Christopher Joachim Lengner, Ph.D.

faculty photo
Professor of Cell and Developmental Biology
Member, Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine
Member, NIH P30 Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania Perelman School of Medicine
Director, Center for Animal Transgenesis, University of Pennsylvania School of Veterinary Medicine
Member, Abramson Cancer Center, University of Pennsylvania
Chair, Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine
Harriet Ellison Woodward Professor, Department of Biomedical Sciences
Department: Cell and Developmental Biology
Graduate Group Affiliations

Contact information
Christopher J. Lengner, PhD
Harriet Ellison Woodward Associate Professor
Department of Biomedical Sciences
School of Veterinary Medicine
3800 Spruce Street, Room 390EA
Philadelphia, PA 19104
Office: 215-746-8425
Ph.D. (Cell and Molecular Biology)
University of Massachusetts Medical School, 2004.
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Description of Research Expertise

The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis. My laboratory employs genetic, genomic, and single-cell analysis approaches in murine systems to address these fundamental questions, and, in parallel, utilizes human induced pluripotent cells and patient samples to translate findings into human systems. Using these approaches we have identified novel pathways underlying the somatic stem cell self-renewal and the ontogeny of hematopoietic and gastrointestinal cancers. These pathways are subsequently being assessed as potential points for therapeutic intervention in cancers and diseases of regenerative failure. We have also begun to unravel the hierarchical structure of the intestinal stem cell compartment with the ultimate goal of understanding how perturbations in this hierarchy contribute to disease states, including cancer, chronic inflammation, and regeneration in response to acute injuries such as ischemia or radiation damage.

Lab Members

Ning Li, M.D., Postdoctoral Fellow
Dong-Hun Woo, Ph.D., Postdoctoral Fellow
Angela Ddamba, Research Specialist
Ryan Cedeno, Graduate Student
Maryam Yousefi, Graduate Student (HHMI International Fellow)
Carla Hoge, Undergraduate (UPenn Vagelos Scholar)

Selected Publications

Johnson NM, Lengner CJ.: MTORC1 and the Rebirth of Stemness. Dev Cell 55: 113-115, Oct 2020.

Song Y, Guerrero-Juarez CF, Chen Z, Tang Y, Ma X, Lv C, Bi X, Deng M, Bu L, Tian Y, Liu R, Zhao R, Xu J, Sheng X, Du S, Liu Y, Zhu Y, Shan SJ, Chen HD, Zhao Y, Zhou G, Shuai J, Ren F, Xue L, Ying Z, Dai X, Lengner CJ, Andersen B, Plikus MV, Nie Q, Yu Z.: The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease. Cell Res 30: 854-872, Oct 2020.

Efimova N, Yang C, Chia JX, Li N, Lengner CJ, Neufeld KL, Svitkina TM.: Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion. J Cell Biol 219: e202003091, Sep 2020.

Sheng X, Lin Z, Lv C, Shao C, Bi X, Deng M, Xu J, Guerrero-Juarez CF, Li M, Wu X, Zhao R, Yang X, Li G, Liu X, Wang Q, Nie Q, Cui W, Gao S, Zhang H, Liu Z, Cong Y, Plikus MV, Lengner CJ, Andersen B, Ren F, Yu Z.: Cycling Stem Cells Are Radioresistant and Regenerate the Intestine. Cell Rep 32: 107952, Jul 2020.

Berry CT, Liu X, Myles A, Nandi S, Chen YH, Hershberg U, Brodsky IE, Cancro MP, Lengner CJ, May MJ, Freedman BD.: BCR-Induced Ca(2+) Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Cell Rep 31: 107474, Apr 2020.

Allensworth-James M, Banik J, Odle A, Hardy L, Lagasse A, Moreira ARS, Bird J, Thomas CL, Avaritt N, Kharas MG, Lengner CJ, Byrum SD, MacNicol MC, Childs GV, MacNicol AM.: Control of the anterior pituitary cell lineage regulator POU1F1 by the stem cell determinant Musashi. Endocrinology ndocrinology, 2020.

Lengner CJ.: MTorc1 at the Crossroads of Facultative Intestinal Stem Cell Activation. Cell Mol Gastroenterol Hepatol 10: 857-858, 2020.

Caldwell BA, Liu MY, Prasasya RD, Wang T, DeNizio JE, Leu NA, Amoh NYA, Krapp C, Lan Y, Shields EJ, Bonasio R, Lengner CJ, Kohli RM, Bartolomei MS.: Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency. Mol Cell ol Cell, 2020.

Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML.: Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Sci Transl Med 11: eaaw3521, Nov 2019.

Park Hanseul, Oh Jungju, Shim Gayong, Cho Byounggook, Chang Yujung, Kim Siyoung, Baek Soonbong, Kim Hongwon, Shin Jeain, Choi Hwan, Yoo Junsang, Kim Junyeop, Jun Won, Lee Minhyung, Lengner Christopher J, Oh Yu-Kyoung, Kim Jongpil: In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease. Nature neuroscience 22(4): 524-528, Apr 2019.

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Last updated: 07/12/2023
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