Yuk Yee Leung, PhD

faculty photo
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
3700 Hamilton Walk
D101 Richards Medical Research Building
Perelman School of Medicine, University of Pennsylvania
Philadelphia, PA 19104
Lab: 215-573-3729
Education:
BEng(MedE)
University of Hong Kong, 2005.
PhD
University of Hong Kong, 2010.
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Description of Clinical Expertise

small RNA biomarkers for Alzheimer's disease and other neurodegenerative diseases

translational bioinformatics in Alzheimer's disease and other neurodegenerative diseases

Description of Research Expertise

Machine Learning
Data Mining
Statistics
Biomarker Discovery
RNA-Seq analysis
Microarray data analysis
Proteomics data analysis

Selected Publications

Leung Y.Y.*, Kuksa P.P*. Amlie-Wolf A., Valladares O., Ungar L.H., Kannan S., Gregory B.D. and Wang L.S.: DASHR - Database of small human noncoding RNA. Nucleic Acids Research 44(D1): D216-D222, 2016 Notes: doi: 10.1093/nar/gkv1188.

Leung Y.Y.*, Ryvkin P.*, Gregory B. and Wang L.S.: CoRAL: Predicting non-coding RNAs from small RNA-sequencing data. Nucleic Acids Research 41(14): e137, 2013 Notes: doi: 10.1093/nar/gkt426.

Ryvkin P.*, Leung Y.Y.*, Silverman I.M.*, Childress M., Valladares O., Dragomir I., Gregory B.D. and Wang L.S.: HAMR: High throughput Annotation of Modified Ribonucleotides. RNA 19(12): 1684-92, 2013 Notes: doi: 10.1261/rna.036806.112.

Leung Y.Y., Toledo J.B, Nefedov A., Polikar R., Raghavan N., Xie S.X., Farnum M., Schultz T., Baek Y., Deerlin V., Hu W.T., Holtzman D.M., Fagan A.M., Perrin R.J., Grossman M., Soares H.D., Kling M.A., Mailman M., Arnold S.E., Narayan V.A., Lee V.M.-Y., Shaw L.M., Baker D., Wittenberg G.M., Trojanowski J.Q., Wang L.S., for the Alzheimer's Disease Neuroimaging Initiative. : Identifying amyloid pathology-related CSF biomarkers for Alzheimer’s disease in a multicohort study. Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring 1(3): 339-348, 2015 Notes: http://dx.doi.org/10.1016/j.dadm.2015.06.008.

Partch A., Valladares O., Cweibel R., Greenfest-Allen E., Childress M., Malamon J., Gangadharan P., Zhao Y., Qu L., Leung Y.Y., Naj A.C., Stoeckert, Jr. C.J., Schellenberg G.D. and Wang L.-S. : NIAGADS: The NIA Genetics of Alzheimer's Disease Data Storage Site. Alzheimer’s and Dementia 12(11): 1200–1203, November 2016 Notes: http://dx.doi.org/10.1016/j.jalz.2016.08.018.

Arnold S.E., Xie S.X., Leung Y.Y., Wang L.S., Kling M.A., Han X., Kim E., Wolk D.A., Bennett D.A., Chen-Plotkin A., Grossman M., Hu W., Lee V.M.-Y., Mackin S., Trojanowski J.Q., Wilson R.S., Shaw L.M. and Alzheimer's Disease Neuroimaging Initiative: Plasma Biomarkers of Depressive Symptoms in Older Adults. Translational Psychiatry 2: e65, 2012 Notes: doi:10.1038/tp.2011.63.

Wang L.S., Leung Y.Y., Chang S.K., Leight S., Knapik-Czajka M., Baek Y., Shaw L.M., Lee V.M., Trojanowski J.Q. and Clark C.M.: Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease 31(2): 439-45, 2012 Notes: doi: 10.3233/JAD-2012-120082.

Leung Y.Y., Chang C.Q. and Hung Y.S.: An Integrated Approach for Identifying Wrongly Labelled Samples When Performing Classification in Microarray Data. PLoS ONE 7(10): e46700, 2012 Notes: http://dx.doi.org/10.1371/journal.pone.0046700.

Arnold S.E., Xie S.X., Leung Y.Y., Kim E., Kling M.A., Wilson R., Bennett D., Hu W., Mackin S., Grossman M., Chen-Plotkin A., Wolk D., Lee V.M.-Y., Trojanowski J.Q., and Shaw L.M. : Biochemical Biomarkers of Depressive Symptoms in ADNI. Alzheimer's & Dementia 7(4): S312, 2011 Notes: DOI: http://dx.doi.org/10.1016/j.jalz.2011.05.907

Crowe E.P., Tuzer F., Gregory B.D., Donahue G., Gosai S.J., Leung Y.Y., Yetkin E., Cohen J., Nativio R., Wang L.-S., Sell C., Bonini N.M., Berger S.L., Johnson F.B. and Torres C.: Changes in the transcriptome of human astrocytes accompanying oxidative stress-induced senescence. Frontiers in Aging Neuroscience 8: 208, 2016 Notes: https://doi.org/10.3389/fnagi.2016.00208.

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Last updated: 04/17/2017
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