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John A. Detre
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Professor of Neurology
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Director, Center for Functional Neuroimaging
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Director, Brain Science Center
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co-Director, Center for Advanced Magnetic Resonance Imaging and Spectroscopy
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Department: Neurology
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Graduate Group Affiliations
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- Bioengineering 64
- Neuroscience e
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Contact information
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3 W Gates Building
1b 3400 Spruce Street
3b Office: 517 Goddard Labs
Philadelphia, PA 19104
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1b 3400 Spruce Street
3b Office: 517 Goddard Labs
Philadelphia, PA 19104
31
Office: (215) 349-8465
34 Fax: (215) 614-1927
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91
34 Fax: (215) 614-1927
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Email:
DETRE@MAIL.MED.UPENN.EDU
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DETRE@MAIL.MED.UPENN.EDU
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Publications
23 a
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Links
97 Search PubMed for articles
3f Neuroscience graduate group faculty webpage.
5d Lab Website
61 Brain Science Center website
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97 Search PubMed for articles
3f Neuroscience graduate group faculty webpage.
5d Lab Website
61 Brain Science Center website
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Education:
21 9 B.S. 16 (Chemistry) c
29 Yale University , 1981.
21 9 M.D. c
28 Yale University, 1986.
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Permanent link21 9 B.S. 16 (Chemistry) c
29 Yale University , 1981.
21 9 M.D. c
28 Yale University, 1986.
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4d magnetic resonance, brain mapping, cerebral blood flow, brain injury
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1a RESEARCH INTERESTS
72 Brain physiology and pathophysiology of functional activation. Clinical and translational neuroimaging.
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8
1b RESEARCH TECHNIQUES
c5 Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.
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18 RESEARCH SUMMARY
200 Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, epilepsy, traumatic brain injury, aging, and dementia. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods.
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1a 29
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Description of Research Expertise
1b KEY WORDS:4d magnetic resonance, brain mapping, cerebral blood flow, brain injury
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1a RESEARCH INTERESTS
72 Brain physiology and pathophysiology of functional activation. Clinical and translational neuroimaging.
8
8
1b RESEARCH TECHNIQUES
c5 Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.
8
8
18 RESEARCH SUMMARY
200 Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, epilepsy, traumatic brain injury, aging, and dementia. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods.
65
Description of Clinical Expertise
37 headache, facial pain syndromes, stroke1a 29
23
1e5 Kim, W. S. H., Luciw, N. J., Atwi, S., Shirzadi, Z., Dolui, S., Detre, J. A., Nasrallah, I. M., Swardfager, W., Bryan, R. N., Launer, L. J., MacIntosh, B. J.: Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy. Hum Brain Mapp 43(12): 3680-3693, 2022.
168 Jiang, H., Simms, A. G., Sadaghiani, S., Jiang, Y. Y., Morgan, J. I. W., Aguirre, G. K., Pattany, P. M., Detre, J. A., Wang, J.: Multi-Center Repeatability of Macular Capillary Perfusion Density Using Optical Coherence Tomography Angiography. Clin Ophthalmol 16: 3069-3078, 2022.
193 Jacobs, P. S., Benyard, B., Cember, A., Nanga, R. P. R., Cao, Q., Tisdall, M. D., Wilson, N., Das, S., Davis, K. A., Detre, J., Roalf, D., Reddy, R.: Repeatability of B1 (+) inhomogeneity correction of volumetric (3D) glutamate CEST via High-permittivity dielectric padding at 7T. Magn Reson Med 88(6): 2475-2484, 2022.
1f5 Hu, F., Weinstein, S. M., Baller, E. B., Valcarcel, A. M., Adebimpe, A., Raznahan, A., Roalf, D. R., Robert-Fitzgerald, T. E., Gonzenbach, V., Gur, R. C., Gur, R. E., Vandekar, S., Detre, J. A., Linn, K. A., Alexander-Bloch, A., Satterthwaite, T. D., Shinohara, R. T.: Voxel-wise intermodal coupling analysis of two or more modalities using local covariance decomposition. Hum Brain Mapp 43(15): 4650-4663, 2022.
