Chris T Derk, MD, MS
Professor of Clinical Medicine (Rheumatology)
Department: Medicine
Contact information
Division of Rheumatology
3400 Spruce Street
5th Floor White Bldg
Philadelphia, PA 19104
3400 Spruce Street
5th Floor White Bldg
Philadelphia, PA 19104
Office: 215-662-2792
Fax: 215-662-4500
Fax: 215-662-4500
Publications
Education:
AA
Harrisburg Area Community College, 1988.
BS (Pre-Medicine)
Pennsylvania State University, 1990.
MD
Thomas Jefferson University, 1994.
MS (Pharmacology)
Thomas Jefferson University, 2006.
Permanent linkAA
Harrisburg Area Community College, 1988.
BS (Pre-Medicine)
Pennsylvania State University, 1990.
MD
Thomas Jefferson University, 1994.
MS (Pharmacology)
Thomas Jefferson University, 2006.
Description of Clinical Expertise
Systemic Sclerosis (Scleroderma) and other fibrotic autoimmune connective tissue disorders ( Eosinophilic Faciitis, Scleromyxedema, Scleredema, Nephrogenic Systemic Fibrosis). Raynaud's phenomenon. Systemic Lupus Erythematosus.Description of Research Expertise
Scleroderma (Systemic Sclerosis) and related diseases clinical outcomes, therapeutic interventions and disease pathogenesis.Selected Publications
Derk CT, Badali A, Mehmetoglu E, Mummadisetty A, Syal A, Parperis K: Transcatheter aortic valve replacement in systemic sclerosis: a case series and review of short- and long-term outcomes. Mediter J Rheumatol 37(1), March 2026.GRASP authors: Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis. Ann Rheum Dis February 2026.
Syal A, derk CT: Systemic Sclerosis-associated interstitial lung disease: improved understanding and advances in management. Br J Hosp Med 86(12), December 2025.
Papchristodoulou E; Kakkoulis L; Chopra R; Derk CT, Parperis K: Clinical Features and Treatment Outcomes in Aseptic Abscess Syndrome: A Systematic Review of 104 Cases. ACR Convergence 44(11), November 2025.
Gkountinaki S, Protopapa F, Syal A, Chatzittofis A, Parperis K, Derk CT: Understanding spiritual well-being in patients with systemic sclerosis and it's effect on the illness: a scoping review. Clin Rheumatol 44(11), November 2025.
GRASP study group: Functional NOTCH4 Variants Drive Vasculopathy and Fibrosis in Systemic Sclerosis. ACR Convergence 44(11), November 2025.
Hajnoczky N, Levin LS, Sandorfi N, Derk CT: Long-term outcomes of vascular grafting of medium-sized vessels of wrist and hand in systemic sclerosis patients with medication refractory Raynaud's. J Scleroderma Relat Disord September 2025.
Parperis K, Papchristodoulou M, Derk C, Psarelis S, Voskarides K , Chatzittofis A: Post-traumatic stress disorder and systemic lupus erythematosus: insights from a systematic review. Rheumatology 64(9): 487-4885, September 2025.
Trottet C, Schurch M, Allam A, et al. EUSTAR Collaborators: Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories- a EUSTAR study. NP J Digit Med 8(1), September 2025.
Mehmetoglu E, Mummadisetty A, Chatzitofis A, Parperis K, Sandorfi N, Derk CT: A systematic review of prevalence and predictors of depression in systemic sclerosis based on the CES-D, BDI and PHQ-9 self-assessment questionnaires. Clin Rheumatol April 2025.