James E Schmitt, MD, PhD

faculty photo
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Attending Neuroradiology, Hospital of the University of Pennsylvania, Philadelphia PA
Attending Neuroradiology, Pennsylvania Hospital, Philadelphia, PA
Attending Neuroradiology, Penn Presbyterian Medical Center, Philadelphia, PA
Active Medical Staff Radiology, Chester County Hospital, West Chester, PA
Department: Radiology

Contact information
Department of Radiology
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Biological Sciences)
Stanford University , 1998.
A.B. (Psychology)
Stanford University , 1998.
M.D.
Medical College of Virginia , 2008.
Ph.D. (Human and Molecular Genetics, Quantitative Track)
Medical College of Virginia, 2008.
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Description of Clinical Expertise

Neuroradiology

Description of Research Expertise

Neuroradiology, Neurogenetics, Quantitative Genetics

Selected Publications

Schmitt JE, Raznahan A, Clasen LS, Wallace GL, Pritikin JN, Lee NR, Giedd JN, Neale MC : The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically-Mediated. Cerebral Cortex 29(11): 4743-4752, Dec 2019 Notes: doi: 10.1093/cercor/bhz007.

Xia K, Schmitt JE, Jha SC, Girault JB, Cornea E, Li G, Shen D, Styner M, Gilmore JH: Genetic Influences on Longitudinal Trajectories of Cortical Thickness and Surface Area During the First Two Years of Life. Cerebral Cortex 32(2): 367-379, Jan 2022 Notes: DOI: 10.1093/cercor/bhab213.

Schmitt JE, Neale MC, Clasen LS, Liu S, Seidlitz J, Pritikin JN, Chu A, Wallace GL, Lee NR, Giedd JN, Raznahan A: A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Area in Youth. Journal of Neuroscience 39(16): 3028-3040, Apr 2019 Notes: doi: 10.1523/JNEUROSCI.2248-18.2019.

Sun D, Ching CRK, Lin A, Forsyth JK, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Villalon-Reina JE, Qu X, Jonas RK, van Amelsvoort T, Bakker G, Kates WR, Antshel KM, Fremont W, Campbell LE, McCabe KL, Daly E, Gudbrandsen M, Murphy CM, Murphy D, Craig M, Vorstman J, Fiksinski A, Koops S, Ruparel K, Roalf DR, Gur RE, Schmitt JE, Simon TJ, Goodrich-Hunsaker NJ, Durdle CA, Bassett AS, Chow EWC, Butcher NJ, Vila-Rodriguez F, Doherty J, Cunningham A, van den Bree MBM, Linden DEJ, Moss H, Owen MJ, Murphy KC, McDonald-McGinn DM, Emanuel B, van Erp TGM, Turner JA, Thompson PM, Bearden CE: Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Molecular Psychiatry. Originally Published Online 6/2018 (eds.). 25(8): 1822-1834, August 2020.

Schmitt JE, Raznahan A, Liu S, Neale MC: The Genetics of Cortical Myelination in Young Adults and its Relationships to Cerebral Surface Area, Cortical Thickness, and Intelligence: a Magnetic Resonance Imaging Study of Twins and Families. NeuroImage 206, February 2020.

Villalón-Reina JE, Martínez K, Qu X, Ching CRK, Nir TM, Kothapalli D, Corbin C, Sun D, Lin A, Forsyth JK, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Jonas RK, van Amelsvoort T, Bakker G, Kates WR, Antshel KM, Fremont W, Campbell LE, McCabe KL, Daly E, Gudbrandsen M, Murphy CM, Murphy D, Craig M, Emanuel B, McDonald-McGinn DM, Vorstman JAS, Fiksinski AM, Koops S, Ruparel K, Roalf D, Gur RE, Eric Schmitt J, Simon TJ, Goodrich-Hunsaker NJ, Durdle CA, Doherty JL, Cunningham AC, van den Bree M, Linden DEJ, Owen M, Moss H, Kelly S, Donohoe G, Murphy KC, Arango C, Jahanshad N, Thompson PM, Bearden CE: Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study. Molecular Psychiatry 25(11): 2818-2831, November 2020 Notes: originally published online 7/2019.

