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Chris T Derk, MD, MS

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Professor of Clinical Medicine (Rheumatology)
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Department: Medicine
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46 Contact information
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Division of Rheumatology
1a 3400 Spruce Street
37 5th Floor White Bldg
Philadelphia, PA 19104
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2e Office: 215-662-2792
32 Fax: 215-662-4500
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13 Education:
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3a Harrisburg Area Community College, 1988.
21 7 BS 19 (Pre-Medicine) c
36 Pennsylvania State University, 1990.
21 7 MD c
34 Thomas Jefferson University, 1994.
21 7 MS 19 (Pharmacology) c
34 Thomas Jefferson University, 2006.
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Description of Clinical Expertise

f3 Systemic Sclerosis (Scleroderma) and other fibrotic autoimmune connective tissue disorders ( Eosinophilic Faciitis, Scleromyxedema, Scleredema, Nephrogenic Systemic Fibrosis). Raynaud's phenomenon. Systemic Lupus Erythematosus.
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Description of Research Expertise

8c Scleroderma (Systemic Sclerosis) and related diseases clinical outcomes, therapeutic interventions and disease pathogenesis.
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Selected Publications

148 Mehmetoglu E, Mummadisetty A, Chatzitofis A, Parperis K, Sandorfi N, Derk CT: A systematic review of prevalence and predictors of depression in systemic sclerosis based on the CES-D, BDI and PHQ-9 self-assessment questionnaires. Clin Rheumatol April 2025.

133 Hajnoczky N, Levin LS, Sandorfi N, Derk CT: Long-term outcomes of vascular grafting of medium-sized vessels of wrist and hand in systemic sclerosis patients with medication refractory Raynaud's. J Scleroderma Relat Disord April 2025.

11a Parperis K, Papachristodoulou M, Derk C, Psarelis S, Voskarides K, Chatzittofis A. : Post-traumatic stress disorder and systemic lupus erythematosus: insights from a systematic review. Rheumatology April 2025.

f3 Aguila T, Madan R, Palmer MB, Derk CT: Zebra bodies in kidney biopsy: Drug-induced phospholipidosis in patient with Systemic Lupus Erythematosus. J Rheumatol March 2025.

107 Papchristodoulou E; Kakkoulis L; Chopra R; Derk CT, Parperis K: Clinical Features and Treatment Outcomes in Aseptic Abscess Syndrome: A Systematic Review of 104 Cases. ACR Convergence 2025.

c3 GRASP study group: Functional NOTCH4 Variants Drive Vasculopathy and Fibrosis in Systemic Sclerosis. ACR Convergence 2025.

116 Parperi K, Costi E, Philippou S, Hadi M, Derk CT: Efficacy of disease modifying antirheumatic drugs in the treatment of granulomatous mastitis: a systematic review. Rheumatol Int 44(11): 2371-79, Nov 2024.

123 GRASP study group: Rare variants in the IL1RAP gene implicate the IL-1 signaling pathway in the pathogenesis of systemic sclerosis in African and European ancestries. ACR annual scientific meeting, Washington DC 2024.

135 GRASP study group: Admixture mapping and gene-based analysis identifies rare variants in genes in the IL-13 and TGF beta signaling pathways in African Americans with systemic sclerosis. ACR annual scientific meeting, Washington DC 2024.

df GRASP study Group: TCR motifs identify unique clones in African Americans with systemic sclerosis ACR annual Scientific meeting, Washington DC 2024.

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26 Last updated: 08/04/2025
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