Gary Freedman, M.D.

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Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Radiation Oncology
Perelman School of Medicine of
the University of Pennsylvania
PCAM / TRC 4 West
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-615-6767
B.A. (Classics)
University of Virginia, 1988.
M.D. (Medicine)
Temple University School of Medicine, 1993.
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Description of Clinical Expertise

My academic and clinical practice is limited to breast cancer. I serve as the clinical chief of the breast service for the Department of Radiation Oncology and am a member of the Senior Leadership Team. I was recognized by Penn Medicine for clinical excellence by induction into the Academy of Master Clinicians in 2013. I have been recognized by my peers with the honor of inclusion in the 2009 - 2015 editions of America’s Top Doctors, and the 2008 – 2019 America’s Top Doctors for Cancer by Castle Connolly Medical LTD.

Description of Research Expertise

I have an academic focus limited to breast cancer. My research interests have been focused on shortening radiation courses by hypofractionation, intensity modulated radiation therapy (IMRT) with concurrent boost, proton beam radiation, and cardiac effects of radiation therapy/techniques to reduce cardiac dose in breast cancer. I have published over 90 peer-reviewed manuscripts, review articles and book chapters about breast cancer, radiation for early and advanced stage disease, radiation for intact breast and post-mastectomy indications, and radiation therapy techniques and side effects. I am co-chair of the Radiation Oncology breast committee with responsibility for the written board examination for the American Board of Radiology. I am a member of the NRG breast cancer committee local-regional subcommittee.

Selected Publications

Le AN, Harton J, Desai H, Powers J, Zelley K, Bradbury AR, Nathanson KL, Shah PD, Doucette A, Freedman GM, Gabriel P, Domchek SM, MacFarland SP, Maxwell KN. : Frequency of radiation-induced malignancies post-adjuvant radiotherapy for breast cancer in patients with Li-Fraumeni syndrome. Breast Cancer Res Treat 181(1): 181-8, 2020 Notes: doi: 10.1007/s10549-020-05612-7.

Reyes SA, Williams AD, Arlow RL, De La Cruz LM, Anderson DN, Ugras S, Brooks AD, Sataloff D, Freedman G, Tchou J: Changing practice patterns of adjuvant radiation among elderly women with early stage breast cancer in the United States from 2004 to 2014. The Breast journal September 2019 Notes:

Barsky AR, O’Grady F, Kennedy C, Taunk NK, Dong L, Metz JM, Li T, Freedman GM.: Initial clinical experience treating patients with breast cancer on a 6MV flattening filter free O-ring linear accelerator Advances in Radiation Oncology. Adv Radiat Oncol 4(4): 571-8, 2019 Notes: doi: 10.1016/j.adro.2019.05.006.

Bekelman JE, Lu H, Pugh S, Baker K, Berg CD, de Gonzalez AB, Braunstein LZ, Bosch W, Chauhan C, Ellenberg S, Fang LC, Freedman GM, Hahn EA, Haffty BG, Khan AJ, Jimenez RB, Kesslering C, Ky B, Lee C, Lu HM, Mishra MV, Mullins CD, Mutter RW, Nagda S, Pankuch M, Powell SN, Prior FW, Schupak K, Taghian AG, Wilkinson JB, MacDonald SM, Cahlon O; RadComp (Radiotherapy Comparative Effectiveness Consortium).: Pragmatic Randomized Clinical Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer: The Radiotherapy Comparative Effectiveness (RadComp) Consortium Trial Protocol. BMJ Open 9(10): e025556, 2019 Notes: doi: 10.1136/bmjopen-2018-025556.

Grewal AS, Freedman GM, Jones JA, Taunk NK.: Hypofractionated radiation therapy for durable palliative treatment of bleeding, fungating breast cancers. Pract Radiat Oncol 9(2): 73-6, 2019 Notes: doi: 10.1016/j.prro.2018.11.003.

Li XA, Moughan J, White JR, Freedman GM, Arthur DW, Galvin J, Xiao Y, McNulty S, Lyons JA, Kavadi VS, Fields MT, Mitchell MP, Anderson BM, Lock MI, Kokeny KE, Bazan JG, Currey AD, Hijal T, Cheston SB, Vicini FA.: Patterns of Failure Observed in the 2-Step Institution Credentialing Process for NRG Oncology/Radiation Therapy Oncology Group 1005 (NCT01349322) and Lessons Learned. Pract Radiat Oncol 2019 Notes: doi: 10.1016/j.prro.2019.11.007.

O’Grady F, Barsky AR, Anamalayil S, Freedman GM, Kennedy C, Cai B, Laugeman E, Dong L, Hugo GD, Metz JM, Mutic S, Taunk NK, Li T: Increase in Superficial Dose in Whole-Breast Irradiation with HalcyonTM Straight-through Linac Compared to Traditional C-arm Linac with Flattening Filter: In-vivo Dosimetry and Planning Study. Adv in Rad Onc 5(1): 120-6, 2019 Notes:

Dreyfuss AD, Barsky A, Taunk NK, Clark A, Freedman GM: The efficacy and safety of hypofractionated radiotherapy with concurrent anti-HER-2 therapy following breast-conserving therapy for breast cancer. The Breast Journal 25(6): 1097-1103, 2019 Notes: doi: 10.1111/tbj.13421.

Demissei BG, Freedman G, Feigenberg SJ, Plastaras JP, Maity A, Smith AM, McDonald C, Sheline K, Simone CB, Lin L, Carver JR, Liu P, Zhang L, Bekelman JE, Ky B: Early changes in cardiovascular biomarkers with contemporary thoracic radiation therapy for breast cancer, lung cancer and lymphoma. Int J Radiat Oncol Biol Phys 2018 Notes: Accepted for publication 11/6/2018.

Venigalla S, Guttmann DM, Jain V, Sharma S, Freedman GM, Shabason JE: Trends and Patterns of Utilization of Hypofractionated Postmastectomy Radiotherapy: A National Cancer Database Analysis. Clin Breast Cancer 18(5): e899-908, 2018 Notes: doi: 10.1016/j.clbc.2018.02.009.

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Last updated: 05/19/2020
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