Jonathan Chernoff, MD, PhD
Adjunct Professor of Pharmacology
Department: Systems Pharmacology and Translational Therapeutics
Contact information
Fox Chase Cancer Center
333 Cottman Avenue - Room W455
Philadelphia, PA 19111
333 Cottman Avenue - Room W455
Philadelphia, PA 19111
Office: 215-728-5319
Fax: 215-728-3616
Lab: 215-728-5320
Fax: 215-728-3616
Lab: 215-728-5320
Email:
Jonathan.Chernoff@fccc.edu
Jonathan.Chernoff@fccc.edu
Publications
Links
Search PubMed for articles
Search PubMed for articles
Link to Fox Chase Cancer Center research web page
Search PubMed for articles
Search PubMed for articles
Link to Fox Chase Cancer Center research web page
Education:
B.A. (Molecular Biophysics/Biochemistry)
Yale College, 1978.
Ph.D. (Biochemistry)
Mount Sinai School of Medicine, 1984.
M.D (Biochemistry)
Mount Sinai School of Medicine, 1984.
Permanent linkB.A. (Molecular Biophysics/Biochemistry)
Yale College, 1978.
Ph.D. (Biochemistry)
Mount Sinai School of Medicine, 1984.
M.D (Biochemistry)
Mount Sinai School of Medicine, 1984.
Selected Publications
Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K.: Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation. Cell Rep 40(11): 111345, September 2022 Notes: 10.1016/j.celrep.2022.111345.Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR.: Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. Mol Cancer Res. May 2022 Notes: 10.1158/1541-7786.MCR-21-0837.
Binder P, Nguyen B, Collins L, Zi M, Liu W, Christou F, Luo X, Hille SS, Frey N, Cartwright EJ, Chernoff J, Müller OJ, Guan K, Wang X.: Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart. Front Cardiovasc Med. March 2022 Notes: 10.3389/fcvm.2022.851419.
Saldivar-Cerón HI, Villamar-Cruz O, Wells CM, Oguz I, Spaggiari F, Chernoff J, Patiño-López G, Huerta-Yepez S, Montecillo-Aguado M, Rivera-Pazos CM, Loza-Mejía MA, Vivar-Sierra A, Briseño-Díaz P, Zentella-Dehesa A, Leon-Del-Rio A, López-Saavedra A, Padierna-Mota L, Ibarra-Sánchez MJ, Esparza-López J, Hernández-Rivas R, Arias-Romero LE.: p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II. Front Cell Dev Biol. January 2022 Notes: 10.3389/fcell.2021.759259.
Chernoff J.: The two-hit theory hits 50. Mol Biol Cell December 2021 Notes: 10.1091/mbc.E21-08-0407.
Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X, Bessler W, Masters A, Edwards D, Burgin C, Jones D, Yates C, Clapp DW, Chernoff J, Park SJ.: PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). Hum Mol Genet August 2021 Notes: 10.1093/hmg/ddab106.
Uribe-Alvarez C, Guerrero-Rodríguez SL, Rhodes J, Cannon A, Chernoff J, Araiza-Olivera D: Targeting effector pathways in RAC1P29S-driven malignant melanoma. Small GTPases July 2021 Notes: doi: 10.1080/21541248.2020.1728469.
Uribe-Alvarez C, Lam Q, Baldwin DA, Chernoff J.: Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests. PLoS One May 2021 Notes: 10.1371/journal.pone.0250202.
Chernoff J.: 2020 in 20/20 hindsight. Mol Biol Cell May 2021 Notes: 10.1091/mbc.E21-01-0022.
Karchugina S, Benton D, Chernoff J.: Regulation of MST complexes and activity via SARAH domain modifications. Biochem Soc Trans April 2021 Notes: doi: 10.1042/BST20200559.