Rosen AF, Roalf DA, Ruparel K, Blake J, Seelaus K, villa P, Cook PA, Davatzikos C, Elliot MA, Garcia de La Garza A, Gennatas ED, Quarmley M, Schmitt JE, Shinohara, Tisdall MD, Craddock C, Gur RE, Gur RC, Satterthwaite TD: Quantitative assessment of structural image quality. NeuroImage 169(1): 407-418, 2018.

Schmitt JE, Raznahan A, Liu S, Neale MC: The Heritability of Cortical Folding: Evidence from the Human Connectome Project. Cerebral Cortex 31(1): 702-715, January 2021.

Schmitt JE, Giedd JN, Raznahan A, Neale MC.: The Genetic Contributions to Maturational Coupling in the Human Cerebrum; A Longitudinal Pediatric Twin Imaging Study Cerebral Cortex Page: 3184-3191, 2018.

Ching CRK, Gutman BA, Sun D, Villalon Reina J, Ragothaman A, Isaev D, Zavaliangos-Petropulu A, Lin A, Jonas RK, Kushan L, Pacheco-Hansen L, Vajdi A, Forsyth JK, Jalbrzikowski M, Bakker G, van Amelsvoort T, Antshel KM, Fremont W, Kates WR, Campbell LE, McCabe KL, Craig MC, Daly E, Gudbrandsen M, Murphy CM, Murphy DG , Murphy KC, Fiksinski A, Koops S, Vorstman J, Crowley TB, Emanuel BS, Gur RE, McDonald-McGinn DM, Roalf D, Ruparel K, Schmitt JE, Zackai EH, Durdle CA, Goodrich-Hunsaker NJ, Simon TJ, Bassett AS, Butcher NJ, Chow EWC, Vila-Rodriguez F, Cunningham A, Doherty J , Linden DE, Moss H, Owen MJ, van den Bree M, Crossley NA, Repetto GM, Thompson PM, Bearden CE: Mapping subcortical brain alterations in 22q11.2 deletion syndrome: Effects of deletion size and convergence with idiopathic neuropsychiatric illness. American Journal of Psychiatry 177, July 2020.

Jha SC, Xia K, Schmitt JE, Ahn M, Girault JB, Murphy VA, Li G, Wang L, Shen D, Zou F, Zhu H, Styner M, Knickmeyer RC, Gilmore JH: Genetic influences on neonatal cortical thickness and surface area. Human Brain Mapping 39(12): 4998-5013, 2018.

ENIGMA 22q11.2 Working Group: Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics. Cerebral Cortex 31(7): 3258-3298, Jun 2021 Notes: Dr. Schmitt belongs to ENIGMA-CNV working group.

Schmitt JE, Vandekar S, Yi J, Ruparel K, Roalf DR, Whinna D, Souders MC, Satterwaite TD, Prabhakaran K, McDonald-McGinn DM, Zakhai EH, Gur RC, Emanuel BS, Gur RE.: Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome. Biological Psychiatry 78(2): 135-143, Nov 2014.

Schmitt JE, Neale MC, Fassassi B, Perez J, Lenroot R, Wells E, Giedd JN. : The dynamic role of genetics on cortical patterning during childhood and adolescence. Proceedings of the National Academy of Sciences of the USA 111(18): 6774-6779, April 2014.

Eyler LT, Prom-Wormley E, Fennema-Notestine C, Fischl B, Franz CE, Lyons MJ, Makris N, Neale MC, Pacheco J, Perry ME, Panizzon MS, Schmitt JE, Seidman LJ, Thermenos H, TsuangMT, Dale AM, Kremen WS.: Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twins study. Human Brain Mapping 32(4): 641-653, Apr 2011.

Rimol LM, Kremen W, Hagler D, Fennema-Notestine C, Eyler LT, Panizzon M, Neale MC, Schmitt JE, Lyons MJ, Franz CE, Fischl B, Seidman LJ, Makris N, Perry M, Pecheco J, Dale A. : Heritability of cortical thickness in a large adult twin sample: The VETSA Project. Human Brain Mapping 2007 Notes: Poster Presentation.