243 Dolui, S., Detre, J. A., Gaussoin, S. A., Herrick, J. S., Wang, D. J. J., Tamura, M. K., Cho, M. E., Haley, W. E., Launer, L. J., Punzi, H. A., Rastogi, A., Still, C. H., Weiner, D. E., Wright, J. T., Jr., Williamson, J. D., Wright, C. B., Bryan, R. N., Bress, A. P., Pajewski, N. M., Nasrallah, I. M.: Association of Intensive vs Standard Blood Pressure Control With Cerebral Blood Flow: Secondary Analysis of the SPRINT MIND Randomized Clinical Trial. JAMA Neurol 79(4): 380-389, 2022.
1ff Clement, P., Castellaro, M., Okell, T. W., Thomas, D. L., Vandemaele, P., Elgayar, S., Oliver-Taylor, A., Kirk, T., Woods, J. G., Vos, S. B., Kuijer, J. P. A., Achten, E., van Osch, M. J. P., Bids maintainers, Detre, J. A., Lu, H., Alsop, D. C., Chappell, M. A., Hernandez-Garcia, L., Petr, J., Mutsaerts, Hjmm: ASL-BIDS, the brain imaging data structure extension for arterial spin labeling. Sci Data 9(1): 543, 2022.
17f Cember, A. T. J., Wilson, N. E., Rich, L. J., Bagga, P., Nanga, R. P. R., Swago, S., Swain, A., Thakuri, D., Elliot, M., Schnall, M. D., Detre, J. A., Reddy, R.: Integrating (1)H MRS and deuterium labeled glucose for mapping the dynamics of neural metabolism in humans. Neuroimage 251: 118977, 2022.
1a7 Bouhrara, M., Triebswetter, C., Kiely, M., Bilgel, M., Dolui, S., Erus, G., Meirelles, O., Bryan, N. R., Detre, J. A., Launer, L. J.: Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Netw Open 5(9): e2231189, 2022.
204 Baller, E. B., Valcarcel, A. M., Adebimpe, A., Alexander-Bloch, A., Cui, Z., Gur, R. C., Gur, R. E., Larsen, B. L., Linn, K. A., O'Donnell, C. M., Pines, A. R., Raznahan, A., Roalf, D. R., Sydnor, V. J., Tapera, T. M., Tisdall, M. D., Vandekar, S., Xia, C. H., Detre, J. A., Shinohara, R. T., Satterthwaite, T. D.: Developmental coupling of cerebral blood flow and fMRI fluctuations in youth. Cell Rep 38(13): 110576, 2022.
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Selected Publications
306 Adebimpe, A., Bertolero, M., Dolui, S., Cieslak, M., Murtha, K., Baller, E. B., Boeve, B., Boxer, A., Butler, E. R., Cook, P., Colcombe, S., Covitz, S., Davatzikos, C., Davila, D. G., Elliott, M. A., Flounders, M. W., Franco, A. R., Gur, R. E., Gur, R. C., Jaber, B., McMillian, C., Allftd Consortium, Milham, M., Mutsaerts, Hjmm, Oathes, D. J., Olm, C. A., Phillips, J. S., Tackett, W., Roalf, D. R., Rosen, H., Tapera, T. M., Tisdall, M. D., Zhou, D., Esteban, O., Poldrack, R. A., Detre, J. A., Satterthwaite, T. D.: ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion. Nat Methods 19(6): 683-686, 2022.1e5 Kim, W. S. H., Luciw, N. J., Atwi, S., Shirzadi, Z., Dolui, S., Detre, J. A., Nasrallah, I. M., Swardfager, W., Bryan, R. N., Launer, L. J., MacIntosh, B. J.: Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy. Hum Brain Mapp 43(12): 3680-3693, 2022.
