Vijay G Bhoj, MD PhD

faculty photo
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
3400 Civic Ctr Blvd.
8-111 South Pavilion Extension
Philadelphia, PA 19104
Lab: 215-573-8931
Education:
B.S. (Biology)
The College of New Jersey, 2002.
MD
University of Texas Southwestern Medical Center, 2010.
PhD (Immunology)
University of Texas Southwestern Medical Center, 2010.
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Description of Clinical Expertise

Transfusion Medicine

Description of Research Expertise

My research expertise lies in the area of cellular immunotherapy. In particular, I have experience in preclinical development of immunotherapy that employ engineered immuno-receptors (e.g. chimeric antigen receptors) for the treatment of cancer and of non-malignant conditions such as autoimmunity and transplant rejection.

In addition to conducting preclinical in vitro and in vivo studies using animal models, I have experience in conducting correlative studies in patients undergoing immunotherapy to study the immune impact of such therapies.

Selected Publications

Vijay G. Bhoj, Lucy Li, Kalpana Parvathaneni, Zheng Zhang, Stephen Kacir, DimitriosArhontoulis, Kenneth Zhou, Bevin McGettigan-Croce, Selene Nunez-Cruz, GayathriGulendran, Alina C. Boesteanu, Laura Johnson, Michael D. Feldman, Enrico Radaelli, Keith Mansfield, MacLean Nasrallah, Rebecca S. Goydel, Haiyong Peng, Christoph Rader, Michael C. Milone, Don L. Siegel: Adoptive T Cell Immunotherapy for Medullary Thyroid Carcinoma Targeting GDNF Family Receptor alpha 4. Molecular Therapy Oncolytics 2021.

Kevin R. Parker, Denis Migliorini, Eric Perkey, Kathryn E. Yost, Puneet Bagga, Mohammad Haris, Neil E. Wilson, Fang Liu, Khatuna Gabunia, John Scholler, Thomas J. Montine, Vijay G. Bhoj, Ravinder Reddy, Suyash Mohan, Ivan Maillard, Carl H. June, Howard Y. Chang, Avery D. Posey, Jr., and Ansuman T. Satpathy: Single-cell analyses identify brain mural cells expressing CD19 as potential off-tumor targets for CAR-T immunotherapies. Cell 183(1): 126-142, October 2020.

Zheng Zhang, Stephen J. Schuster, Simon F. Lacey, Michael C. Milone, Dimitri Monos, and Vijay G. Bhoj: Stable HLA antibodies following sustained CD19+ cell depletion implicate a long-lived plasma cell source. Blood Advances 4(18): 4292-4295, September 2020.

Vinodh Pillai, Kavitha Muralidharan, Wenzhao Meng, Asen Bagashev, Derek A Oldridge, Jaclyn Rosenthal, John Van Arnam, Jos J Melenhorst, Diwakar Mohan, Amanda M DiNofia, Minjie Luo, Sindhu Cherian, Jonathan R Fromm 5, Gerald Wertheim, Andrei Thomas-Tikhonenko, Michele Paessler, Carl H June, Eline T Luning Prak, Vijay G Bhoj, Stephan A Grupp, Shannon L Maude, Susan R Rheingold: CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy. Blood Advances 2019.

Milone Michael C, Bhoj Vijay G: The Pharmacology of T Cell Therapies. Molecular therapy. Methods & clinical development 8: 210-221, Mar 2018.

Ruella Marco, Xu Jun, Barrett David M, Fraietta Joseph A, Reich Tyler J, Ambrose David E, Klichinsky Michael, Shestova Olga, Patel Prachi R, Kulikovskaya Irina, Nazimuddin Farzana, Bhoj Vijay G, Orlando Elena J, Fry Terry J, Bitter Hans, Maude Shannon L, Levine Bruce L, Nobles Christopher L, Bushman Frederic D, Young Regina M, Scholler John, Gill Saar I, June Carl H, Grupp Stephan A, Lacey Simon F, Melenhorst J Joseph: Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature medicine 24(10): 1499-1503, 10 2018.

Schuster SJ, Svoboda J, Chong EA, Nasta SD, Mato AR, Anak O, Brogdon JL, Pruteanu-Malinici I, Bhoj V, Landsburg D, Wasik M, Levine BL, Lacey SF, Melenhorst JJ, Porter DL, June CH: CAR-T cells (CTL019) for Refractory B-cell Lymphomas. New England Journal of Medicine 377(26): 2545-2554, Dec 2017 Notes: DOI: 10.1056/NEJMoa1708566.

Schuster Stephen J, Svoboda Jakub, Chong Elise A, Nasta Sunita D, Mato Anthony R, Anak Özlem, Brogdon Jennifer L, Pruteanu-Malinici Iulian, Bhoj Vijay, Landsburg Daniel, Wasik Mariusz, Levine Bruce L, Lacey Simon F, Melenhorst Jan J, Porter David L, June Carl H: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. The New England journal of medicine 377(26): 2545-2554, 12 2017.

Metjian Ara, Tanhehco Yvette C, Aqui Nicole, Bhoj Vijay G, Jamensky Lita, Marques Marisa B, Onwuemene Oluwatoyosi, Pham Huy P, Arepally Gowthami M: The thrombotic microangiopathy Registry of North America: A United States multi-institutional TMA network. Journal of clinical apheresis 31(5): 448-53, Oct 2016.

Ellebrecht Christoph T, Bhoj Vijay G, Nace Arben, Choi Eun Jung, Mao Xuming, Cho Michael Jeffrey, Di Zenzo Giovanni, Lanzavecchia Antonio, Seykora John T, Cotsarelis George, Milone Michael C, Payne Aimee S: Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353(6295): 179-84, Jul 2016.

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Last updated: 02/02/2021
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