John Charles O'Donnell, BA, MS, PhD

faculty photo
Research Assistant Professor of Neurosurgery
Department: Neurosurgery
Graduate Group Affiliations

Contact information
3900 Woodland Ave
Philadelphia, PA 19104
Education:
BA (Biology, Philosophy Minor)
LaSalle University, 2004.
MS (Biology)
Towson University, 2009.
PhD (Neuropharmacology)
University of Pennsylvania, 2016.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Traumatic Brain Injury; Disorders of Consciousness; Neurotrauma Rehabilitation and Recovery; Neuroregenerative Medicine; Neurotherapeutics Development; Tissue Engineering to Facilitate Repair, Regeneration, and Recovery after Neurotrauma and Neurodegeneration; Astrocytes; Mitochondria; Biomedical Translation/Commercialization

Selected Publications

Karthikeyan Rajagopal, Thomas P Schaer, Kyle D Meadows, Madeline Boyes, Rachel Hilliard, John C O'Donnell, George R Dodge, Dmitriy Petrov, Dawn M Elliott, Robert L Mauck, Lachlan J Smith, Neil R Malhotra: In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration. JOR spine June 2025.

Daniel J. Han, Kevin D. Browne, D. Kacy Cullen, Dmitriy Petrov, John C. O’Donnell: Acute Intracranial Hypertension in a Swine Neurointensive Care Unit following Rotational Acceleration Traumatic Brain Injury. Annual Meeting of the National Neurotrauma Society, Philadelphia, PA June 2025.

D. J. HAN, K. D. BROWNE, K. WOFFORD, D. CULLEN, D. Petrov, J. C. O'DONNELL: Intracranial hypertension and changes in astrocytic endfeet in a large animal model of rotational acceleration traumatic brain injury. Annual meeting of the Society for Neuroscience, Chicago, IL October 2024 Notes: Poster presentation.

Daniel J. Han, Kevin D. Browne, Kathryn L. Wofford, Dmitriy Petrov, D. Kacy Cullen, John C. O’Donnell: The Effects of Rotational Acceleration Traumatic Brain Injury on Intracranial Hypertension and Astrocytic Proteins Associated with Cerebral Edema. Annual Meeting of the National Neurotrauma Society, San Francisco, CA June 2024 Notes: Poster presentation.

Purvis EM, Garcia-Epelboim AD, Krizman EN, O'Donnell JC*, Cullen DK* (*CO-SENIOR) : A three-dimensional tissue-engineered rostral migratory stream as an in vitro platform for subventricular zone-derived cell migration Frontiers in Bioengineering and Biotechnology 12: 1410717, Jun 2024 Notes: eCollection 2024.

Dimple Chouhan, Wisberty J Gordián Vélez, Laura A Struzyna, Dayo Adewole, Erin R Cullen, Justin C Burrell, John C O'Donnell, D Kacy Cullen: Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks. Frontiers in Molecular Neuroscience 17: 1346696, Mar 2024.

O’Donnell JC: Disorders of nomenclature. CNS Neuroscience & Therapeutics 30(1): e14541, Jan 2024.

O’Donnell JC, Petrov D.: Porcine Models of Neurotrauma and Neurological Disorders. Biomedicines 12(1): 245, Jan 2024.

Daniel Han, Kevin D. Browne, Natalia Fedorczak, Michael R. Grovola, Elizabeth Krizman, Dmitriy Petrov, D. Kacy Cullen, John C. O’Donnell: Astrocytic changes after closed-head, rotational acceleration TBI in swine. Annual Meeting of the Society for Neuroscience, Washington DC November 2023 Notes: Poster presentation.

Krizman E, Purvis EM, Garcia-Epelboim AD, O’Donnell JC, Cullen DK: A tissue-engineered rostral migratory stream as an in vitro platform to investigate subventricular zone-derived neuroblast migration. Annual meeting of the Society for Neuroscience, Washington DC November 2023 Notes: Poster presentation.

back to top
Last updated: 06/29/2025
The Trustees of the University of Pennsylvania