Saba Ghassemi, PhD

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Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Center for Cellular Immunotherapies
3400 Civic Center Blvd
8-303 SPE
Philadelphia, PA 19104
B.Sc. (Mechanical Engineering)
K.N.T. University of Technology, 2001.
M.Sc. (Mechanical Engineering)
Villanova University, 2004.
M.Phil. (Mechanical Engineering)
Columbia University, 2010.
Ph.D. (Mechanical Engineering)
Columbia University, 2011.
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Description of Research Expertise

CAR-T cell manufacturing; T cell activation, proliferation and differentiation; Lentiviral, retroviral and mRNA-based gene transfer; Nano-engineered cell culture platforms; Microfluidics

Selected Publications

Saba Ghassemi, Francisco J. Martinez-Becerra, Alyssa M. Master, Sarah A. Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos Garcia-Canaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D. Rabinowitz, Michael C. Milone, Roddy S. O’Connor: Enhancing Chimeric Antigen Receptor (CAR)-T cell anti-tumor function through advanced media design Molecular Therapy Methods & clinical Development 18(no issue number): 595-606, July 2020.

Saba Ghassemi, Michael C Milone: Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy. Journal of Visualized Experiments 154(no issue number): no page number, Dec 2019.

Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, Melenhorst JJ, Milone MC: Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Cancer Immunol Res 6(9): 1100-1109, September 2018.

O'Connor RS, Guo L, Ghassemi S, Snyder NW, Worth AJ, Weng L, Kam Y, Philipson B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC.: The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep 8(1): 6289, Apr 2018.

June CH, O'Connor RS, Kawalekar OU, Ghassemi S, Milone MC.: CAR T cell immunotherapy for human cancer Science 359(6382): 1361-1365, Mar 2018.

Ghassemi S, Carreno BM.: Heating Up Cancer Vaccines. Sci Immunol 2(17): no page number, Nov 2017.

Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP: α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions. Mol Biol Cell 27(22): 3471-3479, Nov 2016.

Chronopoulos A, Robinson B, Sarper M, Cortes E, Auernheimer V, Lachowski D, Attwood S, García R, Ghassemi S, Fabry B, Del Río Hernández A.: ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nat Commun 7(12630): no page number, Sep 2016.

Hu J, Gondarenko AA, Dang AP, Bashour KT, O'Connor RS, Lee S, Liapis A, Ghassemi S, Milone MC, Sheetz MP, Dustin ML, Kam LC, Hone JC.: High Throughput Mechanobiology Screening Platform Using Micro- and Nano-topology. Nano Lett 16(4): 2198-204, Apr 2016.

Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP.: Tropomyosin Controls Sarcomere-like Contractions for Rigidity Censing and Suppressing Growth on Soft Matrices. Nat Cell Biol 18(1): 33-42, Jan 2015.

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Last updated: 09/10/2020
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