Mona Al Mukaddam, M.D., M.S.
Associate Professor of Clinical Medicine (Endocrinology, Diabetes and Metabolism)
Department: Medicine
Contact information
3rd floor Penn Medicine University City
3737 Market Street
Philadelphia, PA 19104
3737 Market Street
Philadelphia, PA 19104
Office: 215-662-9905
Links
CDC sponsored virtual grand round on evaluation and management of bone health in patients with Thalassemia https://www.cdc.gov/ncbddd/thalassemia/webinar-archives.html
Remembering Carol Orzel, FOP patient, who donated her skeleton to the the mutter museum.
Interviewed for a Penn primary care podcast to discuss osteoporosis
Interviewed by checkrare after Palovarotene was approved by the FDA and the first and only treatment for FOP.
Penn Primary Care Podcast discussing osteoporosis Hosted by Drs Amber Bird, Deepa Rani Nandiwada and Mona Al Mukaddam
Official website for International Clinical Council on Fibrodysplasia Ossificans Progressiva
CME titled "First Do No Harm: Realizing Timely Diagnosis and Treatment for Patients with Fibrodysplasia Ossificans Progressiva"
Report on a patient with a rare bone disease correctly diagnosed at the Penn Bone Center
Commentary regarding type 1 diabetes and bone in medpage today
Global CME on treatment considerations in Fibrodysplasia Ossificans Progressiva (FOP)
Webinar on COVID-19 vaccinations in FOP patients
Penn bone Center featured in Penn Medicine Women's health newsletter
Endocrinology Spotlight Series: Management of Calcium and Metabolic Bone Disorders Expert Guidance for Challenging Cases
Podcast on Women's Health in FOP
Penn Bone Center
International Fibrodysplasia Ossificans Progressiva Association
Webinar for BMT organization on "Bone Health after Transplant"
CDC sponsored virtual grand round on evaluation and management of bone health in patients with Thalassemia https://www.cdc.gov/ncbddd/thalassemia/webinar-archives.html
Remembering Carol Orzel, FOP patient, who donated her skeleton to the the mutter museum.
Interviewed for a Penn primary care podcast to discuss osteoporosis
Interviewed by checkrare after Palovarotene was approved by the FDA and the first and only treatment for FOP.
Penn Primary Care Podcast discussing osteoporosis Hosted by Drs Amber Bird, Deepa Rani Nandiwada and Mona Al Mukaddam
Official website for International Clinical Council on Fibrodysplasia Ossificans Progressiva
CME titled "First Do No Harm: Realizing Timely Diagnosis and Treatment for Patients with Fibrodysplasia Ossificans Progressiva"
Report on a patient with a rare bone disease correctly diagnosed at the Penn Bone Center
Commentary regarding type 1 diabetes and bone in medpage today
Global CME on treatment considerations in Fibrodysplasia Ossificans Progressiva (FOP)
Webinar on COVID-19 vaccinations in FOP patients
Penn bone Center featured in Penn Medicine Women's health newsletter
Endocrinology Spotlight Series: Management of Calcium and Metabolic Bone Disorders Expert Guidance for Challenging Cases
Podcast on Women's Health in FOP
Penn Bone Center
International Fibrodysplasia Ossificans Progressiva Association
Webinar for BMT organization on "Bone Health after Transplant"
Education:
BS
American University of Beirut, Lebanon, 2001.
MD
American University of Beirut, Lebanon, 2005.
MS
University of Pennsylvania, Institute of Translational Medicine and Therapeutics, 2013.
Permanent linkBS
American University of Beirut, Lebanon, 2001.
MD
American University of Beirut, Lebanon, 2005.
MS
University of Pennsylvania, Institute of Translational Medicine and Therapeutics, 2013.
Description of Clinical Expertise
Metabolic bone and calcium disorders including osteoporosis, Paget's disease, hypo- and hyper-parathyroidism as well as bone diseases related to transplant, medications (example aromatase inhibitors and glucocorticoids) and iron overload.Rare bone disease including Fibrodysplasia Ossificans Progressiva and hypophosphatasia.
Description of Research Expertise
Clinical research in Fibrodysplasia Ossificans Progressiva.Evaluation of osteoporosis and the effects of treatment/diseases on "bone quality" using high resolution imaging of bone (uMRI).
