Vivek K. Narayan, MD, MSCE

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-111
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-360-0737
Fax: 215-615-5122
BA (Neuroscience, History )
University of Virginia , 2005.
MD (Medicine )
University of Virginia , 2010.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2016.
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Description of Clinical Expertise

Prostate Cancer
Renal Cell Carcinoma/Kidney Cancer
Bladder Cancer

Description of Research Expertise

Prostate Cancer
Renal Cell Carcinoma/Kidney Cancer
Bladder Cancer

Selected Publications

Narayan, V.; Keefe, S.; Haas, NB.; Wang, L.; Puzanov, I.; Putt, M.; Catino, A.; Fang, J.; Agarwal, N.; Hyman, D.; Smith, AM.; Finkelman, B.; Narayan, HK.; Ewer, S.; ElAmm, C.; Lenihan, D.; Ky, B.: Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic Renal Cell Carcinoma. Clin Cancer Res 23(14): 3601-3609, July 2017.

Sharma, P.; Pachynski, RK.; Narayan, V.; Fléchon, A.; Gravis, G.; Galsky, M.; Mahammedi, H.; Patnaik, A.; Subudhi, SK.; Ciprotti, M.; Simsek, B.; Saci, A.; Hu, Y.; Han, GC.; Fizazi, K. : Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial. Cancer Cell Aug 2020 Notes: In Press.

Narayan, V.; Harrison, M.; Cheng, H.; Kenfield, S.; Aggarwal, R.; Kwon, D.; McKay, R.; Hauger, R.; Hart, N.; Conzen, S.; Borno, H.; Jim, H.; Dicker, A.; Dorff, T.; Moslehi, J.; Mucci, L.; Parsons, JK.; Saad, F.; Soule, H.; Morgans, A.; Ryan, CJ.: Improving Research for Prostate Cancer Survivorship: A Statement from the SuRECaP (Survivorship Research in Prostate Cancer) Working Group. Urologic Oncology: Seminars and Original Investigations 38(3): 83-93, Mar 2020.

Narayan, V.; Puligandla, M.; Haas, NB.; Subramanian, P.; DiPaola, RS.; Uzzo, R.: Patterns of Relapse and Implications for Post-Nephrectomy Surveillance for Patients with High-Risk Non-Clear Cell Renal Cell Carcinoma: Subgroup Analysis of the Phase 3 ECOG-ACRIN E2805 Trial. J Urol 201(1): 62-68, Jan 2019.

Narayan, V.; Vapiwala, N.; Mick, R.; Subramanian, P.; Christodouleas, J.; Bekelman, J.; Deville, C.; Rajendran, R.; Haas, NB.: Phase I Trial of Everolimus and Radiation Therapy for Salvage Treatment of Biochemical Recurrence in Prostate Cancer Patients Following Prostatectomy. Int J Radiat Oncol Biol Phys 97(2): 355-361, Feb 2017.

Ravi, P.; Mantia, C.; Su, C.; Sorenson, K.; Elhag, D.; Rathi, N.; Bakouny, Z.; Agarwal, N.; Zakharia, Y.; Costello, BA.; McKay, RR.; Narayan, V.; Alva, A.; McGregor, BA.; Gao, X.; McDermott, DF.; Choueiri, TK.: Evaluation of the Safety and Efficacy of Immunotherapy Rechallenge in Patients With Renal Cell Carcinoma. JAMA Oncology May 2020 Notes: Published online May 29, 2020. doi:10.1001/jamaoncol.2020.2169.

Narayan, V.; Thompson, EW.; Demissei, B.; Ho, JE.; Januzzi, JL.; Ky, B.: Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease. J Am Coll Cardiology 75(21), June 2020.

Chanzá, NM.; Xie, W.; Bilen, MA.; Dzimitrowicz, H.; Burkart, J.; Geynisman, DM.; Balakrishnan, A.; Bowman, IA.; Jain, R.; Stadler, W.; Zakharia, Y.; Narayan, V.; Beuselinck, B.; McKay, R.; Tripathi, A.; Pachynski, R.; Hahn, AW.; Hsu, J.; Shah, SA.; Lam, ET.; Rose, TL.; Mega, AE.; Vogelzang, N.; Harrison, MR.; Mortazavi, A.; Plimack, ER.; Vaishampayan, U.; Hammers, H.; George, S.; Haas, N.; Agarwal, N.; Pal, SK.; Srinivas, S.; Carneiro, BA.; Heng, D.; Bosse, D.; Choueiri, T.; Harshman, LC. : Cabozantinib in advanced non-clear cell renal carcinoma: a multicenter retrospective cohort analysis. Lancet Oncol 20(4): 581-590, April 2019.

