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John Charles O'Donnell, BA, MS, PhD
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Research Assistant Professor of Neurosurgery
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Department: Neurosurgery
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Graduate Group Affiliations
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- Neuroscience e
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Contact information
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3900 Woodland Ave
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Publications
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Links
b6 Search PubMed for articles
81 Website for the Cullen Laboratory and associates.
b8 Faculty page with the Institute for Translational Medicine and Therapeutics
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b6 Search PubMed for articles
81 Website for the Cullen Laboratory and associates.
b8 Faculty page with the Institute for Translational Medicine and Therapeutics
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Education:
21 7 BA 26 (Biology, Philosophy Minor) c
2b LaSalle University, 2004.
21 7 MS 14 (Biology) c
2a Towson University, 2009.
21 8 PhD 1e (Neuropharmacology) c
33 University of Pennsylvania, 2016.
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Permanent link21 7 BA 26 (Biology, Philosophy Minor) c
2b LaSalle University, 2004.
21 7 MS 14 (Biology) c
2a Towson University, 2009.
21 8 PhD 1e (Neuropharmacology) c
33 University of Pennsylvania, 2016.
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Description of Research Expertise
157 Traumatic Brain Injury; Disorders of Consciousness; Neurotrauma Rehabilitation and Recovery; Neuroregenerative Medicine; Neurotherapeutics Development; Tissue Engineering to Facilitate Repair, Regeneration, and Recovery after Neurotrauma and Neurodegeneration; Astrocytes; Mitochondria; Biomedical Translation/Commercializatione 29
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167 Aihara Y, Chiba K, Oda Y, Browne K, Petrov D, Kawamata T, O’Donnell JC: Translational Evaluation of an Intraparenchymal Collagen Matrix Tamponade: Initial Preclinical and Clinical Experiments to Prevent CSF Reflux Following Endoscopic Brain Surgery. IJMS 26(18): 9081, September 2025.
162 Dimitris Boufidis, Elizabeth N. Krizman, Cybelle M. Smith, Yihan Xie, Raghav Garg, John C. O'Donnell, Flavia Vitale, D. Kacy Cullen: Astrocyte Interactions With Ti3C2Tx MXene Flakes: Insights Into Viability, Morphology, and Functionality. Advanced Materials Interfaces August 2025.
1b8 Karthikeyan Rajagopal, Thomas P Schaer, Kyle D Meadows, Madeline Boyes, Rachel Hilliard, John C O'Donnell, George R Dodge, Dmitriy Petrov, Dawn M Elliott, Robert L Mauck, Lachlan J Smith, Neil R Malhotra: In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration. JOR spine June 2025.
16b Daniel J. Han, Kevin D. Browne, D. Kacy Cullen, Dmitriy Petrov, John C. O’Donnell: Acute Intracranial Hypertension in a Swine Neurointensive Care Unit following Rotational Acceleration Traumatic Brain Injury. Annual Meeting of the National Neurotrauma Society, Philadelphia, PA June 2025.
180 D. J. HAN, K. D. BROWNE, K. WOFFORD, D. CULLEN, D. Petrov, J. C. O'DONNELL: Intracranial hypertension and changes in astrocytic endfeet in a large animal model of rotational acceleration traumatic brain injury. Annual meeting of the Society for Neuroscience, Chicago, IL October 2024 Notes: Poster presentation.
1b0 Daniel J. Han, Kevin D. Browne, Kathryn L. Wofford, Dmitriy Petrov, D. Kacy Cullen, John C. O’Donnell: The Effects of Rotational Acceleration Traumatic Brain Injury on Intracranial Hypertension and Astrocytic Proteins Associated with Cerebral Edema. Annual Meeting of the National Neurotrauma Society, San Francisco, CA June 2024 Notes: Poster presentation.
10c Purvis EM, Garcia-Epelboim AD, Krizman EN, O'Donnell JC*, Cullen DK* (*CO-SENIOR) : A three-dimensional tissue-engineered rostral migratory stream as an in vitro platform for subventricular zone-derived cell migration 34 Frontiers in Bioengineering and Biotechnology 43 12: 1410717, Jun 2024 Notes: eCollection 2024.
