Edward Cantu III, MD, MSCE

faculty photo
Associate Professor of Surgery at the Hospital of the University of Pennsylvania
Department: Surgery

Contact information
Hospital of the University of Pennsylvania
Department of Surgery
Division of Cardiovascular Surgery
3400 Spruce Street
6 Silverstein
Philadelphia, PA 19104-4283
Office: 215-615-6582
Fax: 215-349-5798
Harvard University, 1994.
Columbia University College of Physicians and Surgeons, 2000.
MS (Clinical Epidemiology )
Perelman School of Medicine at the University of Pennsylvania , 2015.
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Description of Clinical Expertise

Lung Transplantation

Description of Research Expertise

Lung donor risk predicion
Donor optimization
Ex Vivo Lung Perfusion
Prediction of lung PGD
Mechanisms of PGD
Therapeutics for PGD

Selected Publications

Natalini JG, Diamond JM, Porteous MK, Lederer DJ, Wille KM, Weinacker AB, Orens JB, Shah PD, Lama VN, McDyer JF, Snyder LD, Hage CA, Singer JP, Ware LB, Cantu E, Oyster M, Kalman L, Christie JD, Kawut SM, Bernstein EJ: Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease. Journal of Heart & Lung Transplantation Jan. 23 2021 (Epub) Notes: doi: 10.1016/j.healun.2021.01.1391.

Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff E, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell J, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD.: The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness. J Clin Invest 131: e139700, Jan 2021.

Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP.: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nat Commun 11: 5640, Nov 2020.

Cantu E, Yan M, Suzuki Y, Buckley T, Galati V, Majeti N, Bermudez CA, Diamond JM, Christie JD, Feng R.: Preprocurement In Situ Donor Lung Tissue Gene Expression Classifies Primary Graft Dysfunction Risk. Am J Respir Crit Care Med 202: 1046-1048, Oct 2020.

Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS.: STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nat Cell Biol 22: 1197-1210, Oct 2020.

Kulkarni HS, Ramphal K, Ma L, Brown M, Oyster M, Speckhart KN, Takahashi T, Byers DE, Porteous MK, Kalman L, Hachem RR, Rushefski M, McPhatter J, Cano M, Kreisel D, Scavuzzo M, Mittler B, Cantu E 3rd, Pilely K, Garred P, Christie JD, Atkinson JP, Gelman AE, Diamond JM.: Local complement activation is associated with primary graft dysfunction after lung transplantation. JCI Insight 5: e138358, Sep 2020.

Martinu T, Koutsokera A, Benden C, Cantu E, Chambers D, Cypel M, Edelman J, Emtiazjoo A, Fisher AJ, Greenland JR, Hayes D Jr, Hwang D, Keller BC, Lease ED, Perch M, Sato M, Todd JL, Verleden S, von der Thüsen J, Weigt SS, Keshavjee S; bronchoalveolar lavage standardization workgroup.: International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation. J Heart Lung Transplant 39: 1171-90, Jul 2020.

Miano T, Flesch J, Feng R, Forker C, Brown M, Oyster M, Kalman L, Rushefski M, Cantu E, Proteus M, Yang W, Localio A, Diamond J, Christie J, Shashaty M, : Early tacrolimus concentrations after lung transplant are predicted by combined clinical and genetic factors and associated with acute kidney injury. Clinical Pharmcology & Therapeutics 107(2): 462-470, February 2020.

Li C, Patel K, Tu Z, Yang X, Kulik L, Alawieh A, Allen P, Cheng Q, Wallace C, Kilkenny J, Kwon J, Gibney B, Cantu E, Sharma A, Pipkin M, Machuca T, Emtiazjoo A, Goddard M, Holers VM, Nadig S, Christie J, Tomlinson S, Atkinson C.: A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. Am J Transplant m J Transplant, 2020.

Magruder JT, Sperry A, Atluri P, Bermudez C, Cantu E, Broniec G, Choi C, Acker MA, Cevasco M.: Relationship of intraoperative perfusion parameters to the need for immediate extracorporeal support following heart transplantation. Perfusion erfusion, 2020.

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Last updated: 05/03/2021
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