Yuk Yee Leung, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
3700 Hamilton Walk
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania
Philadelphia, PA 19104
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania
Philadelphia, PA 19104
Lab: 215-573-3729
Email:
yyee@mail.med.upenn.edu
yyee@mail.med.upenn.edu
Education:
BEng (Medical Engineering )
University of Hong Kong, 2005.
PhD (Electrical and Electronic Engineering (Bioinformatics))
University of Hong Kong, 2010.
Permanent linkBEng (Medical Engineering )
University of Hong Kong, 2005.
PhD (Electrical and Electronic Engineering (Bioinformatics))
University of Hong Kong, 2010.
Description of Clinical Expertise
non-coding variants for Alzheimer's disease and other neurodegenerative diseasessmall RNA biomarkers for Alzheimer's disease and other neurodegenerative diseases
translational bioinformatics in Alzheimer's disease and other neurodegenerative diseases
Description of Research Expertise
Machine LearningBiomarker Discovery
Translational bioinformatics
Alzheimer's disease genetics & genomics
Selected Publications
Yuk Yee Leung, Adam C Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Kaylyn Clark, Amanda B Kuzma, Wan-Ping Lee, Laura Cantwell, Heather Nicaretta, Jonathan Haines, Lindsay Farrer, Sudha Seshadri, Zoran Brkanac, Carlos Cruchaga, Margaret Pericak-Vance, Richard P Mayeux, William S Bush, Anita Destefano, Eden Martin, Gerard D Schellenberg, Li-San Wang: Human whole-exome genotype data for Alzheimer’s disease. Nature Communication Jan 2024 Notes: doi: 10.1038/s41467-024-44781-7.Emily Greenfest‐Allen, Otto Valladares, Pavel P Kuksa, Prabhakaran Gangadharan, Wan‐Ping Lee, Jeffrey Cifello, Zivadin Katanic, Amanda B Kuzma, Nicholas Wheeler, William S Bush, Yuk Yee Leung, Gerard Schellenberg, Christian J Stoeckert Jr, Li‐San Wang: NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge. Alzheimers Dement Feb 2024 Notes: doi: 10.1002/alz.13509.
Jeffrey Cifello, Pavel P Kuksa, Naveensri Saravanan, Otto Valladares, Li-San Wang, Yuk Yee Leung: hipFG: high-throughput harmonization and integration pipeline for functional genomics data Bioinformatics Nov 2023 Notes: doi: 10.1093/bioinformatics/btad673.
Kuksa P.P., Liu C.-L., Fu W., Qu L., Zhao Y., Katanic Z., Kuzma A.B., Ho P.-C., Tzeng K.-T., Valladares O., Chou S.-Y, Naj A.C, Schellenberg G.D., Wang L.-S., Leung Y.Y: Alzheimer's disease variant portal (ADVP): a catalog of genetic findings for Alzheimer's disease. Journal of Alzheimer's disease 86(1): 461-477, Jan 2022 Notes: https://pubmed.ncbi.nlm.nih.gov/35068457/
Kuksa P.P, Gangadharan P., Katanic Z., Kleidermacher L., Amlie-Wolf A., Lee C.-Y., Qu L., Greenfest-Allen E., Valladares O., Leung Y.Y., Wang L.-S. : FILER: a framework for harmonizing and querying large-scale functional genomics knowledge. NAR Genomics and Bioinformatics 4(1), Jan 2022 Notes: https://pubmed.ncbi.nlm.nih.gov/35047815/
Alexandre Amlie-Wolf, Mitchell Tang, Jessica Way, Beth Dombroski, Ming Jiang, Nicholas Vrettos, Yi-Fan Chou, Yi Zhao, Amanda Kuzma, Elisabeth E. Mlynarski, Yuk Yee Leung, Christopher D. Brown, Li-San Wang, Gerard D. Schellenberg: Inferring the molecular mechanisms of noncoding Alzheimer's disease-associated genetic variants. Journal of Alzheimer's Disease 72(1): 301-318, Oct 2019 Notes: doi: 10.3233/JAD-190568.
Leung YY, Valladares O, Chou Y-F, Lin H-J, Kuzma A, Cantwell L, Qu L, Gangadharan P, Alzheimers Disease Sequencing Project (ADSP), Salerno W.J., Schellenberg G.D., Wang L-S.: VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project. Bioinformatics 35(10): 1768-1770, May 2019 Notes: https://doi.org/10.1093/bioinformatics/bty894.
Pavel P Kuksa, Alexandre Amlie-Wolf, Živadin Katanić, Otto Valladares, Li-San Wang, Yuk Yee Leung: DASHR 2.0: integrated database of human small non-coding RNA genes and mature products. Bioinformatics 35(6): 1033-1039, Aug 2018 Notes: https://doi.org/10.1093/bioinformatics/bty709.
Kuksa PP, Amlie-Wolf A, Katanic Z, Valladares O, Wang LS, Leung YY: SPAR: Small RNA-seq Portal for Analysis of sequencing expeRiments. Nucleic Acids Research WebServer Issue 46(W1): W36-W42, July 2018 Notes: https://doi.org/10.1093/nar/gky330.
Leung Y.Y., Toledo J.B, Nefedov A., Polikar R., Raghavan N., Xie S.X., Farnum M., Schultz T., Baek Y., Deerlin V., Hu W.T., Holtzman D.M., Fagan A.M., Perrin R.J., Grossman M., Soares H.D., Kling M.A., Mailman M., Arnold S.E., Narayan V.A., Lee V.M.-Y., Shaw L.M., Baker D., Wittenberg G.M., Trojanowski J.Q., Wang L.S., for the Alzheimer's Disease Neuroimaging Initiative. : Identifying amyloid pathology-related CSF biomarkers for Alzheimer’s disease in a multicohort study. Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring 1(3): 339-348, Sep 2015 Notes: http://dx.doi.org/10.1016/j.dadm.2015.06.008.