James E Schmitt, MD, PhD

Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Attending Neuroradiology, Hospital of the University of Pennsylvania, Philadelphia PA
Attending Neuroradiology, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Neuroradiology, Pennsylvania Hospital, Philadelphia, PA
Active Medical Staff Radiology, Chester County Hospital, West Chester, PA
Associate Program Director, Penn Neuroradiology Fellowship
Department: Radiology
Contact information
Department of Radiology
Division of Neuroradiology
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Division of Neuroradiology
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Email:
james.schmitt@uphs.upenn.edu
james.schmitt@uphs.upenn.edu
Education:
A.B. (Psychology)
Stanford University , 1998.
B.S. (Biological Sciences)
Stanford University , 1998.
M.D.
Medical College of Virginia , 2008.
Ph.D. (Human and Molecular Genetics, Quantitative Track)
Medical College of Virginia, 2008.
Permanent linkA.B. (Psychology)
Stanford University , 1998.
B.S. (Biological Sciences)
Stanford University , 1998.
M.D.
Medical College of Virginia , 2008.
Ph.D. (Human and Molecular Genetics, Quantitative Track)
Medical College of Virginia, 2008.
Description of Clinical Expertise
NeuroradiologyDescription of Research Expertise
Neuroradiology, Neurogenetics, Quantitative GeneticsSelected Publications
Schmitt JE, Alexander-Bloch A, Sleiditz J, Raznahan A, Neale MC: The Genetics of Spatiotemporal Variation in Cortical Thickness in Youth. Communications Biology 7(1): 1301, October 2024 Notes: doi: 10.1038/s42003-024-06956-2. PMID: 39390064; PMCID: PMC11467331.Eom T, Schmitt JE, Li Y, Steinberg J, Bonnan A, Davenport C, Alam S, Ryu YS, Paul L, Hansen B, Khairy K, Pelletier S, Pruett-Miller S, Roalf D, Gur RE, Emanuel B, McDonald-McGinn D, Smith J, Li C, Christie J, Northcot P, Zakharenko S: Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome. Nature Communications 15(1): 10510, December 2024 Notes: doi: 10.1038/s41467-024-54837-3. PMID: 39638997; PMCID: PMC11621701
Alexander-Bloch A, Huguet G, Schultz LM, Huffnagle N, Jacquemont S, Seidlitz J, Saci Z, Moore TM, Bethlehem RI, Mollon J, Knowles EK, Raznahan A, Merikangas A, Chaiyachati BH, Harshini R, Schmitt JE, Barzilay R, Calkins ME, Shinohara RT, Satterthwaite TD, Gur RC, Glahn DC, Almasy L, Gur RE, Hakonarson H, Glessner J: Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort. JAMA Psychiatry 79(7): 699-709, May 2022 Notes: PMID: 35544191 PMCID: PMC9096695 DOI: 10.1001/jamapsychiatry.2022.1017.
Ching CRK, Gutman BA, Sun D, Villalon Reina J, Ragothaman A, Isaev D, Zavaliangos-Petropulu A, Lin A, Jonas RK, Kushan L, Pacheco-Hansen L, Vajdi A, Forsyth JK, Jalbrzikowski M, Bakker G, van Amelsvoort T, Antshel KM, Fremont W, Kates WR, Campbell LE, McCabe KL, Craig MC, Daly E, Gudbrandsen M, Murphy CM, Murphy DG , Murphy KC, Fiksinski A, Koops S, Vorstman J, Crowley TB, Emanuel BS, Gur RE, McDonald-McGinn DM, Roalf D, Ruparel K, Schmitt JE, Zackai EH, Durdle CA, Goodrich-Hunsaker NJ, Simon TJ, Bassett AS, Butcher NJ, Chow EWC, Vila-Rodriguez F, Cunningham A, Doherty J , Linden DE, Moss H, Owen MJ, van den Bree M, Crossley NA, Repetto GM, Thompson PM, Bearden CE: Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness. American Journal of Psychiatry 177(7): 589-600, Jul 2020 Notes: PMID: 32046535 PMCID: PMC7419015 DOI: 10.1176/appi.ajp.2019.19060583.
Schabdach JM, Schmitt JE, Sotardi S, Vossough A, Andronikou S, Roberts TP, Huang H, Padmanabhan V, Ortiz-Rosa A, Gardner M, Covitz S, Bedford SA, Mandal AS, Chaiyachati BH, White SR, Bullmore E, Bethlehem RAI, Shinohara RT, Billot B, Iglesias JE, Ghosh S, Gur RE, Satterthwaite TD, Roalf D, Seidlitz J, Alexander-Bloch A: Brain Growth Charts for Quantitative Analysis of Pediatric Clinical Brain MRI Scans with Limited Imaging Pathology. Radiology 309(1): e230096, Oct 2023 Notes: PMID: 37906015 PMCID: PMC10623207 DOI: 10.1148/radiol.230096.
Schmitt JE, Neale MC, Clasen LS, Liu S, Seidlitz J, Pritikin JN, Chu A, Wallace GL, Lee NR, Giedd JN, Raznahan A: A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Area in Youth. Journal of Neuroscience 39(16): 3028-3040, Apr 2019 Notes: PMID: 30833512 PMCID: PMC6468099 DOI: 10.1523/JNEUROSCI.2248-18.2019.
Schmitt JE, Neale MC, Fassassi B, Perez J, Lenroot R, Wells E, Giedd JN. : The dynamic role of genetics on cortical patterning during childhood and adolescence. Proceedings of the National Academy of Sciences of the USA 111(18): 6774-6779, April 2014 Notes: PMID: 24753564 PMCID: PMC4020057 DOI: 10.1073/pnas.1311630111.
Schmitt JE, Giedd JN, Raznahan A, Neale MC.: The Genetic Contributions to Maturational Coupling in the Human Cerebrum; A Longitudinal Pediatric Twin Imaging Study Cerebral Cortex Page: 3184-3191, 2018 Notes: PMID: 28968785 PMCID: PMC6095207 DOI: 10.1093/cercor/bhx190.
Schmitt JE, Raznahan A, Clasen LS, Wallace GL, Pritikin JN, Lee NR, Giedd JN, Neale MC : The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically-Mediated. Cerebral Cortex 29(11): 4743-4752, Dec 2019 Notes: PMID: 30715232 PMCID: PMC6917515 DOI: 10.1093/cercor/bhz007.
Schmitt JE, Raznahan A, Liu S, Neale MC: The Genetics of Cortical Myelination in Young Adults and its Relationships to Cerebral Surface Area, Cortical Thickness, and Intelligence: a Magnetic Resonance Imaging Study of Twins and Families. NeuroImage 206: 116319, February 2020 Notes: PMID: 31678229 PMCID: PMC7871660 DOI: 10.1016/j.neuroimage.2019.116319.
Schmitt JE, Raznahan A, Liu S, Neale MC: The Heritability of Cortical Folding: Evidence from the Human Connectome Project. Cerebral Cortex 31(1): 702-715, January 2021 Notes: PMID: 32959043 PMCID: PMC7727360 DOI: 10.1093/cercor/bhaa254.
Maes HHM, Lapato DM, Schmitt JE, Luciana M, Banich MT, Bjork JM, Hewitt JK, Madden PA, Heath AC, Barch DM, Thompson WK, Iacono WG, Neale MC: Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study® Behavior Genetics 53(1): 1-24, Feb 2023 Notes: PMID: 36357558 PMCID: PMC9823057 DOI: 10.1007/s10519-022-10123-w.