Saba Ghassemi, PhD
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Center for Cellular Immunotherapies
3400 Civic Center Blvd
9-101 SPE
Philadelphia, PA 19104
3400 Civic Center Blvd
9-101 SPE
Philadelphia, PA 19104
Office: 212-898-5040
Education:
B.Sc. (Mechanical Engineering)
K.N.T. University of Technology, 2001.
M.Sc. (Mechanical Engineering)
Villanova University, 2004.
M.Phil. (Mechanical Engineering)
Columbia University, 2010.
Ph.D. (Mechanical Engineering)
Columbia University, 2011.
Permanent linkB.Sc. (Mechanical Engineering)
K.N.T. University of Technology, 2001.
M.Sc. (Mechanical Engineering)
Villanova University, 2004.
M.Phil. (Mechanical Engineering)
Columbia University, 2010.
Ph.D. (Mechanical Engineering)
Columbia University, 2011.
Description of Research Expertise
CAR-T cell manufacturing; T cell activation, proliferation and differentiation; Lentiviral, retroviral and mRNA-based gene transfer; Nano-engineered cell culture platforms; MicrofluidicsSelected Publications
Behnia Akbari, Zahra Hosseini, Pardis Shahabinejad, SabaGhassemi, Hamid RezaMirzaei, Roddy S.O'Connor: Metabolic and epigenetic orchestration of (CAR) T cell fate and function. Cancer Letters 550(no issue): 215948, December 2022 Notes: doi: 10.1016/j.canlet.2022.215948. Epub 2022 Oct 7. Review.Lunan Liu, Chao Ma, Zhuoyu Zhang, Matthew T Witkowski, Iannis Aifantis, Saba Ghassemi, Weiqiang Chen: Computational model of CAR T-cell immunotherapy dissects and predicts leukemia patient responses at remission, resistance, and relapse. Journal for ImmunoTherapy of Cancer 10(12): e005360, December 2022 Notes: doi: 10.1136/jitc-2022-005360.
Joseph S Durgin, Radhika Thokala, Lexus Johnson, Edward Song, John Leferovich, Vijay Bhoj, Saba Ghassemi, Michael Milone, Zev Binder, Donald M O'Rourke, Roddy S O'Connor: Enhancing CAR T Function with the Engineered Secretion of C. Perfringens Neuraminidase. Molecular therapy 30(3): 1201-1214, March 2022 Notes: doi: 10.1016/j.ymthe.2021.11.014. Epub 2021 Nov 20.
Saba Ghassemi, Joseph S. Durgin, Selene Nunez-Cruz, Jai Patel, John Leferovich1, Marilia Pinzone, Feng Shen, Katherine D. Cummins, Gabriela Plesa, Vito Adrian Cantu, Shantan Reddy, Frederic D. Bushman, Saar I. Gill, Una O'Doherty, Roddy S. O’Connor, Michael C. Milone: Rapid manufacturing of non-activated potent CAR T cells. Nature Biomedical Engineering 6(2): 118-128, February 2022 Notes: doi: 10.1038/s41551-021-00842-6. Epub 2022 Feb 21.
Navid Ghahri-Saremi, Behnia Akbari, Tahereh Soltantoyeh, Jamshid Hadjati, Saba Ghassemi, Hamid Reza Mirzaei1: Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors. Front. Immunol 12(no issue): 738456, October 2021 Notes: doi: 10.3389/fimmu.2021.738456. eCollection 2021. Review.
Juan C Garcia-Canaveras, David Heo, Sophie Trefely, John Leferovich, Chong Xu, Benjamin I Philipson, Saba Ghassemi, Michael C Milone, Edmund K Moon, Nathaniel W Snyder, Carl H June, Joshua D Rabinowitz, Roddy S O'Connor: CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells 10(9): 2334, September 2021 Notes: doi: 10.3390/cells10092334.
Behnia Akbari, Navid Ghahri-Saremi, Tahereh Soltantoyeh, Jamshid Hadjati, Saba Ghassemi, Hamid Reza Mirzaei: Epigenetic strategies to boost CAR T cell therapy. Molecular Therapy S1525-0016(21): 00397-X, August 2021 Notes: doi: 10.1016/j.ymthe.2021.08.003.
Saba Ghassemi, Francisco J. Martinez-Becerra, Alyssa M. Master, Sarah A. Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos Garcia-Canaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D. Rabinowitz, Michael C. Milone, Roddy S. O’Connor: Enhancing Chimeric Antigen Receptor (CAR)-T cell anti-tumor function through advanced media design Molecular Therapy Methods & clinical Development 18(no issue number): 595-606, July 2020 Notes: doi: 10.1016/j.omtm.2020.07.008. eCollection 2020 Sep 11.
Saba Ghassemi, Michael C Milone: Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy. Journal of Visualized Experiments 154(no issue number): no page number, Dec 2019.
Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, Melenhorst JJ, Milone MC: Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Cancer Immunol Res 6(9): 1100-1109, September 2018.