Vijay G Bhoj, MD PhD
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
3400 Civic Ctr Blvd.
8-111 South Pavilion Extension
Philadelphia, PA 19104
8-111 South Pavilion Extension
Philadelphia, PA 19104
Lab: 215-573-8931
Email:
vbhoj@pennmedicine.upenn.edu
vbhoj@pennmedicine.upenn.edu
Publications
Education:
B.S. (Biology)
The College of New Jersey, 2002.
PhD (Immunology)
University of Texas Southwestern Medical Center, 2010.
MD
University of Texas Southwestern Medical Center, 2010.
Permanent linkB.S. (Biology)
The College of New Jersey, 2002.
PhD (Immunology)
University of Texas Southwestern Medical Center, 2010.
MD
University of Texas Southwestern Medical Center, 2010.
Description of Clinical Expertise
Transfusion MedicineDescription of Other Expertise
Engineered Cell Therapy, ImmunotherapyDescription of Research Expertise
My clinical expertise is in transfusion medicine, which includes therapeutic apheresis and blood banking.My research expertise is in the area of cellular immunotherapy. Specifically, my laboratory conducts translational research that spans preclinical development of immunotherapies to patient correlative studies to phase I clinical trials.
While I have developed therapies for the treatment of cancer, my primary focus is on using engineered cells for immune modulation and treatment of non-malignant conditions such as autoimmunity and transplantation. In this regard, we have ongoing projects focused on immune Thrombotic Thrombocytopenic Purpura (iTTP), Type 1 Diabetes (T1D), multiple sclerosis (MS), Systemic Lupus Erythematosus (SLE), Hemophilia A, and organ transplantation. Our preclinical studies involve in vitro, murine, and non-human primate models.
On the clinical research side, my lab has played lead roles in a number of studies of immunity in the context of CAR T cell therapy and/or vaccination and these efforts are ongoing. Finally, I serve in an advisory capacity and my lab assists with mechanistic studies related to a phase I CAR T cell trial for medullary thyroid carcinoma and I co-lead a phase I trial to evaluate the safety and utility of CAR T cells as a desensitization strategy in highly allosensitized kidney transplant candidates.
Selected Publications
Ivan J Cohen, Audrey C Bochi-Layec, Jean Lemoine, Scott Jenks, Pedram Bayat, Ki Hyun Kim, Huiwu Zhao, Ositadimma Ugwuanyi, Federico Stella, Guido Ghilardi, Giulia Gabrielli, Sarah McCuaig, Anastasia Iatrou, Elisavet Vlachonikola, Maria Karipidou, Eleni Bouziani, David Espie, Ranjani Ramasubramanian, Andreas Agathangelidis, Aditya Bhosale, Luca Paruzzo, Giovanni Medico, Bronte Kolar, Regina Bugrovsky, Puneeth Guruprasad, Li-Ping Wang, Jaryse Harris, Evgeny Arons, Yunlin Zhang, Raymone Pajarillo, Portia A Kreiger, Chi-Ping Day, S Cenk Sahinalp , Chih Hao Wu, Alessia Santi, Bria Fulmer, Marcos Cases, Matthew B Palmer, Patrizia Porazzi, E John Wherry, Robert J Kreitman, Enrico Tiacci, Sokratis A Apostolidis, Edward M Behrens, Vijay Bhoj, Ignacio Sanz, Giorgio Inghirami, Stephen J Schuster, Paolo Ghia, Kostas Stamatopoulos, Marco Ruella: Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells. Science Translational Medicine 18(835): eadr9382, February 2026.Xiuxiu Yang, Qian Xu, Jue Wang, Shanwei Ye, Caroline Markmann, Shujia Zhang, Qian Zhang, Vijay G Bhoj, Liang Huang, Zheng Zhang: Engineered extracellular vesicles displaying bi-specific T-cell engagers for targeted therapy of B-cell malignancies. Experimental Hematology & Oncology 15(1), February 2026.
