Description of Clinical Expertise

I am a board-certified pediatric anatomic pathologist. My clinical interest and expertise is in the diagnosis of pediatric gastrointestinal and liver disease. Particular areas of interest include neonatal cholestasis, very early onset inflammatory bowel disease (VEO-IBD), and Hirschsprung disease. In addition to these areas, I sign out cases encompassing a wide spectrum of pediatric pathology, including perinatal pathology (fetal autopsy and placenta), pediatric autopsy, and surgical pathology of neoplastic, medical, and congenital diseases.

Description of Research Expertise

My research focus is on collaborative studies that characterize phenotypes related to gastrointestinal and liver diseases in human subjects and animal models (mouse and zebrafish). Current studies include multiple projects related to eosinophilic esophagitis; clinicopathologic study of bile duct paucity in neonatal cholestasis; liver fibrosis in patients with long-standing single ventricle (Fontan) physiology; and histopathologic characterization of patients with very early onset inflammatory bowel disease (VEO-IBD). My prior laboratory research focused primarily on the role of CIRH1A in liver development using zebrafish as a model system, and mechanisms whereby the recessive CIRH1A R565W mutation found in patients with Progressive Cholestasis of Northwestern Quebec (formerly North American Indian Childhood Cirrhosis) lead to congenital biliary disease.