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Gary Freedman, M.D.
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Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
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Attending Physician, Hospital of the University of Pennsylvania, Perelman School of Medicine, Radiation Oncology
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Medical Staff, Penn Presbyterian Medical Center, Radiation Oncology
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Professional Staff, Pennsylvania Hospital, Radiology/Radiation Oncology
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Department: Radiation Oncology
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Contact information
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Radiation Oncology
23 Perelman School of Medicine
1a PCAM / TRC 4 West
39 3400 Civic Center Blvd
Philadelphia, PA 19104
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23 Perelman School of Medicine
1a PCAM / TRC 4 West
39 3400 Civic Center Blvd
Philadelphia, PA 19104
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Office: 215-615-6767
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Education:
21 9 B.A. 15 (Classics) c
2f University of Virginia, 1988.
21 9 M.D. 15 (Medicine) c
3d Temple University School of Medicine, 1993.
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Permanent link21 9 B.A. 15 (Classics) c
2f University of Virginia, 1988.
21 9 M.D. 15 (Medicine) c
3d Temple University School of Medicine, 1993.
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Description of Clinical Expertise
144 My academic and clinical practice is limited to breast cancer. I was recognized by Penn Medicine for clinical excellence by induction into the Academy of Master Clinicians in 2013. I have been recognized by my peers with the honor of inclusion in the 2009 - 2025 Castle Connolly / Philadelphia Top Doctors.71
Description of Research Expertise
266 I have an academic focus limited to breast cancer. My research interests have been focused on shortening radiation courses by hypofractionation, intensity modulated radiation therapy (IMRT) with concurrent boost, proton beam radiation, and cardiac effects of radiation therapy/techniques to reduce cardiac dose in breast cancer. I have published over 100 peer-reviewed manuscripts, review articles and book chapters about breast cancer, radiation for early and advanced stage disease, radiation for intact breast and post-mastectomy indications, and radiation therapy techniques and side effects.e 29
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1d7 Berlin E, Ko K, Ma L, Messing I, Hollawell C, Smith AM, Taunk NK, Narayan V, Upshaw JN, Clark AS, Shah PD, Knollman H, Bhattacharya S, Koropeckyj-Cox D, Wang J, Yegya-Raman N, Han IS, Lefebvre B, Li T, Wilcox NS, Jung W, Chen J, Freedman GM, Ky B: Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy. JACC: CardioOncology 2025 Notes: Accepted 1/15/2025.
182 Barrett M, Demissei BG, Hu R, Smith AM, Freedman G, Plastaras J, Feigenberg S, Berlin E, Narayan HK, Lefebvre B, Crosbie MS, Fradley M, Carver J, Chen J, Ky B: 3D Echocardiographic Phenotyping of Left Ventricular Mechanics and Function With Contemporary Radiation Therapy. Adv Rad Onc 10(7), 2025 Notes: Accepted date: 7 April 2025 3f https://doi.org/10.1016/j.adro.2025.101786.
13d Cederquist GY, Boe LA, Walsh M, Freedman GM, Maxwell KN, Taunk N, Braunstein LZ: Radiation-Associated Secondary Cancer in Patients With Breast Cancer Harboring TP53 Germline Variants. JAMA Oncology 9 2024 Notes: doi:10.1001/jamaoncol.2024.3683.
163 Novick K, Chadha M, Daroui P, Freedman G, Gao W, Hunt K, Park C, Rewari A, Suh W, Walker W, Wong J, Harris EE: American Radium Society Appropriate Use Criteria Postmastectomy Radiation Therapy: Executive Summary of Clinical Topics. Int J Radiat Oncol Biol Phys 118(2): 458-65, 2024.
16f Hahn EA, Pugh SL, Lu HL, Vela AM, Gillespie EF, Nichols EM, Wright JL, MacDonald SM, Cahlon O, Baas C, Braunstein LZ, Fang LC, Freedman GM, Jimenez RB, Kesslering CM, Mishra MV, Mutter RW, Ohri N, Rosen LR, Urbanic JJ, Jagsi R, Mitchell SA, Bekelman JE, Cella D; RadComp (Radiotherapy Comparative Effectiveness Consortium). 112 : Validation of Patient-Reported Outcomes in Patients With Nonmetastatic Breast Cancer Receiving Comprehensive Nodal Irradiation in the RadComp Trial. Int J Radiat Oncol Biol Phys 120: 149-161, 2024 Notes: doi.org/10.1016/j.ijrobp.2024.03.020.
1f7 Jagsi R, Griffith KA, Harris EE, Wright JL, Recht A, Taghian AG, Lee L, Moran MS, Small Jr W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell SN, Sharp J, Sabel M, Schott A, El-Tamer M: Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA. J Clin Oncol 42: 390-8, 2024 Notes: Accepted for publication 10/24/2023.
15b Iwai Y, Perez-Rojas S, Thomas SM, Tadros AB, Woodward SG, Zhang JQ, Elmore LC, Freedman GM, Tchou JC, Bleznak AD, Fayanju OM: Guideline-Concordant Surgical Care for Lobular Versus Ductal Inflammatory Breast Cancer. Ann Surg Oncol 2024 Notes: doi: 10.1245/s10434-024-15540-1.
