2e 2 5d 16
19
1b
38

Jonathan Chernoff, MD, PhD

88 faculty photo 46
Adjunct Professor of Pharmacology
7 8a
Department: Systems Pharmacology and Translational Therapeutics
4 1 b
1d
46 Contact information
 45
Fox Chase Cancer Center
41 333 Cottman Avenue - Room W455
Philadelphia, PA 19111
26
2e Office: 215-728-5319
32 Fax: 215-728-3616
32 Lab: 215-728-5320
18
95
Email: Jonathan.Chernoff@fccc.edu
12
4 3 3 1d
18 Publications
23
62 6f
26 Search PubMed for articles c
a
3 2 29
Links
ae Search PubMed for articles
 85 Search PubMed for articles
44 Link to Fox Chase Cancer Center research web page
c
4 b 1f
13 Education:
21 9 B.A. 2e (Molecular Biophysics/Biochemistry) c
25 Yale College, 1978.
 21 8 M.D 19 (Biochemistry) c
37 Mount Sinai School of Medicine, 1984.
 21 a Ph.D. 19 (Biochemistry) c
37 Mount Sinai School of Medicine, 1984.
 c
3 3 3 3 8d Permanent link
2 29
 
1d
25
21
b6 > Perelman School of Medicine   > Faculty   > Details a
1e 1d
2b 29
23

Selected Publications

144 Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K.: Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation. Cell Rep 40(11): 111345, September 2022 Notes: 10.1016/j.celrep.2022.111345.

 1a9 Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR.: Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. Mol Cancer Res. May 2022 Notes: 10.1158/1541-7786.MCR-21-0837.

 18b Binder P, Nguyen B, Collins L, Zi M, Liu W, Christou F, Luo X, Hille SS, Frey N, Cartwright EJ, Chernoff J, Müller OJ, Guan K, Wang X.: Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart. Front Cardiovasc Med. March 2022 Notes: 10.3389/fcvm.2022.851419.

 278 Saldivar-Cerón HI, Villamar-Cruz O, Wells CM, Oguz I, Spaggiari F, Chernoff J, Patiño-López G, Huerta-Yepez S, Montecillo-Aguado M, Rivera-Pazos CM, Loza-Mejía MA, Vivar-Sierra A, Briseño-Díaz P, Zentella-Dehesa A, Leon-Del-Rio A, López-Saavedra A, Padierna-Mota L, Ibarra-Sánchez MJ, Esparza-López J, Hernández-Rivas R, Arias-Romero LE.: p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II. Front Cell Dev Biol. January 2022 Notes: 10.3389/fcell.2021.759259.

 ad Chernoff J.: The two-hit theory hits 50. Mol Biol Cell December 2021 Notes: 10.1091/mbc.E21-08-0407.

 1d4 Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X, Bessler W, Masters A, Edwards D, Burgin C, Jones D, Yates C, Clapp DW, Chernoff J, Park SJ.: PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). Hum Mol Genet August 2021 Notes: 10.1093/hmg/ddab106.

 129 Uribe-Alvarez C, Guerrero-Rodríguez SL, Rhodes J, Cannon A, Chernoff J, Araiza-Olivera D: Targeting effector pathways in RAC1P29S-driven malignant melanoma. Small GTPases July 2021 Notes: doi: 10.1080/21541248.2020.1728469.

 115 Uribe-Alvarez C, Lam Q, Baldwin DA, Chernoff J.: Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests. PLoS One May 2021 Notes: 10.1371/journal.pone.0250202.

 a5 Chernoff J.: 2020 in 20/20 hindsight. Mol Biol Cell May 2021 Notes: 10.1091/mbc.E21-01-0022.

 f4 Karchugina S, Benton D, Chernoff J.: Regulation of MST complexes and activity via SARAH domain modifications. Biochem Soc Trans April 2021 Notes: doi: 10.1042/BST20200559.

 2c
7 1d
2c back to top
26 Last updated: 10/03/2022
34 The Trustees of the University of Pennsylvania c
1f
27
24
 
1d
18
1 49 2 2 18