Schmitt JE, Lenroot RK, Wallace GL, Ordaz S, Taylor KN, Kabani N, Greenstein D, Lerch JP, Kendler KS, Neale MC, Giedd JN: Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings. Cerebral Cortex 18(8): 1737-1747, Jan 2008.

Kendler KS, Schmitt JE, Aggen SA, Prescott CA: Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use across the life cycle. Archives of General Psychiatry 65(6): 674-682, June 2008.

Schmitt JE, Lenroot RK, Ordaz SE, Wallace GL, Lerch JP, Evans AC, Prom EC, Kendler KS, Neale MC, Giedd JN: Variance decomposition of MRI-based covariance maps using genetically informative samples and structural equation modeling. NeuroImage 47(1): 56-64, Aug 2009.

Dinglasan LA, Oh J, Schmitt JE, Trerotola SO, Stavropoulos, SW: Complicated IVC filter retrievals: Associated factors identified on pre-retrieval CT. Radiology 266(1): 347-354, Jan 2013.

Gilmore JH, Schmitt JE, Knickmeyer RC, Smith JK, Lin W, Styner M, Gerig G, Neale MC: Genetic and environmental contributions to neonatal brain structure: A twin study. Human Brain Mapping 31(8): 1174-1182, Aug 2010.

Schmitt JE, Wallace GL, Rosenthal MA, Ordaz, S.J., Malloy EA, Clasen LS, Blumenthal JD, Rose AB, Kendler KS, Neale MC, Giedd, JN: Multivariate analyses of neuroanatomy in a genetically informative pediatric sample. NeuroImage 35(1): 70-82, March 2007.

Eliez S, Barnea-Goraly N, Schmitt JE, Liu Y, Reiss AL: Increased basal ganglia volumes in velo-cardio-facial syndrome (deletion 22q11.2). Biological Psychiatry 1(52): 68-70, July 2002.

Galaburda A, Schmitt JE, Atlas SW, Eliez S, Bellugi U, Reiss AL.: Dorsal Forebrain Anomaly in Williams Syndrome. Archives of Neurology 58(11): 1865-1869, Nov 2001.

Eliez S, Schmitt JE, White CD, Wellis VG, Reiss AL: A Quantitative MRI study of Posterior Fossa Development in Velo-cardio-facial Syndrome. Biological Psychiatry 49(6): 540-546, March 2001.

Pinter J, Eliez S, Schmitt JE, Capone G, Reiss AL: Neuroanatomy of Down Syndrome: A High-Resolution MRI Study. American Journal of Psychiatry 158: 1659-1665, Oct 2001.

Eliez S, Schmitt JE, White CD, Reiss AL: Children and Adolescents with Velo-Cardio-Facial Syndrome: a Volumetric MRI Study. American Journal of Psychiatry 157(3): 409-415, March 2000.

Fennema-Notestine C, Eyler LT, Schmitt JE, Lyons MJ, Franz CE, Eisen SA, Fischl B, Seidman LJ, Makris N, Neale M, Thermenos H, Perry M, Pacheco J, Grant M, Tsuang MT, Dale A, Kremen WS. : Genetic and Environmental Influences on Brain Structures in 320 Adult Twins: The VETSA Project. Human Brain Mapping 2007 Notes: Poster Presentation.

Eliez S, Antonarakis SE, Schmitt JE, Blasey CM, Barnea-Goraly N, Reiss AL : Velocardiofacial syndrome (deletion 22q11.2): A fascinating developmental model for schizophrenia genetic imprinting. Biological Psychiatry 49(8): 79, 2001 Notes: Poster Presentation.

Yushkevich PA, Pashchinskiy A, Oguz I, Mohan S, Schmitt JE, Stein JM, Zukić D, Vicory J, McCormick M, Yushkevich N, Schwartz N, Gao Y, Gerig G: User-Guided Segmentation of Multi-modality Medical Imaging Datasets with ITK-SNAP. Neuroinformatics 17(1): 83-102, Jan 2019.

Gur RE, Tang S, Calkins M, Roalf D, Schmitt JE, Coulter D, Gur RG: Brain-Behavior Phenotypes in 22q11.2 Deletion Syndrome, Idiopathic Psychosis and a Mouse Model. Biological Psychiatry 85(10): S103, 2019.

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Last updated: 03/28/2024
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