Payman Zamani, MD, MTR
Assistant Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
Hospital of The University of Pennsylvania
South Pavilion, Floor 11, 11-176
3400 Civic Center Boulevard
Philadelphia, PA 19104
South Pavilion, Floor 11, 11-176
3400 Civic Center Boulevard
Philadelphia, PA 19104
Education:
BA
Dartmouth College, 2001.
MD (Medicine)
Harvard Medical School, 2007.
MTR (Master of Science of Translational Research)
University of Pennsylvania, 2015.
Permanent linkBA
Dartmouth College, 2001.
MD (Medicine)
Harvard Medical School, 2007.
MTR (Master of Science of Translational Research)
University of Pennsylvania, 2015.
Description of Clinical Expertise
Heart Failure with Reduced Ejection FractionHeart Failure with Preserved Ejection Fraction
Exercise
Description of Research Expertise
exerciseSelected Publications
Benyard B, Mathur A, Roy D, Swain A, Kohkhar SK, Soni ND, Wilson N, Haris M, Zamani P, Reddy R, Kumar D: Dual-Breathing CrCEST: A Novel Imaging Method to Distinguish Oxygen Delivery and Utilization in Exercised Muscle. International Society for Magnetic Resonance in Medicine, Cape Town, South Africa May 2026.Vidula MK, Schurgers LJ, Zhao L, Dib MJ, Zhao M, Wang Z, Ebert C, Salman O, Azzo JD, Zamani P, van Empel V, Richards AM, Doughty R, Javaheri A, Mann DL, Rietzschell E, Kammerhoff K, Schafer P, Seiffert DA, Ramirez-Valle F, Cappola TP, Chirinos JA: Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure. Circ Heart Fail 19: e012734, 2026 Notes: DOI: 10.1161/CIRCHEARTFAILURE.124.012734.
Lin KY, Bucha A, McSweeney K, Wade KL, Karaj A, Tamaroff J, O’Malley S, Chung NM, Cilenti NA, Wanner J, Adzika GK, Mesaros C, Rojsajjakul T, Blair IA, Serai S, Farmer J, Bryant K, Harhay MO, Lu Y, Paridon SM, Weber DR, Seifert W, Putt ME, Zamani P, Baur JA, Lynch DR, McCormack SE. : Individualized exercise and NAD+ precursor supplementation in Friedreich’s Ataxia: a randomized controlled trial. Lancet: Neurology 2026 Notes: Accepted for publication, February 2026.
Vajargah KK, Dib MJ, Tavolinejad H, Zamani P, Richards AM, Mann DL, Rietzschel E, van Empel V, Burgess S, Cappola TP, Chirinos JA. : Proteome-Wide Genetic Investigation of Kidney Function in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail Page: 102771, November 2025 Notes: doi: 10.1016/j.jchf.2025.102771.
Saw EL, Werner LD, Cooper H, Pimental DR, Zamani P, Chirinos JA, Valero-Muñoz M, Sam F. : Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction Circ Heart Fail 18(6): e012350, Jun 2025.
Selvaraj S, Karaj A, Chirinos JA, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner SB, Cohen JB, Ischiropoulos H, Rickels MR, Poole DC, Church DD, Wolfe RR, Kelly DP, Putt M, Margulies KB, Zamani P: Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure with Preserved Ejection Fraction. JACC Heart Fail 13(12): 102435, March 2025.
Selvaraj S; Kwee LC; Thompson EJ; He M; Hornik CP; Devore AD; Patel CB; Mentz RJ; Fudim M; Taylor L; Milosovic S; Hurdle M; Cade WT; Ilkayeva O; Muehlbauer MJ; Newgard CB; Kelly DP; Zamani P; Margulies KB; Shah SH: Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF. J Am Coll Cardiol Basic Trans Science 10(3): 290-303, Mar 2025.
Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C, Mohanty I, Miyake MM, Adusumalli S, Margulies KB, Prenner SB, Poole DC, Wilson N, Reddy R, Townsend RR, Ischiropoulos H, Cappola TP, Chirinos JA : Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA Cardiol. 10(3): 284, Mar 2025.
Selvaraj S, Karaj A, Chirinos JA, Denney N, Fernando M, Chambers K, Demastus C, Langham M, Maynard H, Pourmussa B, Prenner SB, Cohen J, Ischiropoulos H, Rickels M, Church D, Wolfe R, Kelly DP, Putt ME, Margulies KB, Zamani P.: FUEL UTILIZATION DURING EXERCISE WITH EXOGENOUS KETONES VERSUS PLACEBO IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: KETO-HFPEF. American College of Cardiology Annual Session, March 29-31, 2025; Chicago, IL. March 2025 Notes: Poster presentation.
Gan S; Azzo JD; Zhao L; Pourmussa B; Dib MJ; Salman O; Erten O; Ebert C; Richards AM; Javaheri A; Mann DL; Rietzschel E; Zamani P; van Empel V; Cappola TP, Chirinos JA: Transferrin Saturation, Serum Iron, and Ferritin in Heart Failure: Prognostic Significance and Proteomic Associations. Circ Heart Fail 18(2): e011728, Feb 2025.