Edward Cantu III, MD, MSCE
Professor of Surgery at the Hospital of the University of Pennsylvania
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Director of Ex Vivo Lung Perfusion , Hospital of the University of Pennsylvania, Philadelphia, PA
Director of Lung Transplant Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Director ILD Service Line, Hospital of the University of Pennsylvania, Philadelphia, PA
Leadership Advisory Board, Penn Center for Transplant Science and Innovation
Department: Surgery
Contact information
Hospital of the University of Pennsylvania
Department of Surgery
Division of Cardiovascular Surgery
One Convention Avenue, Pavilion 2 City
Philadelphia, PA 19104-4283
Department of Surgery
Division of Cardiovascular Surgery
One Convention Avenue, Pavilion 2 City
Philadelphia, PA 19104-4283
Office: 215-615-6582
Fax: 215-349-5798
Fax: 215-349-5798
Email:
edward.cantu@uphs.upenn.edu
edward.cantu@uphs.upenn.edu
Publications
Education:
BA
Harvard University, Cambridge, MA, 1994.
MD
Columbia University College of Physicians and Surgeons, New York, NY, 2000.
MS (Clinical Epidemiology )
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2015.
Permanent linkBA
Harvard University, Cambridge, MA, 1994.
MD
Columbia University College of Physicians and Surgeons, New York, NY, 2000.
MS (Clinical Epidemiology )
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2015.
Description of Clinical Expertise
Lung TransplantationDescription of Research Expertise
Lung donor risk predicionDonor optimization
Ex Vivo Lung Perfusion
Prediction of lung PGD
Mechanisms of PGD
Therapeutics for PGD
Selected Publications
Mellors PW, Nottingham AN, Casino Remondo B, Shestov M, Planer JD, Peterson AR, Ying Y, Zhou S, Christie JD, Diamond JM, Cantu E, Basil MC, Gill S.: Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome. JCI Insight Apr 2025.Koons B, Mendez JD, Anderson MR, Cantu E, Hartwig M, Merlo C, Pandya K, Vail E, Singer JP, Christie JD.: Clinical and System-Level Factors Driving Donor Lung Utilization Decisions: A Qualitative Study. Ann Am Thorac Soc Mar 2025.
Cantu E, Isenberg D, Marquis A, Alcudia A, Yusuf S, Saleh A, Raevsky A, Li F, Harhay MO.: A Pilot Study to Capture Provider Perspectives on Clinically Relevant Effects in Thoracic Transplant Trials. Am J Respir Crit Care Med Mar 2025.
Banaschewski BJH, Michki SN, Sitaraman S, Pan R, Wang JY, Stewart D, Goldy MK, Lin SM, Cantu E, Katzen JB, Basil MC, Emtiazjoo AM, Todd JL, Gokey JJ, Kropski JA, Frank DB, Zepp JA, Young LR.: Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis. Commun Biol 8: 284, Feb 2025.
Niethamer TK, Planer JD, Morley MP, Babu A, Zhao G, Basil MC, Cantu E, Frank DB, Diamond JM, Nottingham AN, Li S, Sharma A, Hallquist H, Levin LI, Zhou S, Vaughan AE, Morrisey EE.: Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states. Cell Stem Cell 32: 302-321, Feb 2025.
Smood B, Vasquez CR, Olia SE, Han JJ, Iyengar A, Patrick WL, Helmers MR, Kelly JJ, Richards T, Usman A, Cantu E 3rd, Takeda K, Langer N, Cevasco M.: Early Extracorporeal Membrane Oxygenation Initiation May Improve Outcomes in Select Patients With Primary Pulmonary Hypertension: An Extracorporeal Life Support Organization Registry Analysis. ASAIO J Feb 2025.
Kukreja J, Campo-Canaveral de la Cruz JL, Van Raemdonck D, Cantu E, Date H, D'Ovidio F, Hartwig M, Klapper JA, Kelly RF, Lindstedt S, Rosso L, Schaheen L, Smith M, Whitson B, Saddoughi SA, Cypel M.: The 2024 American Association for Thoracic Surgery expert consensus document: Current standards in donor lung procurement and preservation. J Thorac Cardiovasc Surg 2025.
Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR.: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight 10: e183483, Dec 2024.
Jones DL, Morley MP, Li X, Ying Y, Zhao G, Schaefer SE, Rodriguez LR, Cardenas-Diaz FL, Li S, Zhou S, Chembazhi UV, Kim M, Shen C, Nottingham A, Lin SM, Cantu E, Diamond JM, Basil MC, Vaughan AE, Morrisey EE.: An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung. Science 386: eado5561, Dec 2024.
Evans JF, Ledwell OA, Tang Y, Rue R, Mukhitov AR, Diesler R, Lin SM, Kanth SV, Basil MC, Cantu E, Henske EP, Krymskaya VP.: The Bi-Steric Inhibitor RMC-5552 Reduces mTORC1 Signaling and Growth in Lymphangioleiomyomatosis. Am J Respir Cell Mol Biol Nov 2024.