168 Jiang, H., Simms, A. G., Sadaghiani, S., Jiang, Y. Y., Morgan, J. I. W., Aguirre, G. K., Pattany, P. M., Detre, J. A., Wang, J.: Multi-Center Repeatability of Macular Capillary Perfusion Density Using Optical Coherence Tomography Angiography. Clin Ophthalmol 16: 3069-3078, 2022.
193 Jacobs, P. S., Benyard, B., Cember, A., Nanga, R. P. R., Cao, Q., Tisdall, M. D., Wilson, N., Das, S., Davis, K. A., Detre, J., Roalf, D., Reddy, R.: Repeatability of B1 (+) inhomogeneity correction of volumetric (3D) glutamate CEST via High-permittivity dielectric padding at 7T. Magn Reson Med 88(6): 2475-2484, 2022.
1f5 Hu, F., Weinstein, S. M., Baller, E. B., Valcarcel, A. M., Adebimpe, A., Raznahan, A., Roalf, D. R., Robert-Fitzgerald, T. E., Gonzenbach, V., Gur, R. C., Gur, R. E., Vandekar, S., Detre, J. A., Linn, K. A., Alexander-Bloch, A., Satterthwaite, T. D., Shinohara, R. T.: Voxel-wise intermodal coupling analysis of two or more modalities using local covariance decomposition. Hum Brain Mapp 43(15): 4650-4663, 2022.
243 Dolui, S., Detre, J. A., Gaussoin, S. A., Herrick, J. S., Wang, D. J. J., Tamura, M. K., Cho, M. E., Haley, W. E., Launer, L. J., Punzi, H. A., Rastogi, A., Still, C. H., Weiner, D. E., Wright, J. T., Jr., Williamson, J. D., Wright, C. B., Bryan, R. N., Bress, A. P., Pajewski, N. M., Nasrallah, I. M.: Association of Intensive vs Standard Blood Pressure Control With Cerebral Blood Flow: Secondary Analysis of the SPRINT MIND Randomized Clinical Trial. JAMA Neurol 79(4): 380-389, 2022.
1ff Clement, P., Castellaro, M., Okell, T. W., Thomas, D. L., Vandemaele, P., Elgayar, S., Oliver-Taylor, A., Kirk, T., Woods, J. G., Vos, S. B., Kuijer, J. P. A., Achten, E., van Osch, M. J. P., Bids maintainers, Detre, J. A., Lu, H., Alsop, D. C., Chappell, M. A., Hernandez-Garcia, L., Petr, J., Mutsaerts, Hjmm: ASL-BIDS, the brain imaging data structure extension for arterial spin labeling. Sci Data 9(1): 543, 2022.
17f Cember, A. T. J., Wilson, N. E., Rich, L. J., Bagga, P., Nanga, R. P. R., Swago, S., Swain, A., Thakuri, D., Elliot, M., Schnall, M. D., Detre, J. A., Reddy, R.: Integrating (1)H MRS and deuterium labeled glucose for mapping the dynamics of neural metabolism in humans. Neuroimage 251: 118977, 2022.
1a7 Bouhrara, M., Triebswetter, C., Kiely, M., Bilgel, M., Dolui, S., Erus, G., Meirelles, O., Bryan, N. R., Detre, J. A., Launer, L. J.: Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Netw Open 5(9): e2231189, 2022.
204 Baller, E. B., Valcarcel, A. M., Adebimpe, A., Alexander-Bloch, A., Cui, Z., Gur, R. C., Gur, R. E., Larsen, B. L., Linn, K. A., O'Donnell, C. M., Pines, A. R., Raznahan, A., Roalf, D. R., Sydnor, V. J., Tapera, T. M., Tisdall, M. D., Vandekar, S., Xia, C. H., Detre, J. A., Shinohara, R. T., Satterthwaite, T. D.: Developmental coupling of cerebral blood flow and fMRI fluctuations in youth. Cell Rep 38(13): 110576, 2022.
2c