redox State. Cell Reports 15(33): 108500, 2020.

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM and Eruslanov EB: Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Sci Transl Med 11(479), 2019.

Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW: Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers 4(11), 2019.

back to top
Last updated: 03/28/2023
The Trustees of the University of Pennsylvania