160 Dimple Chouhan, Wisberty J Gordián Vélez, Laura A Struzyna, Dayo Adewole, Erin R Cullen, Justin C Burrell, John C O'Donnell, D Kacy Cullen: Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks. Frontiers in Molecular Neuroscience 2b 17: 1346696, Mar 2024.
ac O’Donnell JC: Disorders of nomenclature. CNS Neuroscience & Therapeutics 30(1): e14541, Jan 2024.
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Selected Publications
116 Grovola MG, Purvis EM, Garcia-Epelboim AD, Krizman EN, O'Donnell JC*(co-senior), Cullen DK*: Astrocyte Transcriptomics in a Three-Dimensional Tissue-Engineered Rostral Migratory Stream. Cells October 2025.167 Aihara Y, Chiba K, Oda Y, Browne K, Petrov D, Kawamata T, O’Donnell JC: Translational Evaluation of an Intraparenchymal Collagen Matrix Tamponade: Initial Preclinical and Clinical Experiments to Prevent CSF Reflux Following Endoscopic Brain Surgery. IJMS 26(18): 9081, September 2025.
162 Dimitris Boufidis, Elizabeth N. Krizman, Cybelle M. Smith, Yihan Xie, Raghav Garg, John C. O'Donnell, Flavia Vitale, D. Kacy Cullen: Astrocyte Interactions With Ti3C2Tx MXene Flakes: Insights Into Viability, Morphology, and Functionality. Advanced Materials Interfaces August 2025.
1b8 Karthikeyan Rajagopal, Thomas P Schaer, Kyle D Meadows, Madeline Boyes, Rachel Hilliard, John C O'Donnell, George R Dodge, Dmitriy Petrov, Dawn M Elliott, Robert L Mauck, Lachlan J Smith, Neil R Malhotra: In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration. JOR spine June 2025.
16b Daniel J. Han, Kevin D. Browne, D. Kacy Cullen, Dmitriy Petrov, John C. O’Donnell: Acute Intracranial Hypertension in a Swine Neurointensive Care Unit following Rotational Acceleration Traumatic Brain Injury. Annual Meeting of the National Neurotrauma Society, Philadelphia, PA June 2025.
180 D. J. HAN, K. D. BROWNE, K. WOFFORD, D. CULLEN, D. Petrov, J. C. O'DONNELL: Intracranial hypertension and changes in astrocytic endfeet in a large animal model of rotational acceleration traumatic brain injury. Annual meeting of the Society for Neuroscience, Chicago, IL October 2024 Notes: Poster presentation.
1b0 Daniel J. Han, Kevin D. Browne, Kathryn L. Wofford, Dmitriy Petrov, D. Kacy Cullen, John C. O’Donnell: The Effects of Rotational Acceleration Traumatic Brain Injury on Intracranial Hypertension and Astrocytic Proteins Associated with Cerebral Edema. Annual Meeting of the National Neurotrauma Society, San Francisco, CA June 2024 Notes: Poster presentation.
10c Purvis EM, Garcia-Epelboim AD, Krizman EN, O'Donnell JC*, Cullen DK* (*CO-SENIOR) : A three-dimensional tissue-engineered rostral migratory stream as an in vitro platform for subventricular zone-derived cell migration 34 Frontiers in Bioengineering and Biotechnology 43 12: 1410717, Jun 2024 Notes: eCollection 2024.
160 Dimple Chouhan, Wisberty J Gordián Vélez, Laura A Struzyna, Dayo Adewole, Erin R Cullen, Justin C Burrell, John C O'Donnell, D Kacy Cullen: Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks. Frontiers in Molecular Neuroscience 2b 17: 1346696, Mar 2024.
ac O’Donnell JC: Disorders of nomenclature. CNS Neuroscience & Therapeutics 30(1): e14541, Jan 2024.
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