Selected Publications
Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS.: Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva. BMC Med Res Methodol Nov 2023.Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS.: Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva. BMC Med Res Methodol Nov 2023.
Robert J Pignolo, Mona Al Mukaddam, Geneviève Baujat, Angela M Cheung, Carmen De Cunto, Edward C Hsiao, Richard Keen, Rose Marino, Andrew Strahs, Frederick S Kaplan: Health Assessments of Normotopic Bone in Individuals with Fibrodysplasia Ossificans Progressiva Poster Presentation at the Annual ASBMR meeting October 2023.
Bassam AlHamer, Ajit Singh, Carmen Patrascu, Mona Al Mukaddam : How an underappreciated electrolyte abnormality led to a rare diagnosis Poster Presentation at ACP meeting (awarded second best poster prize) October 2023.
Kathryn M. Dahir, Jennifer McGinniss, Eduardo Forleo-Neto, Scott Mellis, Robert J. Sanchez, Maja Di Rocco, Richard Keen, Philippe Orcel, Christian Roux, Jacek Tabarkiewicz, Javier Bachiller-Corral, Angela M. Cheung, Mona Al Mukaddam, Kusha Mohammadi, Dushyanth Srinivasan, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Frederick S. Kaplan, E. Marelise W. Eekhoff, Robert J. Pignolo: Flare-Ups in Patients with Fibrodysplasia Ossificans Progressiva Reduced by Garetosmab Treatment: LUMINA-1 Data Poster Presentation at the Annual ASBMR meeting October 2023.
Edward C. Hsiao, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, Staffan K. Berglund, Angela M. Cheung, Carmen De Cunto, Patricia Delai, Peter Kannu, Richard Keen, Edna E. Mancilla, Rose Marino, Andrew Strahs, Frederick S. Kaplan : Long-Term Impact of Palovarotene Treatment on Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: Data from the Phase III MOVE Trial. Poster Presentation at ASBMR annual meeting October 2023.
Richard Keen, Jennifer McGinniss, Eduardo Forleo-Neto, Scott Mellis, Kathryn M. Dahir, Maja Di Rocco, Jacek Tabarkiewicz, Javier Bachiller-Corral, Angela M. Cheung, Mona Al Mukaddam, Jing Gu, Aris N. Economides, Dushyanth Srinivasan, Dinko Gonzalez Trotter, Frederick S. Kaplan, Marelise W. Eekhoff, Robert J. Pignolo: The Relationship of Flare-Ups and Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: LUMINA-1 Data. Plenary Poster Presentation at Annual ASBMR meeting October 2023.
Edward C. Hsiao, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, Staffan K. Berglund, Angela M. Cheung, Carmen De Cunto, Patricia Delai, Peter Kannu, Richard Keen, Edna E. Mancilla, Rose Marino, Andrew Strahs, Frederick S. Kaplan : Efficacy of Palovarotene for the Reduction of New Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: Sensitivity Analyses from the Phase III MOVE Trial Poster Presentation at Annual ASBMR meeting October 2023.
Di Rocco M, Forleo-Neto E, Pignolo RJ, Keen R, Orcel P, Funck-Brentano T, Roux C, Kolta S, Madeo A, Bubbear JS, Tabarkiewicz J, Szczepanek M, Bachiller-Corral J, Cheung AM, Dahir KM, Botman E, Raijmakers PG, Al Mukaddam M, Tile L, Portal-Celhay C, Sarkar N, Hou P, Musser BJ, Boyapati A, Mohammadi K, Mellis SJ, Rankin AJ, Economides AN, Trotter DG, Herman GA, O'Meara SJ, DelGizzi R, Weinreich DM, Yancopoulos GD, Eekhoff EMW, Kaplan FS. : Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial. Nature Medicine Oct 2023.
Jones BC, Wehrli FW, Kamona N, Deshpande RS, Vu BD, Song HK, Lee H, Grewal RK, Chan TJ, Witschey WR, MacLean MT, Josselyn NJ, Iyer SK, Al Mukaddam M, Snyder PJ, Rajapakse CS: Automated, calibration-free quantification of cortical bone porosity and geometry in postmenopausal osteoporosis from ultrashort echo time MRI and deep learning. Bone June 2023.