Sean Hennessy, PharmD, PhD

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Professor of Epidemiology in Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology
Graduate Group Affiliations

Contact information
University of Pennsylvania
423 Guardian Drive
803 Blockley Hall
Philadelphia, PA 19104-6021
Office: 215-898-9112
Fax: 215-573-5315
Education:
BS (Pharmacy)
Philadelphia College of Pharmacy and Science, 1989.
PharmD (Clinical Pharmacy)
Philadelphia College of Pharmacy and Science, 1990.
MSCE (Clinical Epidemiology)
University of Pennsylvania School of Medicine, 1996.
PhD (Epidemiology with Biostatistics minor)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Hennessy conducts research in the field of pharmacoepidemiology, which is the study of the health effects of drugs and other medical products in populations. His team identified a survival benefit of potassium supplementation in users of loop diuretics, and studied serious health consequences of drug-drug interactions involving high-risk drugs including anticoagulants, antidiabetic agents and antiplatelet agents. His research has produced crucial knowledge about the cardiovascular safety of many widely-used drugs for mental health conditions in including ADHD, depression, and schizophrenia. He also evaluated an early approach to using medical insurance data to improve prescribing, finding it ineffective despite its federal mandate. This contributed to the omission of a requirement for drug utilization review programs in Medicare Part D. He co-led a pair of studies demonstrating the effectiveness and safety of the SA14-14-2 vaccine for Japanese encephalitis (JE), which subsequently led to the immunization of millions of children per year in populous countries including Cambodia, India, Malaysia, Nepal, Sri Lanka, and Thailand. Use of that vaccine has been credited with reducing the incidence of JE. He co-developed the trend-in-trend research design for studying the effects of rapidly increasing or declining exposures. He was the senior author of one of two citizen petitions to the US Food and Drug Administration that led to re-labeling of metformin, the best-proven oral drug for diabetes, to permit its use in persons with mild to moderate renal insufficiency. He is an elected member of the US National Academy of Medicine.

Description of Other Expertise

Dr. Hennessy is a past scientific chair and past president of the International Society for Pharmacoepidemiology, and has served on FDA’s Drug Safety and Risk Management Advisory Committee and on the board of directors of the American Society for Clinical Pharmacology and Therapeutics. He is a co-editor of the books Pharmacoepidemiology, 5th edition and Textbook of Pharmacoepidemiology, 2nd edition.

Additional Positions:
Director, Center for Pharmacoepidemiology Research & Training
Senior Scholar, Center for Clinical Epidemiology and Biostatistics
Director, Pharmacoepidemiology Concentration of the Master of Science in Clinical Epidemiology Program
Senior Fellow, Leonard Davis Institute of Health Economics
Fellow, Institute on Aging
Co-Chair, Drug Use and Effects Committee, Hospital of the University of Pennsylvania
Member, Pharmacy Council, University of Pennsylvania Health System

Courses Led:
EPI 666: Pharmacoepidemiology Research Methods

Honors:
1998 Stanley A. Edlavitch Award for Best Abstract Submitted by a Student, International Society for Pharmacoepidemiology
2002 Saul Winegrad Award for Outstanding Dissertation in Epidemiology and Biostatistics, University of Pennsylvania
2005 Young Alumnus Award, University of the Sciences in Philadelphia
2008 Leon I Goldberg Young Investigator Award, American Society for Clinical Pharmacology & Therapeutics
2013 Samuel Martin Health Evaluation Sciences Research Award, University of Pennsylvania Perelman School of Medicine
2014 Julius W. Sturmer Memorial Lecture Award, Alpha Tau Chapter of the Rho Chi Society, Philadelphia College of Pharmacy, University of the Sciences
2015 Elected Member, National Academy of Medicine

Selected Publications

Carnahan RM, Gagne JJ, Hampp C, Leonard CE, Toh S, Fuller CC, Hennessy S, Hou L, Cocoros NM, Panucci G, Woodworth T, Cosgrove A, Iyer A, Chrischilles EA: Evaluation of the US Food and Drug Administration Sentinel analysis tools using a comparator with a different indication: Comparing the rates of gastrointestinal bleeding in warfarin and statin users. Pharmaceutical Medicine 2019 (forthcoming).

Nam YH, Bilker WB, Leonard CE, Bell ML, Hennessy S: Outdoor temperature and survival benefit of empiric potassium in users of furosemide in us Medicaid enrollees: a cohort study BMJ Open 2019 (forthcoming).

Dasgupta N, Bailey JE, Schwartz J, Hennessy S, Ertefaie A, Dart R : Causal inference for evaluating prescription opioid abuse using the trend-in-trend design. Pharmacoepidemiology and Drug Safety 2019 (forthcoming).

Mantri S, Fullard M, Gray SL, Hubbard RA, Weintraub D, Hennessy S, Willis AW: Patterns of dementia treatment and frank prescribing errors in Parkinson disease. JAMA Neurology 2018 doi:10.1001/jamaneurol.2018.2820.

: Noe MH, Shin DB, Hubbard RA, Hennessy S, Gelfand JM: Influenza vaccination rates in adults with psoriasis compared to adults with other chronic diseases [research letter] Journal of Investigative Dermatology 2018 (doi:10.1016/j.jid.2018.09.012).

Na L, Hennessy S, Xie S, Saliba D, Pan Q, Kwong P, Kurichi J, Bogner HR, Streim JE: Premorbid activity limitation stages are associated with post-hospitalization discharge disposition. American Journal of Physical Medicine & Rehabilitation 2018 (doi: 10.1097/PHM.0000000000000896).

Delgado MK, Huang Y, Meisel Z, Hennessy S, Yokell M, Polsky D, Perrone D: National variation in opioid prescribing and risk of prolonged use for opioid-naïve patients treated in the emergency department for ankle sprains. Annals of Emergency Medicine 2018 (DOI: 0.1016/j.annemergmed.2018.06.003).

Ertefaie A, Small DS, Ji X, Leonard CE, Hennessy S: Statistical power for the trend-in-trend design [research letter] Epidemiology 29(3): e21-e23, 2018.

Nam YH, Brensinger CM, Bilker WB, Leonard CE, Kasner SE, Grosser T, Li X, Hennessy S: Nonsteroidal anti-inflammatory drug choice and adverse outcomes in clopidogrel users: a retrospective cohort study. PLoS One 14: e0193800, 2018.

Nam YH, Brensinger C, Bilker WB, Leonard CE, Han X, Hennessy S: Serious hypoglycemia and use of warfarin in combination with sulfonylureas or metformin. Clinical Pharmacology and Therapeutics 72(4): 389-400.e1, 2018.

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Last updated: 01/10/2019
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