Benjamin J Wilkins, MD, PhD

faculty photo
Assistant Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine

Contact information
Children's Hospital of Philadelphia
Main Hospital 5NW08
3401 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-426-1074
Fax: 215-590-1736
Education:
B.S. (Biology)
John Carroll University, Cleveland, Ohio, 1998.
Ph.D. (Molecular and Developmental Biology)
University of Cincinnati College of Medicine, Cincinnati, Ohio, 2004.
M.D.
University of Cincinnati College of Medicine, Cincinnati, Ohio, 2006.
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Description of Clinical Expertise

I am a board-certified pediatric anatomic pathologist. My clinical interest and expertise is in the diagnosis of pediatric gastrointestinal and liver disease.

Description of Research Expertise

My laboratory research focuses primarily on elucidating the pathophysiologic mechanisms of pediatric gastrointestinal and liver diseases, primarily through modeling in zebrafish. Currently, the lab's primary focus is studying the role of CIRH1A in liver development, and mechanisms whereby the recessive CIRH1A R565W mutation found in patients with North American Indian Childhood Cirrhosis lead to congenital biliary disease.

In addition to my lab's own research, I also have an interest in collaborative studies where I can use my clinical diagnostic expertise to characterize phenotypes related to gastrointestinal and liver diseases in mammalian models and human tissues. Prior and ongoing studies have covered a wide range of disease models, including hepatotoxicity, hepatic steatosis, and eosinophilic esophagitis.

Selected Publications

Wilkins BJ, Gilbert M, Sivilich S, Muthumani M, Panettieri RA, Moreland RS, Spinner N, Pack M: Smooth muscle myosin dysregulation causes multiple visceral pathologies in a mouse model. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition November 2017.

Menard-Katcher Calies, Benitez Alain J, Pan Zhaoxing, Ahmed Faria N, Wilkins Benjamin J, Capocelli Kelley E, Liacouras Chris A, Verma Ritu, Spergel Jonathan M, Furuta Glenn T, Muir Amanda B: Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort. The American journal of gastroenterology 112(9): 1466-1473, Sep 2017.

Wang Ting, Liu Jian, McDonald Caitlin, Lupino Katherine, Zhai Xiandun, Wilkins Benjamin J, Hakonarson Hakon, Pei Liming: GDF15 is a heart-derived hormone that regulates body growth. EMBO molecular medicine 9(8): 1150-1164, Aug 2017.

Wilkins BJ and Pack M: Zebrafish cirh1a, the homolog of the North American Indian Childhood Cirrhosis (NAIC) disease gene, is required for ribosome biogenesis and liver and gastrointestinal development. The Liver Meeting, American Association for the Study of Liver Disease (AASLD) November 2016.

Zhao Xiao, Lorent Kristin, Wilkins Benjamin J, Marchione Dylan M, Gillespie Kevin, Waisbourd-Zinman Orith, So Juhoon, Koo Kyung Ah, Shin Donghun, Porter John R, Wells Rebecca G, Blair Ian, Pack Michael: Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology (Baltimore, Md.) 64(3): 894-907, Sep 2016.

Chandramouleeswaran PM, Shen D, Lee AJ, Benitez A, Dods K, Gambanga F, Wilkins BJ, Merves J, Noah Y, Toltzis S, Yearley JH, Spergel JM, Nakagawa H, Malefyt Rd, Muir AB, Wang ML.: Preferential Secretion of Thymic Stromal Lymphopoietin (TSLP) by Terminally Differentiated Esophageal Epithelial Cells:Relevance to Eosinophilic Esophagitis (EoE). PLoS One 11(3): e0150968, March 2016.

Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge C, Wang L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza A, Lewis J, Daikhin Y, Nissim I, Yudkoff M, Bushman F, Wu G.: Engineering the gut microbiota to treat hyperammonemia. J Clin Invest 25(7): 2841-50, Jul 2015.

Mistovich RJ, O'Toole PO, Chauvin NA, Wilkins BJ, Ganley TJ: Left knee pain and bilateral knee swelling in an adolescent. Clin Orthop Relat Res 472(11): 3591-8, Nov 2014.

Wilkins BJ, Gong W, Pack M: A novel keratin18 promoter that drives reporter gene expression in the intrahepatic and extrahepatic biliary system allows isolation of cell-type specific transcripts from zebrafish liver. Gene Expr Patterns 14(2): 62-8, Mar 2014.

Wilkins BJ, Lorent K, Matthews RP, Pack M: p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis. PLoS One 8(10): e77670, Oct 2013.

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Last updated: 10/17/2017
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