Ho M, Paruzzo L, Noll JH, Stella F, Devi P, Ndeupen S, Day YA, Chen GM, Cohen IJ, Ramirez-Fernandez A, Waxman A, Kapur S, Chen F, Xu R, Huff A, Jarocha D, Patel V, Bochi-Layec AC, Ramasubramanian R, Liu S, Bouvier R, de Souza VB, Patel H, Li Z, Carturan A, Michener P, Hopkins CR, Koucky O, Minehart J, Dimitri A, Nabar NR, Hasanali ZS, Ciccarelli BT, Hung P, Williams E, Bartoszek R, Lavorando M, Mohan S, Gonzalez VE, Porazzi P, Bhoj VG, Apostolidis SA, Vogl DT, Porter DL, Scholler J, Diorio C, Roche AM, Everett JK, Bushman FD, Nathanson KL, Stadtmauer EA, Susanibar-Adaniya SP, Garfall AL, Ruella M, Cohen AD, Fraietta JA: CD4+ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy. Nature Medicine 32(2): 702-716, February 2026.
Vijay G. Bhoj, Mary Kaminski, Huiwu Zhao, Kyle Jackson, Wei Wang, Chengyang Liu, Robert A. Montgomery, Nicole Ali, Massimo Mangiola, Thomas R. Spitzer, Kassem Safa, Vikram Pattanayak, Raeda Taj, Joy Chiu, Thanh-Mai Bui, Elizabeth M. Sonnenberg, James F. Markmann, Michael C. Milone, Carl H. June, Don L. Siegel, Joseph A. Fraietta, Vanessa Gonzalez, Michela Locci, Matthew Palmer, Dimitri Monos, Wei-Ting Hwang, Tina Sledge, Nancy D. Bridges, Julia S. Goldstein, Jonah Odim, Stuart C. Sweet, Behdad D. Besharatian, Sabiha M. Hussain, Nicholas K. Brown, Malek Kamoun, Alfred L. Garfall, and Ali Naji: Kidney Transplant in Two Highly-Sensitized Candidates Post-CAR T Cell Therapy. New England Journal of Medicine (Accepted for publication) 2026.
Bernhard Dumoulin, Jonathan Levinsohn, Konstantin Klötzer, Chenyu Li, Liran Mao, Eunji Ha, Samer Mohandes, Thao Nguyen, Luca Paruzzo, Daigoro Hirohama, Victoria Fang, Vijay G Bhoj, Hamideh Parhiz, Magaiver Andrade Silva, Amin Abedini, Andi Bergeson, Daniel Traum, Michael J. May, Klaus H Kaestner, Marco Ruella, Fiona Elizabeth McAllister, Ari A Hakimi, Mingyao Li, Matthew Palmer, E. John Wherry, Christopher A. Hunter, Michael Paul Cancro, TRIDENT consortium, Katalin Susztak: Spatial Atlas of Diabetic Kidney Disease Reveals a B-Cell-Rich Subgroup (accepted for publication). Nature accepted for publication, 2026.
Guruprasad P, Ramasubramanian R, Nason S, Carturan A, Liu S, Paruzzo L, Hornet V, Plesset J, Patel RP, Bhoj V, Beatty GL, Ruella M.: Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy. Nature Protocols 20(12): 3629-3654, December 2025.
Doshi BS, Markmann CA, Novak N, Rojas SJ, Davidson R, Chau JQ, Wang W, Carrig S, Rus CM, Samelson-Jones BJ, Small JC, Bhoj VG*, George LA*: Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies. Molecular Therapy 33(7): 3073-3085, July 2025 Notes: *co-corresponding authors.
Papadaki GF, Li Y, Monos DS, Bhoj VG: Cars pick up another passenger: Organ transplantation. Human Immunology 86(1): 111180, November 2024.
Lee K, Chau JQ, Suber YB, Sternberg AR, Pishko AM, George LA, Bhoj VG, Doshi BS, Samelson-Jones BJ: Enhanced procoagulant activity of select hemophilia B causing factor IX variants with emicizumab. Blood 144(11): 1230-1235, September 2024.
Mack EA, Dougher MC, Ginda A, Cahill CQ, Murter M, Schell K, Tanhehco YC, Bhoj V, Fesnak AD, Siegel DL, Kambayashi T, Aqui N, O'Doherty U: Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis. Blood 143(11): 1049-1054, March 2024.