Narayan, V.; Ky, B.: Common Cardiovascular Complications of Cancer Therapy: Epidemiology, Risk Prediction, and Prevention. Annu Rev Med 69(1): 97-111, Jan 2018.

Finkelman, BS., Putt, M., Wang, T., Wang, L., Narayan, H., Domchek, S., DeMichele, A., Fox, K., Matro, J., Shah, P., Clark, A., Bradbury, A., Narayan, V., Carver, J., Tang, WH., Ky, B.: Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients with Breast Cancer. J Am Coll Cardiology 70(2): 152-162, July 2017.

Narayan, V., Haas, N.: Axitinib in the treatment of renal cell carcinoma: patient selection and perspectives. Int J Nephrol 9: 65-72, Mar 2016.

Demissei, B.; Finkelman, B.; Hubbard, RA.; Zhang, L.; Smith, AM.; Sheline, K.; McDonald, C.; Narayan, HK.; Narayan, V.; Waxman, AJ.; Domchek, S.; DeMichele, A.; Shah, P.; Clark, A.; Bradbury, A.; Carver, J.; Upshaw, J.; Armenian, SH.; Liu, P.; Ky, B. : Detailed Phenotyping Reveals Distinct Trajectories of Cardiovascular Function and Symptoms with Exposure to Modern Breast Cancer Therapy. Cancer 125(16):2762-2771, Aug 2019.

Mohiuddin, J.; Narayan, V.; Venigalla, S.; Vapiwala, N. : Variations in patterns of concurrent androgen deprivation therapy use based on dose escalation with external beam radiotherapy vs. brachytherapy boost for prostate cancer. Brachytherapy 18(3):322-331, May 2019.

Narayan, V.; Gunnarsson, O.; Hwang, WT.; Nathanson, KL.; Stadtmauer, EA.; Vaughn, DJ.: Risk-Stratified Initial Salvage Therapy for Relapsed or Refractory Metastatic Germ Cell Tumor. Clin Genitourin Cancer 14(6): 524-529, Dec 2016.

Narayan, V.; Mamtani, R.; Keefe, S.; Guzzo, T.; Malkowicz, SB.; Vaughn, DJ.: A Phase II Study of Cisplatin, Gemcitabine, and Lapatinib as Neoadjuvant Therapy for Muscle-Invasive Bladder Cancer. Cancer Res Treat 48(3): 1084-91, July 2016.

Demissei BG; Finkelman B; Hubbard RA; Smith AM; Narayan HK; Narayan V; Shah P; Waxman AJ; Domchek SM; Ky B.: Cardiovascular Function Phenotypes in Response to Cardiotoxic Breast Cancer Therapy. J Am Coll Cardiology 73(2): 248-249, Jan 2019.

Zhang, KW; Finkelman, BS; Gulati, G; Narayan, HK; Upshaw, J; Narayan, V; Plappert, T; Englefield, V; Smith, AM; Zhang, C; Hundley, WG; Ky B.: Abnormalities in 3-Dimensional Left Ventricular Mechanics With Anthracycline Chemotherapy Are Associated With Systolic and Diastolic Dysfunction. JACC Cardiovasc Imaging 11(8): 1059-1068, Aug 2018.

Narayan, V.; Hwang, WT.; Lal, P.; Rosen, M.; Gallagher, M.; O'Dwyer, P.; Vaughn, DJ.: Cyclin-Dependent Kinase 4/6 Inhibition for the Treatment of Mature Teratoma: Long-term Follow-up of a Phase II Study. Clin Genitourin Cancer 14(6): 504-510, Dec 2016.

Narayan, V.; Deshpande, C.; Bermudez, CA.; Golato, JM.; Lee, J.; Diamond, J.; Vaughn, DJ.: Bilateral Lung Transplantation for Bleomycin-Associated Lung Injury. Oncologist 22(5): 620-622, May 2017.

Narayan, V.; Vaughn, D.: Pharmacokinetic and toxicity considerations in the use of neoadjuvant chemotherapy for bladder cancer. Expert Opin Drug Metab Toxicol 11(5): 731-42, May 2015.

Feld, E.; Harton, J.; Meropol, NJ.; Adamson, BJS.; Cohen, A.; Parikh, RB.; Galsky, MD.; Narayan, V.; Christodouleas, J.; Vaughn, DJ.; Hubbard, RA.; Mamtani, R.: Effectiveness of First-line Immune Checkpoint Blockade Versus Carboplatin-based Chemotherapy for Metastatic Urothelial Cancer. Eur Urol 76(4):524-532, Oct 2019.

