James E Schmitt, MD, PhD

faculty photo
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Department of Radiology
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
B.S. (Biological Sciences)
Stanford University , 1998.
A.B. (Psychology)
Stanford University , 1998.
Ph.D. (Human and Molecular Genetics, Quantitative Track)
Medical College of Virginia, 2008.
Medical College of Virginia , 2008.
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Description of Clinical Expertise


Description of Research Expertise

Neuroradiology, Neurogenetics, Quantitative Genetics

Selected Publications

Schmitt JE, Raznahan A, Clasen LS, Wallace GL, Pritikin JN, Lee NR, Giedd JN, Neale MC : The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically-Mediated. Cerebral Cortex epub ahead of print, Jan 2019 Notes: doi: 10.1093/cercor/bhz007.

Schmitt JE, Neale MC, Clasen LS, Liu S, Seidlitz J, Pritikin JN, Chu A, Wallace GL, Lee NR, Giedd JN, Raznahan A: A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Area in Youth. Journal of Neuroscience epub ahead of print, Mar 2019 Notes: doi: 10.1523/JNEUROSCI.2248-18.2019.

Sun D, Ching CRK, Lin A, Forsyth JK, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Villalon-Reina JE, Qu X, Jonas RK, van Amelsvoort T, Bakker G, Kates WR, Antshel KM, Fremont W, Campbell LE, McCabe KL, Daly E, Gudbrandsen M, Murphy CM, Murphy D, Craig M, Vorstman J, Fiksinski A, Koops S, Ruparel K, Roalf DR, Gur RE, Schmitt JE, Simon TJ, Goodrich-Hunsaker NJ, Durdle CA, Bassett AS, Chow EWC, Butcher NJ, Vila-Rodriguez F, Doherty J, Cunningham A, van den Bree MBM, Linden DEJ, Moss H, Owen MJ, Murphy KC, McDonald-McGinn DM, Emanuel B, van Erp TGM, Turner JA, Thompson PM, Bearden CE: Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Molecular Psychiatry epub ahead of print, 2018.

Schmitt JE, Raznahan A, Liu S, Neale MC: The Genetics of Cortical Myelination in Young Adults and its Relationships to Cerebral Surface Area, Cortical Thickness, and Intelligence: a Magnetic Resonance Imaging Study of Twins and Families. NeuroImage 206, 2020.

Bearden C, Villalon-Reina J, Martínez J, Qu X, Ching C, Nir T, Kothapalli D, Corbin C, Sun D, Lin A, Forsyth J, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Jonas R, van Amelsvoort T, Bakker G, Kates W, Antshe Kl, Fremont W, Campbell L, McCabe K, Daly E, Gudbrandsen M, Murphy C, Murphy D, Craig M, Emanuel B, McDonald-McGinn D, Vorstman J, Fiksinski A, Koops S, Ruparel K, Roalf D, Gur RE, Schmitt JE, Simon TJ, Goodrich-Hunsaker N, Durdle C, Doherty J, Cunningham A, van den Bree M, Linden D, Owen M, Moss H, Kelly S, Donohoe G, Murphy K, Arango C, Jahanshad N, Thompson PM: Altered White Matter Microstructure in 22q11.2 Deletion Syndrome: A Multi-Site Diffusion Tensor Imaging Study. Molecular Psychiatry July 2019.

Rosen AF, Roalf DA, Ruparel K, Blake J, Seelaus K, villa P, Cook PA, Davatzikos C, Elliot MA, Garcia de La Garza A, Gennatas ED, Quarmley M, Schmitt JE, Shinohara, Tisdall MD, Craddock C, Gur RE, Gur RC, Satterthwaite TD: Quantitative assessment of structural image quality. NeuroImage 169(1): 407-418, 2018.

Schmitt JE, Raznahan A, Liu S, Neale MC: The Heritability of Cortical Folding: Evidence from the Human Connectome Project. Cerebral Cortex in press.

Schmitt JE, Giedd JN, Raznahan A, Neale MC.: The Genetic Contributions to Maturational Coupling in the Human Cerebrum; A Longitudinal Pediatric Twin Imaging Study Cerebral Cortex Page: 3184-3191, 2018.