17f Freedman GM, Li T, Garver E, Shillington K, Shinkle B, Tchou JC, Fayanju OM, Lin L, Taunk NK: Five-year outcomes of a phase I/II trial of accelerated partial breast irradiation using proton therapy for women with stage 0-IIA breast cancer. Advances in Radiation Oncology 9(2), July 2023 Notes: Accepted for publication 7/21/2023 3f https://doi.org/10.1016/j.adro.2023.101334.
15a Manik R, Grady CB, Elmore LC, Fieber JH, Freedman GM, Jankowitz RC, Tchou JC, Zhang JQ, Hubbard RA, Fayanju OM: Temporal Trends and Factors Associated with Receipt of Post-Mastectomy Radiation after Neoadjuvant Chemotherapy in Women with cT3 Breast Cancer. ASO 2023 Notes: Accepted 5/25/2023 3f https://doi.org/10.1245/s10434-023-13730-x.
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Selected Publications
1bd Choi JI, Freedman G, Guttman D, Ahmed K, Gao W, Walker E, Harris L, Gonzalez V, Ye J, Nead K, Taunk N, Tadros A, Dang C, Daroui P, Novick K: Executive Summary of the American Radium Society (ARS) Appropriate Use Criteria (AUC): Regional Nodal Irradiation for Breast Cancer. American Journal of Clinical Oncology 48(3), March 2025 Notes: Accepted for publication 8/14/2024.1d7 Berlin E, Ko K, Ma L, Messing I, Hollawell C, Smith AM, Taunk NK, Narayan V, Upshaw JN, Clark AS, Shah PD, Knollman H, Bhattacharya S, Koropeckyj-Cox D, Wang J, Yegya-Raman N, Han IS, Lefebvre B, Li T, Wilcox NS, Jung W, Chen J, Freedman GM, Ky B: Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy. JACC: CardioOncology 2025 Notes: Accepted 1/15/2025.
182 Barrett M, Demissei BG, Hu R, Smith AM, Freedman G, Plastaras J, Feigenberg S, Berlin E, Narayan HK, Lefebvre B, Crosbie MS, Fradley M, Carver J, Chen J, Ky B: 3D Echocardiographic Phenotyping of Left Ventricular Mechanics and Function With Contemporary Radiation Therapy. Adv Rad Onc 10(7), 2025 Notes: Accepted date: 7 April 2025 3f https://doi.org/10.1016/j.adro.2025.101786.
13d Cederquist GY, Boe LA, Walsh M, Freedman GM, Maxwell KN, Taunk N, Braunstein LZ: Radiation-Associated Secondary Cancer in Patients With Breast Cancer Harboring TP53 Germline Variants. JAMA Oncology 9 2024 Notes: doi:10.1001/jamaoncol.2024.3683.
163 Novick K, Chadha M, Daroui P, Freedman G, Gao W, Hunt K, Park C, Rewari A, Suh W, Walker W, Wong J, Harris EE: American Radium Society Appropriate Use Criteria Postmastectomy Radiation Therapy: Executive Summary of Clinical Topics. Int J Radiat Oncol Biol Phys 118(2): 458-65, 2024.
16f Hahn EA, Pugh SL, Lu HL, Vela AM, Gillespie EF, Nichols EM, Wright JL, MacDonald SM, Cahlon O, Baas C, Braunstein LZ, Fang LC, Freedman GM, Jimenez RB, Kesslering CM, Mishra MV, Mutter RW, Ohri N, Rosen LR, Urbanic JJ, Jagsi R, Mitchell SA, Bekelman JE, Cella D; RadComp (Radiotherapy Comparative Effectiveness Consortium). 112 : Validation of Patient-Reported Outcomes in Patients With Nonmetastatic Breast Cancer Receiving Comprehensive Nodal Irradiation in the RadComp Trial. Int J Radiat Oncol Biol Phys 120: 149-161, 2024 Notes: doi.org/10.1016/j.ijrobp.2024.03.020.
1f7 Jagsi R, Griffith KA, Harris EE, Wright JL, Recht A, Taghian AG, Lee L, Moran MS, Small Jr W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell SN, Sharp J, Sabel M, Schott A, El-Tamer M: Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA. J Clin Oncol 42: 390-8, 2024 Notes: Accepted for publication 10/24/2023.
15b Iwai Y, Perez-Rojas S, Thomas SM, Tadros AB, Woodward SG, Zhang JQ, Elmore LC, Freedman GM, Tchou JC, Bleznak AD, Fayanju OM: Guideline-Concordant Surgical Care for Lobular Versus Ductal Inflammatory Breast Cancer. Ann Surg Oncol 2024 Notes: doi: 10.1245/s10434-024-15540-1.
17f Freedman GM, Li T, Garver E, Shillington K, Shinkle B, Tchou JC, Fayanju OM, Lin L, Taunk NK: Five-year outcomes of a phase I/II trial of accelerated partial breast irradiation using proton therapy for women with stage 0-IIA breast cancer. Advances in Radiation Oncology 9(2), July 2023 Notes: Accepted for publication 7/21/2023 3f https://doi.org/10.1016/j.adro.2023.101334.
15a Manik R, Grady CB, Elmore LC, Fieber JH, Freedman GM, Jankowitz RC, Tchou JC, Zhang JQ, Hubbard RA, Fayanju OM: Temporal Trends and Factors Associated with Receipt of Post-Mastectomy Radiation after Neoadjuvant Chemotherapy in Women with cT3 Breast Cancer. ASO 2023 Notes: Accepted 5/25/2023 3f https://doi.org/10.1245/s10434-023-13730-x.
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