Narayan, V.; Vaughn, DJ.; Ky, B.: Cardiovascular Toxicities of Therapy for Genitourinary Malignancies. Urologic Oncology: Seminars and Original Investigations 38(3): 121-128, Mar 2020.

Narayan, V.; Gladney, W.; Plesa, G.; Vapiwala, N.; Carpenter, E.; Maude, SL.; Lal, P.; Lacey, S.; Melenhorst, J.; Sebro, R.; Farwell, M.; Hwang, WT.; Moniak, M.; Gilmore, J.; Lledo, L.; Dengel, K.; Marshall, A.; Coughlin, C.; June, CH.; Haas, NB.: A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer. American Society of Clinical Oncology Genitourinary Cancers Symposium, San Francisco, CA J Clin Oncol 37(suppl 7S; abstr TPS347), Feb 2019.

Osterman, CK.; Alanzi, J.; Lewis, JD.; Kaufman, EL.; Narayan, V.; Boursi, B.; Vajravelu, RK.; Scott, FI.; Malkowicz, SB.; Mamtani, R.: Association Between Symptomatic Versus Asymptomatic Recurrence and Survival in Bladder Cancer. Clin Genitourin Cancer 16(3): 235-239, Jun 2018.

Osterman, CK.; Babu, DS.; Geynisman, D.; Lewis, B.; Somerd, RA.; Balar, AV.; Zibelman, MR.; Guancial, EA.; Antinori, G.; Yu, S.; Narayan, V.; Guzzo, TJ.; Plimack, ER.; Vaughn, DJ.; Fung, C.; Mamtani, R.: Efficacy of Split Schedule Versus Conventional Schedule Neoadjuvant Cisplatin‐Based Chemotherapy for Muscle‐Invasive Bladder Cancer. Oncologist 24(5): 688-90, May 2019.

Catino, AB; Hubbard, RA; Chirinos, JA; Townsend, R; Keefe, S; Haas, NB; Puzanov, I; Fang, JC; Agarwal, N; Hyman, D; Smith, AM; Gordon, M; Plappert, T; Englefield, V; Narayan, V; Ewer, S; ElAmm, C; Lenihan, D; Ky, B.: Longitudinal Assessment of Vascular Function With Sunitinib in Patients With Metastatic Renal Cell Carcinoma. Circ Heart Fail 11(3): e004408, Mar 2018.

Li, L.; Huang, L.; Vergis, A.; Ye, H.; Bajwa, A.; Narayan, V.; Strieter, R.; Rosin, D.; Okusa, M. : IL-17 produced by neutrophils regulates interferon gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest 120(1): 331-42, Jan 2010.

Hwang, A.; Narayan, V.; Yang, YX.: Type 2 Diabetes Mellitus and Survival in Pancreatic Adenocarcinoma: A Retrospective Cohort Study. Cancer 119(2): 404-10, Jan 2013.

Demissei, B.; Hubbard, RA.; Zhang, L.; Smith, AM.; Sheline, K.; McDonald, C.; Narayan, V.; Domchek, SM.; DeMichele, A.; Shah, P.; Clark, AS.; Fox, K.; Matro, J.; Bradbury, AR.; Knollman, H.; Getz, KD.; Armenian, SH.; Januzzi, JL.; Tang, W.; Liu, P.; Ky, B.: Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction. J Am Heart Assoc 21;9(2):e014708, Jan 2020.

Narayan, V.: Metastatic Prostate Cancer. Radiation Oncology: A Question Based Review. Wolters Kluwer, 3rd Edition, Sept 2018.

Taku, N.; Narayan, V.; Wang, X.; Vapiwala, N.: Prevalence, predictors, and implications for appropriate use of active surveillance management among black men diagnosed with low-risk prostate cancer. Am J Clin Oncol 42(6): 507-511, June 2019.

Chao, HH.; Feld, EK.; Narayan, V.; Sebro, R.; Jones, JA.: Radiation Recall Myositis Following Carboplatin/Docetaxel Chemotherapy. Pract Radiat Oncol 10(1):e50-e52., Jan 2020.

Demissei, B.; Adusumalli, S.; Hubbard, RA.; Denduluri, S.; Narayan, V.; Clark, A.; Shah, P.; Knollman, H.; Getz, KD.; Aplenc, R.; Carver, JR.; Ky, B.: Cardiology Involvement in Patients With Breast Cancer Treated With Trastuzumab. JACC: CardioOncology 2(2), June 2020.

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Last updated: 08/15/2020
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