Selected Publications

Xu Han, Michelle Burrows, Laura C. Kim, Jimmy P. Xu, Will Vostrejs, Tran Ngoc Van Le, Carson Poltorack, Yanqing Jiang, Edna Cukierman, Ben Z. Stanger, Kim A. Reiss, Sydney M. Shaffer, Clementina Mesaros, Brian Keith, M. Celeste Simon: Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment. Cell Reports 43(11): 8-9, November 2024 Notes: doi: https://doi.org/10.1016/j.celrep.2024.114972.

Raúl A Reyes Hueros , Rodrigo A Gier, Sydney M Shaffer: Non-genetic differences underlie variability in proliferation among esophageal epithelial clones. PLOS Computational Biology October 2024 Notes: doi: 10.1371/journal.pcbi.1012360.

Ariana Vargas-Castillo , Yizhi Sun , Amanda L Smythers , Louisa Grauvogel , Phillip A Dumesic , Margo P Emont , Linus T Tsai , Evan D Rosen , Nathan W Zammit , Sydney M Shaffer , Martha Ordonez, Edward T Chouchani , Steven P Gygi , Tongtong Wang , Anand K Sharma , Miroslav Balaz , Christian Wolfrum, Bruce M Spiegelman : Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle. Cell Metabolism Page: 2146-2155, July 2024 Notes: DOI: 10.1016/j.cmet.2024.07.002.

Schaff DL*, Fasse AJ*, White PE, Vander Velde R, Shaffer SM: Clonal differences underlie variable responses to sequential and prolonged treatment. Cell Systems Page: 213-226, March 2024 Notes: https://doi.org/10.1016/j.cels.2024.01.011.

Ouellet M, Kim JZ, Guillaume H, Shaffer SM, Bassett LC, Bassett DS: Breaking reflection symmetry: evolving long dynamical cycles in Boolean systems. New Journal of Physics February 2024.

Parham LR, Williams PA, Katada K, Nettleford SK, Chatterji P, Acheampong KK, Danan CH, Ma X, Simon LA, Naughton KE, Mizuno R, Karakasheva T, McMillan EA, Whelan KA, Brady DC, Shaffer SM, Hamilton KE: IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B. Cellular and Molecular Gastroenterology and Hepatology Page: 439-451, January 2024.

Harmange G, Reyes Hueros RA, Schaff D, Emert B, Saint-Antoine M, Nellore S, Fane ME, Alicea GM, Weeraratna AT, Singh A, Shaffer SM: Disrupting cellular memory to overcome drug resistance. Nature Communications 14(7130), November 2023 Notes: https://doi.org/10.1038/s41467-023-41811-8.

Hailong Song, Alexandra Tomasevich, Kofi K Acheampong, Dylan L Schaff, Sydney M Shaffer, Jean-Pierre Dolle, Victoria E Johnson, Bailey Mikytuck, Edward B Lee, Amber Nolan, C Dirk Keene, Susan R Weiss, William Stewart, Douglas H Smith: Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2. Acta Neuropathologica 146(5): 771-775, August 2023 Notes: doi: 10.1007/s00401-023-02624-7. Epub 2023 Aug 25.

Raymond W S Ng, Sydney M Shaffer: Patterns of tumour transcriptional variability. Nature 618(7965): 464-465, June 2023 Notes: doi: 10.1038/d41586-023-01744-0.

Gier RA, Reyes Hueros RA, Rong J, DeMarshall M, Karakasheva TA, Muir AB, Falk GW, Zhang NR, Shaffer SM: Clonal cell states link Barrett’s esophagus and esophageal adenocarcinoma. bioRxiv Jan 2023 Notes: https://doi.org/10.1101/2023.01.26.525564.