Ching CRK, Gutman BA, Sun D, Villalon Reina J, Ragothaman A, Isaev D, Zavaliangos-Petropulu A, Lin A, Jonas RK, Kushan L, Pacheco-Hansen L, Vajdi A, Forsyth JK, Jalbrzikowski M, Bakker G, van Amelsvoort T, Antshel KM, Fremont W, Kates WR, Campbell LE, McCabe KL, Craig MC, Daly E, Gudbrandsen M, Murphy CM, Murphy DG , Murphy KC, Fiksinski A, Koops S, Vorstman J, Crowley TB, Emanuel BS, Gur RE, McDonald-McGinn DM, Roalf D, Ruparel K, Schmitt JE, Zackai EH, Durdle CA, Goodrich-Hunsaker NJ, Simon TJ, Bassett AS, Butcher NJ, Chow EWC, Vila-Rodriguez F, Cunningham A, Doherty J , Linden DE, Moss H, Owen MJ, van den Bree M, Crossley NA, Repetto GM, Thompson PM, Bearden CE: Mapping subcortical brain alterations in 22q11.2 deletion syndrome: Effects of deletion size and convergence with idiopathic neuropsychiatric illness. American Journal of Psychiatry 177, 2020.

Jha SC, Xia K, Schmitt JE, Ahn M, Girault JB, Murphy VA, Li G, Wang L, Shen D, Zou F, Zhu H, Styner M, Knickmeyer RC, Gilmore JH: Genetic influences on neonatal cortical thickness and surface area. Human Brain Mapping 39(12): 4998-5013, 2018.

ENIGMA 22q11.2 Working Group: Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics. Cerebral Cortex in press.

Schmitt JE, Vandekar S, Yi J, Ruparel K, Roalf DR, Whinna D, Souders MC, Satterwaite TD, Prabhakaran K, McDonald-McGinn DM, Zakhai EH, Gur RC, Emanuel BS, Gur RE.: Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome. Biological Psychiatry 78(2): 135-143, Nov 2014.

Schmitt JE, Neale MC, Fassassi B, Perez J, Lenroot R, Wells E, Giedd JN. : The dynamic role of genetics on cortical patterning during childhood and adolescence. Proceedings of the National Academy of Sciences of the USA 111(18): 6774-6779, April 2014.

Eyler LT, Prom-Wormley E, Fennema-Notestine C, Fischl B, Franz CE, Lyons MJ, Makris N, Neale MC, Pacheco J, Perry ME, Panizzon MS, Schmitt JE, Seidman LJ, Thermenos H, TsuangMT, Dale AM, Kremen WS.: Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twins study. Human Brain Mapping 32(4): 641-653, Apr 2011.

Rimol LM, Kremen W, Hagler D, Fennema-Notestine C, Eyler LT, Panizzon M, Neale MC, Schmitt JE, Lyons MJ, Franz CE, Fischl B, Seidman LJ, Makris N, Perry M, Pecheco J, Dale A. : Heritability of cortical thickness in a large adult twin sample: The VETSA Project. Human Brain Mapping 2007 Notes: Poster Presentation.

Schmitt JE, Lenroot RK, Wallace GL, Ordaz S, Taylor KN, Kabani N, Greenstein D, Lerch JP, Kendler KS, Neale MC, Giedd JN: Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings. Cerebral Cortex 18(8): 1737-1747, Jan 2008.

Kendler KS, Schmitt JE, Aggen SA, Prescott CA: Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use across the life cycle. Archives of General Psychiatry 65(6): 674-682, June 2008.

Schmitt JE, Lenroot RK, Ordaz SE, Wallace GL, Lerch JP, Evans AC, Prom EC, Kendler KS, Neale MC, Giedd JN: Variance decomposition of MRI-based covariance maps using genetically informative samples and structural equation modeling. NeuroImage 47(1): 56-64, Aug 2009.

Dinglasan LA, Oh J, Schmitt JE, Trerotola SO, Stavropoulos, SW: Complicated IVC filter retrievals: Associated factors identified on pre-retrieval CT. Radiology 266(1): 347-354, Jan 2013.

Yushkevich PA, Pashchinskiy A, Oguz I, Mohan S, Schmitt JE, Stein JM, Zukić D, Vicory J, McCormick M, Yushkevich N, Schwartz N, Gao Y, Gerig G: User-Guided Segmentation of Multi-modality Medical Imaging Datasets with ITK-SNAP. Neuroinformatics 17(1): 83-102, Jan 2019.

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Last updated: 03/17/2021
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