Payman Zamani, MD, MTR
Assistant Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
Hospital of The University of Pennsylvania
South Pavilion, Floor 11, 11-176
3400 Civic Center Boulevard
Philadelphia, PA 19104
South Pavilion, Floor 11, 11-176
3400 Civic Center Boulevard
Philadelphia, PA 19104
Education:
BA
Dartmouth College, 2001.
MD (Medicine)
Harvard Medical School, 2007.
MTR (Master of Science of Translational Research)
University of Pennsylvania, 2015.
Permanent linkBA
Dartmouth College, 2001.
MD (Medicine)
Harvard Medical School, 2007.
MTR (Master of Science of Translational Research)
University of Pennsylvania, 2015.
Description of Clinical Expertise
Heart Failure with Reduced Ejection FractionHeart Failure with Preserved Ejection Fraction
Exercise
Description of Research Expertise
exerciseSelected Publications
Selvaraj S, Karaj A, Chirinos JA, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner SB, Cohen JB, Ischiropoulos H, Rickels MR, Poole DC, Church DD, Wolfe RR, Kelly DP, Putt M, Margulies KB, Zamani P. : Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure with Preserved Ejection Fraction. JACC HF. Elsevier, In Press 2025.Selvaraj S, Karaj A, Chirinos JA, Denney N, Fernando M, Chambers K, Demastus C, Langham M, Maynard H, Pourmussa B, Prenner SB, Cohen J, Ischiropoulos H, Rickels M, Church D, Wolfe R, Kelly DP, Putt ME, Margulies KB, Zamani P.: FUEL UTILIZATION DURING EXERCISE WITH EXOGENOUS KETONES VERSUS PLACEBO IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: KETO-HFPEF. American College of Cardiology Annual Session, March 29-31, 2025; Chicago, IL. March 2025.
Saw EL, Werner LD, Cooper H, Pimental DR, Zamani P, Chirinos JA, Valero-Muñoz M, Sam F. : Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction Circ Heart Fail Epub: e012350, May 2025.
Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C, Mohanty I, Miyake MM, Adusumalli S, Margulies KB, Prenner SB, Poole DC, Wilson N, Reddy R, Townsend RR, Ischiropoulos H, Cappola TP, Chirinos JA : Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA Cardiol. 10(3), Mar 2025.
Dib MJ; Azzo JD; Zhao L; Salman O; Gan S; De Buyzere ML; De Meyer T; Ebert C; Gunawardhana K; Liu L; Gordon D; Seiffert D; Ching-Pin C; Zamani P; Cohen JB; Pourmussa B; Kun S; Gill D; Burgess S; van Empel V; Richards AM; Dennis D; Javaheri A; Mann DL; Cappola TP; Rietzschel E; Chirinos JA: Proteome-Wide Genetic Investigation of Large Artery Stiffness. JACC Basic Transl Sci 9(10): 1178-1191, Aug 2024.
Selvaraj S, He C, Thompson E, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Kwee LC, Taylor L, Milosovic S, Hurdle M, Cade W, Ilkayeva O, Muehlbauer M, Newgard C, Kelly DP, Zamani P, Margulies KB, Shah SH: Metabolic and Pharmacokinetic Profiling of Ketone Ester by Background SGLT2 Inhibitor Therapy in Heart Failure with Reduced Ejection: A Phase I Clinical Trial. American Heart Association Scientific Sessions November 2024.
Selvaraj S; Kwee LC; Thompson EJ; He M; Hornik CP; Devore AD; Patel CB; Mentz RJ; Fudim M; Taylor L; Milosovic S; Hurdle M; Cade WT; Ilkayeva O; Muehlbauer MJ; Newgard CB; Kelly DP; Zamani P; Margulies KB; Shah SH: Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF. J Am Coll Cardiol Basic Trans Science 10(3): 290-303, Mar 2025.
Selvaraj S, Chirinos JA, Putt M, Karaj A, Prenner SB, Cohen JA, Denney N, Gross G, Fernando M, Chambers K, Demastus C, Langham M, Kumar D, Maynard H, Poumussa B, Poole DC, Church DC, Wolfe RR, Margulies KB, Zamani P: Effects Of Exogenous Ketone Therapy On Exercise Capacity In Heart Failure With Preserved Ejection Fraction: KETO-HFpEF. Heart Failure Society of America Annual Session Sept 2024.
Carland C, Azzo JD, Zhao L, Liu L, Gunawardhana K, Ebert C, Zamani P, Van Empel V, Richards M, Rietzschel ER, Javaheri A, Mann DL, Cappola TP, Chirinos JA. : Sex Differences in Plasma Proteomics and Associated Clinical Outcomes in Heart Failure with Reduced Ejection Fraction. American College of Cardiology Annual Scientific Session April 2024 Notes: Atlanta, GA.
Carland C, Zhao L, Salman O, Cohen JB, Zamani P, Xiao Q, Dongre A, Wang Z, Ebert C, Greenawalt D, van Empel V, Richards AM, Doughty RN, Rietzschel E, Javaheri A, Wang Y, Schafer PH, Hersey S, Carayannopoulos LN, Seiffert D, Chang CP, Gordon DA, Ramirez-Valle F, Mann DL, Cappola TP, Chirinos JA. : Urinary Proteomics and Outcomes in Heart Failure with Preserved Ejection Fraction. J Am Heart Assoc. 13(9): e033410, April 2024.